Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older

A cross-sectional study was conducted to estimate the age-stratified normal levels and age-related changes in the risk predictors of benign prostatic hyperplasia(BPH)progression.A total of 4706 male participants aged 40 years or older in Zhengzhou(China)were enrolled.The values of the International Prostate Symptom Score(IPSS),prostate-specific antigen(PSA),prostate volume(PV),and postvoid residual urine volume(PVR)significantly increased with age.Nonlinear relationships between age and IPSS scores≥8(P for nonlinearity=0.046),PSA level≥1.6 ng ml^(-1),PV≥31 ml,or PVR≥39 ml(all P for nonlinearity<0.001)were observed.After the age of 61 years,the risk indicators related to BPH progression were positively correlated with age(odds ratio[OR]>1),regardless of the predictors of the IPSS score,PSA level,PV,or PVR;and the OR values increased gradually.Therefore,after the age of 61 years,the risk predictors related to BPH progression were positively correlated with age.

中国男性良性前列腺增生与体重指数和代谢综合征的关系

Previous studies have showed that men suffering from diabetes mellitus, metabolic syndrome （MetS） and obesity have a higher risk of benign prostatic hyperplasia （BPH）. The present study aimed to examine the association between BPH, obesity, and features of MetS among men of the Hunan area of China. For this cross-sectional study, 904 males （aged 50-59 years） were included. MetS parameters, International Prostate Symptom Score （IPSS）, prostate-specific antigen （PSA） levels, total prostate volume （TPV）, postvoid residual volume （PVR） and maximum urine flow rate （Qmax） were measured. Results showed that MetS was associated with TPV （P = 0.048）, PVR （P = 0.004） and IPSS （P = 0.011）, but not with other indicators of BPH progression such as PSA levels or Qmax. MetS was associated with the voiding symptoms score （P〈 0.05）, but not with the storage symptom score. In addition, body mass index and fasting blood glucose positively correlated with TPV （r= 0.416, P〈 0.001; and r= 0.310, P= 0.011, respectively）. In conclusion, results suggest that MetS is associated with higher prostatic volume, prostate symptom score and voiding symptoms, but not with other features of prostatic hyperplasia such as PSA levels or Qmax. Changes in lifestyle factors, including physical activity and prevention of MetS, might be useful to prevent BPH and its progression, but further studies are needed.

Postphalloplasty urinary function test:an observational study of novel outcome instrument to capture urinary dysfunction and quality of life after phalloplasty

Due to growing social acceptance,there has been an increasing number of gender-affirmation surgeries performed in North America.Most research in this patient population focuses on surgical outcomes and advancing techniques.However,little work has been done to study functional outcomes.To better evaluate urinary dysfunction in the postphalloplasty trans men patient population,our group developed a novel patient-reported outcome instrument-the postphalloplasty urinary function test(PP UFT)and protocol to measure postvoid urethral volume(PVUR),and we present our preliminary results.We conducted a cross-sectional pilot study in a cohort of 15 adult trans men who had undergone phalloplasty with urethral lengthening surgery between 2018 and 2021.Patients had stable urinary function via the neophallus at the time of survey.Patients filled out the PP UFT and were asked to record their PVUR as per our protocol.The average PP UFT score was 8.9 out of 40 and the average quality-of-life(QOL)score was 2.6.Postvoid dribbling constituted the major complaint and on average comprised 63.2%of the reported PP UFT score.The average PVUR was 2.2 ml(range:0.5-5.6 ml).There was a positive correlation between higher PP UFT and worse-reported quality of life(P<0.01;R?=0.4).Current questionnaires accepted in cis-male urology have limitations for accurately capturing urinary dysfunction in this specific patient group.The combination of PP UFT and PVUR measurement offers potential for quantifying urinary function and quality of life in patients who undergo phalloplasty.Future studies will validate these instruments.