Objective Mild encephalopathy with reversible splenial lesion(MERS)is associated with a variety of infections and anti-epileptic drug withdrawal.Here we report the clinical characteristics of H1N1 influenza A-associat...Objective Mild encephalopathy with reversible splenial lesion(MERS)is associated with a variety of infections and anti-epileptic drug withdrawal.Here we report the clinical characteristics of H1N1 influenza A-associated MERS based on our experience of four pediatric cases.Methods A detailed retrospective analysis of four patients with H1N1 influenza A-associated MERS was performed at Guangzhou Women and Children’s Medical Center.Results All patients exhibited mild influenza-like illness and seizures.Three patients presented with a new-onset seizure with fever after 5 years of age.75%patients had altered mental status.For all four patients,influenza A(H1N1)viral RNA was detected in throat swab specimens at least twice.Brain magnetic resonance images revealed similar ovoid lesions in the corpus callosum,mainly in the splenium and for one patient in the splenium and genu of the corpus callosum.Only one patient had an abnormal electroencephalogram tracing.Cells and protein in the cerebrospinal fluid were normal in all patients.All patients received oseltamivir and one patient received intravenous immunoglobulin.As a result,all patients fully recovered after 2 months and showed no neurologic sequelae at discharge.Conclusion This case series provides insight towards clinical features of H1N1 influenza A-associated MERS.展开更多
Objective The aim of the study was to investigate the clinical features,imaging features,and prognosis of splenium of the corpus callosum in children in order to improve the clinical understanding.Methods The clinical...Objective The aim of the study was to investigate the clinical features,imaging features,and prognosis of splenium of the corpus callosum in children in order to improve the clinical understanding.Methods The clinical data and imaging data of 30 children with splenium of the corpus callosum treated in Xiamen Children’s Hospital from June 2017 to October 2019 were retrospectively analyzed.Results Thirty children aged from 19 months to 12 years,with an average age of 5.4 years were included in the study;all had fever and other prodromal infections at acute onset,including 15 cases of respiratory tract infection,9 cases of digestive tract infection,and 6 cases of central nervous system infection.According to cranial magnetic resonance imaging(MRI)findings,23 cases had type I syndrome and 7 cases had type II syndrome;23 children had clinical symptoms disappeared after 1 week,7 children had clinical symptoms disappeared after 1 month,and 23 children had the abnormal signal disappeared after 2 weeks of reexamination,and the abnormal signal disappeared completely after 1 month of reexamination in 7 children.Conclusion Central nervous system infection is also a predisposing factor for the pressor syndrome of the corpus callosum in children in addition to upper respiratory tract infection and gastrointestinal tract infection,and all children have good prognosis.展开更多
基金supported by the Medical Scientific Research Foundation of Guangdong Province of China(No.A2020502).
文摘Objective Mild encephalopathy with reversible splenial lesion(MERS)is associated with a variety of infections and anti-epileptic drug withdrawal.Here we report the clinical characteristics of H1N1 influenza A-associated MERS based on our experience of four pediatric cases.Methods A detailed retrospective analysis of four patients with H1N1 influenza A-associated MERS was performed at Guangzhou Women and Children’s Medical Center.Results All patients exhibited mild influenza-like illness and seizures.Three patients presented with a new-onset seizure with fever after 5 years of age.75%patients had altered mental status.For all four patients,influenza A(H1N1)viral RNA was detected in throat swab specimens at least twice.Brain magnetic resonance images revealed similar ovoid lesions in the corpus callosum,mainly in the splenium and for one patient in the splenium and genu of the corpus callosum.Only one patient had an abnormal electroencephalogram tracing.Cells and protein in the cerebrospinal fluid were normal in all patients.All patients received oseltamivir and one patient received intravenous immunoglobulin.As a result,all patients fully recovered after 2 months and showed no neurologic sequelae at discharge.Conclusion This case series provides insight towards clinical features of H1N1 influenza A-associated MERS.
文摘Objective The aim of the study was to investigate the clinical features,imaging features,and prognosis of splenium of the corpus callosum in children in order to improve the clinical understanding.Methods The clinical data and imaging data of 30 children with splenium of the corpus callosum treated in Xiamen Children’s Hospital from June 2017 to October 2019 were retrospectively analyzed.Results Thirty children aged from 19 months to 12 years,with an average age of 5.4 years were included in the study;all had fever and other prodromal infections at acute onset,including 15 cases of respiratory tract infection,9 cases of digestive tract infection,and 6 cases of central nervous system infection.According to cranial magnetic resonance imaging(MRI)findings,23 cases had type I syndrome and 7 cases had type II syndrome;23 children had clinical symptoms disappeared after 1 week,7 children had clinical symptoms disappeared after 1 month,and 23 children had the abnormal signal disappeared after 2 weeks of reexamination,and the abnormal signal disappeared completely after 1 month of reexamination in 7 children.Conclusion Central nervous system infection is also a predisposing factor for the pressor syndrome of the corpus callosum in children in addition to upper respiratory tract infection and gastrointestinal tract infection,and all children have good prognosis.
