AIM：To evaluate and compare structural optical coherence tomography（OCT）-based parameters,such as Bruch’s membrane opening-minimum rim width（BMO-MRW）,and retinal nerve fiber layer（RNFL）thickness in glaucoma pa...AIM：To evaluate and compare structural optical coherence tomography（OCT）-based parameters,such as Bruch’s membrane opening-minimum rim width（BMO-MRW）,and retinal nerve fiber layer（RNFL）thickness in glaucoma patients with visual field（VF）defects,and to correlate both to mean deviation（MD）values of obtained standard achromatic perimetry（SAP）examinations.METHODS：Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals.All study participants underwent a full ophthalmic examination and VF testing with SAP.Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT.Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.RESULTS：A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36healthy right eyes of 36 individuals in the control group.Global MD of values correlated significantly with global RNFL（Pearson corr.coeff：0.632,P=0.001）and global BMO-MRW（Pearson corr.coeff：0.746,P〈0.001）values in the glaucoma group.Global MD and sectorial RNFL or BMO-MRW values correlated less significantly.In the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients（〉4 diopters）within the glaucoma group（n=6）revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.CONCLUSION：In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.展开更多
Dear Sir,Ifound the article by Sobac1etal[1]very interesting.The authors concluded that repeated intravitreal injection(IVI)of ranibizumab or bevacizumab didn’t seem have adverse effects on retinal nerve fiber layer(...Dear Sir,Ifound the article by Sobac1etal[1]very interesting.The authors concluded that repeated intravitreal injection(IVI)of ranibizumab or bevacizumab didn’t seem have adverse effects on retinal nerve fiber layer(RNFL)thickness in wet age-related macular degeneration(AMD)patients.展开更多
目的应用相干光断层扫描仪(OCT)测量中国正常人视网膜神经纤维层(RNFL)厚度并探讨年龄、屈光度、性别及视盘面积对平均RNFL厚度的影响。方法运用Stratus OCT 4.0测量202例不同年龄及不同屈光度正常人(年龄8～74岁,屈光度-8～+4D)各钟点...目的应用相干光断层扫描仪(OCT)测量中国正常人视网膜神经纤维层(RNFL)厚度并探讨年龄、屈光度、性别及视盘面积对平均RNFL厚度的影响。方法运用Stratus OCT 4.0测量202例不同年龄及不同屈光度正常人(年龄8～74岁,屈光度-8～+4D)各钟点、象限及平均RNFL厚度,建立多元线性回归方程探讨年龄、屈光度、性别及视盘面积对平均RNFL厚度的影响;同时采用方差分析的方法比较不同年龄及屈光度者平均RNFL厚度的差异。结果①正常人RNFL平均厚度为(108.63±9.70)μm,下方象限RNFL(I):(139.17±15.79)μm最厚,其次为上方象限(S):(134.61±17.80)μm,颞侧象限(T):(85.37±21.25)μm,鼻侧象限(N):(75.19±17.06)μm最薄,即I>S>T>N。②所得多元线性回归方程为y=-0.262x1+1.588x2+121.690(P1=0.000,P2=0.000;y代表平均RNFL厚度,x1代表年龄,x2代表屈光度),即平均RNFL厚度随着年龄的增长或近视度数的增加而变薄,未发现RNFL厚度与性别或视盘面积有关;方差分析表明50岁以上者平均RNFL厚度显著变薄,高度近视者平均RNFL厚度显著薄于正视者。结论OCT测得的正常人平均RNFL厚度主要与年龄、屈光度有关;未发现RNFL厚度与性别或视盘面积有关;应用规范、统一的OCT测量标准,建立人群为基础的并经相关影响因素校正的中国人RNFL正常值数据库对青光眼的早期诊断是非常必要的。展开更多
目的:应用Cirrus HD OCT检测近视眼视网膜神纤维层厚度,探讨近视眼神经纤维层厚度分布特点及其与屈光度的关系。方法:将近视眼106例196眼分为低、中、高度近视组和正常对照组38例60眼,应用Cirrus HD OCT进行以视盘为中心,直径3.46mm圆周...目的:应用Cirrus HD OCT检测近视眼视网膜神纤维层厚度,探讨近视眼神经纤维层厚度分布特点及其与屈光度的关系。方法:将近视眼106例196眼分为低、中、高度近视组和正常对照组38例60眼,应用Cirrus HD OCT进行以视盘为中心,直径3.46mm圆周的RNFL厚度测量,计算各组平均、各象限及各钟点RNFL厚度,各近视组分别与正常对照组对比,研究近视眼RNFL厚度与屈光度的关系。结果:各近视组平均、上方象限及下方象限RNFL厚度较正常对照组变薄,其中中度、高度近视与正常对照组相比有统计学差异(P<0.05),鼻侧象限RNFL厚度变薄,无统计学显著性差异(P>0.05),颞侧象限RNFL厚度增加,有统计学差异(P<0.05);各近视组2∶00,6∶00,12∶00位RNFL厚度较正常对照组变薄,有统计学差异(P<0.05),8∶00,9∶00,10∶00位RNFL厚度较正常对照组增加,有统计学差异(P<0.05),中、高度近视1∶00,5∶00位厚度较正常对照组变薄,有统计学差异(P<0.05)。结论:近视眼平均、上方及下方象限、2∶00,6∶00,12∶00位RNFL厚度较正常对照组变薄,颞侧象限、8∶00,9∶00,10∶00位RNFL厚度较正常对照组相比明显增加,这是近视眼RNFL厚度的特点,当临床出现RNFL厚度异常时,应考虑屈光度的影响,综合评价其临床意义;近视眼7∶00,8∶00,10∶00,11∶00位RNFL厚度与正常对照组相比均未变薄,出现异常变薄时,应考虑青光眼可能。展开更多
文摘AIM：To evaluate and compare structural optical coherence tomography（OCT）-based parameters,such as Bruch’s membrane opening-minimum rim width（BMO-MRW）,and retinal nerve fiber layer（RNFL）thickness in glaucoma patients with visual field（VF）defects,and to correlate both to mean deviation（MD）values of obtained standard achromatic perimetry（SAP）examinations.METHODS：Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals.All study participants underwent a full ophthalmic examination and VF testing with SAP.Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT.Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.RESULTS：A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36healthy right eyes of 36 individuals in the control group.Global MD of values correlated significantly with global RNFL（Pearson corr.coeff：0.632,P=0.001）and global BMO-MRW（Pearson corr.coeff：0.746,P〈0.001）values in the glaucoma group.Global MD and sectorial RNFL or BMO-MRW values correlated less significantly.In the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients（〉4 diopters）within the glaucoma group（n=6）revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.CONCLUSION：In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.
文摘Dear Sir,Ifound the article by Sobac1etal[1]very interesting.The authors concluded that repeated intravitreal injection(IVI)of ranibizumab or bevacizumab didn’t seem have adverse effects on retinal nerve fiber layer(RNFL)thickness in wet age-related macular degeneration(AMD)patients.
文摘目的应用相干光断层扫描仪(OCT)测量中国正常人视网膜神经纤维层(RNFL)厚度并探讨年龄、屈光度、性别及视盘面积对平均RNFL厚度的影响。方法运用Stratus OCT 4.0测量202例不同年龄及不同屈光度正常人(年龄8～74岁,屈光度-8～+4D)各钟点、象限及平均RNFL厚度,建立多元线性回归方程探讨年龄、屈光度、性别及视盘面积对平均RNFL厚度的影响;同时采用方差分析的方法比较不同年龄及屈光度者平均RNFL厚度的差异。结果①正常人RNFL平均厚度为(108.63±9.70)μm,下方象限RNFL(I):(139.17±15.79)μm最厚,其次为上方象限(S):(134.61±17.80)μm,颞侧象限(T):(85.37±21.25)μm,鼻侧象限(N):(75.19±17.06)μm最薄,即I>S>T>N。②所得多元线性回归方程为y=-0.262x1+1.588x2+121.690(P1=0.000,P2=0.000;y代表平均RNFL厚度,x1代表年龄,x2代表屈光度),即平均RNFL厚度随着年龄的增长或近视度数的增加而变薄,未发现RNFL厚度与性别或视盘面积有关;方差分析表明50岁以上者平均RNFL厚度显著变薄,高度近视者平均RNFL厚度显著薄于正视者。结论OCT测得的正常人平均RNFL厚度主要与年龄、屈光度有关;未发现RNFL厚度与性别或视盘面积有关;应用规范、统一的OCT测量标准,建立人群为基础的并经相关影响因素校正的中国人RNFL正常值数据库对青光眼的早期诊断是非常必要的。
文摘目的:应用Cirrus HD OCT检测近视眼视网膜神纤维层厚度,探讨近视眼神经纤维层厚度分布特点及其与屈光度的关系。方法:将近视眼106例196眼分为低、中、高度近视组和正常对照组38例60眼,应用Cirrus HD OCT进行以视盘为中心,直径3.46mm圆周的RNFL厚度测量,计算各组平均、各象限及各钟点RNFL厚度,各近视组分别与正常对照组对比,研究近视眼RNFL厚度与屈光度的关系。结果:各近视组平均、上方象限及下方象限RNFL厚度较正常对照组变薄,其中中度、高度近视与正常对照组相比有统计学差异(P<0.05),鼻侧象限RNFL厚度变薄,无统计学显著性差异(P>0.05),颞侧象限RNFL厚度增加,有统计学差异(P<0.05);各近视组2∶00,6∶00,12∶00位RNFL厚度较正常对照组变薄,有统计学差异(P<0.05),8∶00,9∶00,10∶00位RNFL厚度较正常对照组增加,有统计学差异(P<0.05),中、高度近视1∶00,5∶00位厚度较正常对照组变薄,有统计学差异(P<0.05)。结论:近视眼平均、上方及下方象限、2∶00,6∶00,12∶00位RNFL厚度较正常对照组变薄,颞侧象限、8∶00,9∶00,10∶00位RNFL厚度较正常对照组相比明显增加,这是近视眼RNFL厚度的特点,当临床出现RNFL厚度异常时,应考虑屈光度的影响,综合评价其临床意义;近视眼7∶00,8∶00,10∶00,11∶00位RNFL厚度与正常对照组相比均未变薄,出现异常变薄时,应考虑青光眼可能。
