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External blast flow field evolution and response mechanism of single-layer reticulated dome structure 被引量:3
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作者 Shao-bo Qi Guang-yan Huang +1 位作者 Xu-dong Zhi Feng Fan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期241-253,共13页
Single-layer reticulated dome structure are commonly high-profile building in the public and can be attractive targets for terrorist bombings,so the public can benefit from enhanced safety with a stronger understandin... Single-layer reticulated dome structure are commonly high-profile building in the public and can be attractive targets for terrorist bombings,so the public can benefit from enhanced safety with a stronger understanding of the behavior of single-layer reticulated dome structure under explosion.This paper investigates the fluid-structure interaction process and the dynamic response performance of the singlelayer reticulated dome under external blast load.Both experimental and numerical results shown that structural deformation is remarkably delayed compared with the velocity of blast wave,which advises the dynamic response of large-span reticulated dome structure has a negligible effect on the blast wave propagation under explosion.Four failure modes are identified by comparing the plastic development of each ring and the residual spatial geometric of the structure,i.e.,minor vibration,local depression,severe damage,and overall collapse.The plastic deformation energy and the displacement potential energy of the structure are the main consumers of the blast energy.In addition,the stress performance of the vertex member and the deep plastic ratio of the whole structure can serve as qualitative indicators to distinguish different failure modes. 展开更多
关键词 External blast loading Reticulated dome structure Fluid-structure interaction Dynamic response mode response mechanism
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Risk warning technologies and emergency response mechanisms in Sichuan-Tibet Railway construction 被引量:2
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作者 Liujiang KANG Hao LI +3 位作者 Cong LI Na XIAO Huijun SUN Nsabimana BUHIGIRO 《Frontiers of Engineering Management》 2021年第4期582-594,共13页
Safety is one of the most critical themes in any large-scale railway construction project.Recognizing the importance of safety in railway engineering,practitioners and researchers have proposed various standards and p... Safety is one of the most critical themes in any large-scale railway construction project.Recognizing the importance of safety in railway engineering,practitioners and researchers have proposed various standards and procedures to ensure safety in construction activities.In this study,we first review four critical research areas of risk warning technologies and emergency response mechanisms in railway construction,namely,(i)risk identification methods of large-scale railway construction projects,(ii)risk management of large-scale railway construction,(iii)emergency response planning and management,and(iv)emergency response and rescue mechanisms.After reviewing the existing studies,we present four corresponding research areas and recommendations on the Sichuan-Tibet Railway construction.This study aims to inject new significant theoretical elements into the decision-making process and construction of this railway project in China. 展开更多
关键词 railway construction risk warning technologies emergency response mechanisms Sichuan-Tibet Railway
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A Preliminary Study on Mechanisms of Well Water Temperature Responses Based on the Modes of Stress Loading
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作者 Chen Daqing Wan Yongfang 《Earthquake Research in China》 2011年第4期477-485,共9页
Based on the studies of the predecessors, and contrasting the modes of stress loading with water level and water temperature response characteristics of a well-aquifer system, this paper draws a preliminary conclusion... Based on the studies of the predecessors, and contrasting the modes of stress loading with water level and water temperature response characteristics of a well-aquifer system, this paper draws a preliminary conclusion on the mechanisms of water temperature responses in a well caused by three modes of stress loading, i.e. gas escape, heat dispersion and cold water penetration mechanisms for elastic seismic wave stress loading; the fracture seepage mechanism for seismic wave stress loading and the hydrodynamic mechanism for earth tide stress loading and stress-dissipative heat mechanism for long period slow stress loading in the earthquake preparation stage. This paper illustrates the typical observation examples for each mode of stress loading and makes a preliminary study on their mechanisms. 展开更多
关键词 Water temperature in well Stress loading response mechanism
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Unveiling the mechanical response and accommodation mechanism of pre-rolled AZ31 magnesium alloy under high-speed impact loading 被引量:4
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作者 Xiao Liu Hui Yang +3 位作者 Biwu Zhu Yuanzhi Wu Wenhui Liu Changping Tang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第4期1096-1108,共13页
Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommo... Split Hopkinson pressure bar(SHPB)tests were conducted on pre-rolled AZ31 magnesium alloy at 150–350℃ with strain rates of 2150s-1,3430s^(-1) and 4160s-1.The mechanical response,microstructural evolution and accommodation mechanism of the pre-rolled AZ31 magnesium alloy under high-speed impact loading were investigated.The twin and shear band are prevailing at low temperature,and the coexistence of twins and recrystallized grains is the dominant microstructure at medium temperature,while at high temperature,dynamic recrystallization(DRX)is almost complete.The increment of temperature reduces the critical condition difference between twinning and DRX,and the recrystallized temperature decreases with increasing strain rate.The mechanical response is related to the competition among the shear band strengthen,the twin strengthen and the fine grain strengthen and determined by the prevailing grain structure.The fine grain strengthen could compensate soften caused by the temperature increase and the reduction of twin and shear band.During high-speed deformation,different twin variants,introduced by pre-rolling,induce different deformation mechanism to accommodate plastic deformation and are in favor for non-basal slip.At low temperature,the high-speed deformation is achieved by twinning,dislocation slip and the following deformation shear band at different deformation stages.At high temperature,the high-speed deformation is realized by twinning and dislocation slip of early deformation stage,transition shear band of medium deformation stage and DRX of final deformation stage. 展开更多
关键词 Mechanical response Pre-twinning Accommodation mechanism Pre-rolled AZ31 magnesium alloy High-speed impact loading
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Acoustic Response and Micro-Damage Mechanism of Fiber Composite Materials under Mode-Ⅱ Delamination 被引量:2
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作者 周伟 吕智慧 +3 位作者 王雅瑞 刘然 陈维业 李晓彤 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第4期73-76,共4页
Realizing the accurate characterization for the dynamic damage process is a great challenge. Here we carry out testing simultaneously for dynamic monitoring and acoustic emission (AE) statistical analysis towards fi... Realizing the accurate characterization for the dynamic damage process is a great challenge. Here we carry out testing simultaneously for dynamic monitoring and acoustic emission (AE) statistical analysis towards fiber composites under mode-Ⅱ delamination damage. The load curve, AE relative energy, amplitude distribution, and amplitude spectrum are obtained and the delamination damage mechanism of the composites is investigated by the microscopic observation of a fractured specimen. The results show that the micro-damage accumulation around the crack tip region has a great effect on the evolutionary process of delamination. AE characteristics and amplitude spectrum represent the damage and the physical mechanism originating from the hierarchical microstructure. Our finding provides a novel aud feasible strategy to simultaneously evaluate the dynamic response and micro-damage mechanism for fiber composites. 展开更多
关键词 der DELAMINATION Acoustic response and Micro-Damage mechanism of Fiber Composite Materials under Mode
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Investigations of the mechanical response of dummy HTPB propellant grain under ultrahigh acceleration overload conditions using onboard flight-test measurements
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作者 Yiming Zhang Ningfei Wang +3 位作者 Weihua Ma Ran Wang Long Bai Yi Wu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期473-484,共12页
In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measuremen... In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were performed.Two projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 g.The onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and analysed.Uniaxial compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching process.During the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant grain.The calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were observed.The dynamic mechanical response process of the dummy propellant grain was analysed in detail.The results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process. 展开更多
关键词 Gun-launched flight test Dummy HTPB propellant Onboard measurements Utrahigh overload Mechanical response
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Comparative analysis of thermodynamic and mechanical responses between underground hydrogen storage and compressed air energy storage in lined rock caverns
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作者 Bowen Hu Liyuan Yu +5 位作者 Xianzhen Mi Fei Xu Shuchen Li Wei Li Chao Wei Tao Zhang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第4期531-543,共13页
Underground hydrogen storage(UHS)and compressed air energy storage(CAES)are two viable largescale energy storage technologies for mitigating the intermittency of wind and solar power.Therefore,it is meaningful to comp... Underground hydrogen storage(UHS)and compressed air energy storage(CAES)are two viable largescale energy storage technologies for mitigating the intermittency of wind and solar power.Therefore,it is meaningful to compare the properties of hydrogen and air with typical thermodynamic storage processes.This study employs a multi-physical coupling model to compare the operations of CAES and UHS,integrating gas thermodynamics within caverns,thermal conduction,and mechanical deformation around rock caverns.Gas thermodynamic responses are validated using additional simulations and the field test data.Temperature and pressure variations of air and hydrogen within rock caverns exhibit similarities under both adiabatic and diabatic simulation modes.Hydrogen reaches higher temperature and pressure following gas charging stage compared to air,and the ideal gas assumption may lead to overestimation of gas temperature and pressure.Unlike steel lining of CAES,the sealing layer(fibre-reinforced plastic FRP)in UHS is prone to deformation but can effectively mitigates stress in the sealing layer.In CAES,the first principal stress on the surface of the sealing layer and concrete lining is tensile stress,whereas UHS exhibits compressive stress in the same areas.Our present research can provide references for the selection of energy storage methods. 展开更多
关键词 Underground hydrogen storage Compressed air energy storage Mechanical response Thermodynamic response Lined rock caverns
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Influence of the boundary effect on the mechanical response test of pavement cushion under the wetting effect of silt
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作者 Luo Qiqi Yu Qian +3 位作者 Zhang Sheng Ma Xinyan Ye Xinyu Du Yinfei 《Journal of Southeast University(English Edition)》 EI CAS 2024年第3期266-274,共9页
Through a self-developed model test system,the mechanical properties of silt and the deformation characteristics of airport runways were investigated during the period of subgrade wetting.Based on the test results,the... Through a self-developed model test system,the mechanical properties of silt and the deformation characteristics of airport runways were investigated during the period of subgrade wetting.Based on the test results,the reliability of the numerical simulation results was verified.Numerical models with different sizes were established.Under the same cushion parameter and loading width ranges,the effects of the cushion parameters and loading conditions on the mechanical responses of the cushion before and after subgrade wetting were analyzed.The results show that the internal friction angles of silt with different wetting degrees are approximately 34°.The cohesion is from 8 to 44 kPa,and the elastic modulus is from 15 to 34 MPa.Before and after subgrade wetting,the variation rates of the cushion horizontal tensile stresses with the same cushion parameters and loading width ranges are different under the influence of boundary effects.After subgrade wetting,the difference in the variation rates of the cushion horizontal tensile stresses under the same cushion parameter range decreases compared with that before subgrade wetting;however,this difference increases under the same loading width range.Before and after subgrade wetting,the influence of the boundary effect on the mechanical response evaluation of the cushion is not beneficial for optimizing the pavement design parameters.When the cushion thickness is more than 0.25 m,the influence of the boundary effect can be disregarded. 展开更多
关键词 pavement cushion silt subgrade WETTING boundary effect mechanical response
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Alpine vegetation responses to snow phenology in the Chinese Tianshan mountainous region 被引量:1
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作者 ZHANG Bo LI Xue-mei +2 位作者 LI Chao NYIRANSENGIYUMVA Christine QIN Qi-yong 《Journal of Mountain Science》 SCIE CSCD 2022年第5期1307-1323,共17页
Investigating the interrelation between snow and vegetation is essential to explain the response of alpine ecosystems to climate change.Based on the MOD10 A1 daily cloud-free snow product and MOD13 A1 NDVI(normalized ... Investigating the interrelation between snow and vegetation is essential to explain the response of alpine ecosystems to climate change.Based on the MOD10 A1 daily cloud-free snow product and MOD13 A1 NDVI(normalized difference vegetation index)data,this study analysed the spatial and temporal patterns of snow phenology including snow onset date,snow end date,snow cover days,and vegetation phenology including the start of growing season,the end of growing season and the length of growing season in the Chinese Tianshan Mountainous Region(CTMR)from 2002 to 2018,and then investigated the snow phenological effects on the vegetation phenology among different ecogeographic zones and diverse vegetation types.The results indicated that snow onset date was earlier at higher elevations and later at lower elevations,while snow end date showed opposite spatial distribution characteristics.The end of growing season occurred later on the northwest slope of the CTMR and the Yili Valley.The earliest end of growing season was in the middle part of the CTMR.A long growing season was mainly distributed along the northern slope and the Yili Valley,while a short growing season was concentrated in the middle part of the CTMR.The response of vegetation phenology to changes in snow phenology varied among vegetation types and ecogeographic zones.The effect of snow phenology on vegetation phenology was more significant in IID5(Yili Valley)than in the other ecogeographic zones.A negative correlation was observed between the start of growing season and snow end date in nearly 54.78%of the study area,while a positive correlation was observed between the start of growing season and the snow end date in 66.85%of the study area.The sensitivity of vegetation phenology to changes in snow cover varied among different vegetation types.Snow onset date had the greatest effect on the start of growing season in the four vegetation cover types(alpine meadows,alpine steppes,shrubs,and alpine sparse vegetation),whereas the snow cover days had the least impact.Snow end date had the greatest impact on the end of growing season in the alpine steppes and shrub areas.The study results are helpful for understanding the vegetation dynamics under ongoing climate change,and can benefit vegetation management and pasture development in the CTMR. 展开更多
关键词 Snow phenology Vegetation phenology Climate change response mechanism Grey correlation analysis Chinese Tianshan Mountainous Region
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Earthquake Emergency Response System of High-speed Railway by Least Square Method
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作者 Qizhou Hu Yikai Wu 《Journal of Harbin Institute of Technology(New Series)》 CAS 2023年第2期1-11,共11页
This paper studies the Least Square Method to define high-speed railway(HSR) earthquake risk and solve the problem of its emergency response mechanism. Based on the construction of a monitoring system for HSR earthqua... This paper studies the Least Square Method to define high-speed railway(HSR) earthquake risk and solve the problem of its emergency response mechanism. Based on the construction of a monitoring system for HSR earthquake emergency response, the technical operational procedures for HSR seismic emergency response are proposed. The quantity, scale, and location of HSR earthquake emergency response mechanism are defined, and the corresponding emergency response system is built. In particular, the earthquake emergency response system can conduct real-time continuous dynamic monitoring of seismic activity along the railway. When earthquake occurs, the intensity of the ground motion is detected by the system. When the earthquake monitoring value reaches the earthquake alarm threshold, it will send an alarm signal to the dispatch center, and the emergency power supply will be forced to cut off. The earthquake emergency response system will continue to monitor the follow-up ground motion acceleration. The system provides the operation scheduling center with a basis for train operation control to resume operation after stopping. The monitoring result of the system reduces the disaster, and the secondary disaster is caused by the earthquake. This paper improves the HSR response mechanism in detecting earthquake disasters. The result improves the ability of HSR to deal with earthquake disasters, and reduces casualties and economic and property loss caused by earthquake disasters. 展开更多
关键词 high-speed railway(HSR) earthquake monitoring emergency response mechanism
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Research Progress on the Mechanism of Crop Saline-alkali Tolerance and Mitigation Measures
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作者 Ting XU Yantao LIU 《Agricultural Biotechnology》 CAS 2021年第5期74-78,共5页
The wide distribution of saline-alkali land in China is a restrictive factor for the sustainable development of agriculture.Saline-alkaline soil inhibits the growth and development of crops,reducing its yield and qual... The wide distribution of saline-alkali land in China is a restrictive factor for the sustainable development of agriculture.Saline-alkaline soil inhibits the growth and development of crops,reducing its yield and quality.In this article,we summarized the germination status,physiological characteristics,response mechanisms and mitigation measures of different crops under saline-alkali stress in recent years,aiming to provide important reference for the study of saline-alkali tolerance mechanism in crops,cultivation of crop varieties tolerant to salts and alkalis and improvement of the utilization rate of saline-alkali land,and put forward suggestions for future development trend of saline-alkali land crops and mitigation measures. 展开更多
关键词 Saline-alkali stress CROP response mechanism Mitigation measures Research progress
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Risk and Response of China Overseas Hydropower Projects--A Vision of Corporate Social Responsibility
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作者 Shi Feng Tiantian Jin Haiying Li 《Journal of Earth Science and Engineering》 2013年第9期639-643,共5页
Recent years, with the quickening of global economic integration and the rapid development of our country, more and more Chinese enterprises begin to implement internationalization strategy and actively develop overse... Recent years, with the quickening of global economic integration and the rapid development of our country, more and more Chinese enterprises begin to implement internationalization strategy and actively develop overseas business. However, the internationalized process of Chinese enterprises is not progressing smoothly. The paper systematically analyzes the risks of China overseas hydropower projects from two aspects: international environment risks and internal risks of hydropower enterprises and points out that effectively fulfilling corporate social responsibility by using Guidance on Social Responsibility (ISO26000) could help Chinese hydropower enterprises to deal with overseas risks. In order to help Chinese hydropower enterprises to improve the CSR (Corporate Social Responsibility) implementation level, the paper integrates the characteristics of hydropower enterprises with the core subjects of ISO26000, examines the key problems on the CSR work of Chinese hydropower enterprises according to requirements of ISO26000 and puts forward effective advices. 展开更多
关键词 Corporate social responsibility China overseas hydropower projects RISK response mechanism ISO26000
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Mechanical response of bridge piles in high-steep slopes and sensitivity study 被引量:11
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作者 赵衡 尹平保 李夕兵 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第10期4043-4048,共6页
The bridge piles located in high-steep slopes not only endure the loads from superstructure, but also the residual sliding force as well as the resistance from the slope. By introducing the Winkler foundation theory, ... The bridge piles located in high-steep slopes not only endure the loads from superstructure, but also the residual sliding force as well as the resistance from the slope. By introducing the Winkler foundation theory, the mechanical model of piles-soils-slopes system was established, and the equilibrium differential equations of pile were derived. Moreover, an analytic solution for identifying the model parameters was provided by means of power series method. A project with field measurement was compared with the proposed method. It is indicated that the lateral loads have great influences on the pile, the steep slope effect is indispensable, and reasonable diameter of the pile could enhance the bending ability. The internal force and displacements of pile are largely based upon the horizontal loads applied on pile, especially in upper part. 展开更多
关键词 BRIDGE mechanical response high-steep slope inclined load power series method
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The effect of strain rate on compressive behavior and failure mechanism of CMDB propellant 被引量:4
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作者 Heng-ning Zhang Hai Chang +2 位作者 Xiao-jiang Li Xiong-gang Wu Qi-wen He 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第3期467-475,共9页
The compressive mechanical behavior of composite modified double base(CMDB)propellant was investigated across a wide scope of strain rates ranging from 10^(-3) s^(-1) to 4210 s^(-1) at room temperature,by applying a c... The compressive mechanical behavior of composite modified double base(CMDB)propellant was investigated across a wide scope of strain rates ranging from 10^(-3) s^(-1) to 4210 s^(-1) at room temperature,by applying a conventional universal testing machine and a split Hopkinson tension bar(SHPB),respectively.The derived stress-strain curves at different strain rates show a strong rate dependence,indicated that yield stress,ultimate stress and strain energy density of CMDB propellant all increase with strain rate by following a power law function,while the amplification of increase are different.The deformation and damage modes of CMDB propellant has changed from a typical ductile manner(cracking along the axial direction)to a brittle manner(maximum shear failure)with increasing of strain rate.Scanning electron microscopy(SEM)was employed to explore the microscopic failure characteristics of CMDB propellant.Under quasi-static loading,the nearly parallel micro-cracks propagating along the axial direction and the debonding of RDX particle without particle crushing can be observed.While under dynamic loading,the micro-crack is 45 angle to the axial direction,and multiple cracking modes of RDX particles appeared.Finally,the correlation between strain energy density and failure mechanisms of CMDB propellant was revealed by developing four characteristic failure modes.The findings of this study is very important to evaluate the structural integrity of CMDB propellant. 展开更多
关键词 CMDB propellant Mechanical response Strain-rate dependence Failure mechanisms
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Mechanical response of transmission lines based on sliding cable element 被引量:4
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作者 刘云 钱振东 夏开全 《Journal of Central South University》 SCIE EI CAS 2014年第8期3370-3377,共8页
In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding ca... In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding catenary element considering the out-of-plane stiffness coefficient are put forward.A two-span and a three-span cable structures are taken as examples to verify the sliding cable elements.By comparing the tensions of the two proposed cable elements with the existing research results,the error is less than 1%,which proves the correctness of the proposed elements.The sliding characteristics should be considered in the practical engineering because of the significant difference between the tensions of sliding cable elements and those of cable element without considering sliding.The out-of-plane stiffness coefficient and friction characteristics do not obviously affect the cable tensions. 展开更多
关键词 transmission lines sliding cable element updated Lagrangian formulation geometric nonlinearity mechanical response
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Quench characteristics and mechanical responses during quench propagation in rare earth barium copper oxide pancake coils 被引量:2
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作者 Mengdie NIU Jing XIA +1 位作者 Huadong YONG Youhe ZHOU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2021年第2期235-250,共16页
Quench and mechanical behaviors are critical issues in high temperature superconducting(HTS)coils.In this paper,the quench characteristics in the rare earth barium copper oxide(REBCO)pancake coil at 4.2K are analyzed,... Quench and mechanical behaviors are critical issues in high temperature superconducting(HTS)coils.In this paper,the quench characteristics in the rare earth barium copper oxide(REBCO)pancake coil at 4.2K are analyzed,and a two-dimensional(2D)axisymmetric electro-magneto-thermal model is presented.The effects of the constituent materials,background field,and coil size are analyzed.An elastoplastic mechanical model is used to study the corresponding mechanical responses during the quench propagation.The variations of the temperature and strain in superconducting layers are compared.The results indicate that the radial strain evolutions can reflect the transverse quench propagation and the tensile hoop and radial stresses in superconducting layers increase with the quench propagation.The possible damages are discussed with the consideration of the effects of the background field and coil size.It is concluded that the high background field significantly increases the maximum tensile hoop and radial stresses in quenching coils and local damage may be caused. 展开更多
关键词 rare earth barium copper oxide(REBCO)pancake coil hoop stress quench characteristic mechanical response radial stress
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Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response 被引量:2
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作者 Yu Wang Qian Li +5 位作者 Fuliang Liu Shanshan Jin Yimei Zhang Ting Zhang Yunyan Zhu Yanheng Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2018年第4期244-252,共9页
The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression,growth and differentiation, has been extensively investigated. However, metabolic regulation... The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression,growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified glucose transporter 1(GLUT1)—the primary glucose transporter in various cells—as a novel mechanosensitive gene in orthodontic tooth movement(OTM). Using an in vivo rat OTM model, we demonstrated the specific induction of Glut1 proteins on the compressive side of a physically strained periodontal ligament. This transcriptional activation could be recapitulated in in vitro cultured human periodontal ligament cells(PDLCs), showing a time-and dose-dependent mechanoresponse. Importantly, application of GLUT1 specific inhibitor WZB117 greatly suppressed the efficiency of orthodontic tooth movement in a mouse OTM model, and this reduction was associated with a decline in osteoclastic activities. A mechanistic study suggested that GLUT1 inhibition affected the receptor activator for nuclear factor-κ B Ligand(RANKL)/osteoprotegerin(OPG)system by impairing compressive force-mediated RANKL upregulation. Consistently, pretreatment of PDLCs with WZB117 severely impeded the osteoclastic differentiation of co-cultured RAW264.7 cells. Further biochemical analysis indicated mutual regulation between GLUT1 and the MEK/ERK cascade to relay potential communication between glucose uptake and mechanical stress response. Together, these cross-species experiments revealed the transcriptional activation of GLUT1 as a novel and conserved linkage between metabolism and bone remodelling. 展开更多
关键词 Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response OTM RANKL
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In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain 被引量:1
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作者 Subburaman Mohan Chetan Girijanand Bhat +1 位作者 Jon E Wergedal Chandrasekhar Kesavan 《Bone Research》 SCIE CAS 2014年第1期55-60,共6页
Although insulin-like growth factor-I (IGF-I) and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling... Although insulin-like growth factor-I (IGF-I) and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling pathways crosstalk with each other in producing a skeletal response to mechanical loading. To test this, at 5 weeks of age, partial ovariectomy (pOVX) or a sham operation was performed on heterozygous IGF-I conditional knockout (H IGF-I KO) and control mice generated using a Cre-loxP approach. At 10 weeks of age, a 10 N axial load was applied on the right tibia of these mice for a period of 2 weeks and the left tibia was used as an internal non-non-loaded control. At the cortical site, partial estrogen loss reduced total volumetric bone mineral density (BMD) by 5% in control pOVX mice (P=0.05, one-way ANOVA), but not in the H IGF-I KO pOVX mice. At the trabecular site, bone volume/total volume (BV/TV) was reduced by 5%-6% in both control pOVX (P〈0.05) and H IGF-I KO pOVX (P=0.05) mice. Two weeks of mechanical loading caused a 7 %-8% and an 11%-13% (P〈0.05 vs. non-loaded bones) increase in cortical BMD and cortical thickness (Ct.Th), respectively, in the control sham, control pOVX and H IGF-I KO sham groups. By contrast, the magnitude of cortical BMD (4%, P=0.13) and Ct.Th (6%, P〈0.05) responses were reduced by 50% in the H IGF-I KO pOVX mice compared to the other three groups. The interaction between genotype and estrogen deficiency on the mechanical loading-induced cortical bone response was significant (P〈0.05) by two-way ANOVA. Two weeks of axial loading caused similar increases in trabecular BV/TV (13%-17%) and thickness (17%-23%) in all four groups of mice. In conclusion, partial loss of both estrogen and IGF-I significantly reduced cortical but not the trabecular bone response to mechanical loading, providing in vivo evidence of the above crosstalk in mediating the bone response to loading. 展开更多
关键词 BONE IGF estrogen crosstalk in mediating the cortical bone response to mechanical strain
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Finite element simulation for mechanical response of surface mounted solder joints under different temperature cycling 被引量:1
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作者 马鑫 钱乙余 《中国有色金属学会会刊:英文版》 CSCD 2001年第4期471-474,共4页
Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of... Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of temperature cycling profile parameters. The results show that temperature cycling history has significant effect on the stress response of the solder joint. Based on the concept of relative damage stress proposed by the authors, it is found that enough high temperature holding time is necessary for designing the temperature cycling profile in accelerated thermal fatigue test. 展开更多
关键词 finite element simulation surface mounted solder joint thermal cycling mechanical response
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Mechanical responses of the bio-nano interface: A molecular dynamics study of graphene-coated lipid membrane 被引量:3
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作者 Zhigong Song Yanlei Wang Zhiping Xu 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2015年第6期231-235,共5页
Bio-nano interfaces between biological materials and functional nanodevices are of vital importance in relevant energy and information exchange processes, which thus demand an in-depth understanding. One of the critic... Bio-nano interfaces between biological materials and functional nanodevices are of vital importance in relevant energy and information exchange processes, which thus demand an in-depth understanding. One of the critical issues from the application viewpoint is the stability of the bio-nano hybrid under mechanical perturbations. In this work we explore mechanical responses of the interface between lipid bilayer and graphene under hydrostatic coating provides remarkable resistance to the pressure or indentation loads, We find that graphene loads, and the intercalated water layer offers additional protection. These findings are discussed based on molecular dynamics simulation results that elucidate the molecular level mechanisms, which provide a basis for the rational design of bionanotechnology- enabled aoolications such as biomedical devices and nanotheraoeutics. 展开更多
关键词 Cell membrane Lipid bilayer Graphene Mechanical responses Bio-nano interfaces
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