Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions

Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.

Research on the rheological properties of pesticide suspension concentrate

This study reports research on pesticide suspension rheology and a new rheological parameter, the relative value of approach, which has great advantage for judging the physical stability of a pesticide suspension concentrate. Experiments showed that the system can form stable dispersions when the value of the relative value of approach (Sr) is less than 0.1.

Optimal paths planning in dynamic transportation networks with random link travel times

A theoretical study was conducted on finding optimal paths in transportation networks where link travel times were stochastic and time-dependent(STD). The methodology of relative robust optimization was applied as measures for comparing time-varying, random path travel times for a priori optimization. In accordance with the situation in real world, a stochastic consistent condition was provided for the STD networks and under this condition, a mathematical proof was given that the STD robust optimal path problem can be simplified into a minimum problem in specific time-dependent networks. A label setting algorithm was designed and tested to find travelers' robust optimal path in a sampled STD network with computation complexity of O(n2+n·m). The validity of the robust approach and the designed algorithm were confirmed in the computational tests. Compared with conventional probability approach, the proposed approach is simple and efficient, and also has a good application prospect in navigation system.

Multiplet relative location approach and waveform correlation correction and their application

The theory and method of relative location technique were described in the paper. The travel-time difference equa-tions for five phases (Pg, Sg, P11, S11 and Pn) were given. By using the multiplet relative location approach and wave correlation correction, the aftershock cluster of the Shunyi earthquake occurred on December 16, 1996 was relocated. The depth calculation was constrained by using multiple seismic phases. The relocation results were compared with that from traditional absolute location techniques.

Kuhnian Understanding of Incommensurability and Implications of Paradigmatic Conception of Knowledge in International Relations

In international relations theory （maybe more than in any other discipline of social sciences）, the paradigmatic construction of Thomas Kuhn and his model of incommensurability might be applied to the theoretical interpretation of phenomena; and it is one of the cornerstones of the methodological toolkit for the interpretation in this field. The paper explores the reason why Kuhn＇s understanding of incommensurability seems to be necessary for the conception of knowledge in international relations： the concept of incommensurability can be considered typical as it is meant to indicate a conflict, of one form or another, between theories. And the discipline of international relations is more than a perfect ground for considering this concept when one is having in mind the high degree of polarized debate among rivalry theoretical schools （for interpreting and describing the identical phenomena） that is present from the very beginning of the discipline. Recalling the Kuhnian conception of science in paradigmatic view with an aim for understanding--international relations theory, the paper analyzes furthermore his rejection of the traditional dichotomy between “objectivisn”and ＂subjectivism.＂

Two topological approaches to resonance energy and the relation between them

Two of the present authors recently put forward a novel approach to resonance energy which is based on a similar topological reasoning as a previously elaborated resonance energy concept. It is shown that these two approaches are not completely equivalent. Several other properties of the new resonance energy are pointed out.

A Relation Matrix Approach to Labelling Temporal Relations in Scheduling

In this paper,we present a relation matrix description of temporal relations.Based on this modela new algorithm for labelling temporal relations is proposed.Under certain conditions the algorithm iscompleted and has a polynomial complexity.In general cases it is still an efficient algorithm comparedto some known algorithms.