In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and...In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.展开更多
Phytochemical investigation on Forsythia suspensa(Thunb.) Vahl afforded ten compounds, including five lignan glycosides and five phenylethanoid glycosides. The compounds were isolated by using HP-20 macroporous resin,...Phytochemical investigation on Forsythia suspensa(Thunb.) Vahl afforded ten compounds, including five lignan glycosides and five phenylethanoid glycosides. The compounds were isolated by using HP-20 macroporous resin, silica gel, octadecyl silica gel(ODS), size exclusion chromatography resin HW-40 chromatography, and preparative HPLC. The structures were established through application of extensive spectroscopic methods, including ESI-MS, 1D- and 2D-NMR spectroscopy. They were identified as forsythialanside E(1), 8′-hydroxypinoresinol-4′-O-β-D-glucoside(2), 8′-hydroxypinoresinol(3), lariciresinol-4′-O-β- D-glucoside(4), lariciresinol-4-O-β-D-glucoside(5), forsythoside H(6), forsythoside I(7), forsythoside F(8), plantainoside B(9), and plantainoside A(10). Compound 1 was a new lignan glycoside.展开更多
基金supported by Chinese National Natural Science Fund(No.81202885)the Natural Science Foundation of Guangdong province of China(No.2015A030313585)
文摘In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.
文摘Phytochemical investigation on Forsythia suspensa(Thunb.) Vahl afforded ten compounds, including five lignan glycosides and five phenylethanoid glycosides. The compounds were isolated by using HP-20 macroporous resin, silica gel, octadecyl silica gel(ODS), size exclusion chromatography resin HW-40 chromatography, and preparative HPLC. The structures were established through application of extensive spectroscopic methods, including ESI-MS, 1D- and 2D-NMR spectroscopy. They were identified as forsythialanside E(1), 8′-hydroxypinoresinol-4′-O-β-D-glucoside(2), 8′-hydroxypinoresinol(3), lariciresinol-4′-O-β- D-glucoside(4), lariciresinol-4-O-β-D-glucoside(5), forsythoside H(6), forsythoside I(7), forsythoside F(8), plantainoside B(9), and plantainoside A(10). Compound 1 was a new lignan glycoside.
