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Rhizoma paridis saponins protected against liver injury in diethylnitrosamine-induced mice
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作者 Chen Luo Jing-Wen Yao +1 位作者 Shu-Li Man Wen-Yuan Gao 《Traditional Medicine Research》 2023年第2期7-12,共6页
Background:Diethylnitrosamine,one of food additives,possessed a strong carcinogenic effect in human.Rhizoma paridis saponins,as the main active components of Paris polyphylla,have a good anti-cancer effect in our prev... Background:Diethylnitrosamine,one of food additives,possessed a strong carcinogenic effect in human.Rhizoma paridis saponins,as the main active components of Paris polyphylla,have a good anti-cancer effect in our previous research.To verify their inhibitory effect on diethylnitrosamine-induced liver cancer,we carried out this study.Methods:We established diethylnitrosamine-induced mouse hepatocarcinoma models to evaluate antitumor of Rhizoma paridis saponins.Subsequently,gas chromatography-mass spectrometry was applied to analyze the metabolites in the urine and serum samples.Results:Rhizoma paridis saponins alleviated diethylnitrosamine-induced hepatocarcinogenesis.On the one hand,Rhizoma paridis saponins down-regulated the levels of liver function markers,such as alanine aminotransferase,aspartate transaminase and alpha fetoprotein.On the other hand,Rhizoma paridis saponins reduced metabolic disorders by increasing fructose and mannose metabolism,and decreasing pentose and glucuronate interconversion,inositol phosphate metabolism,and the process of saturated fatty acids transforming to unsaturated fatty acids,which based on the regulating mRNA expression of glucose transporter type 4,lactate dehydrogenase A,fatty acid synthetas,acetyl-CoA carboxylase and apolipoprotein A-I.Conclusion:Rhizoma paridis saponins has the potential application to inhibit chemical-induced hepatocarcinogenesis in the future. 展开更多
关键词 rhizoma paridis saponins liver injury DIETHYLNITROSAMINE METABOLITES
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Phytochemistry,Pharmacology,Toxicology,and Structure-Cytotoxicity Relationship of Paridis Rhizome Saponin 被引量:3
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作者 MAN Shu-li WANG Yan-li +3 位作者 LI Yuan-yuan GAO Wen-yuan HUANG Xian-xiao MA Chao-yi 《Chinese Herbal Medicines》 CAS 2013年第1期33-46,共14页
The rhizomes of Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis are used as traditional herbal medicines in many parts of China. The Paridis Rhizome saponin (PRS),as the active ingredient,has played... The rhizomes of Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis are used as traditional herbal medicines in many parts of China. The Paridis Rhizome saponin (PRS),as the active ingredient,has played an important role in hemostasis,antibacterial action,and inflammation counteraction,bearing some analogy to Gongxuening and Yunnanbaiyao in efficacy. Modern pharmacological experiments have proved that PRS possesses two main sapogenins: diosgenin and pennogenin,which could provide a lot of clinical treatment effects (anti-oxidation,anti-inflammation,anti-apoptosis,anti-metastasis,and immunostimulant,etc.). In the past,several main steroid saponins have been studied in a number of randomized controlled trials for their effects and mechanisms mainly on antitumor performance. The extensive results have demonstrated that PRS was an effective group of active components to antitumor clinical trials. In this article,we reviewed the reported phytochemical,pharmacological,and toxicological properties of PRS and compared the structure-cytotoxicity relationship of PRS in antitumor effects. 展开更多
关键词 paridis rhizoma saponin PHARMACOLOGY PHYTOCHEMISTRY structure-cytotoxicity relationship TOXICOLOGY
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