Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the ...Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the active ingredients and target genes of Fuzi using oral bioavailability and drug similarity as screening conditions,and the GeneCards database was used to screen the target genes of AR.The online tool Venny2.1 was used to screen the target genes of Fuzi for the treatment of Allergic Rhinitis;the STRING database was used to obtain the protein-protein interaction(PPI)network of drug-disease targets,and the key target genes were identified by the MCC algorithm.The potential biological processes and signaling pathways were identified by GO enrichment and KEGG enrichment analysis.Finally,animal experiments were conducted to demonstrate the therapeutic effect ofFuzi on Allergic Rhinitis.Results:The TCMSP,PubChem and GeneCards databases were used to screen the 21 active compound components of Fuzi and 68 potential therapeutic target genes of Fuzi for Allergic Rhinitis.PPI network analysis identified the top ten key target genes,namely:PTGS2,TNF,IL6,AKT1,ALB,STAT3,CCL2,CXCL8,VEGFA and JUN,GO functional and KEGG pathway enrichment analysis showed that the significantly enriched functions and pathways of Fuzi on Allergic Rhinitis were closely related to Allergic Rhinitis.Finally,animal experiments were conducted to verify that Fuzi is effective in the treatment of Allergic rhinitis.Conclusion:Increased expression of IL-6 and TNF-αin nasal mucosal tissues of patients with Allergic Rhinitis was positively correlated with indicators related to the disease activity of AllergicRhinitis.Fuzi ameliorated the inflammatory changes in mice with Allergic Rhinitis by inhibiting the activation of Toll-like signaling pathway in the nasal mucosa and decreasing the expression activity of IL-6 and TNF-α.展开更多
Allergic rhinitis affect 10%-20% of pediatric population and it is caused by the Ig E-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence pati...Allergic rhinitis affect 10%-20% of pediatric population and it is caused by the Ig E-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual immunotherapy(SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT for allergic rhinitis to grass pollens in children, whereas trials regarding pediatric allergic rhinitis to house dust mites present lower quality, although several studies supported its usefulness.展开更多
Objective: To assess the relationship between allergic conjunctivitis(AC) and allergic rhinitis(AR) in pediatric ophthalmology and E.N.T outpatient clinic. Methods:Eight hundred and ninety two patients were enro...Objective: To assess the relationship between allergic conjunctivitis(AC) and allergic rhinitis(AR) in pediatric ophthalmology and E.N.T outpatient clinic. Methods:Eight hundred and ninety two patients were enrolled in survey during Mar. 2005-Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic. The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results:302(74%), 374(92%), 116(29%) in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334(69%), 430(89%), 145(30%) in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference(x2=2,6, P 〉 0.05). The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference (x2=3.08; x2=0.21, P 〉 0.05). The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis(SAC) and perennial allergic conjunctivitis(PAC), the clinical signs of AR were always severer(x2=258.2, P 〈 0.05) than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis(VKC)(x2=66.5, P 〈 0.05); Eosinophils were revealed in 50(57%) conjunctival scrapings and nasal mucosa scrapings(x2=1.5, P〉 0.05), 47(53%) cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp. Conclusion:The two disorders were shown to share more similarities than differences, as suggested that allergic conjunctivitis should be considered in future guidelines on preventing the development of rhinitis and asthma in children.展开更多
A numerical simulation of a patient’s nasal airflow was developed via computational fluid dynamics.Accordingly,computerized tomography scans of a patient with septal deviation and allergic rhinitis were obtained.The ...A numerical simulation of a patient’s nasal airflow was developed via computational fluid dynamics.Accordingly,computerized tomography scans of a patient with septal deviation and allergic rhinitis were obtained.The three-dimensional(3D)nasal model was designed using InVesalius 3.0,which was then imported to(computer aided 3D interactive application)CATIA V5 for modification,and finally to analysis system(ANSYS)flow oriented logistics upgrade for enterprise networks(FLUENT)to obtain the numerical solution.The velocity contours of the cross-sectional area were analyzed on four main surfaces:the vestibule,nasal valve,middle turbinate,and nasopharynx.The pressure and velocity characteristics were assessed at both laminar and turbulent mass flow rates for both the standardized and the patient’s model nasal cavity.The developed model of the patient is approximately half the size of the standardized model;hence,its velocity was approximately two times more than that of the standardized model.展开更多
Objective:Our objective was to review skin prick allergy testing(SPAT)results in patients with symptomatic rhinitis in an Irish population.Methods:A fifteen-year retrospective review of our database of symptomatic pat...Objective:Our objective was to review skin prick allergy testing(SPAT)results in patients with symptomatic rhinitis in an Irish population.Methods:A fifteen-year retrospective review of our database of symptomatic patients with rhinitis was performed.All patients who had SPAT performed during this interval were included.Data was analysed in terms of demographics and dominant allergens.Results:1158 patients were included.617 Females vs 541 Males.Age range five to eighty-five years old.Mean age thirty-four years.49%of our patients tested positive to at least one aeroallergen.The most common allergens were dust mites(23%)and timothy grass(22%).Patients born during the Irish pollen season(April-July)were between 5 and 7 times more likely to be sensitive to timothy and ryegrass pollens compared to others tested.241 patients had both SPAT and serum allergen specific IgE testing(SASIgET)performed;positive results were consistent between both groups.Conclusion:Results demonstrated that half of our patients with symptomatic rhinitis had allergen sensitisation.Dust mites and grass were the main allergens in our area.Our nurse led clinic has allowed efficient patient education and the development of a unique Irish SPAT database.Retesting a patient with a known allergy test result it is not indicated.展开更多
As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens,dust mites,and molds,our objective was to assess the potential overlap between the COVID-19mRNA vaccines fromPfizer-BioNtec...As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens,dust mites,and molds,our objective was to assess the potential overlap between the COVID-19mRNA vaccines fromPfizer-BioNtech andModerna and known allergens.We found 7 common allergens with potential for cross-reactivity with the Pfizer vaccine and 19 with theModerna vaccine,including common grasses,molds,and dust mites.T-cell mediated antigen cross-reactivity between viruses and allergens is a relatively new area of study in clinical immunology;a discipline that may be particularly useful regarding the SARS-CoV-2 virus and the allergic response in humans.These results suggest that vaccination with the Pfizer-BioNtech andModerna COVID-19 vaccinesmay contribute to T-cell cross-reactivity with allergens that impact allergic asthma and allergic rhinitis.Further research should assess the clinical implications of COVID-19 vaccination on the severity and symptomatology of the allergic disease,in addition to natural viral infection.展开更多
In a comparative study on treatment of type Ⅰ allergic diseases,acupuncture and desensitizationtherapies were performed in 143 cases.The results showed that acupuncture therapy had an ex-tensive and remarkable action...In a comparative study on treatment of type Ⅰ allergic diseases,acupuncture and desensitizationtherapies were performed in 143 cases.The results showed that acupuncture therapy had an ex-tensive and remarkable action against type Ⅰ allergic reaction.The curative effect was higher inthe acupuncture group than in the desensitization group in allergic asthma,allergic rhinitis andchronic urticaria.展开更多
The prevalence of allergic diseases including atopic dermatitis,asthma,allergic rhinitis(AR)and food allergy is increasing worldwide and they cause a big economic and social burden.Understanding of reasons thatcontrib...The prevalence of allergic diseases including atopic dermatitis,asthma,allergic rhinitis(AR)and food allergy is increasing worldwide and they cause a big economic and social burden.Understanding of reasons thatcontribute to the etiology of allergic diseases as well as new treatment approaches are very important for the follow-up and prevention of these diseases.In recent years,probiotics seem to be promising for allergic diseases.The effect of probiotics in the prevention and treatment of eczema is more extensively studied,but little is known about the association of the microbial flora of the host and allergic airway diseases and the efficacy of probiotics in decreasing the symptoms of patients with asthma and rhinitis.Hitherto,there is no strong evidence for use of probiotics in the treatment of eczema;however,administration of probiotics in breastfeeding mothers in the prenatal period and infants in the postnatal period can be accepted as a safe and helpful option in the prevention of eczema.In contrast,there is not yet reliable evidence or recommendations on use of probiotics for the prevention or treatment of asthma,AR,food allergy,and anaphylaxis currently.More standardized studies should be performed with different strains of probiotics to evaluate the protective and therapeutic effects of probiotics on other allergic diseases as well as eczema.In this review,the relationship between allergy and probiotics is handled in the light of current literature.展开更多
Background: The prevalence of respiratory allergies is increasing worldwide, with important consequences especially for little children. Objective: The aim of this study was to assess the prevalence of respiratory all...Background: The prevalence of respiratory allergies is increasing worldwide, with important consequences especially for little children. Objective: The aim of this study was to assess the prevalence of respiratory allergies, such as rhinitis and asthma, and to point out the risk factors and their relationship with allergic diseases in a specific area of Northern Italy. Methods: 110 children, male and female, from our outpatient service for allergic children, between 3 and 17 years old, were examined. After a skin prick test and a nasal cytology, the written questionnaire of the International Study of Asthma and Allergies in Childhood was filled by parents together with their children. Results: 110 children were examined. 74% of children had rhinitis and 71% asthma. 88 patients were allergic, grass pollen and house dust mite was the most frequent allergens. A family history of atopy, family background, geographic area, active and passive smoking and home pets were associated to allergies. Older children (6 - 15 years old) had more often rhinitis associated with asthma and conjunctivitis as compared to younger. 21 Children were also affected by non allergic rhinitis. Conclusions: Respiratory allergies are widespread and associated to a low quality of life among little children. Sensitization to Ragweed is increasing with important consequences. Rhinitis precedes the onset of asthmatic symptoms. Moreover non allergic rhinitis is increasing and frequently underdiagnosed.展开更多
2013年9月《European Journal of Allergy and Clinical Immunology》杂志发表了《儿童鼻炎意见书》。本意见书由欧洲变态反应与临床免疫学会儿童鼻炎工作组Roberts等11位学者共同完成。该意见书在收集分析相关文献的基础上,参考医学专...2013年9月《European Journal of Allergy and Clinical Immunology》杂志发表了《儿童鼻炎意见书》。本意见书由欧洲变态反应与临床免疫学会儿童鼻炎工作组Roberts等11位学者共同完成。该意见书在收集分析相关文献的基础上,参考医学专家的意见,对推荐等级进行分级,充分反映所依赖数据的可靠程度。此意见书旨在为儿童鼻炎的诊断与治疗提供循证医学意见,主要针对社区全科医师、实习医师、儿科医师、耳鼻咽喉头颈外科医师和变态反应科医师。我们将该意见书与《变应性鼻炎及其对哮喘的影响》、《欧洲鼻-鼻窦炎和鼻息肉意见书》及我国制定的儿童变应性鼻炎诊断和治疗指南进行比较,借以解读。展开更多
多年来,对变应性鼻炎患者进行药物治疗的目的多以控制症状为主,疗效评价标准也以症状改善程度为主。《变应性鼻炎及其对哮喘的影响》(Allergic Rhinitis and Its Impacton Asthma,ARIA,2001)指南推荐的病情分类和阶梯性治疗方案也...多年来,对变应性鼻炎患者进行药物治疗的目的多以控制症状为主,疗效评价标准也以症状改善程度为主。《变应性鼻炎及其对哮喘的影响》(Allergic Rhinitis and Its Impacton Asthma,ARIA,2001)指南推荐的病情分类和阶梯性治疗方案也多以症状为基础,因此对症状控制的程度也成为评价某一药物疗效的“金标准”,一旦症状得以控制,药物治疗也随之停止。但最近公布的ARIA(2008)”勺虽调,对经过药物控制,症状消失或仍有轻微症状者仍应继续给予与药物治疗。展开更多
基金Natural Science Foundation of Hainan Province(No.820RC627)。
文摘Objective:To study the key target genes and signaling pathways in the treatment of Allergic Rhinitis(AR)with Radix Aconiti Lateralis Preparata(aka Fuzi).Methods:The TCMPS and PubChem databases were used to screen the active ingredients and target genes of Fuzi using oral bioavailability and drug similarity as screening conditions,and the GeneCards database was used to screen the target genes of AR.The online tool Venny2.1 was used to screen the target genes of Fuzi for the treatment of Allergic Rhinitis;the STRING database was used to obtain the protein-protein interaction(PPI)network of drug-disease targets,and the key target genes were identified by the MCC algorithm.The potential biological processes and signaling pathways were identified by GO enrichment and KEGG enrichment analysis.Finally,animal experiments were conducted to demonstrate the therapeutic effect ofFuzi on Allergic Rhinitis.Results:The TCMSP,PubChem and GeneCards databases were used to screen the 21 active compound components of Fuzi and 68 potential therapeutic target genes of Fuzi for Allergic Rhinitis.PPI network analysis identified the top ten key target genes,namely:PTGS2,TNF,IL6,AKT1,ALB,STAT3,CCL2,CXCL8,VEGFA and JUN,GO functional and KEGG pathway enrichment analysis showed that the significantly enriched functions and pathways of Fuzi on Allergic Rhinitis were closely related to Allergic Rhinitis.Finally,animal experiments were conducted to verify that Fuzi is effective in the treatment of Allergic rhinitis.Conclusion:Increased expression of IL-6 and TNF-αin nasal mucosal tissues of patients with Allergic Rhinitis was positively correlated with indicators related to the disease activity of AllergicRhinitis.Fuzi ameliorated the inflammatory changes in mice with Allergic Rhinitis by inhibiting the activation of Toll-like signaling pathway in the nasal mucosa and decreasing the expression activity of IL-6 and TNF-α.
文摘Allergic rhinitis affect 10%-20% of pediatric population and it is caused by the Ig E-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual immunotherapy(SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT for allergic rhinitis to grass pollens in children, whereas trials regarding pediatric allergic rhinitis to house dust mites present lower quality, although several studies supported its usefulness.
文摘Objective: To assess the relationship between allergic conjunctivitis(AC) and allergic rhinitis(AR) in pediatric ophthalmology and E.N.T outpatient clinic. Methods:Eight hundred and ninety two patients were enrolled in survey during Mar. 2005-Jan. 2007, 407 allergic conjunctivitis cases were placed in the ophthalmology clinic group and 485 allergic rhinitis cases were from the E.N.T clinic. The comorbid disorders, histories, symptoms, signs of patients were recorded. Type 1 allergy was tested in 479 cases by a specific IgE antibody blood test. Eosinophils were detected in superficial conjunctival scrapings of the superior tarsal conjunctiva and mucosa surface scrapings of middle nasal meatus in 88 cases with both diseases. Results:302(74%), 374(92%), 116(29%) in 407 cases with allergic conjunctivitis had concomitant eczema, rhinitis and asthma, respectively; 334(69%), 430(89%), 145(30%) in 485 cases with allergic rhinitis had concomitant eczema, allergic conjunctivitis and asthma, respectively. The prevalence of allergic conjunctivitis concomitant allergic rhinitis and allergic rhinitis concomitant allergic conjunctivitis had no significant difference(x2=2,6, P 〉 0.05). The prevalence of allergic conjunctivitis and allergic rhinitis concomitant eczema and asthma also had no significant difference (x2=3.08; x2=0.21, P 〉 0.05). The degree of severity of two kinds of disease symptoms is not parallel, in the patients with seasonal allergic conjuctivitis(SAC) and perennial allergic conjunctivitis(PAC), the clinical signs of AR were always severer(x2=258.2, P 〈 0.05) than those of AC. However, the results coincided with the cases with vernal keratoconjuctivitis(VKC)(x2=66.5, P 〈 0.05); Eosinophils were revealed in 50(57%) conjunctival scrapings and nasal mucosa scrapings(x2=1.5, P〉 0.05), 47(53%) cases had positive results in both scrapings. The main aeroallergens were house dust mites, house dust and fungi, and the main food-allergens were fish, crab and shrimp. Conclusion:The two disorders were shown to share more similarities than differences, as suggested that allergic conjunctivitis should be considered in future guidelines on preventing the development of rhinitis and asthma in children.
基金This research was funded by the Universiti Sains Malaysia,No.1001/PAERO/814276.
文摘A numerical simulation of a patient’s nasal airflow was developed via computational fluid dynamics.Accordingly,computerized tomography scans of a patient with septal deviation and allergic rhinitis were obtained.The three-dimensional(3D)nasal model was designed using InVesalius 3.0,which was then imported to(computer aided 3D interactive application)CATIA V5 for modification,and finally to analysis system(ANSYS)flow oriented logistics upgrade for enterprise networks(FLUENT)to obtain the numerical solution.The velocity contours of the cross-sectional area were analyzed on four main surfaces:the vestibule,nasal valve,middle turbinate,and nasopharynx.The pressure and velocity characteristics were assessed at both laminar and turbulent mass flow rates for both the standardized and the patient’s model nasal cavity.The developed model of the patient is approximately half the size of the standardized model;hence,its velocity was approximately two times more than that of the standardized model.
文摘Objective:Our objective was to review skin prick allergy testing(SPAT)results in patients with symptomatic rhinitis in an Irish population.Methods:A fifteen-year retrospective review of our database of symptomatic patients with rhinitis was performed.All patients who had SPAT performed during this interval were included.Data was analysed in terms of demographics and dominant allergens.Results:1158 patients were included.617 Females vs 541 Males.Age range five to eighty-five years old.Mean age thirty-four years.49%of our patients tested positive to at least one aeroallergen.The most common allergens were dust mites(23%)and timothy grass(22%).Patients born during the Irish pollen season(April-July)were between 5 and 7 times more likely to be sensitive to timothy and ryegrass pollens compared to others tested.241 patients had both SPAT and serum allergen specific IgE testing(SASIgET)performed;positive results were consistent between both groups.Conclusion:Results demonstrated that half of our patients with symptomatic rhinitis had allergen sensitisation.Dust mites and grass were the main allergens in our area.Our nurse led clinic has allowed efficient patient education and the development of a unique Irish SPAT database.Retesting a patient with a known allergy test result it is not indicated.
文摘As the SARS-CoV-2 virus shares relatively large protein sequences homologous to grass pollens,dust mites,and molds,our objective was to assess the potential overlap between the COVID-19mRNA vaccines fromPfizer-BioNtech andModerna and known allergens.We found 7 common allergens with potential for cross-reactivity with the Pfizer vaccine and 19 with theModerna vaccine,including common grasses,molds,and dust mites.T-cell mediated antigen cross-reactivity between viruses and allergens is a relatively new area of study in clinical immunology;a discipline that may be particularly useful regarding the SARS-CoV-2 virus and the allergic response in humans.These results suggest that vaccination with the Pfizer-BioNtech andModerna COVID-19 vaccinesmay contribute to T-cell cross-reactivity with allergens that impact allergic asthma and allergic rhinitis.Further research should assess the clinical implications of COVID-19 vaccination on the severity and symptomatology of the allergic disease,in addition to natural viral infection.
文摘In a comparative study on treatment of type Ⅰ allergic diseases,acupuncture and desensitizationtherapies were performed in 143 cases.The results showed that acupuncture therapy had an ex-tensive and remarkable action against type Ⅰ allergic reaction.The curative effect was higher inthe acupuncture group than in the desensitization group in allergic asthma,allergic rhinitis andchronic urticaria.
文摘The prevalence of allergic diseases including atopic dermatitis,asthma,allergic rhinitis(AR)and food allergy is increasing worldwide and they cause a big economic and social burden.Understanding of reasons thatcontribute to the etiology of allergic diseases as well as new treatment approaches are very important for the follow-up and prevention of these diseases.In recent years,probiotics seem to be promising for allergic diseases.The effect of probiotics in the prevention and treatment of eczema is more extensively studied,but little is known about the association of the microbial flora of the host and allergic airway diseases and the efficacy of probiotics in decreasing the symptoms of patients with asthma and rhinitis.Hitherto,there is no strong evidence for use of probiotics in the treatment of eczema;however,administration of probiotics in breastfeeding mothers in the prenatal period and infants in the postnatal period can be accepted as a safe and helpful option in the prevention of eczema.In contrast,there is not yet reliable evidence or recommendations on use of probiotics for the prevention or treatment of asthma,AR,food allergy,and anaphylaxis currently.More standardized studies should be performed with different strains of probiotics to evaluate the protective and therapeutic effects of probiotics on other allergic diseases as well as eczema.In this review,the relationship between allergy and probiotics is handled in the light of current literature.
文摘Background: The prevalence of respiratory allergies is increasing worldwide, with important consequences especially for little children. Objective: The aim of this study was to assess the prevalence of respiratory allergies, such as rhinitis and asthma, and to point out the risk factors and their relationship with allergic diseases in a specific area of Northern Italy. Methods: 110 children, male and female, from our outpatient service for allergic children, between 3 and 17 years old, were examined. After a skin prick test and a nasal cytology, the written questionnaire of the International Study of Asthma and Allergies in Childhood was filled by parents together with their children. Results: 110 children were examined. 74% of children had rhinitis and 71% asthma. 88 patients were allergic, grass pollen and house dust mite was the most frequent allergens. A family history of atopy, family background, geographic area, active and passive smoking and home pets were associated to allergies. Older children (6 - 15 years old) had more often rhinitis associated with asthma and conjunctivitis as compared to younger. 21 Children were also affected by non allergic rhinitis. Conclusions: Respiratory allergies are widespread and associated to a low quality of life among little children. Sensitization to Ragweed is increasing with important consequences. Rhinitis precedes the onset of asthmatic symptoms. Moreover non allergic rhinitis is increasing and frequently underdiagnosed.
文摘2013年9月《European Journal of Allergy and Clinical Immunology》杂志发表了《儿童鼻炎意见书》。本意见书由欧洲变态反应与临床免疫学会儿童鼻炎工作组Roberts等11位学者共同完成。该意见书在收集分析相关文献的基础上,参考医学专家的意见,对推荐等级进行分级,充分反映所依赖数据的可靠程度。此意见书旨在为儿童鼻炎的诊断与治疗提供循证医学意见,主要针对社区全科医师、实习医师、儿科医师、耳鼻咽喉头颈外科医师和变态反应科医师。我们将该意见书与《变应性鼻炎及其对哮喘的影响》、《欧洲鼻-鼻窦炎和鼻息肉意见书》及我国制定的儿童变应性鼻炎诊断和治疗指南进行比较,借以解读。
文摘多年来,对变应性鼻炎患者进行药物治疗的目的多以控制症状为主,疗效评价标准也以症状改善程度为主。《变应性鼻炎及其对哮喘的影响》(Allergic Rhinitis and Its Impacton Asthma,ARIA,2001)指南推荐的病情分类和阶梯性治疗方案也多以症状为基础,因此对症状控制的程度也成为评价某一药物疗效的“金标准”,一旦症状得以控制,药物治疗也随之停止。但最近公布的ARIA(2008)”勺虽调,对经过药物控制,症状消失或仍有轻微症状者仍应继续给予与药物治疗。