Insights from an academic endeavor into central nervous system drug discovery

Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

Parental Educational Expectations,Academic Pressure,and Adolescent Mental Health:An Empirical Study Based on CEPS Survey Data

Background:This study aimed to investigate the relationship between parental educational expectations and adolescent mental health problems,with academic pressure as a moderating variable.Methods:This study was based on the baseline data of the China Education Panel Survey,which was collected within one school year during 2013–2014.It included 19,958 samples from seventh and ninth graders,who ranged from 11 to 18 years old.After removing missing values and conducting relevant data processing,the effective sample size for analysis was 16344.The OLS(Ordinary Least Squares)multiple linear regression analysis was used to examine the relationship between parental educational expectations,academic pressure,and adolescents’mental health problems.In addition,we established an interaction term between parents’educational expectations and academic pressure to investigate the moderating effect of academic stress.Results:The study found that adolescents whose parents had high educational expectations reported less mental health problems.(β=−0.195;p<0.001).Additionally,adolescents who had high academic pressure reported more mental health problems.(β=0.649;p<0.001).Furthermore,the study found that academic pressure had a significant moderating effect on the relationship between parental educational expectations and adolescents’mental health problems(β=0.082;p<0.001).Conclusion:Parental educational expectations had a close relationship with adolescents’mental health problems,and academic pressure moderated this relationship.For those adolescents with high levels of academic pressure,the association between high parental educational expectations and mental health problems became stronger.On the contrary,for those adolescents with low levels of academic pressure,the association between high parental educational expectations and mental health problems became weaker.These findings shed new light on how parental educational expectations affected adolescent mental health problems and had significant implications for their healthy development.

Ethical Literary Criticism and Overseas Promotion of Chinese Academics

As a new method of literary criticism raised by Chinese scholars,ethical literary criticism has created a theoretical system with Chinese characteristics and become the successful"going global"model of Chinese academics by standing on the Chinese context and adhering to the spirit of not forgetting the origin,absorbing the foreign,and facing the future through more than10 years of advocacy and practice.This paper analyzes and summarizes the inheritance,nationality,integration and innovation of the theory of literary ethical criticism on the basis of combing the development history of ethical literary criticism at home and abroad,and then analyzes four important reasons why ethical literary criticism can successfully represent the"going global"of Chinese academics.This paper also discusses the current situation,problems,solutions,trend and future of ethical literary criticism,and points out that ethical literary criticism provides model and reference for realizing the grand blueprint of the"going global"of Chinese academics.

Chinese Academics Going to the World： A Chinese BlueprintResponding to the Problems in the Age of Neo-globalization

＂The Chinese Communists and the Chinese people are full of confidence to supply the human beings witha Chinese blueprint for the exploration of a better social system.＂ The grand transforming from the old globalizationto the new one serves as a historical field domain for the Chinese blueprint to come on the stage. The neo-Chinesemodernism surpassing the western modern and linear logic has become the essence of the Chinese blueprint aiming atthe great rejuvenation of Chinese nation. The logic of the localization of Marxism in China needs to focus profoundlyon the problems China, hold fast to the Chinese standpoint, gaze at the Chinese field of vision, create Chinese theo-ries and Chinese Discourse, and become the subjective condition of a Chinese blueprint, To compose a Chinese blue-print of ＂a better social system＂, it is necessary that the Chinese academics especially the localized Marxism in Chinashould innovate, adhering to the ＂Four Self-confidences＂, to go to the world creatively, on the base of summarizingconstantly, comprehensively and thoroughly the experience of the exploration for a Chinese Path. The presence of aChinese blueprint signifies a grand transforming of the age of neo-globalization from ＂the world coming to China＂ to＂China going to the world＂, signifies a sharp rise of ＂the community of human destiny＂ in the context of the age ofneo-globalization, signifies a historical undertaking by the localized Marxism in China of the great mission of goingto the world and taking the lead of the human development.

Study on Talent Cultivation Mode and Teaching Methods Reform in Military Academics

Military talents are those who have higher culture and scientific quality, much strong innovation consciousness and thinking ability. The overall objective of military talent training is to cultivate the comprehensive-quality military personnel that meet the requirements of military modernization and preparations for military struggle. In this paper, we construct the military talent training objectives model, and on this basis, we propose the innovative military talent training mode, from the perspective of curriculum content system and talent quality assurance system.

The Influence of Confucius＇ Moral Standards on Wellbeing of Academics in Higher Education in China in the Context of the Chinese Dream

The Chinese Dream, adopted by General Secretary Xi Jinping, was used and spread in China. It is about Chinese prosperity, collective effort, socialism and national glory. It is also about the welfare, wellbeing, and quality of life of every Chinese. Academics in higher education in China are facing changes both across the globe and in China, they must take the challenges. This paper does research on wellbeing of the academics from the aspects of the definition of wellbeing, the situation both in the world and in China, the Chinese concept of happiness, the possible influence of Confucius moral standards on wellbeing of Chinese. This paper may help school leaders implement policies that foster effective work environment in the new era in China.

Thanks to our academic editors and peer reviewers

The Editorial Office of Water Science and Engineering would like to express their sincere appreciation to the academic editors including Prof.Carlo Gualtieri from University of Napoli Federico II,Italy,Prof.Guo-qing Wang and Prof.Zhong-zhi Fu from Nanjing Hydraulic Research Institute,China,and Prof.Yan-hui Ao,Prof.Ching-sheng Huang,Prof.Guang-qiu Jin,Prof.Bin Xu,Prof.Sai-yu Yuan,Prof.Zeng Zhou,Prof.Bo Chen,and Prof Da-wei Guan from Hohai Uiversity,China,for their great effort and contribution to WSE in the year 2023.

Transcultural Validation and Adaptation of the Academic Stress Questionnaire (CEA) in Students of Puerto Rico

Background: There are multiple questionnaires to measure academic stress in university students, which have been used in nursing students. In Puerto Rico, a questionnaire valid in content and reliability was required to measure the variable of academic stress in nursing students. Purpose: The aim of this study was to adapt transculturally and validate the Academic Stress Questionnaire (CEA) for its use in Puerto Rico. Materials and Methods: Used for the first phase of this study consisted in the evaluation of the validity of content and appearance, whereas the second phase was the actual administering of the questionnaire to 20 (twenty) nursing students, to pilot test its internal consistency using the Cronbach’s α test. Results: Validity of content and appearance allowed for the modification of the questionnaire into one, consisting of 42 items, thus eliminating 34 premises from the original 76 items the questionnaire was composed of. Furthermore, the appearance of the questionnaire was modified by placing the measuring scales in columns, adapting social, demographic, and academic data to the required Puerto Rican reality. The sections meant to measure the academic stress variables were left intact, except for the linguistics adaptation, which was accomplished by a team of experts in the Spanish language. With an α global of 0.80 and coefficients larger than 0.7 in the multi-item sub scales, which oscillated between 0.750 and 0.860, the questionnaire provides a high reliability. Conclusion: Although the values reported in this study are somewhat lower than previous research, they were comparable the Cronbach’s Alpha coefficients reported by Cabanach, in which the numbers reported are considered high (α > 0.70) which show acceptable confiability of the subscales included in the study and a high degree of consistency and thus can be relied upon in future research. In synthesis, the Academic Stress Questionnaire (CEA) modified and adapted, thoroughly fulfills the established criteria of confiability and validity to evaluate academic stress of Puertorrican nursing students.

Effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 years.Methods:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,respectively.Outcomes included academic performance(average grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;p<0.001),and balance(d=0.24;p=0.015).There was a trend towards significant benefits for flexibility(d=0.24;p=0.056).No significant benefits were observed for other variables,including psychosocial difficulties,emotional symptoms,hyperactivity/inattention,peer problems,or prosocial behaviour(all p>0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school children.The results support the inclusion of karate during physical education lessons.

How Autonomy Support Environment Influences Student Online Game Addiction:The Mediating Roles of Academic Motivation and Academic Perseverance

Background:Online game addiction has become a serious global public health problem among adolescents.However,its influencing factors and mediating mechanisms remain ambiguous.Methods:The present study adopted stratified random sampling to collect 6146 junior high school student samples in China's Mainland.We used regression analysis,and Bootstrap mediation test through SPSS 26.0 and AMOS 24.0 to reveal the tendency of students’online game addiction with different background characteristics and whether autonomy support from parents and teachers can effectively reduce online game addiction.Results:The results showed that parental(β=−0.112,p<0.001)and teacher(β=−0.225,p<0.001)autonomy support were conducive to reducing students’online game addiction.Academic perseverance(β=−0.080,95%CI=[−0.103,−0.058])and academic motivation(β=−0.073,95%CI=[−0.095,−0.052])partially mediated the relationship between autonomy support and online game addiction.Conclusion:This result provides a theoretical basis for educational interventions.It suggests that strengthening autonomy support could enhance students’academic perseverance and motivation and further reduce online game addiction.This study utilized a cross-sectional research design,making it difficult to determine the causal relationship between autonomy support environment and online game addiction.

Ranking academic institutions based on the productivity,impact,and quality of institutional scholars

Purpose:The quantitative rankings of over 55,000 institutions and their institutional programs are based on the individual rankings of approximately 30 million scholars determined by their productivity,impact,and quality.Design/methodology/approach:The institutional ranking process developed here considers all institutions in all countries and regions,thereby including those that are established,as well as those that are emerging in scholarly prowess.Rankings of individual scholars worldwide are first generated using the recently introduced,fully indexed ScholarGPS database.The rankings of individual scholars are extended here to determine the lifetime and last-five-year Top 20 rankings of academic institutions over all Fields of scholarly endeavor,in 14 individual Fields,in 177 Disciplines,and in approximately 350,000 unique Specialties.Rankings associated with five specific Fields(Medicine,Engineering&Computer Science,Life Sciences,Physical Sciences&Mathematics,and Social Sciences),and in two Disciplines(Chemistry,and Electrical&Computer Engineering)are presented as examples,and changes in the rankings over time are discussed.Findings:For the Fields considered here,the Top 20 institutional rankings in Medicine have undergone the least change(lifetime versus last five years),while the rankings in Engineering&Computer Science have exhibited significant change.The evolution of institutional rankings over time is largely attributed to the recent emergence of Chinese academic institutions,although this emergence is shown to be highly Field-and Discipline-dependent.Practical implementations:Existing rankings of academic institutions have:(i)often been restricted to pre-selected institutions,clouding the potential discovery of scholarly activity in emerging institutions and countries;(ii)considered only broad areas of research,limiting the ability of university leadership to act on the assessments in a concrete manner,or in contrast;(iii)have considered only a narrow area of research for comparison,diminishing the broader applicability and impact of the assessment.In general,existing institutional rankings depend on which institutions are included in the ranking process,which areas of research are considered,the breadth(or granularity)of the research areas of interest,and the methodologies used to define and quantify research performance.In contrast,the methods presented here can provide important data over a broad range of granularity to allow responsible individuals to gauge the performance of any institution from the Overall(all Fields)level,to the level of the Specialty.The methods may also assist identification of the root causes of shifts in institution rankings,and how these shifts vary across hundreds of thousands of Fields,Disciplines,and Specialties of scholarly endeavor.Originality/value:This study provides the first ranking of all academic institutions worldwide over Fields,Disciplines,and Specialties based on a unique methodology that quantifies the productivity,impact,and quality of individual scholars.

The Impact of Sleep Patterns on Academic Performance and Social Integration among Medical Students

Introduction: The impact of sleep on student life is crucial, particularly for those in demanding fields such as medicine. This study examines the relationships between sleep patterns, academic performance, and social integration among medical students, who often face irregular sleep cycles and sleep deprivation due to rigorous academic demands. Aim: This study aims to assess how sleep issues affect academic achievement and social relationships among medical students. Method: Data were collected from 215 medical students through surveys and academic records. Quantitative data provided insights into sleep quality and academic performance, while qualitative interviews explored the effects of sleep on social interactions. Results: The findings revealed a significant correlation between sleep quality and academic performance, with students reporting better sleep hygiene achieving higher grades. Qualitative data indicated that poor sleep negatively impacts social interactions, leading to feelings of isolation and reduced social participation. Conclusions: The study highlights the importance of promoting good sleep practices in medical schools to enhance academic success and social well-being. Interventions aimed at improving sleep quality may help reduce burnout and improve overall well-being among medical students. Future research should focus on longitudinal studies to better understand the long-term effects of sleep on academic and social outcomes in this population.

The Risk Role of Defeat on the Mental Health of College Students:A Moderated Mediation Effect of Academic Stress and Interpersonal Relationships

Background:College students face significant academic and physiological changes,making them more susceptible to psychological issues such as depression,self-injury,and suicidal ideation.Feelings of defeat can exacerbate these risks by increasing academic stress.However,interpersonal relationships can moderate the impact of academic stress on students’mental health.Utilizing the presage–process–product model,this study aims to empirically investigate how feelings of defeat influence depression,self-injury,and suicidal ideation among college students.Additionally,it explores the mediating role of academic stress and the moderating role of various types of interpersonal relationships.Methods:A total of 1612 college students(750 females,862 males,mean age=19.64±0.62 years)were recruited through cluster sampling.Data were collected via offline questionnaires administered by a trained psychology teacher and a postgraduate student,ensuring high reliability with two examiners per class.Latent profile analysis(LPA)was used to examine the impact of defeat on mental health outcomes,while mediation analysis was conducted to assess the roles of academic stress and interpersonal relationships.Results:1.Defeat is identified as a significant risk factor for mental health issues among college students;2.Four distinct patterns of interpersonal relationships were identified:the interpersonal-relationship risk group,the father–child-relationship high-risk group,the general interpersonal-relationship group,and the superior interpersonal-relationship group;3.Academic stress partially mediates the relationship between defeat and mental health issues such as depression,self-injury,and suicidal ideation;4.Different interpersonal relationship models moderate the impact of academic stress on depression and suicidal ideation.Conclusion:Defeat is a significant risk factor for mental health problems in college students.Academic stress partially mediates the negative impact of defeat on mental health,while patterns of interpersonal relationships moderate this impact.Effective early prevention and intervention should focus on monitoring students’stress levels and fostering warm,positive parent–child relationships.

International academic symposium of ISO/TC 312 held in Beijing

The international academic symposium of ISO/TC 312, Excellence in ser vice, was held in Beijing on February 27, which was a part of the 11th plenary meeting of the committee. Directed by SAC, organized by China National Institute of Standardization(CNIS), and supported by China Association for Standardization(CAS) and China Civil Airports Association(CCAA), the symposium was attended by over 20,000 representatives in hybrid forms.

Analysis on the Translation Methods of the Reported Speech in German Academic Papers-Taking the Translation of“Die Internationalisierung der deutschen Hochschulen”as an Example

Reporting is essential in language use,including the re-expression of other people’s or self’s words,opinions,psychological activities,etc.Grasping the translation methods of reported speech in German academic papers is very important to improve the accuracy of academic paper translation.This study takes the translation of“Internationalization of German Universities”(Die Internationalisierung der deutschen Hochschulen),an academic paper of higher education,as an example to explore the translation methods of reported speech in German academic papers.It is found that the use of word order conversion,part of speech conversion and split translation methods can make the translation more accurate and fluent.This paper helps to grasp the rules and characteristics of the translation of reported speech in German academic papers,and also provides a reference for improving the quality of German-Chinese translation.

Forecasting the Academic Performance by Leveraging Educational Data Mining

The study aims to recognize how efficiently Educational DataMining(EDM)integrates into Artificial Intelligence(AI)to develop skills for predicting students’performance.The study used a survey questionnaire and collected data from 300 undergraduate students of Al Neelain University.The first step’s initial population placements were created using Particle Swarm Optimization(PSO).Then,using adaptive feature space search,Educational Grey Wolf Optimization(EGWO)was employed to choose the optimal attribute combination.The second stage uses the SVMclassifier to forecast classification accuracy.Different classifiers were utilized to evaluate the performance of students.According to the results,it was revealed that AI could forecast the final grades of students with an accuracy rate of 97%on the test dataset.Furthermore,the present study showed that successful students could be selected by the Decision Tree model with an efficiency rate of 87.50%and could be categorized as having equal information ratio gain after the semester.While the random forest provided an accuracy of 28%.These findings indicate the higher accuracy rate in the results when these models were implemented on the data set which provides significantly accurate results as compared to a linear regression model with accuracy(12%).The study concluded that the methodology used in this study can prove to be helpful for students and teachers in upgrading academic performance,reducing chances of failure,and taking appropriate steps at the right time to raise the standards of education.The study also motivates academics to assess and discover EDM at several other universities.

Managing Homework-Related Stress:Strategies for Balancing Academic Demands and Mental Well-Being in Students

This paper examines the growing issue of homework-related stress among students,focusing on the impact of academic demands,parental expectations,and social comparisons on students’mental health.While homework serves as an important educational tool,its excessive volume and pressure can lead to psychological issues such as anxiety,depression,and burnout.Parental involvement,although beneficial,can heighten stress when coupled with unrealistic expectations.Additionally,social media exacerbates these pressures by promoting comparisons and idealized standards.The paper proposes a holistic approach,involving educators,parents,and students,to mitigate these stressors.Key strategies include assigning meaningful homework,fostering open communication,teaching time management skills,and encouraging a balance between academic success and mental well-being.By addressing homework-related stress,students can be supported in achieving both academic and personal success while maintaining their mental health.

Academic Stress Assessment Using Virtual Reality as an Educational Tool in Spine Surgery

Introduction: The evaluation of academic stress in medical students and residents is a topic of significant interest, given the considerable challenges they face during their learning process with traditional teaching methods. The use of technologies like virtual reality presents an opportunity to enhance their skills through simulations and training. The main objective of this study is to qualitatively assess the stress levels experienced by medical students and residents by integrating virtual reality into their current learning methods, aiming to improve their ability to manage stressors in their practice. Material and Methods: A questionnaire was conducted with 12 medical students and 12 Traumatology and orthopedics residents. The purpose of the questionnaire was to evaluate the levels of academic stress using the SISCO inventory. The stress levels were calculated by transforming average values into percentages, and the following criteria were assigned: 0 to 33% for Mild Stress, 34 to 66% for Moderate Stress, and 67 to 100% for Deep Stress. Then, a virtual reality class focused on spine surgery was provided. Both medical students and residents were trained using the Non Nocere SharpSurgeon software platform and Oculus Quest 2 virtual reality glasses. At the end of the session, a second questionnaire related to the practice with virtual reality was conducted with the same evaluation criteria and a comparative analysis was carried out. Results: 12 undergraduate students from Hospital Angeles Mexico, CDMX and 12 traumatology and orthopedics residents at Hospital Santa Fe, Bogota were evaluated. The students in CDMX reported an average qualitative stress of 28.50% during habitual practices, which decreased to an average of 14.67% after virtual reality practice. Residents in Bogotá experienced an average qualitative stress of 30.50% with their current learning methods but this reduced to an average of 13.92% after using virtual reality. These findings indicate that the use of virtual reality has a positive impact on reducing stress levels qualitatively. Conclusions: The use of virtual reality as a learning method for medical students and residents qualitatively improves stress levels. Further studies are required to define the potential uses of Virtual Reality to improve learning methods and emotional state in medical students and residents and for a quantitative assessment to validate the training as certified learning methods.

通用学术词表Academic Vocabulary List(AVL)修订述略

学术英语词汇是学术英语教学的重点和难点,不同时代和学科曾编写过各类学术词表。加德纳和戴维斯(2014)基于学术语料容量达1.2亿的COCA语料库推出学术词表Academic Vocabulary List(AVL),该词表在学术英语教学和研究中得到广泛应用。然而实践表明,AVL词表收录的3015个词元存在词汇重复、以词元为单位排列的词表和以词族为单位排列的词表不相吻合等问题。本研究尝试以科学性原则、适切性原则、时效性原则为指导,基于AVL词表原有的比率、分布、离散度、学科指数四条选词标准,增加最低频次和经验判断两条新标准对AVL词表予以完善和修订。完善修订后的AVL词表由先前的1991个词族、3015个词元缩减至709个词族1715个词元,较修订前更具简洁性和高效性。希望依据3项原则和6项标准所做的修订为学术英语教与学以及学术英语教材编写和选用带来新的参考。