目的:探讨弯钳撬拔术在股骨近端髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗难复性股骨粗隆间骨折中的应用效果。方法:选择2021年6月—2023年5月在罗定市中医院接受手术治疗的难复性股骨粗隆间骨折患者144例,用随机数...目的:探讨弯钳撬拔术在股骨近端髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗难复性股骨粗隆间骨折中的应用效果。方法:选择2021年6月—2023年5月在罗定市中医院接受手术治疗的难复性股骨粗隆间骨折患者144例,用随机数字表法将患者分为对照组(n=72,接受切开复位PFNA内固定治疗)、观察组(n=72,接受弯钳撬拔PFNA内固定治疗)。对比两组手术基本情况、骨折愈合情况、髋关节功能评分、并发症发生情况。结果:两组手术时间比较,差异无统计学意义(P>0.05);观察组术中出血量较对照组少,差异有统计学意义(P<0.05)。观察组术后住院时间、负重开始时间、骨折愈合时间均较对照组短,差异均有统计学意义(P<0.05)。术后6个月,观察组髋关节功能评分较对照组高,差异有统计学意义(P<0.05)。两组术后6个月的髋关节功能优良率比较,差异无统计学意义(P>0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:弯钳撬拔PFNA内固定治疗难复性股骨粗隆间骨折较切开复位PFNA内固定治疗更具优势,在促进术后骨折愈合、恢复患侧髋关节功能方面的作用均较理想,且不会增加并发症,是一种优质的手术模式。展开更多
Chronic wounds are wounds that cannot heal properly due to various factors,such as underlying diseases,infection or reinjury,and improper healing of skin wounds and ulcers can cause a serious economic burden.Numerous ...Chronic wounds are wounds that cannot heal properly due to various factors,such as underlying diseases,infection or reinjury,and improper healing of skin wounds and ulcers can cause a serious economic burden.Numerous studies have shown that extracellular vesicles(EVs)derived from stem/progenitor cells promote wound healing,reduce scar formation and have significant advantages over traditional treatment methods.EVs are membranous particles that carry various bioactive molecules from their cellular origins,such as cytokines,nucleic acids,enzymes,lipids and proteins.EVs can mediate cell-to-cell communication and modulate various physiological processes,such as cell differentiation,angiogenesis,immune response and tissue remodelling.In this review,we summarize the recent advances in EV-based wound healing,focusing on the signalling pathways that are regulated by EVs and their cargos.We discuss how EVs derived from different types of stem/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt/β-catenin,phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin,vascular endothelial growth factor,transforming growth factorβand JAK-STAT pathways.Moreover,we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.展开更多
BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic...BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.展开更多
BACKGROUND Patients with keloids who receive radiotherapy(RT)after surgery can develop refractory wounds that cannot be healed by the patient's own repair system.Such chronic wounds are uneven and complex due to p...BACKGROUND Patients with keloids who receive radiotherapy(RT)after surgery can develop refractory wounds that cannot be healed by the patient's own repair system.Such chronic wounds are uneven and complex due to persistent abscess and ulceration.Without external intervention,they can easily result in local tissue necrosis or,in severe cases,large area tissue resection,amputation,and even death.CASE SUMMARY This article describes the use of hydrogen to treat a 42-year-old female patient with a chronic wound on her left shoulder.The patient had a skin graft that involved implanting a dilator under the skin of her left shoulder,and then transferring excess skin from her shoulder onto scar tissue on her chest.The skin grafting was followed by two rounds of RT,after which the shoulder wound had difficulty healing.For six months,the patient was treated with 2 h of hydrogen inhalation(HI)therapy per day,in addition to application of sterile gauze on the wound and periodic debridement.We also performed one deep,large,sharp debridement to enlarge the wound area.The wound healed completely within 6 mo of beginning the HI treatment.CONCLUSION After HI therapy,the patient showed superior progress in reepithelialization and wound repair,with eventual wound closure in 6 mo,in comparison with the previous failures of hyperbaric oxygen and recombinant bovine basic fibroblast growth factor therapies.Our work showed that HI therapy could be a new strategy for wound healing that is cleaner,more convenient,and less expensive than other therapies,as well as easily accessible for further application in clinical wound care.展开更多
文摘目的:探讨弯钳撬拔术在股骨近端髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗难复性股骨粗隆间骨折中的应用效果。方法:选择2021年6月—2023年5月在罗定市中医院接受手术治疗的难复性股骨粗隆间骨折患者144例,用随机数字表法将患者分为对照组(n=72,接受切开复位PFNA内固定治疗)、观察组(n=72,接受弯钳撬拔PFNA内固定治疗)。对比两组手术基本情况、骨折愈合情况、髋关节功能评分、并发症发生情况。结果:两组手术时间比较,差异无统计学意义(P>0.05);观察组术中出血量较对照组少,差异有统计学意义(P<0.05)。观察组术后住院时间、负重开始时间、骨折愈合时间均较对照组短,差异均有统计学意义(P<0.05)。术后6个月,观察组髋关节功能评分较对照组高,差异有统计学意义(P<0.05)。两组术后6个月的髋关节功能优良率比较,差异无统计学意义(P>0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:弯钳撬拔PFNA内固定治疗难复性股骨粗隆间骨折较切开复位PFNA内固定治疗更具优势,在促进术后骨折愈合、恢复患侧髋关节功能方面的作用均较理想,且不会增加并发症,是一种优质的手术模式。
基金supported by grants from the National Natural Science Foundation of China(81902784)the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-004)+2 种基金Fund of Sichuan Provincial Department of Science and Technology(2022YFSY0058)the Research Funding(RCDWJS 2020-20)Research and Development Program(RD-02-202002)fromWest China School/Hospital of Stomatology Sichuan University.
文摘Chronic wounds are wounds that cannot heal properly due to various factors,such as underlying diseases,infection or reinjury,and improper healing of skin wounds and ulcers can cause a serious economic burden.Numerous studies have shown that extracellular vesicles(EVs)derived from stem/progenitor cells promote wound healing,reduce scar formation and have significant advantages over traditional treatment methods.EVs are membranous particles that carry various bioactive molecules from their cellular origins,such as cytokines,nucleic acids,enzymes,lipids and proteins.EVs can mediate cell-to-cell communication and modulate various physiological processes,such as cell differentiation,angiogenesis,immune response and tissue remodelling.In this review,we summarize the recent advances in EV-based wound healing,focusing on the signalling pathways that are regulated by EVs and their cargos.We discuss how EVs derived from different types of stem/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt/β-catenin,phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin,vascular endothelial growth factor,transforming growth factorβand JAK-STAT pathways.Moreover,we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.
基金Supported by Shenzhen Longhua District Science and Innovation Bureau for Key Laboratory Construction,No.20160919A0410022Shenzhen Longhua District Science and Innovation Bureau Fund for Medical Institutions,No.2020038 and No.2017136。
文摘BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds.
基金Supported by National Natural Science Foundation of China,No.81602408Military Logistics Key Open Research Projects,China,No.BHJ17L018.
文摘BACKGROUND Patients with keloids who receive radiotherapy(RT)after surgery can develop refractory wounds that cannot be healed by the patient's own repair system.Such chronic wounds are uneven and complex due to persistent abscess and ulceration.Without external intervention,they can easily result in local tissue necrosis or,in severe cases,large area tissue resection,amputation,and even death.CASE SUMMARY This article describes the use of hydrogen to treat a 42-year-old female patient with a chronic wound on her left shoulder.The patient had a skin graft that involved implanting a dilator under the skin of her left shoulder,and then transferring excess skin from her shoulder onto scar tissue on her chest.The skin grafting was followed by two rounds of RT,after which the shoulder wound had difficulty healing.For six months,the patient was treated with 2 h of hydrogen inhalation(HI)therapy per day,in addition to application of sterile gauze on the wound and periodic debridement.We also performed one deep,large,sharp debridement to enlarge the wound area.The wound healed completely within 6 mo of beginning the HI treatment.CONCLUSION After HI therapy,the patient showed superior progress in reepithelialization and wound repair,with eventual wound closure in 6 mo,in comparison with the previous failures of hyperbaric oxygen and recombinant bovine basic fibroblast growth factor therapies.Our work showed that HI therapy could be a new strategy for wound healing that is cleaner,more convenient,and less expensive than other therapies,as well as easily accessible for further application in clinical wound care.
