Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells,...Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination.展开更多
Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The fu...Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The functional features of Treg cells are facilitated by multiple T cell differentiation-related transcription factors that therefore endow them with adaption capability to dynamic microenvironments.Recent studies also recalled the importance of immune cell metabolism,which is intimately linked with Treg cell differentiation,proliferation and function.Understanding the molecular mechanism underlying the functional stability of Treg cells could provide therapeutic opportunities to treat major human inflammatory diseases including infection,autoimmunity,allergy and cancer.展开更多
基金NIH/NCI R01 grants(R01CA133620)(WZ)and the NIH through the University of Michigan’s Cancer Center Support Grant(5 P30 CA46592).
文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination.
基金supported by the National Basic Research Program of China(Grant Nos.2014CB541803 and 2014CB541903)the National Natural Science Foundation of China(Grant Nos.81330072,31370863,31200647,81271835 and 81161120417)the National Science and Technology Major Project(Grant Nos.2012ZX10002007-003 and STCSM 14JC1406100)
文摘Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The functional features of Treg cells are facilitated by multiple T cell differentiation-related transcription factors that therefore endow them with adaption capability to dynamic microenvironments.Recent studies also recalled the importance of immune cell metabolism,which is intimately linked with Treg cell differentiation,proliferation and function.Understanding the molecular mechanism underlying the functional stability of Treg cells could provide therapeutic opportunities to treat major human inflammatory diseases including infection,autoimmunity,allergy and cancer.
