BACKGROUND Hemorrhagic chronic radiation proctitis(CRP) is a common late complication of irradiation of the pelvis and seriously impairs life quality. There is no standard treatment for hemorrhagic CRP. Medical treatm...BACKGROUND Hemorrhagic chronic radiation proctitis(CRP) is a common late complication of irradiation of the pelvis and seriously impairs life quality. There is no standard treatment for hemorrhagic CRP. Medical treatment, interventional treatment, and surgery are available, but they are limited in their applications due to nondefinite efficacy or side effects. Chinese herbal medicine(CHM), as a complementary or alternative therapy, may provide another option for hemorrhagic CRP treatment.CASE SUMMARY A 51-year-old woman with cervical cancer received intensity-modulated radiation therapy and brachytherapy with a total dose of 93 Gy fifteen days after hysterectomy and bilateral adnexectomy. She received six additional cycles of chemotherapy with carboplatin and paclitaxel. Nine months after radiotherapy treatment, she mainly complained of 5-6 times diarrhea daily and bloody purulent stools for over 10 d. After colonoscopy examinations, she was diagnosed with hemorrhagic CRP with a giant ulcer. After assessment, she received CHM treatment. The specific regimen was 150 mL of modified Gegen Qinlian decoction(GQD) used as a retention enema for 1 mo, followed by replacement with oral administration of 150 mL of modified GQD three times per day for 5 mo. After the whole treatment, her diarrhea reduced to 1-2 times a day. Her rectal tenesmus and mild pain in lower abdomen disappeared. Both colonoscopy and magnetic resonance imaging confirmed its significant improvement. During treatment,there were no side effects, such as liver and renal function damage.CONCLUSION Modified GQD may be another effective and safe option for hemorrhagic CRP patients with giant ulcers.展开更多
Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing S...Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing Shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism.展开更多
目的梳理中药炮制学中制霜法的定义以及英文翻译词,探讨其概念范围和英文翻译词的准确性。方法汇总分析包括中药炮制学教材在内的权威文献中制霜法的概念定义,及其英文翻译词。结果关于制霜法的定义、概念范围及英文翻译在不同文献中存...目的梳理中药炮制学中制霜法的定义以及英文翻译词,探讨其概念范围和英文翻译词的准确性。方法汇总分析包括中药炮制学教材在内的权威文献中制霜法的概念定义,及其英文翻译词。结果关于制霜法的定义、概念范围及英文翻译在不同文献中存在较大差异,易造成偏颇和混淆。结论制霜法应包括传统的去油制霜、渗析制霜、升华制霜、煎煮制霜4种,难以用单一英文词汇对应“制霜法”一词,根据中文“霜”字的含义和制霜法的中药炮制品性状,可将制霜法翻译为method of making frostlike powder。展开更多
目的比较中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产的有效性、安全性、经济性,促进临床合理用药。方法收集2021年1—6月于南方医科大学附属深圳妇幼保健院中医科住院使用中药煮散和中药饮片联合米非司酮及米索...目的比较中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产的有效性、安全性、经济性,促进临床合理用药。方法收集2021年1—6月于南方医科大学附属深圳妇幼保健院中医科住院使用中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产102例相关病例数据,进行有效性、安全性的比较分析;使用Treeage Pro 2011决策软件,对成本和效果进行最小成本分析和敏感性分析。最后对中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产进行药物经济学评价。结果两组方案在治疗早期妊娠稽留流产的有效率分别为96.67%和95.24%,差异无统计学意义(P>0.05);两组方案安全性一致;中药煮散组方案在治疗早期妊娠稽留流产成本更低,敏感性分析结果一致。结论中药煮散组方案较中药饮片组方案治疗早期妊娠稽留流产更具药物经济学优势。展开更多
基金Supported by The Chongqing Research Program of Basic Research and Frontier Technology,No. cstc2018jcyj AX0775The Open Foundation of The Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment。
文摘BACKGROUND Hemorrhagic chronic radiation proctitis(CRP) is a common late complication of irradiation of the pelvis and seriously impairs life quality. There is no standard treatment for hemorrhagic CRP. Medical treatment, interventional treatment, and surgery are available, but they are limited in their applications due to nondefinite efficacy or side effects. Chinese herbal medicine(CHM), as a complementary or alternative therapy, may provide another option for hemorrhagic CRP treatment.CASE SUMMARY A 51-year-old woman with cervical cancer received intensity-modulated radiation therapy and brachytherapy with a total dose of 93 Gy fifteen days after hysterectomy and bilateral adnexectomy. She received six additional cycles of chemotherapy with carboplatin and paclitaxel. Nine months after radiotherapy treatment, she mainly complained of 5-6 times diarrhea daily and bloody purulent stools for over 10 d. After colonoscopy examinations, she was diagnosed with hemorrhagic CRP with a giant ulcer. After assessment, she received CHM treatment. The specific regimen was 150 mL of modified Gegen Qinlian decoction(GQD) used as a retention enema for 1 mo, followed by replacement with oral administration of 150 mL of modified GQD three times per day for 5 mo. After the whole treatment, her diarrhea reduced to 1-2 times a day. Her rectal tenesmus and mild pain in lower abdomen disappeared. Both colonoscopy and magnetic resonance imaging confirmed its significant improvement. During treatment,there were no side effects, such as liver and renal function damage.CONCLUSION Modified GQD may be another effective and safe option for hemorrhagic CRP patients with giant ulcers.
基金National Basic Research Program of China ("973" Program) (2007CB5126072006CB504703)National Science Fund for Distinguished Young Scholars (30625042)
文摘Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica (CMM) through the different effects of Mahuang decoction (MHD) and Maxing Shigan decoction (MSD) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of the temperature tropism between two groups of mice treated by MHD and MSD, respectively. Meanwhile, the activities of adenosine triphosphatase (ATPase), superoxide dismutase, succinate dehydrogenase, and malondialdehyde were measured. Results After treated by MHD, the macroscopic behavioral index of remaining rate on warm pad (40 ℃ ) of mice decreased significantly (P < 0.05), suggesting the enhancement of cold tropism, meanwhile, the internal indices of ATPase activity and oxygen consuming volume increased significantly (P < 0.05), suggesting the enhancement of energy metabolism. On the other hand, the above-mentioned indices in MSD group changed on the inverse way. Conclusion The relative drug nature of MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition. It indicates that the internal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropism which might be internally regulated by body energy metabolism.
文摘目的梳理中药炮制学中制霜法的定义以及英文翻译词,探讨其概念范围和英文翻译词的准确性。方法汇总分析包括中药炮制学教材在内的权威文献中制霜法的概念定义,及其英文翻译词。结果关于制霜法的定义、概念范围及英文翻译在不同文献中存在较大差异,易造成偏颇和混淆。结论制霜法应包括传统的去油制霜、渗析制霜、升华制霜、煎煮制霜4种,难以用单一英文词汇对应“制霜法”一词,根据中文“霜”字的含义和制霜法的中药炮制品性状,可将制霜法翻译为method of making frostlike powder。
文摘目的比较中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产的有效性、安全性、经济性,促进临床合理用药。方法收集2021年1—6月于南方医科大学附属深圳妇幼保健院中医科住院使用中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产102例相关病例数据,进行有效性、安全性的比较分析;使用Treeage Pro 2011决策软件,对成本和效果进行最小成本分析和敏感性分析。最后对中药煮散和中药饮片联合米非司酮及米索前列醇治疗早期妊娠稽留流产进行药物经济学评价。结果两组方案在治疗早期妊娠稽留流产的有效率分别为96.67%和95.24%,差异无统计学意义(P>0.05);两组方案安全性一致;中药煮散组方案在治疗早期妊娠稽留流产成本更低,敏感性分析结果一致。结论中药煮散组方案较中药饮片组方案治疗早期妊娠稽留流产更具药物经济学优势。
