The article analyzes the natural distribution area of the species <i>Tulipa kaufmanniana</i> Regel using the programs of type MaxEnt and ArcGis, the endemic of Central Asia (past, current, future). Accordi...The article analyzes the natural distribution area of the species <i>Tulipa kaufmanniana</i> Regel using the programs of type MaxEnt and ArcGis, the endemic of Central Asia (past, current, future). According to the results of the study, it is proved that the main distribution of the species coincides with the boundaries of the areali Tien-Shan mountain system (Uzbekistan, Kazakhstan). It is noted that the climatic factors that are optimal for the species are sufficient temperature and annual precipitation.展开更多
A new triterpenoid saponins, raddeanoside R19 （1） was isolated from the rhizome of Anemone raddeana Regel. The effects of raddeanoside R119 on superoxide generation in human neutrophil were evaluated. The compound s...A new triterpenoid saponins, raddeanoside R19 （1） was isolated from the rhizome of Anemone raddeana Regel. The effects of raddeanoside R119 on superoxide generation in human neutrophil were evaluated. The compound suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine （fMLP）, phorbol 12-myristate 13-acetate （PMA） and arachidonic acid （AA） in a different concentration-dependent manner.展开更多
The results of the study Crocus korolkovii Regel & Maw, were introduced into the Tashkent Botanical Garden. Bioecological features, morphological and anatomical characteristics of Crocus korolkovii were studied. P...The results of the study Crocus korolkovii Regel & Maw, were introduced into the Tashkent Botanical Garden. Bioecological features, morphological and anatomical characteristics of Crocus korolkovii were studied. Phenology was studied by I.N. Beideman, biology bloom by A.P. Ponomarev, breeding and seed production of plants by T.T. Rakhimova. The study of the biology of flowering determined the optimal humidity, air temperature and soil surface. The anatomic study used fresh tissue samples which were fixed in 70% alcohol. A cross-section of the sheet and the structure of the flower in the introduction of conditions were studied.展开更多
In this article we review some of the most important and relevant literature on the properties of ice. We focus on three of its surface properties, namely, the slipperiness of ice, the phenomena of a string under load...In this article we review some of the most important and relevant literature on the properties of ice. We focus on three of its surface properties, namely, the slipperiness of ice, the phenomena of a string under load passing through a block of ice without cutting the block in half, and pressure melting and adhesion of blocks of ice. We then provide an argument for the most plausible factor responsible for each of these effects.展开更多
Objective:To study the cardioprotective effect of Baitouwen(Pulsatilla chinensis Regel,PR)in isoproterenol(ISO)induced heart failure in mice,and investigated the molecular targets using network pharmacological predict...Objective:To study the cardioprotective effect of Baitouwen(Pulsatilla chinensis Regel,PR)in isoproterenol(ISO)induced heart failure in mice,and investigated the molecular targets using network pharmacological prediction and experimental validation.Methods:PR were orally administered to ISO induced HF mice for two weeks.The cardiac function was analyzed by echocardiography.Hematoxylin-eosinstaining(HE)was used to evaluate the pathological changes.The PR targets for HF were predicted by bioinformatics analysis tool(BATMAN-TCM).The expression of atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP),and HF related genes Phosphodiesterase(PDEs),were detected by real-time fluorescence quantitative PCR or Immunohistochemical staining in heart tissues.Results:Cardiac hypertrophy was observed after ISO treatment,and hypertrophic cardiomyocytes were arranged in disorder.Moreover,the expression of ANP and BNP gene in myocardium were upregulated(P<0.05).Treatment of HF mice with PR aqueous extract improved cardiac function characterized by enhanced ejection fraction(EF)and fraction shortening(FS).Furthermore,PR extract also downregulated the expression of ANP and BNP in the heart tissues.Arrangement of cardiomyocytes was also improved.Furthermore,administration of PR group decreased target genes PDE5 and PDE1C expression in the hearts.In addition,PR treatment also improved myocardial fiber distribution and decreased myocardial thickness in the hearts of HF mice.Conclusion:PR treatment may suppress cardiac hypertrophy and improve myocardial function in HF mice via inhibiting the predicted targets PDE5 expression.These results suggest the potential of using PR in preventing the development of HF.展开更多
文摘The article analyzes the natural distribution area of the species <i>Tulipa kaufmanniana</i> Regel using the programs of type MaxEnt and ArcGis, the endemic of Central Asia (past, current, future). According to the results of the study, it is proved that the main distribution of the species coincides with the boundaries of the areali Tien-Shan mountain system (Uzbekistan, Kazakhstan). It is noted that the climatic factors that are optimal for the species are sufficient temperature and annual precipitation.
基金supported by National Natural Science Foundation of China(No.30500050)by Natural Science Foundation of Liaoning province of China(No.2050340)
文摘A new triterpenoid saponins, raddeanoside R19 （1） was isolated from the rhizome of Anemone raddeana Regel. The effects of raddeanoside R119 on superoxide generation in human neutrophil were evaluated. The compound suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine （fMLP）, phorbol 12-myristate 13-acetate （PMA） and arachidonic acid （AA） in a different concentration-dependent manner.
文摘The results of the study Crocus korolkovii Regel & Maw, were introduced into the Tashkent Botanical Garden. Bioecological features, morphological and anatomical characteristics of Crocus korolkovii were studied. Phenology was studied by I.N. Beideman, biology bloom by A.P. Ponomarev, breeding and seed production of plants by T.T. Rakhimova. The study of the biology of flowering determined the optimal humidity, air temperature and soil surface. The anatomic study used fresh tissue samples which were fixed in 70% alcohol. A cross-section of the sheet and the structure of the flower in the introduction of conditions were studied.
文摘In this article we review some of the most important and relevant literature on the properties of ice. We focus on three of its surface properties, namely, the slipperiness of ice, the phenomena of a string under load passing through a block of ice without cutting the block in half, and pressure melting and adhesion of blocks of ice. We then provide an argument for the most plausible factor responsible for each of these effects.
文摘Objective:To study the cardioprotective effect of Baitouwen(Pulsatilla chinensis Regel,PR)in isoproterenol(ISO)induced heart failure in mice,and investigated the molecular targets using network pharmacological prediction and experimental validation.Methods:PR were orally administered to ISO induced HF mice for two weeks.The cardiac function was analyzed by echocardiography.Hematoxylin-eosinstaining(HE)was used to evaluate the pathological changes.The PR targets for HF were predicted by bioinformatics analysis tool(BATMAN-TCM).The expression of atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP),and HF related genes Phosphodiesterase(PDEs),were detected by real-time fluorescence quantitative PCR or Immunohistochemical staining in heart tissues.Results:Cardiac hypertrophy was observed after ISO treatment,and hypertrophic cardiomyocytes were arranged in disorder.Moreover,the expression of ANP and BNP gene in myocardium were upregulated(P<0.05).Treatment of HF mice with PR aqueous extract improved cardiac function characterized by enhanced ejection fraction(EF)and fraction shortening(FS).Furthermore,PR extract also downregulated the expression of ANP and BNP in the heart tissues.Arrangement of cardiomyocytes was also improved.Furthermore,administration of PR group decreased target genes PDE5 and PDE1C expression in the hearts.In addition,PR treatment also improved myocardial fiber distribution and decreased myocardial thickness in the hearts of HF mice.Conclusion:PR treatment may suppress cardiac hypertrophy and improve myocardial function in HF mice via inhibiting the predicted targets PDE5 expression.These results suggest the potential of using PR in preventing the development of HF.
