Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participat...Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.展开更多
The lung Is an Important open organ and the primary site of respiration. Many life.threatening diseases develop in the lung, e.g., pneumonia, asthma, chronic obstructive pulmonary diseases （COPDs）, pulmonary fibrosi...The lung Is an Important open organ and the primary site of respiration. Many life.threatening diseases develop in the lung, e.g., pneumonia, asthma, chronic obstructive pulmonary diseases （COPDs）, pulmonary fibrosis, and lung cancer. In the lung, innate Immunity serves as the frontline in both anti-irritant response and anti-tumor defense and is also critical for mucosal homeostasis; thus, it plays an important role In containing these pul- monary diseases. Innate lymphoid cells （ILCs）, charac. terized by their strict tissue residence and distinct function in the mucosa, are attracting Increased atten. tion In innate Immunity. Upon sensing the danger slg- nals from damaged epithelium, ILCs activate, proliferate, and release numerous cytoklnes with specific local functions; they also participate in mucosal immune- surveillance, Immune-regulation, and homeostasis. However, when their functions become uncontrolled, ILCs can enhance pathological states and Induce dis- eases. In this review, we discuss the physiologicel and pathological functions of ILC subsets 1 to 3 in the lung, and how the pathogenic environment affects the func- tion and plasticity of ILCs.展开更多
基金supported by grants from the National Natural Science Foundation of China (81788104, 81630044, 81601432, 81550023, 81771763)the National Science Fund for Distinguished Young Scholars of China (81325019)+2 种基金National Key Research and Development Program: "Precise Medical Research”(2016YFC0903900)Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFM2016-12M-1-003, 2017-12M-1-008, 2016-12M-1-008)2016 Peking Union Medical College Hospital Fund for Junior Faculty (pumch-2016-2.1)
文摘Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.
文摘The lung Is an Important open organ and the primary site of respiration. Many life.threatening diseases develop in the lung, e.g., pneumonia, asthma, chronic obstructive pulmonary diseases （COPDs）, pulmonary fibrosis, and lung cancer. In the lung, innate Immunity serves as the frontline in both anti-irritant response and anti-tumor defense and is also critical for mucosal homeostasis; thus, it plays an important role In containing these pul- monary diseases. Innate lymphoid cells （ILCs）, charac. terized by their strict tissue residence and distinct function in the mucosa, are attracting Increased atten. tion In innate Immunity. Upon sensing the danger slg- nals from damaged epithelium, ILCs activate, proliferate, and release numerous cytoklnes with specific local functions; they also participate in mucosal immune- surveillance, Immune-regulation, and homeostasis. However, when their functions become uncontrolled, ILCs can enhance pathological states and Induce dis- eases. In this review, we discuss the physiologicel and pathological functions of ILC subsets 1 to 3 in the lung, and how the pathogenic environment affects the func- tion and plasticity of ILCs.
