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Comparison of uniform resampling and nonuniform sampling direct-reconstruction methods in k-space for FD-OCT
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作者 Yanrong Yang Yun Dai +1 位作者 Yuehua Zhou Yaliang Yang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2023年第5期93-106,共14页
The nonuniform distribution of interference spectrum in wavenumber k-space is a key issue to limit the imaging quality of Fourier-domain optical coherence tomography(FD-OCT).At present,the reconstruction quality at di... The nonuniform distribution of interference spectrum in wavenumber k-space is a key issue to limit the imaging quality of Fourier-domain optical coherence tomography(FD-OCT).At present,the reconstruction quality at different depths among a variety of processing methods in k-space is still uncertain.Using simulated and experimental interference spectra at different depths,the effects of common six processing methods including uniform resampling(linear interpolation(LI),cubic spline interpolation(CSI),time-domain interpolation(TDI),and K-B window convolution)and nonuniform sampling direct-reconstruction(Lomb periodogram(LP)and nonuniform discrete Fourier transform(NDFT))on the reconstruction quality of FD-OCT were quantitatively analyzed and compared in this work.The results obtained by using simulated and experimental data were coincident.From the experimental results,the averaged peak intensity,axial resolution,and signal-to-noise ratio(SNR)of NDFT at depth from 0.5 to 3.0mm were improved by about 1.9 dB,1.4 times,and 11.8 dB,respectively,compared to the averaged indices of all the uniform resampling methods at all depths.Similarly,the improvements of the above three indices of LP were 2.0 dB,1.4 times,and 11.7 dB,respectively.The analysis method and the results obtained in this work are helpful to select an appropriate processing method in k-space,so as to improve the imaging quality of FD-OCT. 展开更多
关键词 Optical coherence tomography signal processing uniform resampling nonuniform sampling direct-reconstruction reconstruction quality.
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ESR-PINNs:Physics-informed neural networks with expansion-shrinkage resampling selection strategies
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作者 刘佳楠 侯庆志 +1 位作者 魏建国 孙泽玮 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期337-346,共10页
Neural network methods have been widely used in many fields of scientific research with the rapid increase of computing power.The physics-informed neural networks(PINNs)have received much attention as a major breakthr... Neural network methods have been widely used in many fields of scientific research with the rapid increase of computing power.The physics-informed neural networks(PINNs)have received much attention as a major breakthrough in solving partial differential equations using neural networks.In this paper,a resampling technique based on the expansion-shrinkage point(ESP)selection strategy is developed to dynamically modify the distribution of training points in accordance with the performance of the neural networks.In this new approach both training sites with slight changes in residual values and training points with large residuals are taken into account.In order to make the distribution of training points more uniform,the concept of continuity is further introduced and incorporated.This method successfully addresses the issue that the neural network becomes ill or even crashes due to the extensive alteration of training point distribution.The effectiveness of the improved physics-informed neural networks with expansion-shrinkage resampling is demonstrated through a series of numerical experiments. 展开更多
关键词 physical informed neural networks resampling partial differential equation
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Deep Learning Based Sentiment Analysis of COVID-19 Tweets via Resampling and Label Analysis
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作者 Mamoona Humayun Danish Javed +2 位作者 Nz Jhanjhi Maram Fahaad Almufareh Saleh Naif Almuayqil 《Computer Systems Science & Engineering》 SCIE EI 2023年第10期575-591,共17页
Twitter has emerged as a platform that produces new data every day through its users which can be utilized for various purposes.People express their unique ideas and views onmultiple topics thus providing vast knowled... Twitter has emerged as a platform that produces new data every day through its users which can be utilized for various purposes.People express their unique ideas and views onmultiple topics thus providing vast knowledge.Sentiment analysis is critical from the corporate and political perspectives as it can impact decision-making.Since the proliferation of COVID-19,it has become an important challenge to detect the sentiment of COVID-19-related tweets so that people’s opinions can be tracked.The purpose of this research is to detect the sentiment of people regarding this problem with limited data as it can be challenging considering the various textual characteristics that must be analyzed.Hence,this research presents a deep learning-based model that utilizes the positives of random minority oversampling combined with class label analysis to achieve the best results for sentiment analysis.This research specifically focuses on utilizing class label analysis to deal with the multiclass problem by combining the class labels with a similar overall sentiment.This can be particularly helpful when dealing with smaller datasets.Furthermore,our proposed model integrates various preprocessing steps with random minority oversampling and various deep learning algorithms including standard deep learning and bi-directional deep learning algorithms.This research explores several algorithms and their impact on sentiment analysis tasks and concludes that bidirectional neural networks do not provide any advantage over standard neural networks as standard Neural Networks provide slightly better results than their bidirectional counterparts.The experimental results validate that our model offers excellent results with a validation accuracy of 92.5%and an F1 measure of 0.92. 展开更多
关键词 Bi-directional deep learning resampling random minority oversampling sentiment analysis class label analysis
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Performance of Resampling Algorithms Based on Particle Filter in Video Target Tracking
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作者 韩华 王裕明 +1 位作者 张玉金 胡一帆 《Journal of Donghua University(English Edition)》 EI CAS 2016年第5期745-748,共4页
Particle filter is a common algorithm in video target tracking.But there are still some shortcomings,for example,particle degradation phenomenon.For solving this problem,the general solution is to introduce resampling... Particle filter is a common algorithm in video target tracking.But there are still some shortcomings,for example,particle degradation phenomenon.For solving this problem,the general solution is to introduce resampling step.At present,four kinds of resampling algorithms are widely used:multinomial resampling,residual resampling,stratified resampling and systematic resampling algorithms.In this paper,the performances of these four resampling algorithms were analyzed from realization principle,uniform distribution theory and computational complexity.Finally,through a series of video target tracking experiments,the systematic resampling algorithm had the smallest calculation load,the shortest running time and the maximum number of effective particles.So,it can be concluded that in the field of video target tracking,the systematic resampling algorithm has more advantages than other three algorithms both in the running time and the number of effective particles. 展开更多
关键词 video target tracking multinomial resampling residual resampling stratified resampling systematic resampling
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Jackknife based generalized resampling reliability approach for rock slopes and tunnels stability analyses with limited data:Theory and applications 被引量:3
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作者 Akshay Kumar Gaurav Tiwari 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第3期714-730,共17页
An efficient resampling reliability approach was developed to consider the effect of statistical uncertainties in input properties arising due to insufficient data when estimating the reliability of rock slopes and tu... An efficient resampling reliability approach was developed to consider the effect of statistical uncertainties in input properties arising due to insufficient data when estimating the reliability of rock slopes and tunnels.This approach considers the effect of uncertainties in both distribution parameters(mean and standard deviation)and types of input properties.Further,the approach was generalized to make it capable of analyzing complex problems with explicit/implicit performance functions(PFs),single/multiple PFs,and correlated/non-correlated input properties.It couples resampling statistical tool,i.e.jackknife,with advanced reliability tools like Latin hypercube sampling(LHS),Sobol’s global sensitivity,moving least square-response surface method(MLS-RSM),and Nataf’s transformation.The developed approach was demonstrated for four cases encompassing different types.Results were compared with a recently developed bootstrap-based resampling reliability approach.The results show that the approach is accurate and significantly efficient compared with the bootstrap-based approach.The proposed approach reflects the effect of statistical uncertainties of input properties by estimating distributions/confidence intervals of reliability index/probability of failure(s)instead of their fixed-point estimates.Further,sufficiently accurate results were obtained by considering uncertainties in distribution parameters only and ignoring those in distribution types. 展开更多
关键词 Statistical uncertainty resampling reliability Moving least square response surface(MLSRSM) Sobol’s global sensitivity Correlation coefficient
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A Comprehensive Evaluation of PAN-Sharpening Algorithms Coupled with Resampling Methods for Image Synthesis of Very High Resolution Remotely Sensed Satellite Data 被引量:6
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作者 Shridhar D. Jawak Alvarinho J. Luis 《Advances in Remote Sensing》 2013年第4期332-344,共13页
The merging of a panchromatic (PAN) image with a multispectral satellite image (MSI) to increase the spatial resolution of the MSI, while simultaneously preserving its spectral information is classically referred as P... The merging of a panchromatic (PAN) image with a multispectral satellite image (MSI) to increase the spatial resolution of the MSI, while simultaneously preserving its spectral information is classically referred as PAN-sharpening. We employed a recent dataset derived from very high resolution of WorldView-2 satellite (PAN and MSI) for two test sites (one over an urban area and the other over Antarctica), to comprehensively evaluate the performance of six existing PAN-sharpening algorithms. The algorithms under consideration were the Gram-Schmidt (GS), Ehlers fusion (EF), modified hue-intensity-saturation (Mod-HIS), high pass filtering (HPF), the Brovey transform (BT), and wavelet-based principal component analysis (W-PC). Quality assessment of the sharpened images was carried out by using 20 quality indices. We also analyzed the performance of nearest neighbour (NN), bilinear interpolation (BI), and cubic convolution (CC) resampling methods to test their practicability in the PAN-sharpening process. Our results indicate that the comprehensive performance of PAN-sharpening methods decreased in the following order: GS > W-PC > EF > HPF > Mod-HIS > BT, while resampling methods followed the order: NN > BI > CC. 展开更多
关键词 PAN-Sharpening WorldView-2 resampling METHODS
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Hardware Architecture of Polyphase Filter Banks Performing Embedded Resampling for Software-Defined Radio Front-Ends 被引量:3
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作者 Mehmood Awan Yannick Le Moullec +1 位作者 Peter Koch Fred Harris 《ZTE Communications》 2012年第1期54-62,70,共10页
In this paper, we describe resourceefficient hardware architectures for softwaredefined radio (SDR) frontends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample r... In this paper, we describe resourceefficient hardware architectures for softwaredefined radio (SDR) frontends. These architectures are made efficient by using a polyphase channelizer that performs arbitrary sample rate changes, frequency selection, and bandwidth control. We discuss area, time, and power optimization for field programmable gate array (FPGA) based architectures in an Mpath polyphase filter bank with modified Npath polyphase filter. Such systems allow resampling by arbitrary ratios while simultaneously performing baseband aliasing from center frequencies at Nyquist zones that are not multiples of the output sample rate. A nonmaximally decimated polyphase filter bank, where the number of data loads is not equal to the number of M subfilters, processes M subfilters in a time period that is either less than or greater than the Mdataload ' s time period. We present a loadprocess architecture (LPA) and a runtime architecture (RA) (based on serial polyphase structure) which have different scheduling. In LPA, Nsubfilters are loaded, and then M subfilters are processed at a clock rate that is a multiple of the input data rate. This is necessary to meet the output time constraint of the down-sampled data. In RA, Msubfilters processes are efficiently scheduled within Ndataload time while simultaneously loading N subfilters. This requires reduced clock rates compared with LPA, and potentially less power is consumed. A polyphase filter bank that uses different resampling factors for maximally decimated, underdecimated, overdecimated, and combined upand downsampled scenarios is used as a case study, and an analysis of area, time, and power for their FPGA architectures is given. For resourceoptimized SDR frontends, RA is superior for reducing operating clock rates and dynamic power consumption. RA is also superior for reducing area resources, except when indices are prestored in LUTs. 展开更多
关键词 SDR FPGA Digital Frontends Polyphase Filter Bank Embedded resampling
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Resampling Factor Estimation via Dual-Stream Convolutional Neural Network 被引量:1
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作者 Shangjun Luo Junwei Luo +4 位作者 Wei Lu Yanmei Fang Jinhua Zeng Shaopei Shi Yue Zhang 《Computers, Materials & Continua》 SCIE EI 2021年第1期647-657,共11页
The estimation of image resampling factors is an important problem in image forensics.Among all the resampling factor estimation methods,spectrumbased methods are one of the most widely used methods and have attracted... The estimation of image resampling factors is an important problem in image forensics.Among all the resampling factor estimation methods,spectrumbased methods are one of the most widely used methods and have attracted a lot of research interest.However,because of inherent ambiguity,spectrum-based methods fail to discriminate upscale and downscale operations without any prior information.In general,the application of resampling leaves detectable traces in both spatial domain and frequency domain of a resampled image.Firstly,the resampling process will introduce correlations between neighboring pixels.In this case,a set of periodic pixels that are correlated to their neighbors can be found in a resampled image.Secondly,the resampled image has distinct and strong peaks on spectrum while the spectrum of original image has no clear peaks.Hence,in this paper,we propose a dual-stream convolutional neural network for image resampling factors estimation.One of the two streams is gray stream whose purpose is to extract resampling traces features directly from the rescaled images.The other is frequency stream that discovers the differences of spectrum between rescaled and original images.The features from two streams are then fused to construct a feature representation including the resampling traces left in spatial and frequency domain,which is later fed into softmax layer for resampling factor estimation.Experimental results show that the proposed method is effective on resampling factor estimation and outperforms some CNN-based methods. 展开更多
关键词 Image forensics image resampling detection parameter estimation convolutional neural network
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Modified sequential importance resampling filter 被引量:1
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作者 Yong Wu Jun Wang +1 位作者 Xiaoyong L Yunhe Cao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第3期441-449,共9页
In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling (MSIR) filter is proposed. In this filter, the resampling is trans... In order to deal with the particle degeneracy and impov- erishment problems existed in particle filters, a modified sequential importance resampling (MSIR) filter is proposed. In this filter, the resampling is translated into an evolutional process just like the biological evolution. A particle generator is constructed, which introduces the current measurement information (CMI) into the resampled particles. In the evolution, new particles are first pro- duced through the particle generator, each of which is essentially an unbiased estimation of the current true state. Then, new and old particles are recombined for the sake of raising the diversity among the particles. Finally, those particles who have low quality are eliminated. Through the evolution, all the particles retained are regarded as the optimal ones, and these particles are utilized to update the current state. By using the proposed resampling approach, not only the CMI is incorporated into each resampled particle, but also the particle degeneracy and the loss of diver- sity among the particles are mitigated, resulting in the improved estimation accuracy. Simulation results show the superiorities of the proposed filter over the standard sequential importance re- sampling (SIR) filter, auxiliary particle filter and unscented Kalman particle filter. 展开更多
关键词 sequential importance resampling (SIR) evolution current measurement information (CMI) unbiased estimation.
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Particle Filter Object Tracking Algorithm Based on Sparse Representation and Nonlinear Resampling 被引量:3
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作者 Zheyi Fan Shuqin Weng +2 位作者 Jiao Jiang Yixuan Zhu Zhiwen Liu 《Journal of Beijing Institute of Technology》 EI CAS 2018年第1期51-57,共7页
Object tracking with abrupt motion is an important research topic and has attracted wide attention.To obtain accurate tracking results,an improved particle filter tracking algorithm based on sparse representation and ... Object tracking with abrupt motion is an important research topic and has attracted wide attention.To obtain accurate tracking results,an improved particle filter tracking algorithm based on sparse representation and nonlinear resampling is proposed in this paper. First,the sparse representation is used to compute particle weights by considering the fact that the weights are sparse when the object moves abruptly,so the potential object region can be predicted more precisely. Then,a nonlinear resampling process is proposed by utilizing the nonlinear sorting strategy,which can solve the problem of particle diversity impoverishment caused by traditional resampling methods. Experimental results based on videos containing objects with various abrupt motions have demonstrated the effectiveness of the proposed algorithm. 展开更多
关键词 object tracking abrupt motion particle filter sparse representation nonlinear resampling
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RESAMPLING TESTS OF STATISTICAL HYPOTHESES
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作者 石坚 《Acta Mathematica Scientia》 SCIE CSCD 1996年第3期279-286,共8页
In this paper, large sample properties of resampling tests of hypotheses on the population mean resampled according to the empirical likelihood and the Kullback-Leibler criteria are investigated. It is proved that und... In this paper, large sample properties of resampling tests of hypotheses on the population mean resampled according to the empirical likelihood and the Kullback-Leibler criteria are investigated. It is proved that under the null hypothesis both of them are superior to the classical one. 展开更多
关键词 test of hypothesis resampling empirical likelihood Kullback-Leibler distance
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Speech Resampling Detection Based on Inconsistency of Band Energy
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作者 Zhifeng Wang Diqun Yan +2 位作者 Rangding Wang Li Xiang Tingting Wu 《Computers, Materials & Continua》 SCIE EI 2018年第8期247-259,共13页
Speech resampling is a typical tempering behavior,which is often integrated into various speech forgeries,such as splicing,electronic disguising,quality faking and so on.By analyzing the principle of resampling,we fou... Speech resampling is a typical tempering behavior,which is often integrated into various speech forgeries,such as splicing,electronic disguising,quality faking and so on.By analyzing the principle of resampling,we found that,compared with natural speech,the inconsistency between the bandwidth of the resampled speech and its sampling ratio will be caused because the interpolation process in resampling is imperfect.Based on our observation,a new resampling detection algorithm based on the inconsistency of band energy is proposed.First,according to the sampling ratio of the suspected speech,a band-pass Butterworth filter is designed to filter out the residual signal.Then,the logarithmic ratio of band energy is calculated by the suspected speech and the filtered speech.Finally,with the logarithmic ratio,the resampled and original speech can be discriminated.The experimental results show that the proposed algorithm can effectively detect the resampling behavior under various conditions and is robust to MP3 compression. 展开更多
关键词 resampling detection logarithmic ratio band energy robustness
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Increased-diversity systematic resampling in particle filtering for BLAST
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作者 Zheng Jianping Bai Baoming Wang Xinmei 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第3期493-498,共6页
Two variants of systematic resampling (S-RS) are proposed to increase the diversity of particles and thereby improve the performance of particle filtering when it is utilized for detection in Bell Laboratories Layer... Two variants of systematic resampling (S-RS) are proposed to increase the diversity of particles and thereby improve the performance of particle filtering when it is utilized for detection in Bell Laboratories Layered Space-Time (BLAST) systems. In the first variant, Markov chain Monte Carlo transition is integrated in the S-RS procedure to increase the diversity of particles with large importance weights. In the second one, all particles are first partitioned into two sets according to their importance weights, and then a double S-RS is introduced to increase the diversity of particles with small importance weights. Simulation results show that both variants can improve the bit error performance efficiently compared with the standard S-P^S with little increased complexity. 展开更多
关键词 systematic resampling particle filtering Markov chain Monte Carlo Bell Laboratories Layered Space- Time (BLAST).
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New slant range model and azimuth perturbation resampling based high-squint maneuvering platform SAR imaging
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作者 XIONG Xuying LI Gen +1 位作者 MA Yanheng CHU Lina 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第3期545-558,共14页
Strong spatial variance of the imaging parameters and serious geometric distortion of the image are induced by the acceleration and vertical velocity in a high-squint synthetic aperture radar(SAR)mounted on maneuverin... Strong spatial variance of the imaging parameters and serious geometric distortion of the image are induced by the acceleration and vertical velocity in a high-squint synthetic aperture radar(SAR)mounted on maneuvering platforms.In this paper,a frequency-domain imaging algorithm is proposed based on a novel slant range model and azimuth perturbation resampling.First,a novel slant range model is presented for mitigating the geometric distortion according to the equal squint angle curve on the ground surface.Second,the correction of azimuth-dependent range cell migration(RCM)is achieved by introducing a high-order time-domain perturbation function.Third,an azimuth perturbation resampling method is proposed for azimuth compression.The azimuth resampling and the time-domain perturbation are used for correcting first-order and high-order azimuthal spatial-variant components,respectively.Experimental results illustrate that the proposed algorithm can improve the focusing quality and the geometric distortion correction accuracy of the imaging scene effectively. 展开更多
关键词 synthetic aperture radar(SAR)imaging maneuvering platform high-squint azimuth perturbation resampling
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Fast Forgery Detection with the Intrinsic Resampling Properties
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作者 Cheng-Chang Lien Cheng-Lun Shih Chih-Hsun Chou 《Journal of Information Security》 2010年第1期11-22,共12页
With the rapid progress of the image processing software, the image forgery can leave no visual clues on the tampered regions and make us unable to authenticate the image. In general, the image forgery technologies of... With the rapid progress of the image processing software, the image forgery can leave no visual clues on the tampered regions and make us unable to authenticate the image. In general, the image forgery technologies often utilizes the scaling, rotation or skewing operations to tamper some regions in the image, in which the resampling and interpolation processes are often demanded. By observing the detectable periodic distribution properties generated from the resampling and interpolation processes, we propose a novel method based on the intrinsic properties of resampling scheme to detect the tampered regions. The proposed method applies the pre-calculated resampling weighting table to detect the periodic properties of prediction error distribution. The experimental results show that the proposed method outperforms the conventional methods in terms of efficiency and accuracy. 展开更多
关键词 IMAGE FORGERY resampling FORGERY Detection INTRINSIC PROPERTIES of resampling
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Resampling Simulator for the Probability of Detecting Invasive Species in Large Populations
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作者 David E. Legg Jeffrey G. Fidgen Krista L. Ryall 《Journal of Software Engineering and Applications》 2014年第6期498-505,共8页
This paper proposes a resampling simulator that will calculate probabilities of detecting invasive species infesting hosts that occur in large numbers. Different methods were examined to determine the bias of observed... This paper proposes a resampling simulator that will calculate probabilities of detecting invasive species infesting hosts that occur in large numbers. Different methods were examined to determine the bias of observed cumulative distribution functions (c.d.f.s), generated from prototype resampling simulators. One involved seeing if they matched theoretical c.d.f.s, which were generated using formulae for calculating the probability of the union of many events (union formulae), which are known to be correct. Others involved assessing the bias of observed c.d.f.s, generated from using prototype resampling simulators operating on much larger simulated populations, when computation of theoretical c.d.f.s from the union formulae was not practical. Examples are given for using the proposed resampling simulator for detecting an invasive insect pest within the context of an invasive species management system. 展开更多
关键词 resampling SIMULATOR Detection of INVASIVE SPECIES INVASIVE SPECIES Management System Large POPULATIONS
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DEA Scores’ Confidence Intervals with Past-Present and Past-Present-Future Based Resampling
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作者 Kaoru Tone Jamal Ouenniche 《American Journal of Operations Research》 2016年第2期121-135,共15页
In data envelopment analysis (DEA), input and output values are subject to change for several reasons. Such variations differ in their input/output items and their decision-making units (DMUs). Hence, DEA efficiency s... In data envelopment analysis (DEA), input and output values are subject to change for several reasons. Such variations differ in their input/output items and their decision-making units (DMUs). Hence, DEA efficiency scores need to be examined by considering these factors. In this paper, we propose new resampling models based on these variations for gauging the confidence intervals of DEA scores. The first model utilizes past-present data for estimating data variations imposing chronological order weights which are supplied by Lucas series (a variant of Fibonacci series). The second model deals with future prospects. This model aims at forecasting the future efficiency score and its confidence interval for each DMU. We applied our models to a dataset composed of Japanese municipal hospitals. 展开更多
关键词 Data Variation resampling Confidence Interval Past-Present-Future DEA Hospital
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Medical Image Retrieval Based on Multi-Layer Resampling Template
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作者 WANG Xin-rui YANG Yun-feng 《Computer Aided Drafting,Design and Manufacturing》 2014年第4期69-73,共5页
Medical image application in clinical diagnosis and treatment is becoming more and more widely, How to use a large number of images in the image management system and it is a very important issue how to assist doctors... Medical image application in clinical diagnosis and treatment is becoming more and more widely, How to use a large number of images in the image management system and it is a very important issue how to assist doctors to analyze and diagnose. This paper studies the medical image retrieval based on multi-layer resampling template under the thought of the wavelet decomposition, the image retrieval method consists of two retrieval process which is coarse and fine retrieval. Coarse retrieval process is the medical image retrieval process based on the image contour features. Fine retrieval process is the medical image retrieval process based on multi-layer resampling template, a multi-layer sampling operator is employed to extract image resampling images each layer, then these resampling images are retrieved step by step to finish the process from coarse to fine retrieval. 展开更多
关键词 medical image retrieval resampling mutual information
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Unveiling protein corona composition:predicting with resampling embedding and machine learning
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作者 Rong Liao Yan Zhuang +7 位作者 Xiangfeng Li Ke Chen Xingming Wang Cong Feng Guangfu Yin Xiangdong Zhu Jiangli Lin Xingdong Zhang 《Regenerative Biomaterials》 SCIE EI CSCD 2024年第1期27-33,共7页
Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration.When nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,for... Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration.When nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of NPs.However,achieving accurate predictions remains a significant challenge.Although several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data distribution.In this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC data.Various ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were obtained.Our ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random Oversampling.Additionally,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification. 展开更多
关键词 NANOPARTICLES protein corona machine learming resampling technique feature analysis
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SimHOEPI:A resampling simulator for generating single nucleotide polymorphism data with a high-order epistasis model
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作者 Yahan Li Xinrui Cai +2 位作者 Junliang Shang Yuanyuan Zhang Jin-Xing Liu 《Quantitative Biology》 CAS CSCD 2024年第2期197-204,共8页
Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.Simulation data is crucial for evaluating epistasis de... Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.Simulation data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data independently.In this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data independently.Highlights of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different aspects.Experimental results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS. 展开更多
关键词 high-order epistasis model penetrance table resampling strategy simulation single nucleotide polymorphisms
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