Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway

Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood cells.Methods:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific emotions.Relative expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also determined.Results:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative emotions.Relative gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia groups.Regarding the emotional score of disgust on video stage,the main effect was significant(F=335.58,P<.001),which showed that watching the three videos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency groups.The symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional status.Our findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological problems and negative emotions,particularly disgust.We also demonstrate that emotional regulation is related to mir191-Riok3-Mxi1 pathway activity,identifying these pathway components are potential targets for genetic therapies in combination with psychological therapy.

Impaired implicit emotion regulation in patients with panic disorder:An event-related potential study on affect labeling

BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly understood.Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance.However,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.AIM To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical evaluations.The study utilized a case-control design with random sampling,selecting participants for the case group from March to December 2018.Participants performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control condition.ERP and behavioral data were recorded to compare the late positive potential(LPP)within and between the groups.RESULTS Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling.In the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease.Importantly,a significant group×condition interaction effect was observed.Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group.Furthermore,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and intensity.CONCLUSION PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative emotions.The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.

Impact of Outdoor Activities in Different Landscape Environments on the Physical and Mental Health of College Students

To investigate whether outdoor activities have an improvement effect on the emotions of young people and the differences in the impact of outdoor activities on the emotions of young people under different landscape environmental conditions,the participating students are asked to engage in outdoor activities in different landscape environments and divided into four groups.Each group is assigned to engage in outdoor activities in four types of landscape areas:open lawn area,low shrub area,dense forest area,and waterfront area.The activities include outdoor yoga and making leaf mandalas.The results show that outdoor yoga has the best effect on reducing pulse and blood pressure and regulating emotions in open lawn area and waterfront area,followed by leaf mantras in waterfront area and outdoor yoga in dense forest area.However,both activities have no significant effect in low shrub area.

Relationship between Authoritative Parenting Style and Preschool Children’s Emotion Regulation:A Moderated Mediation Model

An authoritative parenting style has been shown to promote children’s emotion regulation in European-American family studies.However,little is known about how sleep problems and the child’s sibling status in Chinese families affect this relationship.Based on family system theory,this study attempts to better understand the relationship between authoritative parenting style and emotion regulation.Mothers of preschool children in Chinese kindergartens completed questionnaires about their children’s sleep habits,their authoritative parenting styles,and children’s emotion regulation.A total of 531 children participated in this study.Results showed that authoritative parenting was positively associated with emotional regulation.Sleep problems mediated the effects of authoritative parenting style on emotion regulation.The child’s sibling status moderated the mediating effects of sleep problems in authoritative parenting and emotion regulation relationships.Specifically,the relationship between the authoritative parenting style and sleep problems was significant for only children,while birth order had no significant influence on the authoritative parenting style and sleep problems in two-child families.These findings suggest that a lowauthoritative parenting style predicts low emotion regulation through sleep problems,and this depends on the child’s sibling status,indicating that children without siblings may impair emotion regulation due to increased sleep problems.

Attachment Styles and Traumatic Responses: Exploring the Impact of Parental Interaction on Child Development and Coping Mechanisms

This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical framework of attachment theory and incorporating contemporary research, the paper discusses how parental interactions shape the neural circuitry of infants and children, influencing their ability to form secure or insecure attachments. These attachment styles, in turn, play a critical role in determining the child’s coping mechanisms when faced with trauma. This paper focuses on trying to understand how attachment theory is connected to the reaction to trauma with a highlight on the four major styles of attachments which are secure, anxious, avoidant, and disorganized to mention but a few, and how they influence stress and adversity in children. Attachment theory holds that human beings’ ability to form affectional bonds in infancy determines their patterns of relatedness across the life cycle. The type of attachment that is secure usually supports healthy adaptation and good coping mechanisms regardless of the trauma in the childhood of the child. While secure attachment mostly facilitates favorable trauma-related outcomes, anxious or avoidant attachment can exacerbate or alter the responses. The caregiving system that is avoidant attachment has implications of autonomous self-functioning which has features of suppression of the emotional response and poor search for emotional support during stress. From the principles of developmental psychology and trauma theory, the paper also focuses on the major significance of the child’s early caregivers’ interactions that define the resilience and vulnerability factor. This knowledge is therefore critical in designing specific interventions based on the improvement of coping behaviors and emotional regulatory systems of children who have been exposed to trauma. Finally, we have the synthesis of new knowledge about the role of secure attachment relationships as its fundamental element in shaping adaptive traumatization and psychological development. The article also delves into the physiological processes involved in emotional regulation and the role of cortisol in disrupting attachment. Finally, the implications of these findings for therapeutic interventions and the challenges of addressing prolonged grief and traumatic responses in clinical settings are considered.

The Application and Development of Music Therapy in Rehabilitation Medicine

Music therapy,as an ancient and continually evolving therapeutic approach,has demonstrated unique effects and extensive potential applications in the field of rehabilitation medicine.This paper first explores the physiological and psychological impacts of music and theoretical models of its therapeutic mechanisms.It further details the specific applications of music therapy in neurological rehabilitation,motor function recovery,psychological and emotional adjustment,and chronic disease and pain management.The article also investigates the prospects of integrating music therapy with modern technologies such as virtual reality and artificial intelligence and emphasizes the importance of interdisciplinary collaboration and policy support in advancing this field.Through comprehensive analysis,the paper identifies future development directions and research needs for music therapy in rehabilitation medicine.

A Study of the Relationship between Emotion Regulation and Job Burnout among Junior High School Novice English Teachers

This study aimed to examine the relationship between junior high school novice English teachers’emotion regulation and job burnout.To achieve this purpose,a survey consisting of various scales was administered to 133 primary school teachers selected from Yunnan Province in China.Statistical analyses revealed gender differences in job burnout and emotion regulation among these teachers and highlighted the association between these two variables.The findings established that male novice English teachers in junior schools generally experience lower levels of job burnout and possess better emotion regulation skills compared to their female counterparts.Additionally,a strong negative correlation was identified between job burnout and emotional regulation skills,indicating that the stronger the emotional regulation skills,the less likely novice English teachers are to experience job burnout.The study further emphasized caution in the use of cognitive reappraisal as an emotion regulation strategy,as it may have an adverse effect on mitigating job burnout.This study concluded with recommendations for providing junior high school novice English teachers with opportunities to develop and enhance their emotion regulation skills to reduce job burnout effectively.

网络思政课教学效果评价研究:基于教学方式和情绪调节视角

针对网络思政课教学效果的评价,通过对不同教学方式和情绪调节方式的比较研究,发现图文视频和互动教学可以显著提高对教学效果的主观评价,情绪调节与教学方式的交互效应显著,认知重评型对图文视频+互动教学评价高,表达抑制型对单向灌输评价高;教学方式对理解成绩的主效应显著,视频图文和互动教学可以显著提高理解成绩,情绪调节方式与教学方式的交互效应显著影响再认和理解成绩,认知重评型在互动教学下的再认和理解成绩更优,表达抑制型在图文视频+互动教学下的再认和理解成绩最高和次高,显示了情绪体验和认知资源分配对网络思政课教学效果评价的重要影响。

Emotional State Transition Model Based on Stimulus and Personality Characteristics

In order to use mathematical methods to study how cognitive reappraisal strategies affect the output state of emotions,Gross's cognitive reappraisal strategy is transformed into a quantitative parameter which is proposed to describe the general perception of emotional events on the basis of the emotion regulation.According to Gross's emotional regulation model,the Finite State Machine(FSM) model is used for describing the process of emotional state transition and the Likert 5 grading scale is introduced to study the level of an individual's reappraisal according to the participant's self-evaluation.The experimental results verify that the algorithm can effectively describe the relationship between the reappraisal strategy,emotional events and an emotiongenerative process.There are multiple dimensions of a human's emotional state.Thus,in the field of human-computer interaction,further research requires the development of a specific algorithm which can be implemented by a computer for the emotion regulation process.

Effects of mindfulness meditation on trait mindfulness,perceived stress,emotion regulation,and quality of life in hemodialysis patients:A randomized controlled trial

Objective:This study aimed to examine the effects of mindfulness meditation on trait mindfulness,perceived stress,emotion regulation,and quality of life in end-stage renal disease patients undergoing hemodialysis.Methods:An experimental study with repeated measures design was conducted among a sample of 74 end-stage renal disease patients undergoing hemodialysis between January and May 2021 in the dialysis center at Jahra hospital,Kuwait.The patients were randomly assigned to the experimental(n?37)and control groups(n?37).The experimental group participated in 30-min mindfulness meditation sessions(three sessions a week for five weeks)held during their hemodialysis sessions;the participants in the control group were instructed to sit with their eyes closed and relaxed for 30 min three times a week for five weeks during hemodialysis sessions.The dependent variables of both groups were measured at baseline(T0),middle of intervention(T1),and end of intervention(T2)using the Mindful Attention Awareness Scale(MAAS),Perceived Stress Scale(PSS),Emotion Regulation Questionnaire(ERQ),and Kidney Disease Quality of Life(KDQOL-36)questionnaire.The study was registered in the ClinicalTrial.gov(Identifier:NCT05176730).Results:The repeated measures ANOVA(within-subject)results for the experimental group showed that mindfulness meditation had significantly decreased perceived stress by the end of the intervention.Also,mindfulness meditation improved mindfulness,emotion regulation,and kidney disease-related quality of life in the experimental group,and this improvement occurred significantly at both T1 and T2.The repeated measures ANOVA(within and between-subject)results showed that the experimental group,as compared to the control group,had lower perceived stress,higher trait mindfulness,higher emotional regulation,and higher kidney disease-related quality of life over time.Conclusions:The positive findings of this study offer health policy-makers and hospital administrators a promising tool to use with patients undergoing hemodialysis as a way to manage stress and improve quality of life.However,this study should be replicated in multiple settings with follow-up assessments.

Effects of therapeutic horseback riding on post-traumatic stress disorder in military veterans

Background:Large numbers of post-deployment U.S.veterans are diagnosed with post-traumatic stress disorder(PTSD)and/or traumatic brain injury(TBI),leading to an urgent need for effective interventions to reduce symptoms and increase veterans’coping.PTSD includes anxiety,flashbacks,and emotional numbing.The symptoms increase health care costs for stress-related illnesses and can make veterans’civilian life difficult.Methods:We used a randomized wait-list controlled design with repeated measures of U.S.military veterans to address our specific aim to test the efficacy of a 6-week therapeutic horseback riding(THR)program for decreasing PTSD symptoms and increasing coping self-efficacy,emotion regulation,social and emotional loneliness.Fiftyseven participants were recruited and 29 enrolled in the randomized trial.They were randomly assigned to either the horse riding group(n=15)or a wait-list control group(n=14).The wait-list control group experienced a 6-week waiting period,while the horse riding group began THR.The wait-list control group began riding after 6 weeks of participating in the control group.Demographic and health history information was obtained from all the participants.PTSD symptoms were measured using the standardized PTSD Checklist-Military Version(PCL-M).The PCL-M as well as other instruments including,The Coping Self Efficacy Scale(CSES),The Difficulties in Emotion Regulation Scale(DERS)and The Social and Emotional Loneliness Scale for Adults-short version(SELSA)were used to access different aspects of individual well-being and the PTSD symptoms.Results:Participants had a statistically significant decrease in PTSD scores after 3 weeks of THR(P≤0.01)as well as a statistically and clinically significant decrease after 6 weeks of THR(P≤0.01).Logistic regression showed that participants had a 66.7%likelihood of having lower PTSD scores at 3 weeks and 87.5%likelihood at 6 weeks.Under the generalized linear model(GLM),our ANOVA findings for the coping self-efficacy,emotion regulation,and social and emotional loneliness did not reach statistical significance.The results for coping self-efficacy and emotion regulation trended in the predicted direction.Results for emotional loneliness were opposite the predicted direction.Logistic regression provided validation that outcome effects were caused by riding longer.Conclusion:The findings suggest that THR may be a clinically effective intervention for alleviating PTSD symptoms in military veterans.

Personality traits and self-harm behaviors among Chinese children and adolescents: The mediating effect of psychological resilience

BACKGROUND Previous studies have shown that personality traits are associated with self-harm(SH)in adolescents.However,the role of resilience in this association remains unclear.Our research aims to explore the hypothesized mediation effect of resilience in the relationship between personality traits and SH in Chinese children and adolescents.AIM To evaluate resilience as a mediator of the association between personality traits and SH.METHODS A population-based cross-sectional survey involving 4471 children and adolescents in Yunnan province in southwestern China was carried out.Relevant data were collected by self-reporting questionnaires.Univariate and multivariate logistic regression models were employed to identify associated factors of SH.A path model was used to assess the mediation effect of resilience with respect to personality traits and SH association.RESULTS Among the 4471 subjects,1795 reported SH,with a prevalence of 40.1%(95%CI:34.4%-46.0%).All dimensions of personality traits were significantly associated with SH prevalence.Resilience significantly mediated the associations between three dimensions of personality(extroversion,neuroticism,psychoticism)and SH,accounting for 21.5%,4.53%,and 9.65%,respectively,of the total associations.Among all dimensions of resilience,only emotional regulation played a significant mediation role.CONCLUSION The results of the study suggest that improving emotion regulation ability might be effective in preventing personality-associated SH among Chinese children and adolescents.

Self-regulation and Emotional Resilience in the Workplace.A Systematic Review

The current project provides a systemic literature review on the self-regulation theory analyzing the history,the main concepts,and an integrated model of analyzing the theory.Following,emotional resilience is described and linked with the self-regulation theory proving their connection,through emotional regulation.The literature review provides tangible resources for individuals to understand and apply in everyday life tactics that will assist them in fostering greater emotional resilience in the workplace,utilizing the self-regulation theory.Finally,a brief discussion is provided in terms of how to evaluate critically the concepts mentioned while limitations and future research are also indicated.This paper aims to invite conversation and collaboration in discovering a relatively new field that could in the future reimagine the workplace.

Application of unified protocol as a transdiagnostic treatment for emotional disorders during COVID-19: An internet-delivered randomized controlled trial

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has been an emotionally challenging time,especially for young adults.It is associated with a substantial increase in the prevalence of mental health problems,negative symptoms,and stressful experiences that compromise well-being.In low-income countries,internet-delivered psychological services could have a remarkable impact on the population’s mental health,given the lack of mental health professionals.AIM To investigate the efficacy of internet-delivered cognitive-behavior therapy(CBT)-transdiagnostic intervention for adults with emotional disorders.METHODS In this internet-delivered randomized controlled trial,102 students with an emotional disorder(mean age=28.20 years,standard deviation=5.07)were randomly allocated to receive unified protocol(UP)(n=51)or treatment as the usual intervention.Following a semi-structured clinical interview,participants completed an online survey including the Overall Anxiety Severity and Impairment Scale,Overall Depression Severity and Impairment Scale,Difficulties in Emotion Regulation Scale,Positive and Negative Affect Schedule,and Emotional Style Questionnaire.RESULTS The participants showed a high degree of adherence.In total,78%(n=40)of the experimental group participants completed the UP treatment.Considering the intention to treat procedure,the results of the analysis of covariance indicated that participants who received UP showed statistically significant changes in depression symptoms[Cohen’s d=-1.50 with 95%confidence interval(CI):-1.90 to-1.10],anxiety(Cohen’s d=-1.06 with 95%CI:-1.48 to-0.65),difficulties with emotion regulation(Cohen’s d=-0.33 with 95%CI:-0.7 to-0.06),positive affect(Cohen's d=1.27 with 95%CI:0.85 to 1.68),negative affect(Cohen’s d=-1.04 with 95%CI:-1.46 to-0.63),and healthy emotionality(Cohen’s d=0.53 with 95%CI:0.09 to 0.13)compared with the control group.CONCLUSION This study’s findings highlight the potential value of transdiagnostic internet-delivered programs for young adults with an emotional disorder during the COVID-19 pandemic,and expand the research examining emotional well-being improvements resulting from CBT-transdiagnostic interventions.The findings suggest that UP,which generally concentrates on reducing negative effects,can increase positive effects.

The incorporation of emotion-regulation skills into couple-and family-based treatments for post-traumatic stress disorder

Post-traumatic stress disorder(PTSD) is a disabling, potentially chronic disorder that is characterized by re-experience and hyperarousal symptoms as well as the avoidance of trauma-related stimuli. The distress experienced by many veterans of the Vietnam War and their partners prompted a strong interest in developing conjoint interventions that could both alleviate the core symptoms of PTSD and strengthen family bonds. We review the evolution of and evidence base for conjoint PTSD treatments from the Vietnam era through the post-911 era. Our review is particularly focused on the use of treatment strategies that are designed to address the emotions that are generated by the core symptoms of the disorder to reduce their adverse impact on veterans, their partners and the relationship. We present a rationale and evidence to support the direct incorporation of emotion-regulation skills training into conjoint interventions for PTSD. We begin by reviewing emerging evidence suggesting that high levels of emotion dysregulation are characteristic of and predict the severity of both PTSD symptoms and the level of interpersonal/marital difficulties reported by veterans with PTSD and their family members. In doing so, we present a compelling rationale for the inclusion of formal skills training in emotional regulation in couple–/family-based PTSD treatments. We further argue that increased exposure to trauma-related memories and emotions in treatments based on learning theory requires veterans and their partners to learn to manage the uncomfortable emotions that they previously avoided. Conjoint treatments that were developed in the last 30 years all acknowledge the importance of emotions in PTSD but vary widely in their relative emphasis on helping participants to acquire strategies to modulate them compared to other therapeutic tasks such as learning about the disorder or disclosing the trauma to a loved one. We conclude our review by describing two recent innovative treatments for PTSD that incorporate a special emphasis on emotion-regulation skills training in the dyadic context: structured approach therapy(SAT) and multi-family group for military couples(MFG-MC). Although the incorporation of emotion-regulation skills into conjoint PTSD therapies appears promising, replication and comparison to cognitive-behavioral approaches is needed to refine our understanding of which symptoms and veterans might be more responsive to one approach versus others.

Exploring the Empathy - Aggression Relationship, and Gender Related Differences in Greek College Students

The present study examined the inverse relationship between empathy(cognitive and affective)and forms of aggression(physical,verbal,anger and hostility).Previous research has continuously argued that empathy mitigates forms of aggression in individuals due to cognitive perspective taking and emotional sharing with others,that buffer hostile behaviour towards one another.However,there is a gap in the literature regarding this association in Greek culture.This correlational analysis examined empathy using the widely known multifaceted Davis Interpersonal Re­activity Index and aggression was explored using the multi-dimensional Buss-Perry Aggression Questionnaire in a sample of 92 Greek under­graduate college students from two private institutions in Athens,Greece.Gender effects on aggression and empathy levels were investigated as well.The results revealed that cognitive and emotional empathy indeed demonstrates a negative relationship with direct physical aggression.However,other forms of aggression such as verbal aggression,hostility and anger were positively associated with personal distress and Empathic fantasy majorly linked to Greek emotional regulation difficulties.Females displayed higher Empathic fantasy scores compared to males.A cultur­al perspective was adopted in exploring the results considering norms,gender roles,collective regulation capacities and societal conditioning,offering links to previous literature and theories.

Differential Impact of an Executive-Function and a Social Cognition Training on Preschoolers with Externalizing Behavior Problems

In preschoolers, externalizing behavior problems are a primary cause of consultation. It is known that externalizing behavior (EB) could result from individual and environmental risk factors. Individual risk factors included notably social cognition (SC) and executive functions (EF). A high level of EB has usually been related to dysfunction in SC and to poor skills in EF. The aim of the present experimental study is to compare the impact of two very targeted child-oriented trainings in the increasing of social competence and decreasing of EB in preschoolers. One training targeted SC abilities while the second one targeted EF capacities. These two trainings were compared on 48 preschoolers presenting clinically relevant levels of EB. The comparison of those results highlighted how each training could help preschoolers with EB in their behavior, emotion regulation and social adjustment. In comparison to a waiting-list control-group, the two trainings were effective in decreasing EB and differentiated impacts of the two trainings were obtained on different dimensions of profiles of social competence and emotion regulation. Results are discussed for their research and clinical implications.

Review and Perspectives on Human Emotion for Connected Automated Vehicles

The progression toward automated driving and the latest advancement in vehicular networking have led to novel and natural human-vehicle-road systems,in which affective human-vehicle interaction is a crucial factor affecting the acceptance,safety,comfort,and traffic efficiency of connected and automated vehicles(CAVs).This development has inspired increasing inter-est in how to develop affective interaction framework for intelligent cockpit in CAVs.To enable affective human-vehicle interactions in CAVs,knowledge from multiple research areas is needed,including automotive engineering,transportation engineering,human-machine interaction,computer science,communication,as well as industrial engineering.However,there is currently no systematic survey considering the close relationship between human-vehicle-road and human emotion in the human-vehicle-road coupling process in the CAV context.To facilitate progress in this area,this paper provides a comprehensive literature survey on emotion-related studies from multi-aspects for better design of affective interaction in intelligent cockpit for CAVs.This paper discusses the multimodal expression of human emotions,investigates the human emotion experiment in driving,and particularly emphasizes previous knowledge on human emotion detection,regulation,as well as their applications in CAVs.The promising research perspectives are outlined for researchers and engineers from different research areas to develop CAVs with better acceptance,safety,comfort,and enjoyment for users.

Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict studies.We investi-gated quadratic affliation in semi-free ranging pigs Sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was known.We collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video analyses.Affiliative and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)conditions.Quadratic affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting bystanders.Thus,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is involved.Quadratic affiliation was lowest after reconciliation and spontaneous triadic contacts.This suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic affiliation.Hence,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social factors.Such non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors

Methyl-CpG binding protein 2 （MeCP2） has a crucial role in transcriptional regulation and neural development （Ausi6 et al., 2014）. Loss of function mutations of MECP2 in human lead to Rett syndrome （RTT）, a severe neurodevelopmental disorders （Amir et al., 1999）, whereas individuals with the chromosomal duplications containing the MECP2 locus showed severe autism-like symptoms （Ramocki et al., 2009）.