In this paper, we consider the general quasi-differential expressions each of order n with complex coefficients and their formal adjoints on the interval (a,b). It is shown in direct sum spaces of functions defined on...In this paper, we consider the general quasi-differential expressions each of order n with complex coefficients and their formal adjoints on the interval (a,b). It is shown in direct sum spaces of functions defined on each of the separate intervals with the cases of one and two singular end-points and when all solutions of the equation and its adjoint are in (the limit circle case) that all well-posed extensions of the minimal operator have resolvents which are HilbertSchmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly solvable operators have all the standard essential spectra to be empty. These results extend those of formally symmetric expression studied in [1-10] and those of general quasi-differential expressions in [11-19].展开更多
The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments.CRISPR-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly ...The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments.CRISPR-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral diseases.Of course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical results.The aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.展开更多
Pulse diagnosis is an important basis for the diagnosis of Chinese medicine.It is the rich experience accumulated by the predecessors in the long and continuous practice,and it is a unique diagnosis method of Chinese ...Pulse diagnosis is an important basis for the diagnosis of Chinese medicine.It is the rich experience accumulated by the predecessors in the long and continuous practice,and it is a unique diagnosis method of Chinese medicine.There are many names of pulse conditions in traditional Chinese medicine.The four elements are analyzed and summarized in terms of position,number,shape,and momentum.The four elements are used as 28 kinds of pulses.Among them,the regularly intermittent pulse and the intermittent pulse are characterized by arrhythmia and intermittent stop of the pulse.Intermittent pulse means irregular intervals;when a pulse comes,Regularly Intermittent pulse have regular stops.This kind of phenomenon is similar to the bradyarrhythmia in modern medicine.The knot pulse is an irregular pulse stopping,which can be seen clinically in sinus arrest,second-degree type I sinus block,second-degree type I atrioventricular block,and escape beats and so on.On the other hand,Regularly Intermittent pulse is a regular pulse stopping,which can be clinically found in the second degree type II sinus block,the second degree type II sinus block,and the second degree type I atrioventricular block with a special 2:1 type of atrioventricular block type and so on.展开更多
In this article, we study the smoothing effect of the Cauchy problem for the spatially homogeneous non-cutoff Boltzmann equation for hard potentials. It has long been suspected that the non-cutoff Boltzmann equation e...In this article, we study the smoothing effect of the Cauchy problem for the spatially homogeneous non-cutoff Boltzmann equation for hard potentials. It has long been suspected that the non-cutoff Boltzmann equation enjoys similar regularity properties as to whose of the fractional heat equation. We prove that any solution with mild regularity will become smooth in Gevrey class at positive time, with a sharp Gevrey index, depending on the angular singularity. Our proof relies on the elementary L^(2) weighted estimates.展开更多
Dear Editor,This letter explores optimal formation control for a network of unmanned surface vessels(USVs).By designing an individual objective function for each USV,the optimal formation problem is transformed into a...Dear Editor,This letter explores optimal formation control for a network of unmanned surface vessels(USVs).By designing an individual objective function for each USV,the optimal formation problem is transformed into a noncooperative game.Under this game theoretic framework,the optimal formation is achieved by seeking the Nash equilibrium of the regularized game.A modular structure consisting of a distributed Nash equilibrium seeker and a regulator is proposed.展开更多
This paper is a continuation of recent work by Guo-Xiang-Zheng[10].We deduce the sharp Morrey regularity theory for weak solutions to the fourth order nonhomogeneous Lamm-Rivière equation △^{2}u=△(V▽u)+div(w▽...This paper is a continuation of recent work by Guo-Xiang-Zheng[10].We deduce the sharp Morrey regularity theory for weak solutions to the fourth order nonhomogeneous Lamm-Rivière equation △^{2}u=△(V▽u)+div(w▽u)+(▽ω+F)·▽u+f in B^(4),under the smallest regularity assumptions of V,ω,ω,F,where f belongs to some Morrey spaces.This work was motivated by many geometrical problems such as the flow of biharmonic mappings.Our results deepens the Lp type regularity theory of[10],and generalizes the work of Du,Kang and Wang[4]on a second order problem to our fourth order problems.展开更多
In differentiable search architecture search methods,a more efficient search space design can significantly improve the performance of the searched architecture,thus requiring people to carefully define the search spa...In differentiable search architecture search methods,a more efficient search space design can significantly improve the performance of the searched architecture,thus requiring people to carefully define the search space with different complexity according to various operations.Meanwhile rationalizing the search strategies to explore the well-defined search space will further improve the speed and efficiency of architecture search.With this in mind,we propose a faster and more efficient differentiable architecture search method,AllegroNAS.Firstly,we introduce a more efficient search space enriched by the introduction of two redefined convolution modules.Secondly,we utilize a more efficient architectural parameter regularization method,mitigating the overfitting problem during the search process and reducing the error brought about by gradient approximation.Meanwhile,we introduce a natural exponential cosine annealing method to make the learning rate of the neural network training process more suitable for the search procedure.Moreover,group convolution and data augmentation are employed to reduce the computational cost.Finally,through extensive experiments on several public datasets,we demonstrate that our method can more swiftly search for better-performing neural network architectures in a more efficient search space,thus validating the effectiveness of our approach.展开更多
In this paper, we study the regularity criterion for the three-dimensional Boussinesq equations in Besov spaces. We show that the smooth solution(u,θ) is regular if the horizonal velocity u_h holds ■.
In view of the composition analysis and identification of ancient glass products, L1 regularization, K-Means cluster analysis, elbow rule and other methods were comprehensively used to build logical regression, cluste...In view of the composition analysis and identification of ancient glass products, L1 regularization, K-Means cluster analysis, elbow rule and other methods were comprehensively used to build logical regression, cluster analysis, hyper-parameter test and other models, and SPSS, Python and other tools were used to obtain the classification rules of glass products under different fluxes, sub classification under different chemical compositions, hyper-parameter K value test and rationality analysis. Research can provide theoretical support for the protection and restoration of ancient glass relics.展开更多
Multi-view Subspace Clustering (MVSC) emerges as an advanced clustering method, designed to integrate diverse views to uncover a common subspace, enhancing the accuracy and robustness of clustering results. The signif...Multi-view Subspace Clustering (MVSC) emerges as an advanced clustering method, designed to integrate diverse views to uncover a common subspace, enhancing the accuracy and robustness of clustering results. The significance of low-rank prior in MVSC is emphasized, highlighting its role in capturing the global data structure across views for improved performance. However, it faces challenges with outlier sensitivity due to its reliance on the Frobenius norm for error measurement. Addressing this, our paper proposes a Low-Rank Multi-view Subspace Clustering Based on Sparse Regularization (LMVSC- Sparse) approach. Sparse regularization helps in selecting the most relevant features or views for clustering while ignoring irrelevant or noisy ones. This leads to a more efficient and effective representation of the data, improving the clustering accuracy and robustness, especially in the presence of outliers or noisy data. By incorporating sparse regularization, LMVSC-Sparse can effectively handle outlier sensitivity, which is a common challenge in traditional MVSC methods relying solely on low-rank priors. Then Alternating Direction Method of Multipliers (ADMM) algorithm is employed to solve the proposed optimization problems. Our comprehensive experiments demonstrate the efficiency and effectiveness of LMVSC-Sparse, offering a robust alternative to traditional MVSC methods.展开更多
The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship bet...The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship between K-aberration and word length pattern is developed.展开更多
The aim of this paper is to broaden the application of Stochastic Configuration Network (SCN) in the semi-supervised domain by utilizing common unlabeled data in daily life. It can enhance the classification accuracy ...The aim of this paper is to broaden the application of Stochastic Configuration Network (SCN) in the semi-supervised domain by utilizing common unlabeled data in daily life. It can enhance the classification accuracy of decentralized SCN algorithms while effectively protecting user privacy. To this end, we propose a decentralized semi-supervised learning algorithm for SCN, called DMT-SCN, which introduces teacher and student models by combining the idea of consistency regularization to improve the response speed of model iterations. In order to reduce the possible negative impact of unsupervised data on the model, we purposely change the way of adding noise to the unlabeled data. Simulation results show that the algorithm can effectively utilize unlabeled data to improve the classification accuracy of SCN training and is robust under different ground simulation environments.展开更多
In this paper, we investigate the local well-posedness, ill-posedness, and Gevrey regularity of the Cauchy problem for Mildly Nonlinear and Non-Boussinesq case-(ABC) system. The local well-posedness of the solution fo...In this paper, we investigate the local well-posedness, ill-posedness, and Gevrey regularity of the Cauchy problem for Mildly Nonlinear and Non-Boussinesq case-(ABC) system. The local well-posedness of the solution for this system in Besov spaces B p,r s 1 × B p,r s with 1≤p,r≤∞ and s>max{ 1 1 p , 3 2 } was firstly established. Next, we consider the continuity of the solution-to-data map, i.e. the ill-posedness of the solution for this system in Besov space B p,∞ s 1 × B p,∞ s was derived. Finally, the Gevrey regularity of the system was presented.展开更多
This paper considers the regularity of solutions to mixed boundary value problems in small-angle regions for elliptic equations. By constructing a specific barrier function, we proved that under the assumption of suff...This paper considers the regularity of solutions to mixed boundary value problems in small-angle regions for elliptic equations. By constructing a specific barrier function, we proved that under the assumption of sufficient regularity of boundary conditions and coefficients, as long as the angle is sufficiently small, the regularity of the solution to the mixed boundary value problem of the second-order elliptic equation can reach any order.展开更多
For the multiplicative background risk model,a distortion-type risk measure is used to measure the tail risk of the portfolio under a scenario probability measure with multivariate regular variation.In this paper,we i...For the multiplicative background risk model,a distortion-type risk measure is used to measure the tail risk of the portfolio under a scenario probability measure with multivariate regular variation.In this paper,we investigate the tail asymptotics of the portfolio loss ∑_(i=1)^(d)R_(i)S,where the stand-alone risk vector R=(R_(1),...,R_(d))follows a multivariate regular variation and is independent of the background risk factor S.An explicit asymptotic formula is established for the tail distortion risk measure,and an example is given to illustrate our obtained results.展开更多
Orphan diseases are rare diseases that affect less than 200000 individuals within the United States.Most orphan diseases are of neurologic and genetic origin.With the current advances in technology,more funding has be...Orphan diseases are rare diseases that affect less than 200000 individuals within the United States.Most orphan diseases are of neurologic and genetic origin.With the current advances in technology,more funding has been devoted to developing therapeutic agents for patients with these conditions.In our review,we highlight emerging options for patients with neurologic orphan diseases,specifically including diseases resulting in muscular deterioration,epilepsy,seizures,neurodegenerative movement disorders,inhibited cognitive development,neuron deterioration,and tumors.After extensive literature review,gene therapy offers a promising route for the treatment of neurologic orphan diseases.The use of clustered regularly interspaced palindromic repeats/Cas9 has demonstrated positive results in experiments investigating its role in several diseases.Additionally,the use of adeno-associated viral vectors has shown improvement in survival,motor function,and developmental milestones,while also demonstrating reversal of sensory ataxia and cardiomyopathy in Friedreich ataxia patients.Antisense oligonucleotides have also been used in some neurologic orphan diseases with positive outcomes.Mammalian target of rapamycin inhibitors are currently being investigated and have reduced abnormal cell growth,proliferation,and angiogenesis.Emerging innovations and the role of genetic treatments open a new window of opportunity for the treatment of neurologic orphan diseases.展开更多
Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an importan...Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted therapy.Despite extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.展开更多
In this paper, we have considered the general ordinary quasi-differential operators generated by a general quasi-differential expression τ<sub>p,q</sub> in L<sup>p</sup>w</sub>-spaces of...In this paper, we have considered the general ordinary quasi-differential operators generated by a general quasi-differential expression τ<sub>p,q</sub> in L<sup>p</sup>w</sub>-spaces of order n with complex coefficients and its formal adjoint τ<sup>+</sup><sub>q',p' </sub>in L<sup>p</sup>w</sub>-spaces for arbitrary p,q∈[1,∞). We have proved in the case of one singular end-point that all well-posed extensions of the minimal operator T<sub>0</sub> (τ<sub>p,q</sub>) generated by such expression τ<sub>p,q</sub> and their formal adjoint on the interval [a,b) with maximal deficiency indices have resolvents which are Hilbert-Schmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly solvable operators have all the standard essential spectra to be empty. Also, a number of results concerning the location of the point spectra and regularity fields of the operators generated by such expressions can be obtained. Some of these results are extensions or generalizations of those in the symmetric case, while others are new.展开更多
The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting p...The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting process with vanadium slag.In this work,CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples were prepared and roasted for different time periods to illustrate and compare the diffusion reaction mechanisms.Then,the changes in the diffusion product and diffusion coefficient were investigated and calculated based on scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analysis.Results show that with the extension of the roasting time,the diffusion reaction gradually proceeds among the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples.The regional boundaries of calcium and vanadium are easily identifiable for the CaO–V_(2)O_(5) diffusion couple.Meanwhile,for the MnO_(2)–V_(2)O_(5) diffusion couple,MnO_(2) gradually decomposes to form Mn_(2)O_(3),and vanadium diffuses into the interior of Mn_(2)O_(3).Only a part of vanadium combines with manganese to form the diffusion production layer.CaV_(2)O_(6) and MnV_(2)O_(6) are the interfacial reaction products of the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples,respectively,whose thicknesses are 39.85 and 32.13μm when roasted for 16 h.After 16 h,both diffusion couples reach the reaction equilibrium due to the limitation of diffusion.The diffusion coefficient of the CaO–V_(2)O_(5) diffusion couple is higher than that of the MnO_(2)–V_(2)O_(5) diffusion couple for the same roasting time,and the diffusion reaction between vanadium and calcium is easier than that between vanadium and manganese.展开更多
文摘In this paper, we consider the general quasi-differential expressions each of order n with complex coefficients and their formal adjoints on the interval (a,b). It is shown in direct sum spaces of functions defined on each of the separate intervals with the cases of one and two singular end-points and when all solutions of the equation and its adjoint are in (the limit circle case) that all well-posed extensions of the minimal operator have resolvents which are HilbertSchmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly solvable operators have all the standard essential spectra to be empty. These results extend those of formally symmetric expression studied in [1-10] and those of general quasi-differential expressions in [11-19].
文摘The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments.CRISPR-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral diseases.Of course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical results.The aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.
基金National Natural Science Foundation of China(81874404)。
文摘Pulse diagnosis is an important basis for the diagnosis of Chinese medicine.It is the rich experience accumulated by the predecessors in the long and continuous practice,and it is a unique diagnosis method of Chinese medicine.There are many names of pulse conditions in traditional Chinese medicine.The four elements are analyzed and summarized in terms of position,number,shape,and momentum.The four elements are used as 28 kinds of pulses.Among them,the regularly intermittent pulse and the intermittent pulse are characterized by arrhythmia and intermittent stop of the pulse.Intermittent pulse means irregular intervals;when a pulse comes,Regularly Intermittent pulse have regular stops.This kind of phenomenon is similar to the bradyarrhythmia in modern medicine.The knot pulse is an irregular pulse stopping,which can be seen clinically in sinus arrest,second-degree type I sinus block,second-degree type I atrioventricular block,and escape beats and so on.On the other hand,Regularly Intermittent pulse is a regular pulse stopping,which can be clinically found in the second degree type II sinus block,the second degree type II sinus block,and the second degree type I atrioventricular block with a special 2:1 type of atrioventricular block type and so on.
基金supported by the NSFC(12101012)the PhD Scientific Research Start-up Foundation of Anhui Normal University.Zeng’s research was supported by the NSFC(11961160716,11871054,12131017).
文摘In this article, we study the smoothing effect of the Cauchy problem for the spatially homogeneous non-cutoff Boltzmann equation for hard potentials. It has long been suspected that the non-cutoff Boltzmann equation enjoys similar regularity properties as to whose of the fractional heat equation. We prove that any solution with mild regularity will become smooth in Gevrey class at positive time, with a sharp Gevrey index, depending on the angular singularity. Our proof relies on the elementary L^(2) weighted estimates.
基金supported by the National Key R&D Program of China(2022ZD0119604)the National Natural Science Foundation of China(NSFC),(62222308,62173181,62221004)+1 种基金the Natural Science Foundation of Jiangsu Province(BK20220139)the Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)。
文摘Dear Editor,This letter explores optimal formation control for a network of unmanned surface vessels(USVs).By designing an individual objective function for each USV,the optimal formation problem is transformed into a noncooperative game.Under this game theoretic framework,the optimal formation is achieved by seeking the Nash equilibrium of the regularized game.A modular structure consisting of a distributed Nash equilibrium seeker and a regulator is proposed.
基金supported by the National Natural Science Foundation of China(12271296,12271195).
文摘This paper is a continuation of recent work by Guo-Xiang-Zheng[10].We deduce the sharp Morrey regularity theory for weak solutions to the fourth order nonhomogeneous Lamm-Rivière equation △^{2}u=△(V▽u)+div(w▽u)+(▽ω+F)·▽u+f in B^(4),under the smallest regularity assumptions of V,ω,ω,F,where f belongs to some Morrey spaces.This work was motivated by many geometrical problems such as the flow of biharmonic mappings.Our results deepens the Lp type regularity theory of[10],and generalizes the work of Du,Kang and Wang[4]on a second order problem to our fourth order problems.
基金This work was supported in part by the National Natural Science Foundation of China under Grant 61305001the Natural Science Foundation of Heilongjiang Province of China under Grant F201222.
文摘In differentiable search architecture search methods,a more efficient search space design can significantly improve the performance of the searched architecture,thus requiring people to carefully define the search space with different complexity according to various operations.Meanwhile rationalizing the search strategies to explore the well-defined search space will further improve the speed and efficiency of architecture search.With this in mind,we propose a faster and more efficient differentiable architecture search method,AllegroNAS.Firstly,we introduce a more efficient search space enriched by the introduction of two redefined convolution modules.Secondly,we utilize a more efficient architectural parameter regularization method,mitigating the overfitting problem during the search process and reducing the error brought about by gradient approximation.Meanwhile,we introduce a natural exponential cosine annealing method to make the learning rate of the neural network training process more suitable for the search procedure.Moreover,group convolution and data augmentation are employed to reduce the computational cost.Finally,through extensive experiments on several public datasets,we demonstrate that our method can more swiftly search for better-performing neural network architectures in a more efficient search space,thus validating the effectiveness of our approach.
基金Supported by Xinyang College Scientific Research Project(Grant Nos.2022-XJLYB-004 and 2022-XJLYB-018)。
文摘In this paper, we study the regularity criterion for the three-dimensional Boussinesq equations in Besov spaces. We show that the smooth solution(u,θ) is regular if the horizonal velocity u_h holds ■.
文摘In view of the composition analysis and identification of ancient glass products, L1 regularization, K-Means cluster analysis, elbow rule and other methods were comprehensively used to build logical regression, cluster analysis, hyper-parameter test and other models, and SPSS, Python and other tools were used to obtain the classification rules of glass products under different fluxes, sub classification under different chemical compositions, hyper-parameter K value test and rationality analysis. Research can provide theoretical support for the protection and restoration of ancient glass relics.
文摘Multi-view Subspace Clustering (MVSC) emerges as an advanced clustering method, designed to integrate diverse views to uncover a common subspace, enhancing the accuracy and robustness of clustering results. The significance of low-rank prior in MVSC is emphasized, highlighting its role in capturing the global data structure across views for improved performance. However, it faces challenges with outlier sensitivity due to its reliance on the Frobenius norm for error measurement. Addressing this, our paper proposes a Low-Rank Multi-view Subspace Clustering Based on Sparse Regularization (LMVSC- Sparse) approach. Sparse regularization helps in selecting the most relevant features or views for clustering while ignoring irrelevant or noisy ones. This leads to a more efficient and effective representation of the data, improving the clustering accuracy and robustness, especially in the presence of outliers or noisy data. By incorporating sparse regularization, LMVSC-Sparse can effectively handle outlier sensitivity, which is a common challenge in traditional MVSC methods relying solely on low-rank priors. Then Alternating Direction Method of Multipliers (ADMM) algorithm is employed to solve the proposed optimization problems. Our comprehensive experiments demonstrate the efficiency and effectiveness of LMVSC-Sparse, offering a robust alternative to traditional MVSC methods.
文摘The study on designs for the baseline parameterization has aroused attention in recent years. This paper focuses on two-level regular designs for the baseline parameterization. A general result on the relationship between K-aberration and word length pattern is developed.
文摘The aim of this paper is to broaden the application of Stochastic Configuration Network (SCN) in the semi-supervised domain by utilizing common unlabeled data in daily life. It can enhance the classification accuracy of decentralized SCN algorithms while effectively protecting user privacy. To this end, we propose a decentralized semi-supervised learning algorithm for SCN, called DMT-SCN, which introduces teacher and student models by combining the idea of consistency regularization to improve the response speed of model iterations. In order to reduce the possible negative impact of unsupervised data on the model, we purposely change the way of adding noise to the unlabeled data. Simulation results show that the algorithm can effectively utilize unlabeled data to improve the classification accuracy of SCN training and is robust under different ground simulation environments.
文摘In this paper, we investigate the local well-posedness, ill-posedness, and Gevrey regularity of the Cauchy problem for Mildly Nonlinear and Non-Boussinesq case-(ABC) system. The local well-posedness of the solution for this system in Besov spaces B p,r s 1 × B p,r s with 1≤p,r≤∞ and s>max{ 1 1 p , 3 2 } was firstly established. Next, we consider the continuity of the solution-to-data map, i.e. the ill-posedness of the solution for this system in Besov space B p,∞ s 1 × B p,∞ s was derived. Finally, the Gevrey regularity of the system was presented.
文摘This paper considers the regularity of solutions to mixed boundary value problems in small-angle regions for elliptic equations. By constructing a specific barrier function, we proved that under the assumption of sufficient regularity of boundary conditions and coefficients, as long as the angle is sufficiently small, the regularity of the solution to the mixed boundary value problem of the second-order elliptic equation can reach any order.
基金supported by the National Key Research and Development Plan(No.2016YFC0800100)the NSFC of China(Nos.11671374,71771203,71631006).
文摘For the multiplicative background risk model,a distortion-type risk measure is used to measure the tail risk of the portfolio under a scenario probability measure with multivariate regular variation.In this paper,we investigate the tail asymptotics of the portfolio loss ∑_(i=1)^(d)R_(i)S,where the stand-alone risk vector R=(R_(1),...,R_(d))follows a multivariate regular variation and is independent of the background risk factor S.An explicit asymptotic formula is established for the tail distortion risk measure,and an example is given to illustrate our obtained results.
文摘Orphan diseases are rare diseases that affect less than 200000 individuals within the United States.Most orphan diseases are of neurologic and genetic origin.With the current advances in technology,more funding has been devoted to developing therapeutic agents for patients with these conditions.In our review,we highlight emerging options for patients with neurologic orphan diseases,specifically including diseases resulting in muscular deterioration,epilepsy,seizures,neurodegenerative movement disorders,inhibited cognitive development,neuron deterioration,and tumors.After extensive literature review,gene therapy offers a promising route for the treatment of neurologic orphan diseases.The use of clustered regularly interspaced palindromic repeats/Cas9 has demonstrated positive results in experiments investigating its role in several diseases.Additionally,the use of adeno-associated viral vectors has shown improvement in survival,motor function,and developmental milestones,while also demonstrating reversal of sensory ataxia and cardiomyopathy in Friedreich ataxia patients.Antisense oligonucleotides have also been used in some neurologic orphan diseases with positive outcomes.Mammalian target of rapamycin inhibitors are currently being investigated and have reduced abnormal cell growth,proliferation,and angiogenesis.Emerging innovations and the role of genetic treatments open a new window of opportunity for the treatment of neurologic orphan diseases.
文摘Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted therapy.Despite extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.
文摘In this paper, we have considered the general ordinary quasi-differential operators generated by a general quasi-differential expression τ<sub>p,q</sub> in L<sup>p</sup>w</sub>-spaces of order n with complex coefficients and its formal adjoint τ<sup>+</sup><sub>q',p' </sub>in L<sup>p</sup>w</sub>-spaces for arbitrary p,q∈[1,∞). We have proved in the case of one singular end-point that all well-posed extensions of the minimal operator T<sub>0</sub> (τ<sub>p,q</sub>) generated by such expression τ<sub>p,q</sub> and their formal adjoint on the interval [a,b) with maximal deficiency indices have resolvents which are Hilbert-Schmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly solvable operators have all the standard essential spectra to be empty. Also, a number of results concerning the location of the point spectra and regularity fields of the operators generated by such expressions can be obtained. Some of these results are extensions or generalizations of those in the symmetric case, while others are new.
基金supported by the National Natural Science Foundation of China(Nos.52174277 and 51874077)the Fundamental Funds for the Central Universities,China(No.N2225032)+1 种基金the China Postdoctoral Science Foundation(No.2022M720683)the Postdoctoral Fund of Northeastern University,China。
文摘The formation mechanism of calcium vanadate and manganese vanadate and the difference between calcium and manganese in the reaction with vanadium are basic issues in the calcification roasting and manganese roasting process with vanadium slag.In this work,CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples were prepared and roasted for different time periods to illustrate and compare the diffusion reaction mechanisms.Then,the changes in the diffusion product and diffusion coefficient were investigated and calculated based on scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDS) analysis.Results show that with the extension of the roasting time,the diffusion reaction gradually proceeds among the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples.The regional boundaries of calcium and vanadium are easily identifiable for the CaO–V_(2)O_(5) diffusion couple.Meanwhile,for the MnO_(2)–V_(2)O_(5) diffusion couple,MnO_(2) gradually decomposes to form Mn_(2)O_(3),and vanadium diffuses into the interior of Mn_(2)O_(3).Only a part of vanadium combines with manganese to form the diffusion production layer.CaV_(2)O_(6) and MnV_(2)O_(6) are the interfacial reaction products of the CaO–V_(2)O_(5) and MnO_(2)–V_(2)O_(5) diffusion couples,respectively,whose thicknesses are 39.85 and 32.13μm when roasted for 16 h.After 16 h,both diffusion couples reach the reaction equilibrium due to the limitation of diffusion.The diffusion coefficient of the CaO–V_(2)O_(5) diffusion couple is higher than that of the MnO_(2)–V_(2)O_(5) diffusion couple for the same roasting time,and the diffusion reaction between vanadium and calcium is easier than that between vanadium and manganese.