[目的]棒位和棒控系统RGL(Rod Position Indication and Rod Control System)是核电机组重要的控制系统之一,其性能好坏直接关系到核电机组的可用性。当该系统出现双夹持故障时会将整个控制棒组闭锁,在机组进行瞬态试验、升降负荷或甩...[目的]棒位和棒控系统RGL(Rod Position Indication and Rod Control System)是核电机组重要的控制系统之一,其性能好坏直接关系到核电机组的可用性。当该系统出现双夹持故障时会将整个控制棒组闭锁,在机组进行瞬态试验、升降负荷或甩负荷期间控制棒组不能及时动作,可能导致反应堆停堆。[方法]结合某CPR1000核电机组出现的RGL系统双夹持故障经验反馈案例,从设计原理的角度对双夹持故障出现的原因进行了分析研究。[结果]分析结果指出控制器软件中的时刻控制器误判MG机架状态,从而输出错误信号导致了双夹持故障触发。[结论]软件缺陷是造成RGL系统双夹持故障的重要因素。展开更多
Aim Ginseng is the dried root of Panax ginseng C. A. Mayer. Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japan. Phar- macol...Aim Ginseng is the dried root of Panax ginseng C. A. Mayer. Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japan. Phar- macological active chemical ingredients and its extract of ginseng are a mixture of triterpenoid saponins, collectively called ginsenosides. Among them, ginsenoside Rgl is the most pharmacological active one. Based on prior experi- mental results and the understanding of alcoholic hepatitis, the major aim of this study is to investigate whether Rgl is beneficial in a rodent model mimic alcoholic hepatic injury associated with binge drinking and explore the under- lying possible mechanisms. Methods C57BL/6 mice were given oral consumption of 6 g · kg^-1 alcohol 1 h after treated with Rgl （ 10, 20 and 40 mg · kg^-1） or dexamethasone （ 1 mg · kg^-1） for 9 consecutive days. Biochemi- cal analyses were performed and liver fragments were processed for microscopy, immunohistochemistry and western blot analysis. Results According to our data, Rgl treatment significantly reversed the high mortality rate induced by alcohol consumption and also alleviated liver impairment as evidenced by the decrease of serum parameters. Meanwhile, histological and ultrastructural analysis of alcoholic groups showed hepatocellular impairment but re- stored in Rgl-treated groups. Overproductive inflammatory cytokines were also suppressed by Rgl in alcohol-intoxi- cated mouse livers. In addition, changes of GR related NF-KB pathway, including phospho-IKB-ot, were also mod- ulated to normal levels. Conclusion This study demonstrates that Rgl might promote GR mediating the repression of NF-KB and inhibit the inflammatory reactions in alcoholic hepatitis.展开更多
文摘[目的]棒位和棒控系统RGL(Rod Position Indication and Rod Control System)是核电机组重要的控制系统之一,其性能好坏直接关系到核电机组的可用性。当该系统出现双夹持故障时会将整个控制棒组闭锁,在机组进行瞬态试验、升降负荷或甩负荷期间控制棒组不能及时动作,可能导致反应堆停堆。[方法]结合某CPR1000核电机组出现的RGL系统双夹持故障经验反馈案例,从设计原理的角度对双夹持故障出现的原因进行了分析研究。[结果]分析结果指出控制器软件中的时刻控制器误判MG机架状态,从而输出错误信号导致了双夹持故障触发。[结论]软件缺陷是造成RGL系统双夹持故障的重要因素。
文摘Aim Ginseng is the dried root of Panax ginseng C. A. Mayer. Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japan. Phar- macological active chemical ingredients and its extract of ginseng are a mixture of triterpenoid saponins, collectively called ginsenosides. Among them, ginsenoside Rgl is the most pharmacological active one. Based on prior experi- mental results and the understanding of alcoholic hepatitis, the major aim of this study is to investigate whether Rgl is beneficial in a rodent model mimic alcoholic hepatic injury associated with binge drinking and explore the under- lying possible mechanisms. Methods C57BL/6 mice were given oral consumption of 6 g · kg^-1 alcohol 1 h after treated with Rgl （ 10, 20 and 40 mg · kg^-1） or dexamethasone （ 1 mg · kg^-1） for 9 consecutive days. Biochemi- cal analyses were performed and liver fragments were processed for microscopy, immunohistochemistry and western blot analysis. Results According to our data, Rgl treatment significantly reversed the high mortality rate induced by alcohol consumption and also alleviated liver impairment as evidenced by the decrease of serum parameters. Meanwhile, histological and ultrastructural analysis of alcoholic groups showed hepatocellular impairment but re- stored in Rgl-treated groups. Overproductive inflammatory cytokines were also suppressed by Rgl in alcohol-intoxi- cated mouse livers. In addition, changes of GR related NF-KB pathway, including phospho-IKB-ot, were also mod- ulated to normal levels. Conclusion This study demonstrates that Rgl might promote GR mediating the repression of NF-KB and inhibit the inflammatory reactions in alcoholic hepatitis.
