Fifth-order isotropic descartes tensor and its existence theorem and representation problems are researched, then a general representation formula of fifth-order isotropic descartes tensor is got.
There is a broad distinction in Descartes’writings between doctrine and method.The staying power of these two elements has been unequal.Descartes’doctrinal influence on contemporary epistemology has been largely as ...There is a broad distinction in Descartes’writings between doctrine and method.The staying power of these two elements has been unequal.Descartes’doctrinal influence on contemporary epistemology has been largely as a foil against which some of its major currents have been developed.The situation is brighter on the methodological side.Here Descartes’practice of beginning with common sense and moving,step by step,to philosophical conclusions is a practice much admired by contemporary philosophers.Still,the negative verdict on doctrine stands as the main verdict overall.I maintain that this verdict is undeserved.I first distinguish between Descartes’general epistemology and the purpose to which he puts it—the quest for certainty.I then argue for a positive verdict for his general epistemology.I do so by showing that Descartes has a non-normative account of knowledge but an“ethics of belief”in which the knowing comes first.Descartes thus anticipates what Sylvan calls the“knowledge-first”approach in general epistemology,which I defend.Relying on Audi’s distinction between“sources”and“reasons,”I show that Descartes’analysis of knowledge proper,which I also defend,anticipates and improves the“factive access”analysis of knowledge due to McDowell.展开更多
Objectives This study aimed to investigate the therapeutic effects of Suan Zao Ren(Semen Ziziphi Spinosae,SZS)extract on insomnia induced by p-chlorophenylalanine(PCPA)in rats and its influence on the thioredoxin-inte...Objectives This study aimed to investigate the therapeutic effects of Suan Zao Ren(Semen Ziziphi Spinosae,SZS)extract on insomnia induced by p-chlorophenylalanine(PCPA)in rats and its influence on the thioredoxin-interacting protein(TXNIP)/nucleotide-binding domain Leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3)inflammasome pathway,and to preliminarily explore themechanism by which SZS extract improves insomnia.Methods Fifty male Sprague–Dawley(SD)rats were used,with 8 rats in the blank group and 42 rats in the modeling group.The modeling group was induced by intraperitoneal injection of PCPA at a dose of 500mg·kg^(-1) for six consecutive days,with daily cage exchange.After 6 days,40 successfully modeled rats were randomly divided into five groups:themodel group(equal volume of distilled water),the positive group(0.75 mg·kg^(-1)),and low-,medium-,and high-dose SZS extract groups(1.5,3,and 6 g·kg^(-1),respectively),with 8 rats in each group.Treatments were administered for seven consecutive days.Enzyme-linked immunosorbent assay was used to measure levels of 5-hydroxytryptamine(5-HT)and gamma-aminobutyric acid(GABA)in the rat cerebral cortex.The thiobarbituric acid(TBA)method was used to determine malondialdehyde(MDA)levels,and the hydroxylamine method was used to determine superoxide dismutase(SOD)levels.The 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)method was used to measure total antioxidant capacity(TAOC)in the cerebral cortex.Pathological changes in the cerebral cortex were observed,and Western blot was used to detect the protein expressions of TXNIP,NLRP3,apoptosis-associated speck-like protein containing a Caspase activation and recruitment domain(CARD),and cysteine–aspartate-specific protease 1(Caspase-1)in the cerebral cortex.Results Compared with the blank group,the model group showed a significantly prolonged sleep latency(p<0.001)and a significantly shortened sleep duration(p<0.001).There were no changes in serum MDA and SOD levels.MDA levels in the cerebral cortex were significantly increased(p<0.001),while SOD and TAOC levels were significantly decreased(p<0.001).The 5-HT level was increased(p<0.05),and the GABA level was significantly decreased(p<0.001).SZS extract improved these conditions to varying degrees.Light microscopy showed no significant changes in cortical neurons but transmission electron microscopy revealed intact mitochondrial structures in the blank group,while the model group showed swollen and unclear mitochondria with reduced organelles.After 7 days of treatment,these conditions improved in the SZS extract groups.Compared with the blank group,the expressions of the four proteins in the model group were increased,and the expressions of these proteins were decreased in the SZS extract groups compared with the model group.Conclusion SZS extract may exert an antioxidant effect to treat insomnia by downregulating the expression of TXNIP/NLRP3 proteins and regulating oxidative stress levels in the cerebral cortex.展开更多
Zinc phosphate coating formed on 6061-A1 alloy was studied with the help of electrochemical measurements, Fourier Transform Infrared （FTIR）, and Scanning Electron Microscopy （SEM）, after dipping it in phosphating ...Zinc phosphate coating formed on 6061-A1 alloy was studied with the help of electrochemical measurements, Fourier Transform Infrared （FTIR）, and Scanning Electron Microscopy （SEM）, after dipping it in phosphating solutions containing different concentrations of Rare Earth Nitrate （REN）. REN, which acted as an accelerator in the phosphating solution, could catalyze the surface reaction and accelerate the phosphating process. REN mainly enabled the P in the phosphate coating to exist in the form of PO4^3- and promoted the hydrolysis of phosphatic acid in a liquid layer at the cathodes. This resulted in the evolution of H2 at the cathodes, which increased the local pH value and in turn drove the precipitation of the phosphate coating. Additionally, REN was adsorbed on the surface of the aluminum substrates to form a gel during the phosphating process. These gel particles were good crystal seeds, which helped to form phosphate crystal nuclei and possess the function of a nucleation agent that could decrease the phosphate crystal size. The corrosion resistance of the formed zinc phosphate coatings was improved.展开更多
The auther has treated 100 cases of chronic pelvic inflammation with needling the acupoints of Chong and Ren channels since 1996. Of them, 44 % cases were cured, 33 % markedly effective and 20 % improved. The total ef...The auther has treated 100 cases of chronic pelvic inflammation with needling the acupoints of Chong and Ren channels since 1996. Of them, 44 % cases were cured, 33 % markedly effective and 20 % improved. The total effective rate was 97%. Acupoints of Ren channel selected: Zhongji (CV 3), Guanyuan(CV 4), Qihai(CV 6) and Yinjiao(CV 7); Crossing acupoints of Chong channel selected: Qixue(KI l3), Siman(KI 14) and Zhongzhu(KI 15). Filiform needles of No. 30, 1. 5 cun were adopted to puncture the above acupoints with the uniform reinforcing-reducing method, and the needles were retained for 30 minutes. At the same time, the moxibustion was applied to the place of retaining needles until the skin flushed.展开更多
文摘Fifth-order isotropic descartes tensor and its existence theorem and representation problems are researched, then a general representation formula of fifth-order isotropic descartes tensor is got.
文摘There is a broad distinction in Descartes’writings between doctrine and method.The staying power of these two elements has been unequal.Descartes’doctrinal influence on contemporary epistemology has been largely as a foil against which some of its major currents have been developed.The situation is brighter on the methodological side.Here Descartes’practice of beginning with common sense and moving,step by step,to philosophical conclusions is a practice much admired by contemporary philosophers.Still,the negative verdict on doctrine stands as the main verdict overall.I maintain that this verdict is undeserved.I first distinguish between Descartes’general epistemology and the purpose to which he puts it—the quest for certainty.I then argue for a positive verdict for his general epistemology.I do so by showing that Descartes has a non-normative account of knowledge but an“ethics of belief”in which the knowing comes first.Descartes thus anticipates what Sylvan calls the“knowledge-first”approach in general epistemology,which I defend.Relying on Audi’s distinction between“sources”and“reasons,”I show that Descartes’analysis of knowledge proper,which I also defend,anticipates and improves the“factive access”analysis of knowledge due to McDowell.
基金Research on the Mechanism of Suan Zao Ren’s(SZS)Hypnotic Effect Based on TXNIP/NLRP3 Signaling Pathway(2023-ZXFZJJ-JW-071).
文摘Objectives This study aimed to investigate the therapeutic effects of Suan Zao Ren(Semen Ziziphi Spinosae,SZS)extract on insomnia induced by p-chlorophenylalanine(PCPA)in rats and its influence on the thioredoxin-interacting protein(TXNIP)/nucleotide-binding domain Leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3)inflammasome pathway,and to preliminarily explore themechanism by which SZS extract improves insomnia.Methods Fifty male Sprague–Dawley(SD)rats were used,with 8 rats in the blank group and 42 rats in the modeling group.The modeling group was induced by intraperitoneal injection of PCPA at a dose of 500mg·kg^(-1) for six consecutive days,with daily cage exchange.After 6 days,40 successfully modeled rats were randomly divided into five groups:themodel group(equal volume of distilled water),the positive group(0.75 mg·kg^(-1)),and low-,medium-,and high-dose SZS extract groups(1.5,3,and 6 g·kg^(-1),respectively),with 8 rats in each group.Treatments were administered for seven consecutive days.Enzyme-linked immunosorbent assay was used to measure levels of 5-hydroxytryptamine(5-HT)and gamma-aminobutyric acid(GABA)in the rat cerebral cortex.The thiobarbituric acid(TBA)method was used to determine malondialdehyde(MDA)levels,and the hydroxylamine method was used to determine superoxide dismutase(SOD)levels.The 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)method was used to measure total antioxidant capacity(TAOC)in the cerebral cortex.Pathological changes in the cerebral cortex were observed,and Western blot was used to detect the protein expressions of TXNIP,NLRP3,apoptosis-associated speck-like protein containing a Caspase activation and recruitment domain(CARD),and cysteine–aspartate-specific protease 1(Caspase-1)in the cerebral cortex.Results Compared with the blank group,the model group showed a significantly prolonged sleep latency(p<0.001)and a significantly shortened sleep duration(p<0.001).There were no changes in serum MDA and SOD levels.MDA levels in the cerebral cortex were significantly increased(p<0.001),while SOD and TAOC levels were significantly decreased(p<0.001).The 5-HT level was increased(p<0.05),and the GABA level was significantly decreased(p<0.001).SZS extract improved these conditions to varying degrees.Light microscopy showed no significant changes in cortical neurons but transmission electron microscopy revealed intact mitochondrial structures in the blank group,while the model group showed swollen and unclear mitochondria with reduced organelles.After 7 days of treatment,these conditions improved in the SZS extract groups.Compared with the blank group,the expressions of the four proteins in the model group were increased,and the expressions of these proteins were decreased in the SZS extract groups compared with the model group.Conclusion SZS extract may exert an antioxidant effect to treat insomnia by downregulating the expression of TXNIP/NLRP3 proteins and regulating oxidative stress levels in the cerebral cortex.
基金Project supported by the Henan Natural Science Foundation Program (200460178)
文摘Zinc phosphate coating formed on 6061-A1 alloy was studied with the help of electrochemical measurements, Fourier Transform Infrared （FTIR）, and Scanning Electron Microscopy （SEM）, after dipping it in phosphating solutions containing different concentrations of Rare Earth Nitrate （REN）. REN, which acted as an accelerator in the phosphating solution, could catalyze the surface reaction and accelerate the phosphating process. REN mainly enabled the P in the phosphate coating to exist in the form of PO4^3- and promoted the hydrolysis of phosphatic acid in a liquid layer at the cathodes. This resulted in the evolution of H2 at the cathodes, which increased the local pH value and in turn drove the precipitation of the phosphate coating. Additionally, REN was adsorbed on the surface of the aluminum substrates to form a gel during the phosphating process. These gel particles were good crystal seeds, which helped to form phosphate crystal nuclei and possess the function of a nucleation agent that could decrease the phosphate crystal size. The corrosion resistance of the formed zinc phosphate coatings was improved.
文摘The auther has treated 100 cases of chronic pelvic inflammation with needling the acupoints of Chong and Ren channels since 1996. Of them, 44 % cases were cured, 33 % markedly effective and 20 % improved. The total effective rate was 97%. Acupoints of Ren channel selected: Zhongji (CV 3), Guanyuan(CV 4), Qihai(CV 6) and Yinjiao(CV 7); Crossing acupoints of Chong channel selected: Qixue(KI l3), Siman(KI 14) and Zhongzhu(KI 15). Filiform needles of No. 30, 1. 5 cun were adopted to puncture the above acupoints with the uniform reinforcing-reducing method, and the needles were retained for 30 minutes. At the same time, the moxibustion was applied to the place of retaining needles until the skin flushed.
