Effects of Combined Inhalation of Budesonide,Formoterol,and Tiotropium Bromide on Arterial Blood Gas and Pulmonary Function Indexes in Patients with Chronic Obstructive Pulmonary Disease

Objective:To analyze the effect of combined inhalation of budesonide formoterol and tiotropium bromide on arterial blood gas and pulmonary function indexes in patients with chronic obstructive pulmonary disease(COPD).Methods:100 patients with COPD treated from January to December 2022 were selected as observation objects,and were divided into a control group(n=50,in which budesonide and formoterol were administered)and an experimental group(n=50,the treatment drug was budesonide formoterol combined with tiotropium bromide)according to the computer grouping method,and compared the treatment results.Results:(i)Before treatment,there was no difference in the partial pressure of carbon dioxide and partial pressure of oxygen between the control group and the experimental group(P>0.05);after treatment,the partial pressure of carbon dioxide and partial pressure of oxygen in the experimental group were higher than those in the control group,with significant differences(P<0.05).(ii)Before treatment,there was no difference in forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC between the control group and the experimental group(P>0.05);after treatment,the FVC,FEV1,and FEV1/FVC in the experimental group were significantly higher than those in the control group(P<0.05).(iii)There was no difference in the levels of CRP,IL-6,and TNF-αbetween the control group and the experimental group(P>0.05);after treatment,the levels of CRP,IL-6,and TNF-αin the experimental group were lower than those in the control group,with significant differences(P<0.05).(iv)Compared to the total incidence of adverse reactions in the control group(28.00%),the incidence of total adverse reactions in the experimental group was lower at 10.00%,and the difference was significant(P<0.05).Conclusion:The combined inhalation of budesonide and formoterol with tiotropium bromide has demonstrated a clear therapeutic efficacy and safety in treating chronic obstructive pulmonary disease.This treatment approach effectively enhances arterial blood gas levels and lung function,showing promising potential for widespread application.

Clinical effect of tiotropium bromide on pulmonary function,arterial blood gas and serum inflammatory cytokine in elderly patients with COPD at stable stage

Objective: To observe the clinical effect of tiotropium bromide in elderly patients with COPD at stable stage and its effects on pulmonary function,blood and serum inflammatory cytokine. Methods: 80 elderly patients with COPD s at stable stage were randomly divided into treatment group and control group with 40 patients in each group. The control group was treated with normal treatment. The treatment group was treated with tiotropium bromide on the basis of control group. 3 months after treatment, the pulmonary function、arterial blood gas and serum inflammatory cytokine were detected and compared in the two groups. Results:There was no significant difference in lung function index and TNF- alpha level between the two groups before treatment (P>0.05). The levels of FVC, FEV1% and PEF were increased and serum TNF-α was decreased significantly after treatment in two groups (P<0.05), and they were better than in treatment group than those in control group (all P<0.05);There was no significant difference in blood gas index between the two groups before treatment (P>0.05);In addition, there were no significant difference in the level of PCT, PaO2, PaCO2 and PaO2/FiO2 after treatment in control group, but the level of PCT and PaCO2 were higher and PaO2 and PaO2/FiO2 were lower obviously after treatment (P<0.01). The treatment group was superior to the control group (all P<0.05);Moreover, the curative effect of treatment group was better than that in control group (P<0.05). Conclusion: Tiotropium bromide can improve pulmonary function, pulmonary function、arterial blood gas and serum inflammatory cytokine in elderly stable COPD patients.

Algorithm-based arterial blood sampling recognition increasing safety in point-of-care diagnostics

AIM To detect blood withdrawal for patients with arterial blood pressure monitoring to increase patient safety and provide better sample dating.METHODS Blood pressure information obtained from a patient monitor was fed as a real-time data stream to an experimental medical framework. This framework was connected to an analytical application which observes changes in systolic, diastolic and mean pressure to determine anomalies in the continuous data stream. Detection was based on an increased mean blood pressure caused by the closing of the withdrawal three-way tap and an absence of systolic and diastolic measurements during this manipulation. For evaluation of the proposed algorithm, measured data from animal studies in healthy pigs were used.RESULTS Using this novel approach for processing real-time measurement data of arterial pressure monitoring, the exact time of blood withdrawal could be successfully detected retrospectively and in real-time. The algorithm was able to detect 422 of 434(97%) blood withdrawals for blood gas analysis in the retrospective analysis of 7 study trials. Additionally, 64 sampling events for other procedures like laboratory and activated clotting time analyses were detected. The proposed algorithm achieved a sensitivity of 0.97, a precision of 0.96 and an F1 score of 0.97.CONCLUSION Arterial blood pressure monitoring data can be used toperform an accurate identification of individual blood samplings in order to reduce sample mix-ups and thereby increase patient safety.

Arterial blood gas test to decide whether to reconstruct single or both the arteries in living donor liver transplantation

Background:The graft used in living donor liver transplantation(LDLT)sometimes has two hepatic arteries.This study aimed to introduce arterial-blood gas(ABG)test on the decision on whether to reconstruct a single or both arteries in LDLT.Methods:Patients with a right lobe graft with two hepatic arteries were enrolled from the prospectively maintained database of our institution.After anastomosis of one of two arteries,the back-bleeding from the second hepatic artery was taken for ABG test.Depending on the results,the second artery was anastomosed or ligated.Results:Between January 2012 and December 2017,a total of 372 patients underwent LDLT,and 21 living donors had two right hepatic arteries.Based on ABG test results,a single anastomosis was created in 15 recipients while double anastomoses were performed in the remaining 6 recipients.All the patients had an uneventful recovery and were discharged in good conditions.Neither hepatic artery thrombosis nor liver dysfunction was observed during the median follow-up of 26 months(range,6–71 months).The overall incidence of biliary complications was 9.5%(2/21).Bile leakage arose in one patient with two hepatic artery reconstructions,and the patient subsequently developed biliary stricture.Biliary stricture occurred in another patient with one hepatic artery reconstruction.The biliary complications were successfully managed with endoscopic or percutaneous intervention.Conclusions:ABG test provides a good measure for deciding whether to reconstruct single or both arteries in LDLT.

Mechanical ventilation and outcomes in COVID-19 patients admitted to intensive care unit in a low-resources setting: A retrospective study

Objective:To describe the strategies and outcomes of mechanical ventilation in a poorly equipped facility.Methods:This retrospective descriptive study included patients with COVID-19 who were admitted to the intensive care unit(ICU)and mechanically ventilated between September 1,2020,and May 31,2021.Data were collected from medical records and databases.Results:54 Patients aged(62.9±13.3)years were included.Among these cases,79.6%had at least one comorbidity.On admission,all patients had hypoxia.The median peripheral oxygen saturation in room air was 76%(61%,83%).Non-invasive ventilation(NIV)was performed in 75.9%of the patients,and invasive mechanical ventilation(IMV)in 68.5%.IMV was performed on patients due to severe coma(8.1%),failure of standard oxygen therapy(27.0%),and failure of NIV(64.9%).An arterial blood gas test was performed in 14.8%of the patients.NIV failed in 90.2%of cases and succeeded in 9.8%.IMV was successful in 5.4%of cases,vs.94.6%of mortality.The overall mortality rate of patients on ventilation in the ICU was 88.9%.The causes of death included severe respiratory distress syndrome(85.2%),multiple organ failure(14.8%),and pulmonary embolism(13.0%).Conclusions:The ventilation management of COVID-19 patients in the ICU with NIV and IMV in a scarce resource setting is associated with a high mortality rate.Shortcomings are identified in ventilation strategies,protocols,and monitoring.Required improvements were also proposed.

The Clinical Value of Artery Umbilical Cord Blood Gas in Predicting Neonate Condition:A Prospective Cohort Study

Objective:To evaluate the predictive ability of neonate condition through the traditional parameters and artery umbilical cord blood gas(aUCBG).Methods:A prospective cohort study was conducted in obstetrics and gynecology department between October 2017 and August 2018 at Tongji Hospital in Wuhan,China,and 360 aUCBG samples were collected.The average age of pregnant women was(29.50±4.42)years,range from 19 to 48 years old.The gestational age range from 28+4 weeks to 41+3 weeks at admission.Logistic regression and area under the curve(AUC)from Receiver operating characteristic curves were used to identify risk factors,such as,premature rupture of membranes(PROM),high blood pressure,premature delivery(PD),low 1-minute Apgar scores(Apgar 1),low 5-minute Apgar scores(Apgar 5),pH,base excess,bicarbonate,neonatal blood sugar(NBS),and so on,to predict neonatal condition and evaluate the predictive ability of traditional and aUCBG parameters.Results:In all cases,PROM,PD,Apgar 1,Apgar 5,pH,base excess,bicarbonate,total carbon dioxide,and neonatal blood sugar were risk factors and were associated with poor condition of neonate.Apgar 1 were an independent risk factor.Combined traditional and aUCBG parameters had higher AUC of 0.895(95%confidence interval(C/):0.830-0.960,P<0.001).In cesarean section subgroup,high blood pressure,PD,and Apgar 1 were risk factors and were associated with poor condition of neonate.Apgar 1 and low pH were the independent risk factors.Combined traditional and aUCBG parameters had highest AUC of 0.940(95%C/:0.886-0.993,P<0.001).In vaginal delivery subgroup,maternal age above 35 years,PROM,PD,Apgar 1,Apgar 5,and male newborn were risk factors and were associated with poor condition of neonate.Maternal age above 35 years was an independent risk factor.Combined traditional and aUCBG parameters had highest AUC of 0.897(95%Cl:0.828-0.965,P<0.001).For pregnant women without comorbidities and complications of pregnancy,aUCBG may not be necessat7.Conclusion:In high-risk pregnancies,especially lower Apgar scores,PD,and maternal age above 35-year old,aUCBG is recommended.Traditional parameters combined with aUCBG might increase the predicting ability of neonate condition.

动脉血气剩余血用于危重患者生化检验的临床应用分析

目的：研究分析动脉血气剩余血用于危重患者生化检验中的临床应用效果。方法选取我院2013年4月～2014年2月收治的危重患者，共73例，并以此作为本次研究的主要对象。将所有危重患者随机分为研究组与对照组，研究组危重患者采用动脉血气剩余血的方式进行生化检验，而对照组患者则采用静脉血的方式进行生化检验。比较研究组与对照组危重患者的血液标本失血状况。结果研究组与对照组血液标本中的各项检测结果差异之间不具有统计学意义，即P〉0.05。而观察组中的患者只用了2.4 ml的血液标本，对照组则使用了9 ml。结论采用动脉血气剩余血对危重患者进行生化检验，有肯定的临床价值性，可以为临床诊断工作提供可靠性较强的指导依据，并且，与静脉血相比，患者所需动脉血气剩余血标本的出血量较少。

祛痰定眩方联合甲磺酸倍他司汀改善良性阵发性位置性眩晕复位后残留症状疗效观察

目的:观察祛痰定眩方联合甲磺酸倍他司汀对改善良性阵发性位置性眩晕(BPPV)手法复位后残留症状(痰浊内蕴证)的临床疗效。方法:将97例BPPV手法复位后残留症状患者随机分为观察组49例与对照组48例,对照组给予甲磺酸倍他司汀口服,观察组在对照组基础上给予祛痰定眩方加减,均治疗30 d。观察比较两组治疗前后眩晕障碍量表(DHI)总分及其子指数躯体(P)、功能(F)、情绪(E)评分,比较中医证候评分以及基底动脉(BA)、左侧椎动脉(LVA)、右侧椎动脉(RVA)血流峰值,监测不良反应。结果:两组治疗后DHI、P、E、F及中医证候评分对比,观察组低于对照组(P<0.05),组内比较,治疗后低于治疗前(P<0.05);两组治疗后BA、LVA、RVA血流峰值对比,观察组表现优于对照组(P<0.05);观察组总缓解率为93.8%,优于对照组的85.4%(P<0.05);两组均未出现不良反应。结论:祛痰定眩方联合甲磺酸倍他司汀对BPPV复位后残留症状有确切疗效,且安全可靠。

Intensivists’response to hyperoxemia in mechanical ventilation patients:The status quo and related factors

BACKGROUND:Due to the still sparse literature in China,the investigation of hyperoxemia management is required.Thus,we aim to conduct a retrospective study to provide more information about hyperoxemia management in intensive care unit(ICU)patients.METHODS:We retrospectively screened the medical records of adult patients(age≥18 years)who required mechanical ventilation(MV)≥24 hours from January 1,2018,to December 31,2018.All arterial blood gas(ABG)tested during MV was retrieved,and MV settings were recorded.The median arterial partial pressure of oxygen(PaO2)>120 mmHg(1 mmHg=0.133 kPa)was defined as mild to moderate hyperoxemia,and PaO2>300 mmHg as extreme hyperoxemia.Intensivists’response to hyperoxemia was assessed based on the reduction of fraction of inspired oxygen(FiO2)within one hour after hyperoxemia was recorded.Multivariable logistic regression analysis was performed to determine the independent factors associated with the intensivists’response to hyperoxemia.RESULTS:A total of 592 patients were fi nally analyzed.The median Acute Physiology and Chronic Health Evaluation II(APACHE II)score was 21(15-26).The PaO2,arterial oxygen saturation(SaO2),FiO2,and positive end expiratory pressure(PEEP)were 96.4(74.0-126.0)mmHg,97.8%(95.2%-99.1%),0.4(0.4-0.5),and 5(3-6)cmH2O,respectively.Totally 174(29.39%)patients had PaO2>120 mmHg,and 19(3.21%)patients had extreme hyperoxemia at PaO2>300 mmHg.In cases of mild to moderate hyperoxemia with FiO2≤0.4,only 13(2.20%)patients had a decrease in FiO2 within one hour.The multivariable logistic regression analysis showed that a positive response was independently associated with FiO2(odds ratio[OR]1.09,95%confi dence interval[CI]1.06-1.12,P<0.001),PaO2(OR 1.01,95%CI 1.00-1.01,P=0.002),and working shifts(OR 5.09,95%CI 1.87-13.80,P=0.001).CONCLUSIONS:Hyperoxemia occurs frequently and is neglected in most cases,particularly when mild to moderate hyperoxemia,hyperoxemia with lower FiO2,hyperoxemia during night and middle-night shifts,or FiO2 less likely to be decreased.Patients may be at a risk of oxygen toxicity because of the liberal oxygen strategy.Therefore,further research is needed to improve oxygen management for patients with MV in the ICUs.

动脉血气剩余血用于危重患者生化检验价值

目的探讨动脉血气剩余血用于危重患者生化检验的临床应用价值分析。方法对患者的临床资料进行回顾性分析,随机选取符合要求的102名患者,所有患者均为2015年4月—2018年4月入院接受治疗的危重患者,使用随机单双数分组法,所有患者均采集动脉血进行动脉血气分析同时进行生化检验,而观察组患者51名患者则使用动脉血气剩余血进行生化检验,观察两组患者的生化检查结果。结果两组患者的生化检查结果相对比差异无统计学意义(P>0.05)。结论采用动脉血气剩余血进行生化检验,与静脉血的检验结果大致相仿,且用血量更少。

CT、DSA和超声造影诊断肝癌HAE术后残余血供的价值对比

目的探讨CT、超声造影在诊断肝癌肝动脉栓塞(HAE)术后残余血供的临床价值。方法收集2017年2月至2018年2月就诊于我院并行HAE治疗的肝癌患者60例(共76个病灶),所有患者均于行HAE术后3至5周接受CT、超声造影检查及DSA复查,以DSA检查结果为金标准,对比分析CT、超声造影诊断术后残余血供的临床价值。结果 60例患者(76个病灶)HAE术后经DSA检查发现,32个病灶存在残余血供。CT检出残余血供病灶22个(68.8%),超声造影检出残余血供病灶17个(53.1%),均与DSA检查结果比较差异有统计学意义(χ^2=11.852、19.592,P<0.001),且CT检查与超声造影检查结果差异无统计学意义(χ^2=1.641,P>0.05);而二者联合检查检出30个,检出率为93.8%,与DSA检查结果比较差异无统计学意义(χ^2=2.065,P>0.05)。结论 CT、超声造影对于肝癌HAE术后残余血供的诊断价值相当,二者联合可优势互补,有助于提高诊断准确度,为后续治疗提供更好指导。

动脉血气剩余血用于危重患者标准化生化检验的临床应用价值

目的:研究分析动脉血气剩余血用于危重患者标准化生化检验的临床效果。方法:规定研究资料入组时间为2020年1月到2021年1月,在此段时间内选择80例湖北省襄阳市湖北文理学院附属谷城医院收治的危重患者,电脑随机均分静脉血生化检验的对照组和采用动脉血剩余血生化检验的实验组,就实验组和对照组检验情况进行统计、分析。结果:经过统计分析,实验组患者在总胆汁酸(TBIL)、乳酸脱氢酶(TBA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、磷酸酶(AKP)、a-羟丁酸脱氢酶(HBDH)、血糖(GLU)、总蛋白(TP)、直接胆红素(DBIL)、总胆红素(TBIL)上无统计学差异,其中总蛋白(TP)、谷丙转氨酶(ALT)、直接胆红素(DBIL)、磷酸酶(AKP)的1/2CLIA88均在允许范围内。结论:动脉血气剩余血用于危重患者标准化生化检验,准确率较高,能为临床诊断提供指导性依据,因此值得在危重患者生化检验中使用推广。

探讨分析为危重症患者选用动脉血气剩余血进行血液检验的临床意义

目的:评价使用动脉血气剩余血为危重症患者进行血液检验的价值和意义。方法:将2014年3月~2015年12月期间某院收治的92例危重症疾病患者纳入本组研究。为患者进行静脉血生化检验,之后使用动脉血气剩余血再一次进行生化检验,并将两次检验的结果进行对比。结果:生化指标检验结果显示,大部分生化指标结果基本相近(P>0.05),ALP、UA、LDH这3项指标,两种方法的检查结果出现了统计学差异(P<0.05)。动脉血气剩余血的采血量明显少于静脉血检验(P<0.05)。结论:采取动脉血气剩余血为危重症患者进行血液检验其结果的准确性与静脉血检验相当,且采血量更少,更加安全。

高血压患者VD、残余胆固醇与颈动脉病变的关系

目的研究高血压患者血清维生素D(Vitamin D,VD)和残余胆固醇(Remmant Cholesterol,Remmant-C)水平变化的临床意义,分析其与颈动脉粥样硬化的相关性。方法选择2019年1月-2021年3月本院收治的137例高血压患者作为研究组,按照高血压分级分为1级、2级和3级,根据彩超检查颈动脉内中膜厚度(Carotid intima-media thickness,CIMT)来判定动脉粥样硬化程度,分为斑块组、内膜增厚组和无病变组,并与对照组进行对比,对比两组受试者各项基本资料的差异,对比不同高血压分级及不同颈动脉病变程度患者各项指标的差异,同时分析高血压患者血清VD和残余胆固醇与不同颈动脉病变程度的相关性。结果高血压分级在斑块组与内膜增厚组、无病变组组间比较差异有统计学意义(P<0.05)。VD水平在斑块组中明显较内膜增厚组、无病变组和对照组低,4组相比差异有统计学意义(P<0.05)。高血压患者的残余胆固醇在斑块组中明显较内膜增厚组、无病变组和对照组高,4组相比差异有统计学意义(P<0.05)。血清残余胆固醇与颈动脉粥样硬化之间呈显著相关性(P<0.05)。结论高血压患者残余胆固醇水平与高血压分级及颈动脉病变程度密切相关,与维生素D呈负相关,维生素D和残余胆固醇可能成为临床评价颈动脉病变程度的新指标。

精神分裂症的中医治疗及研究概况

精神分裂症的中医治疗及研究概况丁波曾国新高涛成都市精神病院（６１００９１）精神分裂症是临床常见的重性精神病之一，是精神科重点科研课题之中的难点。目前采用的抗精神病药物治疗有较好疗效，但存在着毒、副作用较大，复发率较高等问题。近年来一些医学工作者发挥中...

危重症患者选用动脉血气剩余血进行血液检验的临床效果分析

目的分析采用危重症患者动脉血气剩余血进行血液检验的临床效果及应用价值。方法于2016年12月——2017年12月选取在我院就诊的120例危重症患者作为研究对象参与临床研究,抽取静脉血用于生化检验,将剩余血样再次进行生化检验,分析比对两次检验的结果。结果分析比对可知,两种检验方法的多数生化指标结果间无显著差别(P>0.05);在ALP、UA、LDH检验结果间存在显著差别(P<0.05);分析平均采血量,动脉血气剩余血生化检验显著低于静脉血生化检验,差距有统计学意义(P<0.05)。结论采用危重症患者动脉血气剩余血进行血液检测,其结果与静脉血检验结果间无显著差别,并显著降低样本的溶血发生率及采血量。

Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge

The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O2, 90% N2) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (Vm) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and Vm (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in Vm than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine haslatent deleterious effects on ventilatory responses elicited by hypoxic challenge.

Correlation between the umbilical artery flow ultrasound parameters of intrauterine fetal distress and fetal ischemic hypoxic damage

Objective: To study the correlation between the umbilical artery flow ultrasound parameters of intrauterine fetal distress and fetal ischemic hypoxic damage. Methods: A total of 158 puerperae who gave birth in our hospital between July 2016 and June 2017 were selected and divided into the intrauterine distress group (Apgar<7 points) and normal pregnancy group (Apgar≥7 points) according to the neonatal Apgar score, the umbilical artery flow ultrasound parameters at 24-30 weeks, 31-36 weeks and 37-41 weeks of gestation were determined, and the umbilical arterial blood gas parameters and oxidative stress molecule levels were determined. Results: At 24-30 weeks, 31-36 weeks and 37-41 weeks of gestation, umbilical arterial RI, PI and S/D of intrauterine distress group were significantly higher than those of normal pregnancy group;umbilical arterial pH and PaO2 of intrauterine distress group were significantly lower than those of normal pregnancy group and negatively correlated with RI, PI and S/D while PaCO2 and lactic acid levels were significantly higher than those of normal pregnancy group and positively correlated with RI, PI and S/D;SOD, GSH-px and CAT levels in umbilical artery of intrauterine distress group were significantly lower than those of normal pregnancy group and negatively correlated with RI, PI and S/D while MDA and 8-OHdG levels were significantly higher than those of normal pregnancy group and positively correlated with RI, PI and S/D. Conclusion: Umbilical artery flow ultrasound characteristics of intrauterine fetal distress are characterized by the increased resistance and decreased blood flow and are correlated with the degree of fetal hypoxia and oxidative stress.

Heliox as a driving gas to atomize inhaled drugs on acute exacerbation of chronic obstructive pulmonary disease： a prospective clinical study

Background Acute exacerbation of chronic obstructive pulmonary disease （AECOPD） is a common condition,which affects not only the quality of life of patients but also their prognosis.The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the glucocorticoid budesonide that were atomized with heliox to treat patients with AECOPD.Methods Twenty-three patients with AECOPD were divided into a treatment group （He/O2=70％/30％） and a control group （N2/O2=70％/30％）.The salbutamol sulfate and budesonide were administered by inhalation twice a day for 7 days.Vital signs,arterial blood gas levels,pulmonary function and the levels of serum myostatin （sMSTN） were measured and lung vibration imaging was performed.Results We found that the PaO2 and PaCO2 values were not significantly different between the two groups at the various time points （P ＞0.05）.There were also no significant differences in any of the parameters of pulmonary function between the two groups.However,after baseline correction,the increase rate of the forced expiratory volume in one second （FEV1）,the forced vital capacity （FVC）,and the maximum minute ventilation （MW） appeared to be significantly increased at some time points compared with the baseline （before treatment） in both groups （P ＜0.05）.Although the values of quantitative lung distribution （QLD） for different regions and the levels of sMSTN were slightly different between the two groups,the repeated measures analysis of variance （ANOVA） revealed that there were no significant differences between the two groups or within any group （P ＞0.05）.Conclusion Although the use of heliox as a driving gas can improve symptoms and benefit patients with AECOPD,the heliox treatment group did not have significant differences in arterial blood gases,lung function,lung vibration response imaging or the levels of sMSTN compared with the control group.（Chinese Clinical Trial Register Center ChiCTR-TRC-00000273）

残余应力对脉搏波速度与动脉血压之间关系的影响

通过脉搏波速度实时监测人体血压波动是目前先进的无创连续血压监测技术.以前研究中脉搏波速度和血压间的理论关系没有考虑到残余应力的影响,这会使结果不准确,特别是没有考虑动脉轴向的残余应力.本文为脉搏波速度-血压关系建立了一个新的分析模型,它考虑了残余应力以及动脉的几何和材料参数对波速的影响.此外,在人体血压范围内将含有残余应力的脉搏波速度-血压关系被证明可以简化为二次函数,并详细讨论了残余应力、动脉的几何和材料参数对函数影响.