36 cases of coronary heart disease with silent myocardial ischemia (SMI) were treated sequentially with Tong Xin Luo (TXL) capsule and isosorbide dinitrate in random order. The results showed that both drugs were effe...36 cases of coronary heart disease with silent myocardial ischemia (SMI) were treated sequentially with Tong Xin Luo (TXL) capsule and isosorbide dinitrate in random order. The results showed that both drugs were effective in decreasing episodes of SMI and shortening the duration of asymptomatic myocardial ischemia. TXL, however, was found with a better action and was superior to isosorbide dinitrate. It was also found that TXL could improve diastolic function of the left ventricle as well.展开更多
Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was establi...Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was established by ligating the left anterior descending （LAD） artery. Twenty- five dogs were randomly divided into 5 groups （5 dogs in each group）： the control group （treated with normal saline 3 mL/kg）, the refined Guanxin Capsule group （精制冠心胶囊, GXC 200 mg/kg）, high and low dose Corocalm groups （48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group） and the Diltiazem group （5 mg/kg）. The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram （EECG） to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood flow （CBF） and serum activity levels of creatine phosphokinase （CK） and lactate dehydrogenase （LDH） were measured by electromagnetic flow meter and automatic biochemical analyzer respectively. The plasma endothelin （ET） content was quantified by radioimmunoassay. Results： Corocalm （48.5 mg/kg and 194.0 mg/kg） significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion： Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.展开更多
Objective： To observe the effect of Kaixin Capsule （开心胶囊, KXC） on myocardial ischemia and plasma endothelin （ET） level in patients with diabetic heart disease （DHD）. Methods： The 72 subjects for observatio...Objective： To observe the effect of Kaixin Capsule （开心胶囊, KXC） on myocardial ischemia and plasma endothelin （ET） level in patients with diabetic heart disease （DHD）. Methods： The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days. Results： On ECG, the total effective rate and markedly ef- fective rate in the treated group was 85. 0% and 37. 5% respectively, higher than those in the control group＇s 68.7% and 28. 1% respectively, and showing significant difference between the two groups （P〈 0.05）. The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant （P〈0.05）. Conclusion： KXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.展开更多
The protective effect of the traditional Chinese compound medicine Yuxingtong (YXT) in cap-sule form on the experimental acute myocardial ischemia formation has been studied in dogs. The plasma en-dotlielin concentrat...The protective effect of the traditional Chinese compound medicine Yuxingtong (YXT) in cap-sule form on the experimental acute myocardial ischemia formation has been studied in dogs. The plasma en-dotlielin concentration and serum creatine phosphokinase activity were measured after coronary occlusion indifferent medication groups and compared with the saline control group. Results showed that YXT could signifi-cantly lowered the plasma endothelin concentration and the serum creatine phosphokinase activity, it sug-gested that both YXT and diltiazem have the similar protective effect on acute myocardial ischemia and necro-sis in dogs.展开更多
文摘36 cases of coronary heart disease with silent myocardial ischemia (SMI) were treated sequentially with Tong Xin Luo (TXL) capsule and isosorbide dinitrate in random order. The results showed that both drugs were effective in decreasing episodes of SMI and shortening the duration of asymptomatic myocardial ischemia. TXL, however, was found with a better action and was superior to isosorbide dinitrate. It was also found that TXL could improve diastolic function of the left ventricle as well.
基金Supported by the National Key Technology Program Foundation during the 9th Five-Year Plan Period (No.96-903-01-02)
文摘Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was established by ligating the left anterior descending （LAD） artery. Twenty- five dogs were randomly divided into 5 groups （5 dogs in each group）： the control group （treated with normal saline 3 mL/kg）, the refined Guanxin Capsule group （精制冠心胶囊, GXC 200 mg/kg）, high and low dose Corocalm groups （48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group） and the Diltiazem group （5 mg/kg）. The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram （EECG） to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood flow （CBF） and serum activity levels of creatine phosphokinase （CK） and lactate dehydrogenase （LDH） were measured by electromagnetic flow meter and automatic biochemical analyzer respectively. The plasma endothelin （ET） content was quantified by radioimmunoassay. Results： Corocalm （48.5 mg/kg and 194.0 mg/kg） significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion： Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.
文摘Objective： To observe the effect of Kaixin Capsule （开心胶囊, KXC） on myocardial ischemia and plasma endothelin （ET） level in patients with diabetic heart disease （DHD）. Methods： The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days. Results： On ECG, the total effective rate and markedly ef- fective rate in the treated group was 85. 0% and 37. 5% respectively, higher than those in the control group＇s 68.7% and 28. 1% respectively, and showing significant difference between the two groups （P〈 0.05）. The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant （P〈0.05）. Conclusion： KXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.
文摘The protective effect of the traditional Chinese compound medicine Yuxingtong (YXT) in cap-sule form on the experimental acute myocardial ischemia formation has been studied in dogs. The plasma en-dotlielin concentration and serum creatine phosphokinase activity were measured after coronary occlusion indifferent medication groups and compared with the saline control group. Results showed that YXT could signifi-cantly lowered the plasma endothelin concentration and the serum creatine phosphokinase activity, it sug-gested that both YXT and diltiazem have the similar protective effect on acute myocardial ischemia and necro-sis in dogs.
