Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people's daily use of English language. This paper would adopt ...Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people's daily use of English language. This paper would adopt the theoretical framework of pragmatics and use relevance theory as well as face theory to discuss the unique pragmatic functions of non-restrictive relational clauses in English news report discourse. The three major pragmatic functions are: (1) optimizing the relevance of information; (2) seeking for the consistence with readers; and (3) avoiding imposing the author's opinion on readers.展开更多
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury.展开更多
Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered...Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered and enforced by the software applications managing such data to guarantee plausibility.The(Elementary)Mathematical Data Model provides 17 types of dyadic-based homogeneous binary function product constraint categories.MatBase,an intelligent data and knowledge base management system prototype,allows database designers to simply declare them by only clicking corresponding checkboxes and automatically generates code for enforcing them.This paper describes the algorithms that MatBase uses for enforcing all 17 types of homogeneous binary function product constraint,which may also be employed by developers without access to MatBase.展开更多
Density functional theory calculations were performed to study the structures and relative stability of the gadolinium complexes, Gd(H2O)n^3+ (n=8,9), in vacuo and in aqueous solution. The polarizable continuum m...Density functional theory calculations were performed to study the structures and relative stability of the gadolinium complexes, Gd(H2O)n^3+ (n=8,9), in vacuo and in aqueous solution. The polarizable continuum model with various radii for the solute cavity was used to study the relative stability in aqueous solution. The calculated molecular geometries for n=8 and 9 obtained in vacuo are consistent with those observed in experiments. It was found that while the nona-aqua complex is favored in the gas phase, in aqueous solution the octa-aqua conformation is preferred. This result, independent of the types of cavities employed, is in agreement with the experimental observation. The reliability of the present calculation was also addressed by comparing the calculated and experimental free energy of hydration, which revealed that the UA0, UAHF, and UAKS cavities are most appropriate when only the first solvation shell is treated explicitly.展开更多
Purpose:Researchers frequently encounter the following problems when writing scientific articles:(1)Selecting appropriate citations to support the research idea is challenging.(2)The literature review is not conducted...Purpose:Researchers frequently encounter the following problems when writing scientific articles:(1)Selecting appropriate citations to support the research idea is challenging.(2)The literature review is not conducted extensively,which leads to working on a research problem that others have well addressed.The study focuses on citation recommendation in the related studies section by applying the term function of a citation context,potentially improving the efficiency of writing a literature review.Design/methodology/approach:We present nine term functions with three newly created and six identified from existing literature.Using these term functions as labels,we annotate 531 research papers in three topics to evaluate our proposed recommendation strategy.BM25 and Word2vec with VSM are implemented as the baseline models for the recommendation.Then the term function information is applied to enhance the performance.Findings:The experiments show that the term function-based methods outperform the baseline methods regarding the recall,precision,and F1-score measurement,demonstrating that term functions are useful in identifying valuable citations.Research limitations:The dataset is insufficient due to the complexity of annotating citation functions for paragraphs in the related studies section.More recent deep learning models should be performed to future validate the proposed approach.Practical implications:The citation recommendation strategy can be helpful for valuable citation discovery,semantic scientific retrieval,and automatic literature review generation.Originality/value:The proposed citation function-based citation recommendation can generate intuitive explanations of the results for users,improving the transparency,persuasiveness,and effectiveness of recommender systems.展开更多
For two subsets W and V of a Banach space X, let Kn(W, V, X) denote the relative Kolmogorov n-width of W relative to V defined by Kn(W,V,X):=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over ...For two subsets W and V of a Banach space X, let Kn(W, V, X) denote the relative Kolmogorov n-width of W relative to V defined by Kn(W,V,X):=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over all n-dimensional linear subspaces Ln of X. Let W2(△^τ) denote the class of 2π-periodic functions f with d-variables satisfying ∫[-π, π]^d|△^τf(x)|^2dx≤1, while △^τ is the r-iterate of Laplace operator △. This article discusses the relative Kolmogorov n-width of W2(△^τ) relative to W2(△^τ) in Lq([-π, π]^d) (1≤ q ≤ ∞), and obtain its weak asymptotic result.展开更多
AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patie...AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patients were recruited among children referred to the Department of Paediatrics,Medical University of Warsaw.Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic criteria.The children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same dosage.The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.RESULTS:Of the 89 eligible children,84(94%) completed the study."No pain" and "treatment success"(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool consistency.GNN demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily activities.CONCLUSION:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.展开更多
Relative clauses in traditional grammars,which are sometimes called attributive clauses,are divided into two types:restrictive and non-restrictive.Building upon the discussion of recursion in Halliday’s Systemic Func...Relative clauses in traditional grammars,which are sometimes called attributive clauses,are divided into two types:restrictive and non-restrictive.Building upon the discussion of recursion in Halliday’s Systemic Functional Grammar(SFG),this paper conducts a functional syntactic analysis of such clauses,aimed at probing into their logical structures.展开更多
A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and...A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and strong in generality. In order to reveal its availability, a comparison is made between the results obtained with it and the experimental results of grey cast iron has be done, both seem to be in good agreement. At the same time, taking the yield function obtained here as a potential function, a new associative plastic constitutive equation taking effect of hydrostatic stress into account is built, and the plastic volume change ratio of plastic deformation is given.展开更多
Background: Cognitive impairment is a major health issue particularly with the increasing aging population. There are around 47.5 million dementia cases globally. Traffic air pollution issue is a chief environmental p...Background: Cognitive impairment is a major health issue particularly with the increasing aging population. There are around 47.5 million dementia cases globally. Traffic air pollution issue is a chief environmental problem principally in the mega cities such as Cairo. Methodology: In a Cross sectional and comparative research study the study subjects recruited involved 200 individuals, categorized into two research groups: 100 from Cairo’s elderly home residents and 100 from EL-Gharbaya’s elderly home residents. Results: Statistical linear regression analysis revealed that fine particulate matter, carbon monoxide, and nitric oxide have a statistically significant impact on cognitive function (p values Conclusions: Traffic related air pollutants were strongly associated with cognitive impairment within elderly population in geriatric home residents in Egypt. Regarding to statistically significant difference in concentration of traffic related air pollutants between urban and rural areas, urban areas were more polluted than rural areas.展开更多
In the paper,by virtue of a general formula for any derivative of the ratio of two differentiable functions,with the aid of a recursive property of the Hessenberg determinants,the authors establish determinantal expre...In the paper,by virtue of a general formula for any derivative of the ratio of two differentiable functions,with the aid of a recursive property of the Hessenberg determinants,the authors establish determinantal expressions and recursive relations for the Bessel zeta function and for a sequence originating from a series expansion of the power of modified Bessel function of the first kind.展开更多
In analogy to the role of Lommel polynomials ?in relation to Bessel functions Jv(z) the theory of Associated Hermite polynomials in the scaled form ?with parmeter v to Parabolic Cylinder functions Dv(z) is developed. ...In analogy to the role of Lommel polynomials ?in relation to Bessel functions Jv(z) the theory of Associated Hermite polynomials in the scaled form ?with parmeter v to Parabolic Cylinder functions Dv(z) is developed. The group-theoretical background with the 3-parameter group of motions M(2) in the plane for Bessel functions and of the Heisenberg-Weyl group W(2) for Parabolic Cylinder functions is discussed and compared with formulae, in particular, for the lowering and raising operators and the eigenvalue equations. Recurrence relations for the Associated Hermite polynomials and for their derivative and the differential equation for them are derived in detail. Explicit expressions for the Associated Hermite polynomials with involved Jacobi polynomials at argument zero are given and by means of them the Parabolic Cylinder functions are represented by two such basic functions.展开更多
The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless ...The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless fermion. It is demonstrated explicitly that the transverse vector vertex function derived this way to one-loop order leads to the same result as one obtained in perturbation theory. This provides a basic approach to determine the transverse part of basic vertex function from the symmetry relations of the system.展开更多
Objective: To explore the effects of Ticagrelor on oxidative stress, coagulation function, platelet function and related factors in patients with coronary artery disease undergoing interventional therapy. Methods: A t...Objective: To explore the effects of Ticagrelor on oxidative stress, coagulation function, platelet function and related factors in patients with coronary artery disease undergoing interventional therapy. Methods: A total of 140 patients with coronary artery disease who underwent percutaneous coronary intervention in our hospital from October 2016 to March 2018 were selected as the study subjects and were divided into control group (70 cases) and observation group (70 cases) by drawing lots. Both groups were treated with symptomatic routine therapy before operation. On this basis, the control group was treated with clopidogrel before operation, and the observation group was treated with Ticagrelor before operation on the basis of routine treatment. The changes of oxidative stress, coagulation index, platelet function and related factors were compared between the two groups before and after treatment. Results: Before treatment, there were no significant differences in oxidative stress factors, coagulation parameters, platelet parameters and related factors factors between the two groups. After treatment, the levels of MDA, MPAR, VEGF and MMP-9 in the two groups were lower than those before treatment, while the levels of SOD, APTT, TT and PT were higher than those before treatment;and the levels of MDA, MPAR, VEGF, MMP-9, APTT and PT in the observation group were significantly lower than those in the control group after treatment, while the levels fo SOD, TT and IPA in the observation group were significantly higher than those in the control group. Conclusions: Ticagrelor can better reduce oxidative stress injury, improve coagulation function and coronary stenosis, and inhibit platelet aggregation in patients with coronary heart disease undergoing PCI than clopidogrel. It has clinical popularization significance.展开更多
Objective:To investigate the prognostic value of Th-22 cells and related functional cytokines in patients with vitiligo.Methods:Thirty-five patients with vitiligo who admitted to the outpatient clinic from June 2016 t...Objective:To investigate the prognostic value of Th-22 cells and related functional cytokines in patients with vitiligo.Methods:Thirty-five patients with vitiligo who admitted to the outpatient clinic from June 2016 to November 2018 in the hospital were selected as the study group.Thirty healthy controls were selected as the control group.Th-22 cells and their related cytokines were analyzed in both groups.Resylts:The levels of cytokines in Th-22 and Th-17 cells in the study group were significantly higher than those in the control group(P<0.05).The expression of Treg lymphocyte-related factors in the study group was lower than that in the control group(P<0.05).The changes in cell and factor levels in patients with vitiligo before and after treatment were significantly different(P<0.05).Conclusion:It is shown that three cells,including Th-22,Th-17 and Treg are related to each other,and they can inhibit and promote the pathogenesis of vitiligo which provides a reference for prognosis and treatment.展开更多
Arsenic can diffuse into high-κ dielectrics during OaAs-based metal oxide semiconductor transistor process, which causes the degradation of gate dielectrics. To explore the origins of the degradation, we employ nonlo...Arsenic can diffuse into high-κ dielectrics during OaAs-based metal oxide semiconductor transistor process, which causes the degradation of gate dielectrics. To explore the origins of the degradation, we employ nonlocal B3LYP hybrid functional to study arsenic related defects in ZrO2. Via band alignments between the OaAs and ZrO2, we are able to determine the defect formation energy in the GaAs relative to the ZrO2 band gap and assess how they will affect the device performance. Arsenic at the interstitial site serves as a source of positive fixed charge while at the oxygen or zirconium substitutional site changes its charge state within the band gap of GaAs. Moreover, it is found that arsenic related defects produce conduction band offset reduction and gap states, which will increase the gate leakage current.展开更多
Using ordered pairs,we can formulate themathematical theory of relations in set-theoreticlanguage.By a relation we mean here something likemarriage (between men and women) or belonging(between elements and sets).Looki...Using ordered pairs,we can formulate themathematical theory of relations in set-theoreticlanguage.By a relation we mean here something likemarriage (between men and women) or belonging(between elements and sets).Looking at any specific relation,such asmarriage for instance,we might be tempted toconsider certain ordered pairs (x,y),namely justthose for which x is a man,y is a woman,and x ismarried to y.We have not yet seen the definition展开更多
BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature tho...BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature though for what happens to such kidneys, in the long run, particularly those which are poorly functioning.AIM To assess the long-term outcomes of ureteric reimplantation in poorly functioning kidneys in children with unilateral primary VUR.METHODS Children with unilateral primary VUR and a relative renal function of less than 35% who underwent open or laparoscopic ureteric reimplantation between January 2005 and January 2017 were included in the study. Patients who had a follow up of less than five years were excluded. Preoperative evaluation consisted of a voiding cystourethrogram and Dimercaptosuccinic acid(DMSA) scan. In the follow-up period, patients underwent a diuretic scan at 6 weeks and 6 months.Follow up ultrasound was done for change in grade of hydronephrosis and retrovesical ureteric diameter. Subsequent follow up was done at 6 monthly intervals with evaluation for proteinuria and hypertension and any recurrent urinary tract infection(UTI). For assessment of cortical function, DMSA was repeated annually for 5 years after surgery. A paired-samples t-test was used to test the mean difference of DMSA between pre-post observations.RESULTS During this period, 36 children underwent ureteric reimplantation for unilateral primary VUR. After excluding those with insufficient follow-up, 31 were included in the analysis. Most of the patients were males(n = 26/31, 83.8%). Patient’s age(mean ± SD, range) was 5.21 ± 3.71, 1-18 years. The grades of VUR were grade Ⅱ(1patient), grade Ⅲ(8 patients), grade Ⅳ(10 patients), and grade Ⅴ(12 patients). The pre and postoperative DMSA was 24.064 ± 12.02 and 24.06 ± 10.93, which was almost the same(statistically equal, paired-samples t-test: P = 0.873). The median(range) follow-up duration was 82(60-120)mo. One patient had persistent reflux after surgery(preoperative: grade Ⅳ, postoperative: grade Ⅲ), and the very same patient developed recurrent UTI. The difference in the preoperative and postoperative DRF was less than 10% in 29 patients. In one patient, the DRF decreased by 17%(22% to 05%) while in another patient, the DRF increased by 12%(25% to 37%) after surgery. None of the patients had an increase in scarring after surgery. 15% of patients were hypertensive before surgery and all of them continued to be hypertensive after surgery while none developed hypertension after surgery. None of the patients had significant proteinuria(> 150 mg/d) during the follow-up period.CONCLUSION Children with unilateral primary VUR and poorly functioning kidney maintain the renal function over the long term in most cases. Hypertension and proteinuria do not progress over time in these patients.展开更多
文摘Traditional syntactic or semantic theories failed to provide a satistactory explanation for the unique features of non-restrictive relational clauses in people's daily use of English language. This paper would adopt the theoretical framework of pragmatics and use relevance theory as well as face theory to discuss the unique pragmatic functions of non-restrictive relational clauses in English news report discourse. The three major pragmatic functions are: (1) optimizing the relevance of information; (2) seeking for the consistence with readers; and (3) avoiding imposing the author's opinion on readers.
基金supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW)National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
文摘Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury.
文摘Homogeneous binary function products are frequently encountered in the sub-universes modeled by databases,spanning from genealogical trees and sports to education and healthcare,etc.Their properties must be discovered and enforced by the software applications managing such data to guarantee plausibility.The(Elementary)Mathematical Data Model provides 17 types of dyadic-based homogeneous binary function product constraint categories.MatBase,an intelligent data and knowledge base management system prototype,allows database designers to simply declare them by only clicking corresponding checkboxes and automatically generates code for enforcing them.This paper describes the algorithms that MatBase uses for enforcing all 17 types of homogeneous binary function product constraint,which may also be employed by developers without access to MatBase.
基金ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (No.10804001, No.10674002, and No.20773024), the National High Technology Research and Development Program of China (No.2006AA09Z243-3), and the Program for Innovative Research Team in Anhui Normal University of China.
文摘Density functional theory calculations were performed to study the structures and relative stability of the gadolinium complexes, Gd(H2O)n^3+ (n=8,9), in vacuo and in aqueous solution. The polarizable continuum model with various radii for the solute cavity was used to study the relative stability in aqueous solution. The calculated molecular geometries for n=8 and 9 obtained in vacuo are consistent with those observed in experiments. It was found that while the nona-aqua complex is favored in the gas phase, in aqueous solution the octa-aqua conformation is preferred. This result, independent of the types of cavities employed, is in agreement with the experimental observation. The reliability of the present calculation was also addressed by comparing the calculated and experimental free energy of hydration, which revealed that the UA0, UAHF, and UAKS cavities are most appropriate when only the first solvation shell is treated explicitly.
基金This work is supported by the National Natural Science Foundation of China(Grant No.7167030644 and 71704137)。
文摘Purpose:Researchers frequently encounter the following problems when writing scientific articles:(1)Selecting appropriate citations to support the research idea is challenging.(2)The literature review is not conducted extensively,which leads to working on a research problem that others have well addressed.The study focuses on citation recommendation in the related studies section by applying the term function of a citation context,potentially improving the efficiency of writing a literature review.Design/methodology/approach:We present nine term functions with three newly created and six identified from existing literature.Using these term functions as labels,we annotate 531 research papers in three topics to evaluate our proposed recommendation strategy.BM25 and Word2vec with VSM are implemented as the baseline models for the recommendation.Then the term function information is applied to enhance the performance.Findings:The experiments show that the term function-based methods outperform the baseline methods regarding the recall,precision,and F1-score measurement,demonstrating that term functions are useful in identifying valuable citations.Research limitations:The dataset is insufficient due to the complexity of annotating citation functions for paragraphs in the related studies section.More recent deep learning models should be performed to future validate the proposed approach.Practical implications:The citation recommendation strategy can be helpful for valuable citation discovery,semantic scientific retrieval,and automatic literature review generation.Originality/value:The proposed citation function-based citation recommendation can generate intuitive explanations of the results for users,improving the transparency,persuasiveness,and effectiveness of recommender systems.
基金Supported partly by National Natural Science Foundation of China (10471010)partly by the project "Representation Theory and Related Topics" of the "985 Program" of Beijing Normal University
文摘For two subsets W and V of a Banach space X, let Kn(W, V, X) denote the relative Kolmogorov n-width of W relative to V defined by Kn(W,V,X):=inf sup inf/Ln f∈W g∈V∩Ln‖f-g‖x, where the infimum is taken over all n-dimensional linear subspaces Ln of X. Let W2(△^τ) denote the class of 2π-periodic functions f with d-variables satisfying ∫[-π, π]^d|△^τf(x)|^2dx≤1, while △^τ is the r-iterate of Laplace operator △. This article discusses the relative Kolmogorov n-width of W2(△^τ) relative to W2(△^τ) in Lq([-π, π]^d) (1≤ q ≤ ∞), and obtain its weak asymptotic result.
文摘AIM:To assess the efficacy of glucomannan(GNN) as the sole treatment for abdominal pain-related functional gastrointestinal disorders(FGIDs).METHODS:We conducted a double-blind,placebocontrolled,randomized trial.Patients were recruited among children referred to the Department of Paediatrics,Medical University of Warsaw.Included in the study were children aged 7-17 years with abdominal pain-related FGIDs classified according to the Rome Ⅲ diagnostic criteria.The children were randomly assigned to receive GNN,a polysaccharide of 1,4-D-glucose and D-mannose,a soluble fiber from the Japanese Konjac plant,at a dosage of 2.52 g/d(1 sachet of 1.26 g 2 times a day),or a comparable placebo(maltodextrin) at the same dosage.The content of each sachet was dissolved in approximately 125 mL of fluid and was consumed twice daily for 4 wk.RESULTS:Of the 89 eligible children,84(94%) completed the study."No pain" and "treatment success"(defined as no pain or a decrease ≥ 2/6 points on the FACES Pain Scale Revised) were similar in the GNN(n = 41) and placebo(n = 43) groups [no pain(12/41 vs 6/43,respectively;RR = 2.1,95%CI:0.87-5.07) as well as treatment success(23/41 vs 20/43;RR = 1.2,95%CI:0.79-1.83)].No significant differences between the groups were observed in the secondary outcomes,such as abdominal cramps,abdominal bloating/gassiness,episodes of nausea or vomiting,or a changed in stool consistency.GNN demonstrated no significant influence on the number of children requiring rescue therapy,school absenteeism,or daily activities.CONCLUSION:In our setting,GNN,as dosed in this study,was no more effective than the placebo in achieving therapeutic success in the management of FGIDs in children.
文摘Relative clauses in traditional grammars,which are sometimes called attributive clauses,are divided into two types:restrictive and non-restrictive.Building upon the discussion of recursion in Halliday’s Systemic Functional Grammar(SFG),this paper conducts a functional syntactic analysis of such clauses,aimed at probing into their logical structures.
文摘A new yield function taking effect of hydrostatic stress into account is presented through establishing and solving the functional equation satisfied by the yield function, and its characteristic is simple in form and strong in generality. In order to reveal its availability, a comparison is made between the results obtained with it and the experimental results of grey cast iron has be done, both seem to be in good agreement. At the same time, taking the yield function obtained here as a potential function, a new associative plastic constitutive equation taking effect of hydrostatic stress into account is built, and the plastic volume change ratio of plastic deformation is given.
文摘Background: Cognitive impairment is a major health issue particularly with the increasing aging population. There are around 47.5 million dementia cases globally. Traffic air pollution issue is a chief environmental problem principally in the mega cities such as Cairo. Methodology: In a Cross sectional and comparative research study the study subjects recruited involved 200 individuals, categorized into two research groups: 100 from Cairo’s elderly home residents and 100 from EL-Gharbaya’s elderly home residents. Results: Statistical linear regression analysis revealed that fine particulate matter, carbon monoxide, and nitric oxide have a statistically significant impact on cognitive function (p values Conclusions: Traffic related air pollutants were strongly associated with cognitive impairment within elderly population in geriatric home residents in Egypt. Regarding to statistically significant difference in concentration of traffic related air pollutants between urban and rural areas, urban areas were more polluted than rural areas.
基金The first author,Mrs.Yan Hong,was partially supported by the Natural Science Foundation of Inner Mongolia(Grant No.2019MS01007)by the Science Research Fund of Inner Mongolia University for Nationalities(Grant No.NMDBY15019)by the Foun-dation of the Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region(Grant Nos.NJZY19157 and NJZY20119)in China。
文摘In the paper,by virtue of a general formula for any derivative of the ratio of two differentiable functions,with the aid of a recursive property of the Hessenberg determinants,the authors establish determinantal expressions and recursive relations for the Bessel zeta function and for a sequence originating from a series expansion of the power of modified Bessel function of the first kind.
文摘In analogy to the role of Lommel polynomials ?in relation to Bessel functions Jv(z) the theory of Associated Hermite polynomials in the scaled form ?with parmeter v to Parabolic Cylinder functions Dv(z) is developed. The group-theoretical background with the 3-parameter group of motions M(2) in the plane for Bessel functions and of the Heisenberg-Weyl group W(2) for Parabolic Cylinder functions is discussed and compared with formulae, in particular, for the lowering and raising operators and the eigenvalue equations. Recurrence relations for the Associated Hermite polynomials and for their derivative and the differential equation for them are derived in detail. Explicit expressions for the Associated Hermite polynomials with involved Jacobi polynomials at argument zero are given and by means of them the Parabolic Cylinder functions are represented by two such basic functions.
基金The project supported by National Natural Science Foundation of China under Grant No. 90303006
文摘The transverse vector vertex function in momentum space in four-dimensional QED is derived in terms of a set of transverse Ward-Takahashi relations for the vector and the axial-vector vertices in the case of massless fermion. It is demonstrated explicitly that the transverse vector vertex function derived this way to one-loop order leads to the same result as one obtained in perturbation theory. This provides a basic approach to determine the transverse part of basic vertex function from the symmetry relations of the system.
文摘Objective: To explore the effects of Ticagrelor on oxidative stress, coagulation function, platelet function and related factors in patients with coronary artery disease undergoing interventional therapy. Methods: A total of 140 patients with coronary artery disease who underwent percutaneous coronary intervention in our hospital from October 2016 to March 2018 were selected as the study subjects and were divided into control group (70 cases) and observation group (70 cases) by drawing lots. Both groups were treated with symptomatic routine therapy before operation. On this basis, the control group was treated with clopidogrel before operation, and the observation group was treated with Ticagrelor before operation on the basis of routine treatment. The changes of oxidative stress, coagulation index, platelet function and related factors were compared between the two groups before and after treatment. Results: Before treatment, there were no significant differences in oxidative stress factors, coagulation parameters, platelet parameters and related factors factors between the two groups. After treatment, the levels of MDA, MPAR, VEGF and MMP-9 in the two groups were lower than those before treatment, while the levels of SOD, APTT, TT and PT were higher than those before treatment;and the levels of MDA, MPAR, VEGF, MMP-9, APTT and PT in the observation group were significantly lower than those in the control group after treatment, while the levels fo SOD, TT and IPA in the observation group were significantly higher than those in the control group. Conclusions: Ticagrelor can better reduce oxidative stress injury, improve coagulation function and coronary stenosis, and inhibit platelet aggregation in patients with coronary heart disease undergoing PCI than clopidogrel. It has clinical popularization significance.
文摘Objective:To investigate the prognostic value of Th-22 cells and related functional cytokines in patients with vitiligo.Methods:Thirty-five patients with vitiligo who admitted to the outpatient clinic from June 2016 to November 2018 in the hospital were selected as the study group.Thirty healthy controls were selected as the control group.Th-22 cells and their related cytokines were analyzed in both groups.Resylts:The levels of cytokines in Th-22 and Th-17 cells in the study group were significantly higher than those in the control group(P<0.05).The expression of Treg lymphocyte-related factors in the study group was lower than that in the control group(P<0.05).The changes in cell and factor levels in patients with vitiligo before and after treatment were significantly different(P<0.05).Conclusion:It is shown that three cells,including Th-22,Th-17 and Treg are related to each other,and they can inhibit and promote the pathogenesis of vitiligo which provides a reference for prognosis and treatment.
基金Supported by the Key Project of Education Department of China under Grant No 211035the Science Foundation from Education Department of Liaoning Province under Grant No L2014445
文摘Arsenic can diffuse into high-κ dielectrics during OaAs-based metal oxide semiconductor transistor process, which causes the degradation of gate dielectrics. To explore the origins of the degradation, we employ nonlocal B3LYP hybrid functional to study arsenic related defects in ZrO2. Via band alignments between the OaAs and ZrO2, we are able to determine the defect formation energy in the GaAs relative to the ZrO2 band gap and assess how they will affect the device performance. Arsenic at the interstitial site serves as a source of positive fixed charge while at the oxygen or zirconium substitutional site changes its charge state within the band gap of GaAs. Moreover, it is found that arsenic related defects produce conduction band offset reduction and gap states, which will increase the gate leakage current.
文摘Using ordered pairs,we can formulate themathematical theory of relations in set-theoreticlanguage.By a relation we mean here something likemarriage (between men and women) or belonging(between elements and sets).Looking at any specific relation,such asmarriage for instance,we might be tempted toconsider certain ordered pairs (x,y),namely justthose for which x is a man,y is a woman,and x ismarried to y.We have not yet seen the definition
文摘BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature though for what happens to such kidneys, in the long run, particularly those which are poorly functioning.AIM To assess the long-term outcomes of ureteric reimplantation in poorly functioning kidneys in children with unilateral primary VUR.METHODS Children with unilateral primary VUR and a relative renal function of less than 35% who underwent open or laparoscopic ureteric reimplantation between January 2005 and January 2017 were included in the study. Patients who had a follow up of less than five years were excluded. Preoperative evaluation consisted of a voiding cystourethrogram and Dimercaptosuccinic acid(DMSA) scan. In the follow-up period, patients underwent a diuretic scan at 6 weeks and 6 months.Follow up ultrasound was done for change in grade of hydronephrosis and retrovesical ureteric diameter. Subsequent follow up was done at 6 monthly intervals with evaluation for proteinuria and hypertension and any recurrent urinary tract infection(UTI). For assessment of cortical function, DMSA was repeated annually for 5 years after surgery. A paired-samples t-test was used to test the mean difference of DMSA between pre-post observations.RESULTS During this period, 36 children underwent ureteric reimplantation for unilateral primary VUR. After excluding those with insufficient follow-up, 31 were included in the analysis. Most of the patients were males(n = 26/31, 83.8%). Patient’s age(mean ± SD, range) was 5.21 ± 3.71, 1-18 years. The grades of VUR were grade Ⅱ(1patient), grade Ⅲ(8 patients), grade Ⅳ(10 patients), and grade Ⅴ(12 patients). The pre and postoperative DMSA was 24.064 ± 12.02 and 24.06 ± 10.93, which was almost the same(statistically equal, paired-samples t-test: P = 0.873). The median(range) follow-up duration was 82(60-120)mo. One patient had persistent reflux after surgery(preoperative: grade Ⅳ, postoperative: grade Ⅲ), and the very same patient developed recurrent UTI. The difference in the preoperative and postoperative DRF was less than 10% in 29 patients. In one patient, the DRF decreased by 17%(22% to 05%) while in another patient, the DRF increased by 12%(25% to 37%) after surgery. None of the patients had an increase in scarring after surgery. 15% of patients were hypertensive before surgery and all of them continued to be hypertensive after surgery while none developed hypertension after surgery. None of the patients had significant proteinuria(> 150 mg/d) during the follow-up period.CONCLUSION Children with unilateral primary VUR and poorly functioning kidney maintain the renal function over the long term in most cases. Hypertension and proteinuria do not progress over time in these patients.