Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of pre...Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of presence and help users achieve better performance in tasks such as searching and training.In the upcoming metaverse era,locomotion will play a critical role in the success of large-scale interactive applications.Perception and redirection are two tightly connected problems in virtual locomotion.Given a limited physical condition and a target virtual scene,how to make the perceived locomotion as natural as possible,and further unknowingly redirect the user in the physical world is an open question.In this special issue,we have selected five papers that provide their latest updates for research problems of view control,virtual jumping,climbing,and searching.展开更多
To enhance user perceived performance,Akamai' s content distribution network(CDN) utilizes the domain name system(DNS) effectively to redirect users to close-by content replicas over short time scale.The use of DN...To enhance user perceived performance,Akamai' s content distribution network(CDN) utilizes the domain name system(DNS) effectively to redirect users to close-by content replicas over short time scale.The use of DNS redirection has brought a significant advantage to Akamai' s CDN.However,the reliance on DNS also poses a fundamental threat to Akamai' s content distribution model.In particular,systematic evaluation and quantification illustrates the impact of recent emerging public DNS resolving services on Akamai' s CDN,including the degradation of corresponding user perceived performance and the benefit damnification of collaborating internet services providers(ISPs) that host Akamai's edge servers.The measurement demonstrates that a considerable penetration of public DNS resolving services(e.g.,OpenDNS and GoogleDNS) effectively corrupts the Akamai' s serving model,namely the large-scale server distribution and quick DNS redirection.展开更多
Background When a user walks freely in an unknown virtual scene and searches for multiple dynamic targets,the lack of a comprehensive understanding of the environment may have a negative impact on the execution of vir...Background When a user walks freely in an unknown virtual scene and searches for multiple dynamic targets,the lack of a comprehensive understanding of the environment may have a negative impact on the execution of virtual reality tasks.Previous studies can help users with auxiliary tools,such as top view maps or trails,and exploration guidance,for example,automatically generated paths according to the user location and important static spots in virtual scenes.However,in some virtual reality applications,when the scene has complex occlusions,and the user cannot obtain any real-time position information of the dynamic target,the above assistance cannot help the user complete the task more effectively.Methods We design a virtual camera priority-based assistance to help the user search dynamic targets efficiently.Instead of forcing users to go to destinations,we provide an optimized instant path to guide them to places where they are more likely to find dynamic targets when they ask for help.We assume that a certain number of virtual cameras are fixed in virtual scenes to obtain extra depth maps,which capture the depth information of the scene and the locations of the dynamic targets.Our method automatically analyzes the priority of these virtual cameras,chooses the destination,and generates an instant path to assist the user in finding the dynamic targets.Our method is suitable for various virtual reality applications that do not require manual supervision or input.Results A user study is designed to evaluate the proposed method.The results indicate that compared with three conventional navigation methods,such as the top-view method,our method can help users find dynamic targets more efficiently.The advantages include reducing the task completion time,reducing the number of resets,increasing the average distance between resets,and reducing user task load.Conclusions We presented a method for improving dynamic target searching efficiency in virtual scenes by virtual camera priority-based path guidance.Compared with three conventional navigation methods,such as the top-view method,this method can help users find dynamic targets more effectively.展开更多
Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imper...Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imperceptible manipulation gains in RDJ was discussed in an empty virtual environment(VE).Methods In this study,we conducted three tasks to investigate the influence of alley width on the detection threshold of jump redirection in a VE.Results The results demonstrated that the imperceptible distance gain range in RDJ was not associated with the width of the alleys.The imperceptible height and rotation gain ranges in RDJ are related to the width of the alleys.Conclusions We preliminarily summarized the relationship between the occlusion distance and manipulation range of the three gains in a complex environment.Simultaneously,the guiding principle for choosing three gains in RDJ according to the occlusion distance in a complex environment is provided.展开更多
Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the p...Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the problem of limited physical space in VR applications.Previous RDJ studies have mainly focused on detection threshold estimation.However,the effect VE or self representation(SR)has on the perception or performance of RDJs remains unclear.Methods In this paper,we report experiments to measure the perception(detection thresholds for gains,presence,embodiment,intrinsic motivation,and cybersickness)and physical performance(heart rate intensity,preparation time,and actual jumping distance)of redirected forward jumping under six different combinations of VE(low and high visual richness)and SRs(invisible,shoes,and human-like).Results Our results indicated that the detection threshold ranges for horizontal translation gains were significantly smaller in the VE with high rather than low visual richness.When different SRs were applied,our results did not suggest significant differences in detection thresholds,but it did report longer actual jumping distances in the invisible body case compared with the other two SRs.In the high visual richness VE,the preparation time for jumping with a human-like avatar was significantly longer than that with other SRs.Finally,some correlations were found between perception and physical performance measures.Conclusions All these findings suggest that both VE and SRs influence users'perception and performance in RDJ and must be considered when designing locomotion techniques.展开更多
DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address t...DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address this issue, encouraging progress has been made in both industry and research communities. In this article,state-of- art solutions for the remote DNS problem are discussed at first. Next, privacy concerns about DNS-based CDNs, including client location as well as redirection privacy, are identified and a representative solution is summarized. Finally, the solution is compared to those in prior works under different measures, and a discussion on DNS-based CDN applications is provided. A model is also established to deepen the underst;anding of CDN performance. We believe that this survey will shed light on the application of DNS-based CDNs, and it is expected to provide design guidelines to CDN service providers.展开更多
Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do t...Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.展开更多
Background In virtual environments(VEs),users can explore a large virtual scene through the viewpoint operation of a head-mounted display(HMD)and movement gains combined with redirected walking technology.The existing...Background In virtual environments(VEs),users can explore a large virtual scene through the viewpoint operation of a head-mounted display(HMD)and movement gains combined with redirected walking technology.The existing redirection methods and viewpoint operations are effective in the horizontal direction;however,they cannot help participants experience immersion in the vertical direction.To improve the immersion of upslope walking,this study presents a virtual climbing system based on passive haptics.Methods This virtual climbing system uses the tactile feedback provided by sponges,a commonly used flexible material,to simulate the tactile sense of a user's soles.In addition,the visual stimulus of the HMD,the tactile feedback of the flexible material,and the operation of the user's walking in a VE combined with redirection technology are all adopted to enhance the user's perception in a VE.In the experiments,a physical space with a hard-flat floor and three types of sponges with thicknesses of 3,5,and 8cm were utilized.Results We recruited 40 volunteers to conduct these experiments,and the results showed that a thicker flexible material increases the difficulty for users to roam and walk within a certain range.Conclusion The virtual climbing system can enhance users'perception of upslope walking in a VE.展开更多
T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T...T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.展开更多
Due to its advantages of universality, flexibility and high performance, fast Ethernet is widely used in readout system design for modern particle physics experiments. However, Ethernet is usually used together with t...Due to its advantages of universality, flexibility and high performance, fast Ethernet is widely used in readout system design for modern particle physics experiments. However, Ethernet is usually used together with the TCP/IP protocol stack, which makes it difficult to implement readout systems because designers have to use the operating system to process this protocol. Furthermore, TCP/IP degrades the transmission efficiency and real-time performance. To maximize the performance of Ethernet in physics experiment applications, a data readout method based on the physical layer(PHY) is proposed. In this method, TCP/IP is replaced with a customized and simple protocol, which makes it easier to implement. On each readout module, data from the front-end electronics is first fed into an FPGA for protocol processing and then sent out to a PHY chip controlled by this FPGA for transmission.This kind of data path is fully implemented by hardware. From the side of the data acquisition system(DAQ),however, the absence of a standard protocol causes problems for the network related applications. To solve this problem, in the operating system kernel space, data received by the network interface card is redirected from the traditional flow to a specified memory space by a customized program. This memory space can easily be accessed by applications in user space. For the purpose of verification, a prototype system has been designed and implemented.Preliminary test results show that this method can meet the requirements of data transmission from the readout module to the DAQ with an efficient and simple manner.展开更多
Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in ord...Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.展开更多
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL tow...Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.展开更多
Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.How...Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.However,the limited physical tracking space usually restricts the exploration of large virtual spaces,and VR users have to use special locomotion techniques to move from one location to another.Among these techniques,redirected walking(RDW)is one of the most natural locomotion techniques to solve the problem based on near-natural walking experiences.The core idea of the RDW technique is to imperceptibly guide users on virtual paths,which might vary from the paths they physically walk in the real world.In a similar way,some RDW algorithms imperceptibly change the structure and layout of the virtual environment such that the virtual environment fits into the tracking space.In this survey,we first present a taxonomy of existing RDW work.Based on this taxonomy,we compare and analyze both contributions and shortcomings of the existing methods in detail,and find view manipulation methods offer satisfactory visual effect but the experience can be interrupted when users reach the physical boundaries,while virtual environment manipulation methods can provide users with consistent movement but have limited application scenarios.Finally,we discuss possible future research directions,indicating combining artificial intelligence with this area will be effective and intriguing.展开更多
With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenz...With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,developed a type of CRISPR-based riboswitch,which was published in Nature Methods(2016,doi:10.展开更多
ip redirect用于数据包的重定向并向源发送一个ICMP信息:假设一个局域网中有两台路由器,R1和R2,同时该LAN中有一台PC,该PC的缺省网关为为R1,当PC要访问A网段时,将数据包转发到R1,R1检测到到达A网段将路由到R2,所以将数据从以太口返回,...ip redirect用于数据包的重定向并向源发送一个ICMP信息:假设一个局域网中有两台路由器,R1和R2,同时该LAN中有一台PC,该PC的缺省网关为为R1,当PC要访问A网段时,将数据包转发到R1,R1检测到到达A网段将路由到R2,所以将数据从以太口返回,并转发到R2出去,同时向PC发送ICMP信息,告诉它以后将到达A网段的数据发往R2出去。展开更多
As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehen...As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in VR.RDW addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained areas.The survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable space.Various RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual disturbances.Furthermore,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR interactions.The practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior patterns.Through a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry professionals.It underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and entertainment.The paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.展开更多
文摘Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of presence and help users achieve better performance in tasks such as searching and training.In the upcoming metaverse era,locomotion will play a critical role in the success of large-scale interactive applications.Perception and redirection are two tightly connected problems in virtual locomotion.Given a limited physical condition and a target virtual scene,how to make the perceived locomotion as natural as possible,and further unknowingly redirect the user in the physical world is an open question.In this special issue,we have selected five papers that provide their latest updates for research problems of view control,virtual jumping,climbing,and searching.
基金Supported by the National Basic Research Program of China(No.2013CB329103)the National Natural Science Foundation of China(No.61133016,61300191)+1 种基金the National High Technology Joint Research Program of China(No.2011AA010706)the Program of SichuanProvince Applied and Basic Research(No.2013JY0116)
文摘To enhance user perceived performance,Akamai' s content distribution network(CDN) utilizes the domain name system(DNS) effectively to redirect users to close-by content replicas over short time scale.The use of DNS redirection has brought a significant advantage to Akamai' s CDN.However,the reliance on DNS also poses a fundamental threat to Akamai' s content distribution model.In particular,systematic evaluation and quantification illustrates the impact of recent emerging public DNS resolving services on Akamai' s CDN,including the degradation of corresponding user perceived performance and the benefit damnification of collaborating internet services providers(ISPs) that host Akamai's edge servers.The measurement demonstrates that a considerable penetration of public DNS resolving services(e.g.,OpenDNS and GoogleDNS) effectively corrupts the Akamai' s serving model,namely the large-scale server distribution and quick DNS redirection.
基金National Key R&D plan(2019YFC1521102)the National Natural Science Foundation of China(61932003,61772051,62172437)+2 种基金the Beijing Natural Science Foundation(L182016)the Beijing Program for International S&T Cooperation(Z191100001619003)the funding of Shenzhen Research Institute of Big Data(Shenzhen 518000).
文摘Background When a user walks freely in an unknown virtual scene and searches for multiple dynamic targets,the lack of a comprehensive understanding of the environment may have a negative impact on the execution of virtual reality tasks.Previous studies can help users with auxiliary tools,such as top view maps or trails,and exploration guidance,for example,automatically generated paths according to the user location and important static spots in virtual scenes.However,in some virtual reality applications,when the scene has complex occlusions,and the user cannot obtain any real-time position information of the dynamic target,the above assistance cannot help the user complete the task more effectively.Methods We design a virtual camera priority-based assistance to help the user search dynamic targets efficiently.Instead of forcing users to go to destinations,we provide an optimized instant path to guide them to places where they are more likely to find dynamic targets when they ask for help.We assume that a certain number of virtual cameras are fixed in virtual scenes to obtain extra depth maps,which capture the depth information of the scene and the locations of the dynamic targets.Our method automatically analyzes the priority of these virtual cameras,chooses the destination,and generates an instant path to assist the user in finding the dynamic targets.Our method is suitable for various virtual reality applications that do not require manual supervision or input.Results A user study is designed to evaluate the proposed method.The results indicate that compared with three conventional navigation methods,such as the top-view method,our method can help users find dynamic targets more efficiently.The advantages include reducing the task completion time,reducing the number of resets,increasing the average distance between resets,and reducing user task load.Conclusions We presented a method for improving dynamic target searching efficiency in virtual scenes by virtual camera priority-based path guidance.Compared with three conventional navigation methods,such as the top-view method,this method can help users find dynamic targets more effectively.
基金the National Natural Science Foundation of China(619320061772051).
文摘Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imperceptible manipulation gains in RDJ was discussed in an empty virtual environment(VE).Methods In this study,we conducted three tasks to investigate the influence of alley width on the detection threshold of jump redirection in a VE.Results The results demonstrated that the imperceptible distance gain range in RDJ was not associated with the width of the alleys.The imperceptible height and rotation gain ranges in RDJ are related to the width of the alleys.Conclusions We preliminarily summarized the relationship between the occlusion distance and manipulation range of the three gains in a complex environment.Simultaneously,the guiding principle for choosing three gains in RDJ according to the occlusion distance in a complex environment is provided.
基金the National Natural Science Foundation of China(61902012)the Young Talents Support Project of China Association for Science and Technology.
文摘Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the problem of limited physical space in VR applications.Previous RDJ studies have mainly focused on detection threshold estimation.However,the effect VE or self representation(SR)has on the perception or performance of RDJs remains unclear.Methods In this paper,we report experiments to measure the perception(detection thresholds for gains,presence,embodiment,intrinsic motivation,and cybersickness)and physical performance(heart rate intensity,preparation time,and actual jumping distance)of redirected forward jumping under six different combinations of VE(low and high visual richness)and SRs(invisible,shoes,and human-like).Results Our results indicated that the detection threshold ranges for horizontal translation gains were significantly smaller in the VE with high rather than low visual richness.When different SRs were applied,our results did not suggest significant differences in detection thresholds,but it did report longer actual jumping distances in the invisible body case compared with the other two SRs.In the high visual richness VE,the preparation time for jumping with a human-like avatar was significantly longer than that with other SRs.Finally,some correlations were found between perception and physical performance measures.Conclusions All these findings suggest that both VE and SRs influence users'perception and performance in RDJ and must be considered when designing locomotion techniques.
文摘DNS-based server redirecting is considered the most popular means of deploying CDNs. However, with the inaeasing use of i"emol:e DNS, DNS-based CDNs face a great challenge in performance degradation. To address this issue, encouraging progress has been made in both industry and research communities. In this article,state-of- art solutions for the remote DNS problem are discussed at first. Next, privacy concerns about DNS-based CDNs, including client location as well as redirection privacy, are identified and a representative solution is summarized. Finally, the solution is compared to those in prior works under different measures, and a discussion on DNS-based CDN applications is provided. A model is also established to deepen the underst;anding of CDN performance. We believe that this survey will shed light on the application of DNS-based CDNs, and it is expected to provide design guidelines to CDN service providers.
文摘Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.
基金the National Key R&D Program of China(2018YFB1404100)National Natural Science Foundation of China(62072405)Zhejiang Provincial Natural Science Foundation of China(LGF20F020017).
文摘Background In virtual environments(VEs),users can explore a large virtual scene through the viewpoint operation of a head-mounted display(HMD)and movement gains combined with redirected walking technology.The existing redirection methods and viewpoint operations are effective in the horizontal direction;however,they cannot help participants experience immersion in the vertical direction.To improve the immersion of upslope walking,this study presents a virtual climbing system based on passive haptics.Methods This virtual climbing system uses the tactile feedback provided by sponges,a commonly used flexible material,to simulate the tactile sense of a user's soles.In addition,the visual stimulus of the HMD,the tactile feedback of the flexible material,and the operation of the user's walking in a VE combined with redirection technology are all adopted to enhance the user's perception in a VE.In the experiments,a physical space with a hard-flat floor and three types of sponges with thicknesses of 3,5,and 8cm were utilized.Results We recruited 40 volunteers to conduct these experiments,and the results showed that a thicker flexible material increases the difficulty for users to roam and walk within a certain range.Conclusion The virtual climbing system can enhance users'perception of upslope walking in a VE.
基金supported by the National Natural Science Foundation of China(Nos.32070940 and 81991491)the China Postdoctoral Science Foundation(No.2021M700115)+2 种基金the Postdoctoral Innovation Talents Support Program(No.BX20220189,China)the Science and Technology Planning Project of Fujian Province(No.2022L3080,China)the CAMS Innovation Fund for Medical Sciences(No.2019RU022,China).
文摘T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.
基金Supported by National Natural Science Foundation of China(11005107)Independent Projects of State Key Laboratory of Particle Detection and Electronics(201301)
文摘Due to its advantages of universality, flexibility and high performance, fast Ethernet is widely used in readout system design for modern particle physics experiments. However, Ethernet is usually used together with the TCP/IP protocol stack, which makes it difficult to implement readout systems because designers have to use the operating system to process this protocol. Furthermore, TCP/IP degrades the transmission efficiency and real-time performance. To maximize the performance of Ethernet in physics experiment applications, a data readout method based on the physical layer(PHY) is proposed. In this method, TCP/IP is replaced with a customized and simple protocol, which makes it easier to implement. On each readout module, data from the front-end electronics is first fed into an FPGA for protocol processing and then sent out to a PHY chip controlled by this FPGA for transmission.This kind of data path is fully implemented by hardware. From the side of the data acquisition system(DAQ),however, the absence of a standard protocol causes problems for the network related applications. To solve this problem, in the operating system kernel space, data received by the network interface card is redirected from the traditional flow to a specified memory space by a customized program. This memory space can easily be accessed by applications in user space. For the purpose of verification, a prototype system has been designed and implemented.Preliminary test results show that this method can meet the requirements of data transmission from the readout module to the DAQ with an efficient and simple manner.
基金This workis supported by Natural Science Foundation of Jiangsu Province (BK2004218 ,BK2003106) Pandeng Project of Nanjing Universities of Postsand Telecommunications.
文摘Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.
文摘Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
基金the National Natural Science Foundation of China under Grant Nos.61902012 and 61932003Frank Steinicke was supported by funds from the BMBF,BMWi,DFG,and EU.
文摘Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.However,the limited physical tracking space usually restricts the exploration of large virtual spaces,and VR users have to use special locomotion techniques to move from one location to another.Among these techniques,redirected walking(RDW)is one of the most natural locomotion techniques to solve the problem based on near-natural walking experiences.The core idea of the RDW technique is to imperceptibly guide users on virtual paths,which might vary from the paths they physically walk in the real world.In a similar way,some RDW algorithms imperceptibly change the structure and layout of the virtual environment such that the virtual environment fits into the tracking space.In this survey,we first present a taxonomy of existing RDW work.Based on this taxonomy,we compare and analyze both contributions and shortcomings of the existing methods in detail,and find view manipulation methods offer satisfactory visual effect but the experience can be interrupted when users reach the physical boundaries,while virtual environment manipulation methods can provide users with consistent movement but have limited application scenarios.Finally,we discuss possible future research directions,indicating combining artificial intelligence with this area will be effective and intriguing.
文摘With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,developed a type of CRISPR-based riboswitch,which was published in Nature Methods(2016,doi:10.
基金supported by the National Key Research and Development Program of China under Grant No.2023YFF0905104the National Natural Science Foundation of China under Grant No.62361146854Tsinghua-Tencent Joint Laboratory for Internet Innovation Technology.
文摘As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in VR.RDW addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained areas.The survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable space.Various RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual disturbances.Furthermore,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR interactions.The practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior patterns.Through a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry professionals.It underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and entertainment.The paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.