Based on the relationship between capacity and load, cascading failure on weighted complex networks is investigated, and a load-capacity optimal relationship （LCOR） model is proposed in this paper. Compared with thr...Based on the relationship between capacity and load, cascading failure on weighted complex networks is investigated, and a load-capacity optimal relationship （LCOR） model is proposed in this paper. Compared with three other kinds of load- capacity linear or non-linear relationship models in model networks as well as a number of real-world weighted networks including the railway network, the airports network and the metro network, the LCOR model is shown to have the best robustness against cascading failure with less cost. Furthermore, theoretical analysis and computational method of its cost threshold are provided to validate the effectiveness of the LCOR model. The results show that the LCOR model is effective for designing real-world networks with high robustness and less cost against cascading failure.展开更多
Hollow cathode,with the highest plasma density,current density,and temperature,becomes one of the most important components in the electro-thruster system.As the electric-propulsion thruster performance is directly re...Hollow cathode,with the highest plasma density,current density,and temperature,becomes one of the most important components in the electro-thruster system.As the electric-propulsion thruster performance is directly related to the ionization rate,reliability,and lifetime of the hollow cathode,this paper develops a global model to study the effects of discharge current,gas flow rate,and gas species on the discharge characteristics in the insert and orifice regions of the hollow cathode.The emitter wall temperatures of hollow cathodes predicted by the global model are compared with experimental results from NSTAR thruster neutralization cathodes,confirming the model's validity.The influence of hollow cathode emitter material and structure sizes on the plasma parameters in the internal regions was also evaluated.The simulation results show that there is an optimal matching relationship between the discharge current and gas flow rate to guarantee the maximum ionization rate.The optimal working region for the hollow cathode has been deter-mined under different energetic,regime and structural parameters.The global model established in this paper can quickly determine the key structure and operating parameters of hollow cathode at the design stage,and provide the theoretical basis for hollow cathode design and development.展开更多
The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapati...The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays.Four different regions of the scaffold were modified to assess the effects on hGRa antagonism and related potency.Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a,as well as an improved chemical stability,which make it a promising lead for the subsequent optimization.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 60804066 and 61165007)the Scientific and Technological Project of Education Department of Jiangxi Province, China (Grant Nos. GJJ12286 and KJLD12068)
文摘Based on the relationship between capacity and load, cascading failure on weighted complex networks is investigated, and a load-capacity optimal relationship （LCOR） model is proposed in this paper. Compared with three other kinds of load- capacity linear or non-linear relationship models in model networks as well as a number of real-world weighted networks including the railway network, the airports network and the metro network, the LCOR model is shown to have the best robustness against cascading failure with less cost. Furthermore, theoretical analysis and computational method of its cost threshold are provided to validate the effectiveness of the LCOR model. The results show that the LCOR model is effective for designing real-world networks with high robustness and less cost against cascading failure.
基金supported by the National Natural Science Foundation of China (Nos.U22B20120,NSFC52202460 and NSFC52177128)the National Key R&D Program of China (Nos.2020YFC2201100 and 2021YFC2202804,2022YFB3403504)+1 种基金the China Postdoctoral Science Foundation (Nos.2021M690392 and 2021TQ0036)the Advanced Space Propulsion Laboratory of BICE and Beijing Engineering Research Center of Efficient and Green Aerospace Propulsion Technology,China (No.LabASP-2021-04).
文摘Hollow cathode,with the highest plasma density,current density,and temperature,becomes one of the most important components in the electro-thruster system.As the electric-propulsion thruster performance is directly related to the ionization rate,reliability,and lifetime of the hollow cathode,this paper develops a global model to study the effects of discharge current,gas flow rate,and gas species on the discharge characteristics in the insert and orifice regions of the hollow cathode.The emitter wall temperatures of hollow cathodes predicted by the global model are compared with experimental results from NSTAR thruster neutralization cathodes,confirming the model's validity.The influence of hollow cathode emitter material and structure sizes on the plasma parameters in the internal regions was also evaluated.The simulation results show that there is an optimal matching relationship between the discharge current and gas flow rate to guarantee the maximum ionization rate.The optimal working region for the hollow cathode has been deter-mined under different energetic,regime and structural parameters.The global model established in this paper can quickly determine the key structure and operating parameters of hollow cathode at the design stage,and provide the theoretical basis for hollow cathode design and development.
基金supported in part by grants from the Ministry of Health of China (Nos. 2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001 and 2013ZX09507002)Shanghai Science and Technology Development Fund (No. 13DZ2290300)Thousand Talents Program in China
文摘The structure–activity relationship（SAR） study of a 1 2 3 4 4a 9a-hexahydro-1H-xanthene series of selective,human glucocorticoid receptor a（hGRa） antagonists is reported.Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays.Four different regions of the scaffold were modified to assess the effects on hGRa antagonism and related potency.Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a,as well as an improved chemical stability,which make it a promising lead for the subsequent optimization.
