Developing Reliable Digital Healthcare Service Using Semi-Quantitative Functional Resonance Analysis

Since entering the era of Industry 4.0,the concept of Healthcare 4.0 has also been put forward and explored by researchers.How to use Information Technology(IT)to better serve people’s healthcare is one of the most featured emerging directions in the academic circle.An important field of Healthcare 4.0 research is the reliability engineering of healthcare service.Because healthcare systems often affect the health and even life of their users,developers must be very cautious in the design,development,and operation of these healthcare systems and services.The problems to be solved include the reliability of business process,system functions,and personal healthcare data.The Functional Resonance Analysis Method(FRAM)has been applied in reliability engineering for safety-critical systems in available studies,using both qualitative and quantitative approaches.However,the method has not been applied in the field of digital healthcare services development.Therefore,to narrow the gap,we present in this paper a semi-quantitative functional resonance analysis method to develop reliable healthcare services for diabetics.Moreover,this paper has tried to improve the reliability design of the service-oriented architecture(SOA)of traditional insulin pump therapy by system thinking.

Resonance analysis of single DOF parameter-varying system of magnetic-liquid double suspension bearing

Magnetic-liquid double suspension bearing(MLDSB)is mainly supported by electromagnetic suspension and supplemented by hydrostatic supporting.Its bearing capacity and stiffness can be greatly improved,and then it is suitable for the occasions of medium speed,heavy load.When the bearing system is excited by periodic force,the flow q and current i regulated by the double-closed-loop control mechanism change periodically.Then the risk of parametric resonance in MLDSB is greatly aggravated by the change of the parameter system,which seriously affects its operation stabil-ity and reliability.Therefore,this paper intends to study the resonance characteristics of the parame-ter system of MLDSB.Firstly,Marshall-Duffing equation of the parametric system is established by taking the flow q and the current i as variables respectively.Then,by using the asymptotic method,the occurrence condition and variation rule of the principal,1/2 Harmonic and 1/3 Harmonic para-metric resonance are solved.The results show that only the 1/2 Harmonic resonance of the flow q parameter varying system occurs accompanied by the resonance condition of high frequency.The principal,1/2 Harmonic and 1/3 Harmonic parametric resonance of the current i occur accompanied by the resonance condition of high frequency.And the 1/2 Harmonic resonance of the current i oc-curs accompanied by the non-single value bifurcation and dynamic bifurcation.The paper can pro-vide theoretical reference for the parameter design and stable operation of MLDSB.

Numerical Analysis of Magnetic-Shielding Effectiveness for Magnetic Resonant Wireless Power Transfer System

Magnetic radiation phenomena appear inevitably in the magnetic-resonance wireless power transfer （MR-WPT） system, and regarding this problem the magnetic-shielding scheme is applied to improve the electromagnetic performance in engineering. In this study, the shielding effectiveness of a two-coil MR-WPT system for different material shields is analyzed in theory using Moser＇s formula and Schelkunoff＇s formula. On this basis a candidate magnetic-shielding scheme with a double-layer structure is determined, which has better shielding effectiveness and coils coupling coefficient. Finally, some finite element simulation results validate the correctness of the theoretical analysis, and the shielding effectiveness with the double-layer shield in maximum is 30？dB larger than the one with the single-layer case.

Influence of nanosized magnesia on the hydration of borehole-sealing cements prepared using different methods

Gas drainage is an efective technology for gas control in coal mines.A high borehole-sealing quality is the fundamental precondition for efcient gas drainage.The expansibilities of cement pastes used in borehole-sealing processes are critical for the borehole-sealing efect.Nanosized magnesia expansive agents are used to improve the expansibilities of cement pastes and improve the borehole-sealing efect.Nuclear magnetic resonance spectrometry and scanning electron microscopy were adopted to study the efects of nanosized magnesia on the hydration of borehole-sealing cements used with diferent preparation methods.The results showed that an increase in the mass fraction of the nanosized magnesia promoted cement hydration,and the mass fraction was positively correlated with the promotion efect.The use of diferent preparation methods did not change the water-phase distribution in the cement.When using the wet-mixing preparation method,nanosized magnesia promoted the induction,acceleration,and deceleration periods of hydration;when using the dry-mixing preparation method,the nanosized magnesia promoted the induction period of cement hydration,and the promotion efect was less obvious than that seen when using the wet-mixing method.When using the wet-mixing preparation method,the nanosized magnesia was uniformly dispersed,thus enlarging the surface area of the reaction,which provided more nucleation sites for the hydration products of the cement and therefore accelerated the hydration reaction.When using the dry-mixing preparation method,the nanosized magnesia powders were dispersed nonuniformly and aggregated.Under these conditions,only a few nanosized magnesia particles on the surfaces of the aggregated clusters took part in hydration,so only a small number of nucleation sites were provided for the hydration products of cement.This led to inconsistent hydration of cement pastes prepared using the dry-mixing method.The surface porosity of the cement prepared with the wet-mixing preparation method frst decreased and then increased with increases in the mass fraction of the nanosized magnesia.The cement surface exhibited compact hydration products and few pores,and the surface was relatively smooth.In comparison,the surface porosity of the cement prepared using the dry-mixing method fuctuated with increasing mass fraction of the nanosized magnesia,resulting in a rough cement surface and microfractures on some surfaces.The two preparation methods both reduced the surface porosity of the cement.The wet-mixing preparation was more efective and consistent in improving the compactness of the cement than the dry-mixing preparation.These results provide important guidance on the addition of nanosized magnesia in borehole-sealing engineering and the selection of cement preparation methods,and they also lay a solid foundation for realizing safe and efcient gas drainage.

Resonance System Reliability and Sensitivity Analysis Method for Axially FGM Pipes Conveying Fluid with Adaptive Kriging Model

This paper aims to solve the resonance failure probability and develop an effective method to estimate the effects of variables and failure modes on failure probability of axially functionally graded material(FGM)pipe conveying fluid.Correspondingly,the natural frequency of axially FGM pipes conveying fluid is calculated using the differential quadrature method(DQM).A variable sensitivity analysis(VSA)is introduced to measure the effect of each random variable,and a mode sensitivity analysis(MSA)is introduced to acquire the importance ranking of failure modes.Then,an active learning Kriging(ALK)method is established to calculate the resonance failure probability and sensitivity indices,which greatly improves the application of resonance reliability analysis for pipelines in engineering practice.Based on the resonance reliability analysis method,the effects of fluid velocity,volume fraction and fluid density of axially FGM pipe conveying fluid on resonance reliability are analyzed.The results demonstrate that the proposed method has great performance in the anti-resonance analysis of pipes conveying fluid.

Effect of wheelset flexibility on wheel–rail contact behavior and a specific coupling of wheel–rail contact to flexible wheelset

The fexibility of a train＇s wheelset can have a large effect on vehicle–track dynamic responses in the medium to high frequency range.To investigate the effects of wheelset bending and axial deformation of the wheel web,a specifi coupling of wheel–rail contact with a fexible wheelset is presented and integrated into a conventional vehicle–track dynamic system model.Both conventional and the proposed dynamic system models are used to carry out numerical analyses on the effects of wheelset bending and axial deformation of the wheel web on wheel–rail rolling contact behaviors.Excitations with various irregularities and speeds were considered.The irregularities included measured track irregularity and harmonic irregularities with two different wavelengths.The speeds ranged from 200 to400km/h.The results show that the proposed model can characterize the effects of fexible wheelset deformation on the wheel–rail rolling contact behavior very well.

Connectivity differences between adult male and female patients with attention deficit hyperactivity disorder according to resting-state functional MRI

Attention deficit hyperactivity disorder（ADHD） is a pervasive psychiatric disorder that affects both children and adults. Adult male and female patients with ADHD are differentially affected, but few studies have explored the differences. The purpose of this study was to quantify differences between adult male and female patients with ADHD based on neuroimaging and connectivity analysis. Resting-state functional magnetic resonance imaging scans were obtained and preprocessed in 82 patients. Group-wise differences between male and female patients were quantified using degree centrality for different brain regions. The medial-, middle-, and inferior-frontal gyrus, superior parietal lobule, precuneus, supramarginal gyrus, superior- and middle-temporal gyrus, middle occipital gyrus, and cuneus were identified as regions with significant group-wise differences. The identified regions were correlated with clinical scores reflecting depression and anxiety and significant correlations were found. Adult ADHD patients exhibit different levels of depression and anxiety depending on sex, and our study provides insight into how changes in brain circuitry might differentially impact male and female ADHD patients.

Nonlinear dynamic response of beam and its application in nanomechanical resonator

Nonlinear dynamic response of nanomechanical resonator is of very important characteristics in its application. Two categories of the tension-dominant and curvaturedominant nonlinearities are analyzed. The dynamic nonlinearity of four beam structures of nanomechanical resonator is quantitatively studied via a dimensional analysis approach. The dimensional analysis shows that for the nanomechanical resonator of tension-dominant nonlinearity, its dynamic nonlinearity decreases monotonically with increasing axial loading and increases monotonically with the increasing aspect ratio of length to thickness; the dynamic nonlinearity can only result in the hardening effects. However, for the nanomechanical resonator of the curvature-dominant nonlinearity, its dynamic nonlinearity is only dependent on axial loading. Compared with the tension-dominant nonlinearity, the curvature-dominant nonlinearity increases monotonically with increasing axial loading; its dynamic nonlinearity

Planning for selective amygdalohippocampectomy involving less neuronal fiber damage based on brain connectivity using tractography

Temporal lobe resection is an important treatment option for epilepsy that involves removal of potentially essential brain regions. Selective amygdalohippocampectomy is a widely performed temporal lobe surgery. We suggest starting the incision for selective amygdalohippocampectomy at the inferior temporal gyrus based on diffusion magnetic resonance imaging（MRI） tractography. Diffusion MRI data from 20 normal participants were obtained from Parkinson＇s Progression Markers Initiative（PPMI） database（www.ppmi-info.org）. A tractography algorithm was applied to extract neuronal fiber information for the temporal lobe, hippocampus, and amygdala. Fiber information was analyzed in terms of the number of fibers and betweenness centrality. Distances between starting incisions and surgical target regions were also considered to explore the length of the surgical path. Middle temporal and superior temporal gyrus regions have higher connectivity values than the inferior temporal gyrus and thus are not good candidates for starting the incision. The distances between inferior temporal gyrus and surgical target regions were shorter than those between middle temporal gyrus and target regions. Thus, the inferior temporal gyrus is a good candidate for starting the incision. Starting the incision from the inferior temporal gyrus would spare the important（in terms of betweenness centrality values） middle region and shorten the distance to the target regions of the hippocampus and amygdala.

Survival of Chemically Modified Titanium Surfaced Implants in Irradiated Jaws of Oral Cancer Patients

Objective: To investigate the clinical performance of implants with chemically modified surfaces in irradiated bone in a period of five-years. Patients & Methods: 15 (6 females, 9 males, 50.2 years with a range of 38 - 60 years) patients who had been operated for oral tumors and had undergone radiotherapy were enrolled and 40 SLActive surface implants were placed (24 in the maxilla, 16 in the mandible). Implants were allowed to integrate for a period of 90 days and the stability of the implants was measured with Resonance Frequency Analyzer/Osstell? Mentor (Integration Diagnostics, Savedalen, Sweden) at implant placement, 30 days later and at the end of the 90th day. Patients follow up periods after the implant placement varied from 20 months to 60 months (mean: 45 months). Results: Two implants were lost in maxilla in healing period as a result of osseointegration failure. The survival rate was 95%. During the observation period, totally 4 implants were lost. The overall success rate was 90%. 3 of the lost implants were in maxilla and one was in mandible. The initial ISQ values of the implants differed from 20 - 71;the second values were between 24 - 71 and the last values were between 30 - 89. The implants which were lost could not show a value greater than 35. Conclusion: There was no any complication on the SLActive surface implant placed bones due to irradiation. Within the limitations of this study, it may be concluded that osseointegrated implants can be placed in irradiated bones, unless a careful patient selection and treatment planning is performed.

Assignment of the non-exchangeable proton resonances and conformational analysis of oligonucleotide DNA d(TTGGGGTT)by twodimensional nuclear magnetic resonance methods

Two-dimensional NMR study on the single-stranded octadeoxynucleotide,d(TT- GGGGTT)is presented.Assignments of the base protons,the H1′,H2′ and H2″ protons were made by two-dimensional Nuclear Overhauser Enhancement Spectroscopy(NOESY)and two-dimensional homonuclear J-correlated Spectroscopy(COSY).The result indicates that the overall structure of the single-stranded d(TTGGGGTT)is a right-handed B-type helix.

Effect of acupuncture plus conventional treatment on brain activity in ischemic stroke patients: a regional homogeneity analysis

OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.

Design and analysis on a Gires-Tournois resonator based interleaver

A flat-top interleaver,in which a mirror on one arm of the Michelson interferomefer is replaced by a G-T resonator,is proposed.In the interleaver,the parameters including the channel spacing of 50 GHz,ripple less than 0.05 dB,-0.5 dB passband of 43 GHz(86% of the spacing),-30 dB stopband of 42 GHz(84% of the spacing),and a channel isolation higher than 40 dB,are achieved.

HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis

Deletion of HAX1 in mice causes a severe reduction in the numbers of lymphocytes in the bone marrow and in the spleen. Additionally, B220＋ B progenitor cells in the bone marrow are reduced, suggesting an important function of HAX1 in B cell development. HAX1 is thought to play a protective role in apoptotic processes; therefore, we investigated the role of HAX1 in bone marrow B progenitor cells and splenic B cells. We did not observe an effect on the survival of Hax1-/- bone marrow cells but detected enhanced survival of splenic Hax1-/- B cells upon in vitro starvation/ growth-factor withdrawal. To explain this apparent inconsistency with previous reports of HAX1 function, we also studied the B cell receptor （BCR）-induced apoptosis of IgM-stimulated splenic naive B cells and found that apoptosis decreased in these cells. We further found impaired internalization of the BCR from Hax1-/- splenic B cells after IgM crosslinking; this impaired internalization may result in decreased BCR signaling and, consequently, decreased BCR-mediated apoptosis. We measured HAX1 binding to the cytoplasmic domains of different Ig subtypes and identified KVKWI（V）F as the putative binding motif for HAX1 within the cytoplasmic domains. Because this motif can be found in almost all Ig subtypes, it is likely that HAX1 plays a general role in BCR-mediated internalization events and BCR-mediated apoptosis.