Clinical Analysis of Dispelling Wind,Eliminating Lung and Relieving Cough Combined with Western Medicine in the Treatment of Cough Variant Asthma in Children

Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.

Novel anti-AD dimeric leads:from relieving symptoms to modifying diseases via multi-targets

Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.

DRUGS FOR RELIEVING COUGH AND ASTHMA——Selected from A Practical English——Chinese Library of Traditional Chinese Medicine

Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,

Summary of 32 Patients with Cardiac Syndrome X Treated by TCM Therapy of Regulating Qi Relieving Chest Stuffiness and Promoting Blood Circulation

Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation） in treating patients with cardiac syndrome X （CSX）. Methods： The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment （32 patients）, and the control group treated with conventional treatment （19 patients） like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results： After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group （P〈0.05）; the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group （P〈0.05）. The treadmill exercise test showed that the maximal metabolic equivalent （Max MET）, the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively （P〈0.05）. Conclusion： The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.

Anticancer Effects of 5-Fluorouracil Combined with Warming and Relieving Cold Phlegm Formula on Human Breast Cancer

Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes compared with the 5-FU group （778 ± 202 mm3, both P〈0.05）. The combination group had the highest tumor inhibition rate （47.7%）, followed by the hWRCP group （35.2%） and 5-FU group （28.3%）. The 5-FU group had a lower body weight increase （1.37± 2.06 g versus 5.60± 0.72 g, P〈0.05） and a lower spleen index （4.064 ± 1.774 rag/10 g versus 5.294 ± 1.796 mg/10 g） as compared with the control group, whereas the combination group reversed the changes in the 5-FU group with the body weight increase of 3.52 ± 1.80 g （P〈0.05） and spleen index of 7.036 ± 1.599 mg/10 g （P〈0.05）. The spleen indices in the hWRCP, mWRCP, and IWRCP group were all significantly higher than that in the 5-FU group （P〈0.01 or P〈0.05）. No significant differences in body weight change were observed in WRCP groups compared with the control group （P〉0.05）. Conclusioa： The treatment combination of WRCP and 5-FU was more effective in the inhibition of tumor growth than either agent alone and may have potentially additional benefit in improving the general condition and immunity of the mice with human breast cancer cell implants. KEYWORDS breast cancer, warming and relieving cold phlegm formula, 5-fluorouracil, angiogenesis

RELIEVING EFFECTS OF CHINESE HERBS,EAR-ACUPUNCTURE AND EPIDURAL MORPHING ON POSTOPERATIVE PAIN IN LIVER CANCER

In the evaluation of Chinese berbs(A),ear-acupuncture(B) and epidural morphine(C) to relieve postoperative pain and abdominal distension,sixteen male patients with primary liver cancer were observed.This study was conducted by means of orthogonal experiment and double blind,randomized design.

Vibrational Spectroscopy of Pain Relievers: Traditional and Remote Raman Techniques

The application of vibrational spectroscopy in the pharmaceutical industry is widely investigated, from the quality assurance of the product during the production process control to the final products’ quality control and the authentication of products on the markets. This study focuses on non-contact and noninvasive detection and identification of pain-relievers at 1-5 meters standoff distances. The specimens analyzed include standard laboratory-grade active ingredients and commercially available pain relievers in powder, solid and liquid forms. All the remote measurements captured revealed the Raman signatures of the specimens, with varying peak intensities. To correlate the band intensities captured with the standoff distances between the laser source and the specimens, the intensity ratios of the two prominent peaks of the laboratory grade reference active ingredient (1607 and 1319 cm-1) normalized with 1319 cm-1 are used. The results of the study suggest the viability of standoff Raman spectroscopy for routine monitoring and identification of pharma-ceuticals, including counterfeit pain relievers.

Lanthanum Relieved Toxic Effects Caused by Nickel in Hydrocharis dubia B L. Backer Leaves

The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the reduction of chlorophyll content, the accumulation of MDA(malondiadehyde) and the elevation of relative membrane penetrability (RMP). After adding 10 mg . L-1 La to the solution, the activities of SOD and CAT in the leaves of Hydrocharis dubia B L. Backer increases compared with those of the single treatment of Ni, while the activity of POD decreases. It reveals that la enhances the abilities of scavenging the activated oxygen in the plant and alleviates the damage to the membranes. The soluble protein content with Ni and La compound treatment is higher than that of single Ni does, and proline content is contrary to the soluble protein content. So La improves the resistance of Hydrocharis dubia B. L. Backer to the stress of Ni. However, La can aggravate the damage to the cells under the extremely high concentration of Ni treatment.

Mechanical and Microstructural Evaluation of Plastically Deformed Brass

The mechanical properties as well as microstructure of Cu-30.6 wt% Zn alloys containing 0.01 wt% lead has been investigated. The brass alloy was cast and then cold rolled at various percentage reductions: 20%, 25%, 30%, 35% and 40% followed by stress relieving annealed at 450℃. Hardness, ultimate tensile strength (UTS) and impact toughness values were evaluated at every stage of reduction. It was discovered that the strength, hardness and impact energy all increased with increased percentage reduction. Finally, the optical microscope of the samples was done and the result achieved correlated with the mechanical properties.

球罐用钢板出厂检验中关于机械性能试验问题的探讨

针对球罐用钢板出厂检验中检验方与采购方产生的分歧,模拟焊后热处理SR后的机械性能试验是否可以替代交货状态下机械性能试验,进行分析和探讨。此次项目采购的钢板材质分别为07MnN iMo VDR和Q370R,在技术附件中采购方要求07MnN iMo VDR钢板的交货状态为淬火加回火热处理状态下交货,Q370R交货状态为正火。36mm、46mm厚07MnN iMo VDR钢板,48mm厚Q370R钢板逐张进行力学性能及冷弯性能试验(及机械性能试验)。只对07MnN iMo VDR材质的钢板要求供方应对每热处理张进行模拟焊后热处理试验SR,SR后的钢板机械性能试验要满足SR前机械性能的要求。

Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal

Objective:To study the effect of Alpinia officinarum Hance(A.officinarum) 80% alcohol extract on the primary dysmenorrhea.Methods:A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins.Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A.officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F_(2α)(PGF_(2α)),prostaglandin E_2(PGE_2) and Ca^(2+) in the uterus were observed in oxytocin-induced female mice.Results:The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A.officinarum 80% alcohol extract and the level of PGF_(2α),PGE_2 and Ca^(2+) in mice uterus was significantly decreased(P<0.05,P<0.01) in groups of mice treated with middle and high dosage of A.officinarum 80% alcohol extract compared with that of model group.Conclusions:These findings suggest that A.Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.

Production Characteristics and the Control Factors of Surface Wells for Relieved Methane Drainage in the Huainan Mining Area

Based on the production data of a large number of surface drainage wells in the Huainan mining area,the present study shows that four types of typical production characteristics for relieved methane wells are recognized,of which the stable type for production and gas concentration is the most dominate,as determined by a comprehensive study on the volume and concentration of drained gases, as well as the stress changes of rocks influenced by mining.Some influence factors for the productive differences of the drainage wells were also been discussed.The results indicate that protective coal-seam mining has a significant effect on overlying strata,which promotes the development of pores and fractures of coal reservoirs for methane desorption and migration;however,the production and the stability of drainage wells are affected by deformation and damage of the overlying strata.The second distribution of strata stress is caused by mining engineering,and if the stress load is larger than the carrying capacity of the extraction well,the gas production would be influenced by the drainage well that has been damaged by rock movement.Furthermore,the case damage occurs first in the weak, lithologic interface by its special mechanical properties.The stability of drainage wells and the production status are also influenced by the different drilling techniques,uneven distribution of gas concentration,and combination of gob gas and methane from the protected layer.

Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis

Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis.

BLOOD-LETTING AT A SINGLE POINT FOR TREATMENT OF ACUTE DISEASES

As a unique therapeutic technique of traditional Chinese medicine, blood-letting by pricking is one of the bleeding therapies. Blood-letting at a single point or superficial blood vessel is often used by the author with a three-edged needle or a thick filiform needle,

Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy

Recent studies showed that pathology of alcoholic encephalopathy was associated with cerebral vascular damage.TMP（tetramethylpyrazine）is widely used in the treatment of cerebrovascular diseases,however,it has not been reported whether TMP can relieve alcohol-induced

CLINICAL OBSERVATIONS ON 278 CASES OF CERVICAL SPONDYLOPATHY TREATED WITH ELECTRO ACUPUNCTURE AND MASSOTHERAPY

From Dec. 1990 to Dec. 1993, 278 cases of cervical spondylopathy were treated with electroacupuncture and massotherapy. The cure rate was 82.7%; but in the control group, it was only 61%, indicating that electroacupuncture may enhance the cure rate (P【 0.05). Of the 278 cases treated by three to five sessions, the pain and numbness disappeared in about 96% of the patients.

Microstructure and properties of S30403+Q345R roll-bonded clad steel plate for pressure vessels

To meet the demand of the domestic pressure vessel industry for roll-bonded clad steel plates, Baosteel has developed an S30403 ＋ Q345R roll-bonded clad steel plate. Comprehensive inspections of the composition, microstructure, and properties are made to systematically evaluate the steel plate in the normalized and normalized ＋ stress relieved states. The results show the cladding interface of the S30403 ＋ Q345R roll-bonded clad steel plate has high shear strength, the base metal has good properties, and the mechanical properties of the steel plate head and tail are uniform. The performance is fully consistent with the technical requirements of the roll-bonded clad steel plate for pressure vessels.

镇痛泵硬膜外腔连续注药在前列腺术后的应用

目的：探讨镇痛泵硬膜外腔连续注药在前列腺术后的应用效果。方法：对我院30例良性前列腺增生患者术后使用镇痛泵硬膜外腔连续注药观察疗效。结果：术后3d内只有1例需用肌注镇痛药加强镇痛，其余病例均未使用镇痛药和解痉药，无明显切口疼痛及尿意或便后急迫感，无1例出现严重继发性出血。用药后胃肠功能一般在24～36h恢复，无腹胀、恶心、呕吐。原麻醉平面皮肤的痛、温觉明显减退，麻醉平面以外部分无明显变化。肢体运动、感觉均无改变，神经生理反射存在，未引出病理征。本组病例未出现臀、背部受压皮损表现，无硬膜外腔感染症状。结论：前列腺术后应用镇痛泵硬膜外腔连续注药镇痛效果良好，可预防膀胱痉挛及其收缩痛，减少严重性继发性出血，膀胱冲洗时间短，患者恢复快，因此镇痛泵硬膜外腔连续注药应在前列腺术后广泛应用。