Epidemiology, Diagnosis and Survival of Breast Cancer: Data from the Population-Based Cancer Registry of the City of Parakou from 2017 to 2021

Background: Breast cancer mortality remains high in the majority of developing countries. The Ministry of Health has established two population-based cancer registries in Benin: the first one in Cotonou in 2014 and the second one in Parakou in 2017. However, there is a scarcity of data on breast cancer survival and prognosis in Benin Republic. Objective: This study sought to investigate epidemiological, diagnostic, and survival aspects of breast cancer in Parakou, based on data from its population-based cancer registry from 2017 to 2021. Method: For descriptive and analytical purposes, we used a retrospective cohort design. From January 24, 2022 to August 31, 2022, data were collected in all health facilities covered by the Parakou population-based cancer registry using an individual questionnaire. Survival and prognosis analysis were performed using KAPLAN MEIER method and David COX proportional hazard model respectively. Result: A total of 81 patients have been included in this study. The incidence rate of breast cancer in Parakou was 17.5 per 100,000 person-years with a mortality rate of 2.76 per 100,000 person-years. The median age at diagnosis was 44.50 years with extremes ranging from 19 to 76 years and a predominance of 40 - 50 years age group. The median survival time was estimated at 30 months with an overall 5-year survival of 47%. Young age at diagnosis (p-value = 0.002) and advanced stage at diagnosis (p-value = 0.000) had a negative impact on survival in women. The combination of surgery and chemotherapy improved survival (p-value = 0.018). Conclusion: Breast cancer is still a public health issue in Parakou. It comes out mandatory that resources be made available to make screening, early diagnosis and appropriate treatment of breast cancer affordable.

How a Cancer Registry Was Set Up in Senegal: An Example to Follow for a Developing Country

Objectives: Senegal, with the support of WHO, had begun the establishment of a National Cancer Registry in 2009, although it had been at a standstill since 1969;the objective of this work was to test the reliability of data collection tools and feasibility stages necessary for the validation of media before the establishment of a national cancer registry. Methodology: We conducted a non-exhaustive preliminary study over a period of three months from the first of January to 31 March 2010 at four major hospitals in Dakar at the time. Results: Two hundred and eighty-nine cases had been identified: 44% of men (n = 127) and 56% of women (n = 162) with a sex ratio of 0.8. The ages ranged from 20 to 90 years with an average of 50 years. The main diagnostic mode was essentially histological, with 76% of cases (n = 219). The most frequent locations were: ORL (ENT meaning Ear, Nose and Throat) with 25% of cases, liver 7% and bronchopulmonary 4.5% of cases. In men, liver cancer was the most common location and women for cervical cancer with 16%. Squamous cell carcinoma was the most common histological type with 68% of cases followed by adenocarcinoma with 22% of cases. Thirty-eight percent of patients were classified as stage III and IV. A quarter of our patients had received palliative treatment. In contrast, 15 (15%) had received chemotherapy and 4% had received radiotherapy. Data collection was satisfactory. Conclusion: Cancer is a reality in Senegal but it remains underdiagnosed. The materials made it possible to make the cancer registry effective throughout the country.

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.

面向领域UDDI Registry的服务注册和查找

作为WebServices三角架构的组成部分之一,UDDIRegistry承担着服务注册和查找的任务,它在开放和分布的WebServices环境中发挥着关键的作用.针对当前UDDIRegistry注册和查询方法的不足,本文给出了一个面向领域的UDDIReg-istry框架,介绍了service的属性模式、关联关系和约束条件等概念,在该框架下提出基于service属性、关系和约束的注册与查找,满足了某些应用领域中service注册和查找的需求.

基于UDDI Registry的智能检索引擎的研究

随着Web Services技术的不断成熟和发展,存储在UDDI Registry中的Web Service信息将会变得越来越庞大,如何从UDDI Registry浩如烟海的信息资源中为用户快速、方便、准确地检索出满足需求的Web Service,将变得十分重要。而传统的基于关键词匹配的检索技术已不能满足用户准确而全面定位信息的要求。因此,以WebService的文本描述信息为研究对象,运用文本挖掘相关方法,构建出用户概念空间,对用户提出的查询要求进行概念检索。着重介绍了用户概念空间的构建方法以及概念检索的匹配运算过程,并给出了应用于UDDI Registry的一种智能检索引擎系统模型。

《临床肝胆病杂志》被开放学术资源库(ROAD)收录

近日,《临床肝胆病杂志》被开放学术资源库ROAD(Directory of Open Access Scholarly Resources)收录,标志着本刊开放获取政策和规范与国际标准进一步接轨。ROAD是ISSN国际中心在联合国教科文组织支持下设立的科学学术开放存取资源库,于2013年底启用,是ISSN国际数据库书目记录的一个子集,书目记录由ISSN网络(包括93个国家中心和ISSN国际中心)制作,并得到来自索引库及相关目录[开放存取期刊目录(DOAJ)、Latindex计划、“The Keepers Registry”(保管机构登记处服务)]的元数据以及相关绩效指数(Scopus)的补充。加入ROAD必须遵守严格的标准,涉及期刊定位、学术内容、同行评审、伦理规则、许可声明、编辑责任和可及性等指标。

STN系统在有机化学领域化合物检索中的应用

通过对医药化学领域一个具体案例的检索分析过程,归纳总结了STN数据库在有机化合物领域的经验和技巧,在检索中通过准确把握发明构思动态调整化学结构,并善用STN数据库中IT字段、时间字段ED=Entry Date确定出的高效准确检索策略,降低检索噪音化合物的干扰,实现快速检索,准确命中目标化合物结构,对化合物检索实践具有一定借鉴意义,为专利申请中涉及化合物结构式的新颖性评判的高效检索提供了新思路。

《化学文摘》联机数据库中Registry文档的应用

STN 国际联机系统针对化合物结构的复杂性推出了登记号文档Registry File,作为书目文档 CA File 的补充,可解决若干 CA File 无法解决的有关化合物结构的问题。本文介绍了其主要用法和一些指令、符号等。

Epidemiology of Hand Injuries That Presented to the Emergency Department of a Tertiary Care Facility in Suburban Mumbai, India: A Study Including 489 Patients

Background: Hand injuries are very common and responsible for a significant number of emergency department (ED) visits, most of which are not to hand specialists [1]. The functionality and outcome of hand injuries can vary significantly depending on the mechanism and pattern of injuries, which is why it is imperative for emergency physicians to recognize the complexities, and the potential repercussion of missed injuries in such cases. Objective: The aim of this study is to provide epidemiological information on hand injuries and their patterns. The objective is 1) to assess whether most hand injuries are superficial (simple), or involve underlying deeper structures (complex) and 2) to assess whether most hand injuries presented to the emergency department were managed by the emergency physician or plastic/orthopaedic surgeon. Methods: This retrospective single-centre observational study conducted at an emergency department in a tertiary care hospital in Mumbai, India collected data from hand trauma patients using a standardized documentation form. Demographic data, trauma-related data, and disposition plans were analysed. Results: A total of 489 cases sustained hand injuries over a period of one year. The patients were predominantly males in the 20 - 30 year age group and injuries were mainly sustained over the right hand. Most of the injuries were sustained at home (42%). The most common mechanism (34%) was sharp object injury (including needle-stick and other sharps in hospital), followed by blunt injury (30%). Among grievous hand injuries, door jamb was a mechanism noted in 11% of patients, accounting for 50% of all crush injuries. Lacerations were the most common pattern (24.7%) noticed, followed closely by fractures (23.3%). Digits II - IV were injured most commonly (54%), followed by carpals (14%) and the thumb (10%). Nearly 80% of the hand injuries were managed by emergency physicians alone, with 61% of cases involving superficial structures. Though 14% of the cases required plastic surgery intervention, the initial evaluation of all these patients was performed by the emergency physician. Conclusions: Our study highlights the burden of hand injuries on the emergency physician, as well as the odds of missed injuries, directly indicating the necessity of a thorough anatomical knowledge of the structures of the hand, and in turn, a proper physical examination. A dedicated registry for hand trauma would help quantify the mechanism and pattern of injuries, and formulate preventive strategies.

Registry(注册簿)的原理及其在Visual Basic 4.0中的应用

本文通过比较Windows95中Registry和Windows3.x中.INI文件的优缺点,介绍了Registry的基本构成及运作机制,并在此基础上介绍了Visual Basic 4.0开发者操作Registry的方法,并给出了应用实例。

The updated incidences and mortalities of major cancers in China, 2011

Introduction: The National Central Cancer Registry(NCCR) of China collected population-based cancer registration data from all cancer registries in China. This study aimed to compile national cancer incidences and mortalities in 2011 and estimate cancer incident new cases and cancer deaths.Methods: In 2014, there were 234 cancer registries that submitted records of new cancer cases and cancer deaths that occurred in 2011 to the NCCR. All datasets were evaluated based on the criteria of data quality of the NCCR. The data of 177 registries was of suicient quality and was compiled to evaluate cancer statistics in 2011. The pooled data were stratiied by area, sex, age group, and cancer type. Cancer incident cases and deaths were estimated using age-standardized rates(ASR) and the Chinese population. All incidences and mortalities were age-standardized to the 2000 Chinese standard population and Segi's population.Results: The estimates of new cancer incident cases and cancer deaths were 3,372,175 and 2,113,048 in 2011, respectively. The crude incidence was 250.28/1,00,000(277.77/1,00,000 for males and 221.37/1,00,000 for females). The ASRs of incidence by the Chinese standard population(ASRIC) and by the world standard population(ASRIW) were 186.34/1,00,000 and 182.76/1,00,000, respectively, with a cumulative incidence(0–74 years old) of 21.20%. Cancers of the lung, female breast, stomach, liver, colorectum, esophagus, cervix, uterus, prostate, and ovary were the most common cancers, accounting for approximately 75% of all new cancer cases. Lung, liver, gastric, esophageal, colorectal, female breast, pancreatic, brain, and cervical cancers and leukemia were the leading causes of cancer death, accounting for approximately 80% of all cancer deaths. Cancer incidence, mortality, and spectrum were all diferent between urban and rural areas and between males and females.Conclusions: The population covered by the cancer registries greatly increased from 2010 to 2011. The data quality and representativeness of cancer registries have gradually improved. Cancer registries have an irreplaceable role in research on cancer prevention and control. The disease burden of cancer is increasing, and the health department must implement efective measures to contain the increased cancer burden in China.

VO-DAS Registry系统的设计与实现

为了给天文学家提供一个统一访问分布存储于世界各地数据中心的异构天文数据资源的方案,中国虚拟天文台项目组设计了虚拟天文台数据访问服务(VO-DAS)。VO-DAS支持国际虚拟天文台联盟(IVOA)制订的各项相关标准,使得它具有良好的互操作性。VO-DAS Registry系统是VO-DAS系统的重要组成部分,它为VO-DAS系统获取数据资源的元数据,从而使得VO-DAS更好的管理和应用这些数据资源。在这个过程中,此系统符合IVOA的相关标准。

Rate of anticoagulant use, and factors associated with not prescribing anticoagulant in older Thai adults with non-valvular atrial fibrillation: A multicenter registry

Objectives To investigate the rate of anticoagulant use,the reasons for not prescribing anticoagulant,and the factors associated with non-prescription of anticoagulant in older Thai adults with non-valvular atrial fibrillation.Methods A multicenter registry of patients with non-valvular atrial fibrillation was conducted during 2014 to 2017 in Thailand.Demographic,medical history,antithrombotic medication,non-antithrombotic medication,and laboratory data were collected and analyzed.Data were compared between the older adult (≥ 65 years) and younger adult (< 65 years) groups.The reasons why anticoagulant was not prescribed were collected,and predictive factors were identified.Results A total of 3218 patients (1873 males) with an average age of 67.3 ± 11.3 years were included.Almost two-thirds (61.0%) of patients were in the older adult group.Anticoagulant was prescribed in 2422 patients (75.3%): 81.4% in the older adult group and 65.7% in the younger adult group.The three main reasons for not prescribing anticoagulant were already taking antiplatelets,patient refusal,and bleeding risk.These reasons were more common in older adults as compared to younger adults.Multivariate analysis revealed current use of antiplatelets to be the most important factor that predict the non-prescription of anticoagulant in older population.Conclusions The prevalence of anticoagulant prescription among older Thai adults with atrial fibrillation is 81.4%.Taking antiplatelet drugs was found to be the strongest reason that predicts the non-prescription of anticoagulant in this patient population.A guideline should be developed to optimize the use of anticoagulant and antiplatelet in older adults.

Description of trauma among French service members in the Department of Defense Trauma Registry: Understanding the nature of trauma and the care provided

Background:Since 2001,the French Armed Forces have sustained many casualties during the Global War on Terror;however,even today,there is no French Military trauma registry.Some French service members(SMs)were treated in US Military Medical Treatment Facilities(MTFs)and were recorded in the US Department of Defense Trauma Registry(Do DTR).Our objective was to conduct a descriptive analysis of the injuries sustained by French SMs reported in the Do DTR and subsequent care provided to them to assist in understanding the importance of building a French Military trauma registry.Methods:Using Do DTR data collected from 2001 to 2017,a retrospective descriptive analysis was conducted.We identified 59 French SMs treated in US MTFs.The characteristics of the SMs’demographics,injuries,care provided to them,and discharge outcomes were summarized.Results:Among the 59 French SMs identified,46(78%)sustained battle injuries(BIs)and 13(22%)sustained nonbattle injuries(NBIs).There were 47(80%)SMs injured in Afghanistan(Opération Pamir),while 12(20%)were injured in Opération Chammal in Iraq and Syria.Explosives accounted for 52.5%of injuries,while 25.4%were due to gunshot wounds;all were BIs.The majority of reported injuries were penetrating(59.3%),most of which were BIs(71.7%).The mean Injury Severity Score for BIs was 12(SD=8.9)compared to 6(SD=1.7)for NBIs.Around half of SMs(n=30;51%)were injured in Afghanistan between the years 2008–2010.Among a total of 246 injuries sustained by 59 patients,extremities were the body part most prone to BIs followed by the head and face.Four SMs died after admission(6.8%).Conclusions:The Do DTR provides extensive data on trauma injuries that can be used to inform injury prevention and clinical care.The majority of injuries sustained by French SMs were BIs,caused by explosives,and predominantly occurring to the extremities;these findings are similar to those of other studies conducted in combat zones.There is a need to establish a French Military trauma registry to improve the combat casualty care provided to French SMs,and its creation may benefit from the Do DTR model.

STATISTICAL TESTS FOR THE COMPARISON OF THE INCIDENCE OR MORTALITY RATES IN CANCER REGISTRY AND DESCRIPTIVE EPIDEMIOLOGY──A MICROCOMPUTER PROGRAM IN BASIC

This paper describes the statistical methods of the comparison of the incidence or mortality rates in cancer registry and descriptive epidemiology, and the features of microcomputer program (CANTEST) which was designed to perform the methods. The program was written in IBM BASIC language. Using the program CANTEST we presented here the user can do several statistical tests or estimations as follow: 1. the comparison of the adjusted rates which were calculated by directly or indirectly standardized methods, 2. the calculation of the slope of regression line for testing the linear trends of the adjusted rates, 3. the estimation of the 95% or 99%conndence intervals of the directly adjusted rates, of the cumulative rates (0-64 and 0-74), and of the cumulative risk. Several examples are presented for testing the performances of the program.

Variations in non-ST-elevation myocardial infarction care across three levels of hospitals in China:analysis from the China Acute Myocardial Infarction Registry

Objective To explore the variation of treatment and outcomes for NSTEMI across different-level hospitals, which potentially influenced by unbalanced economy and disparate medical care.Methods The China AMI registry consists of 108 hospitals across three levels (province, prefecture and county) throughout China.

International Clinical Trials Registry Platform(ICTRP)

Introduction The mission of the WHO International Clinical Trials Registry Platform is to ensure that a complete view of research is accessible to all those involved in health care decision making. This will improve research transparency and will ultimately strengthen the validity and value of the scientific evidence base. The registration of all interventional trials is a scientific, ethical and moral responsibility.

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multicentre registry network

BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease(PIBD).AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform.METHODS Clinical,endoscopic and radiologic data at diagnosis from the registry were extracted between 1^(st) January 1995 to 31^(st) December 2019.Disease phenotypic characteristics were classified as per the Paris classification system.RESULTS There was a distinct rise in new PIBD cases:Nearly half(48.6%)of the cohort was diagnosed in the most recent 5 years(2015-2019).The ratio of Crohn’s disease(CD):Ulcerative colitis(UC):IBDUnclassified was 55.9%:38.3%:5.8%.The mean age was 9.07 years with a high proportion of very early onset IBD(VEO-IBD)(29.3%)and EO-IBD(52.7%).An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort(6.8%-9.0%Indians in census).Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease(P=0.003).CD patients presented with significantly more constitutional symptoms(fever,anorexia,malaise/fatigue and muscle-wasting)than UC and higher inflammatory indices(higher C-reactive protein and lower albumin levels).CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity.South Asian CD patients were more likely to have symptomatic perianal disease.

Secular decreasing trends in gastric cancer incidence in Taiwan:A population-based cancer registry study

BACKGROUND Gastric cancer remains a leading cause of cancer death worldwide.In Taiwan,gastric cancer is the sixth leading cause of cancer mortality in both males and females.AIM To evaluate secular trends in gastric cancer incidence according to age,sex,and Helicobacter pylori(H.pylori)treatment in Taiwan.METHODS In this population-based study,we used the national Taiwan Cancer Registry database.Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan.Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H.pylori infection.RESULTS The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females.However,the decreasing trends differed by sex,with an annual percent change of-2.58%in males and-2.14%in females.The age-specific incidence rates increased with age.Within the same age group,more recent time periods showed lower incidence rates than greater time periods.Similarly,the sex ratio was lower in later birth cohorts than in earlier birth cohorts.Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H.pylori infection during 2005 to 2016(r=0.72).CONCLUSION We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan.These results support H.pylori eradication programs in Taiwan.

Using Blockchain Technology in Mobile Network to create decentralized Home Location Registry(HLR)

Blockchain can mean many things to many people.It is a set of protocols and encryption technologies for securely storing data on a distributed network for the developers.It is a distributed ledger for business and finance and the technology underlying the explosion of new digital currencies.For technologists,it is the driving force behind the next generation of the internet.On the other hand,it is a transformational technology facilitating large-scale human progress in previously unimagined ways for the rest of the people,a tool for radically reshaping society and economy.Some view it as a disruptive technology that can be the source of a great deal of fraud,illegal activity,where others see opportunities to bring into existing systems by providing decentralization,transparency,and efficiency.This complex technological,economic,and social phenomenon has been the subject of fervent debate.It calls into question what might have been seen to be established parameters of the modern world like currency,economics,trust,value,and exchange.It is a revolutionary new computing paradigm and one of the most significant,fundamental digital platforms’advances since the internet.It is an emergent technology experiencing very rapid evolution,and so is our understanding of what it is and what it can be.This paper is subject to the use of Blockchain concepts in mobile networks to strengthen the Home Location Registry(HLR)database and make it decentralized for secure transactions and in banking and financial centers.Blockchain also holds potential implications for global commerce.It could make trade more efficient by removing the manual and paper-based processes and introducing streamlined and automated processes.