Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on s...Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on surrounding brain tissue further aggravates the disease.The improvement of modern medical equipment and medical technology can provide early intervention treatment for patients.However,due to the particularity of the disease and the complexity of pathological and physiological reactions,irreversible damage often occurs in the central nervous system,with high disability rate and mortality.In recent years,it has been found that the related biological markers in the process of TBI are related to brain tissue injury and neurological function,and have important clinical application value in judging the severity of brain injury and prognosis evaluation,which has been widely studied.This paper intends to summarize the clinical research progress of TBI-related prognostic markers.展开更多
Endomucin is a type I integral membrane glycoprotein,which is expressed in venous and capillary endothelial cells.It consists of 261 amino acids with an extracellular domain that is highly O-glycosylated at serine and...Endomucin is a type I integral membrane glycoprotein,which is expressed in venous and capillary endothelial cells.It consists of 261 amino acids with an extracellular domain that is highly O-glycosylated at serine and threonine residues and has several potential N-glycosylation sites.Endomucin plays an important role in biological processes such as cell interaction,molecular cell signaling,angiogenesis and cell migration,and in recent years it has also been identified as an anti-adhesion molecule and a marker of endothelial cells.While it has been shown to be involved in a number of physiological and pathological mechanisms,many of its functions remain unknown,and further study is needed.This article reviews research progress on the function of endomucin to date,in order to provide guidance for future studies.展开更多
Decreased hedonic and motivational capacity,namely anhedonia,is one of the cardinal features for patients with major depressive disorder（MDD）.Recent studies suggest that this reduced ability to experience pleasure i...Decreased hedonic and motivational capacity,namely anhedonia,is one of the cardinal features for patients with major depressive disorder（MDD）.Recent studies suggest that this reduced ability to experience pleasure is also a marker or endophenotype for MDD and represents a genetic predisposition to this disorder.Dr.展开更多
Objective To investigate the differences of biochemical markers between the patients with pulmonary hypertension related to left heart disease(PH-LHD)and LHD;to explore the sensitive biomarkers which may predict PH in...Objective To investigate the differences of biochemical markers between the patients with pulmonary hypertension related to left heart disease(PH-LHD)and LHD;to explore the sensitive biomarkers which may predict PH in LHD patients.Methods A total of 355 LHD patients admitted to our hospital from 2014-01 to展开更多
基金Hainan Health and Family Planning Industry Research Project(No.19A200017)。
文摘Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on surrounding brain tissue further aggravates the disease.The improvement of modern medical equipment and medical technology can provide early intervention treatment for patients.However,due to the particularity of the disease and the complexity of pathological and physiological reactions,irreversible damage often occurs in the central nervous system,with high disability rate and mortality.In recent years,it has been found that the related biological markers in the process of TBI are related to brain tissue injury and neurological function,and have important clinical application value in judging the severity of brain injury and prognosis evaluation,which has been widely studied.This paper intends to summarize the clinical research progress of TBI-related prognostic markers.
基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences,Grant/Award Number:2016-I2M-3-019National Science and Technology Major Project,Grant/Award Number:2017ZX10304402。
文摘Endomucin is a type I integral membrane glycoprotein,which is expressed in venous and capillary endothelial cells.It consists of 261 amino acids with an extracellular domain that is highly O-glycosylated at serine and threonine residues and has several potential N-glycosylation sites.Endomucin plays an important role in biological processes such as cell interaction,molecular cell signaling,angiogenesis and cell migration,and in recent years it has also been identified as an anti-adhesion molecule and a marker of endothelial cells.While it has been shown to be involved in a number of physiological and pathological mechanisms,many of its functions remain unknown,and further study is needed.This article reviews research progress on the function of endomucin to date,in order to provide guidance for future studies.
文摘Decreased hedonic and motivational capacity,namely anhedonia,is one of the cardinal features for patients with major depressive disorder（MDD）.Recent studies suggest that this reduced ability to experience pleasure is also a marker or endophenotype for MDD and represents a genetic predisposition to this disorder.Dr.
文摘Objective To investigate the differences of biochemical markers between the patients with pulmonary hypertension related to left heart disease(PH-LHD)and LHD;to explore the sensitive biomarkers which may predict PH in LHD patients.Methods A total of 355 LHD patients admitted to our hospital from 2014-01 to
