Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column...Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy.Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-(4'- methoxyphenylethyl)ether(1),1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose(2),4-ethoxy-phenylethanol acetate(3),p-hydroxyacetophenone (4),p-hydroxy-benzoic acid ethylester(5),4-hydroxybenzoic acid(6),4-hydroxybenzaldehyde(7),R(-)-mellein (8),stigmasterol(9),4-methoxy-phenylethanol(10),and methylgallate(11).Among them,1 and 2 are new compounds; compounds 3,5,7,8,and 10 were isolated from Rhodiola genus for the first time;and compounds 4,6,9,and 11 were isolated from Rhodiola kirilowii(Regl) Maxim.for the first time.展开更多
Chemical constituents of the whole herb ofRhodiola kirilowii （Regl） Maxim. were investigated. The separation of the constituents was achieved by using a combination of various chromatographic techniques including co...Chemical constituents of the whole herb ofRhodiola kirilowii （Regl） Maxim. were investigated. The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic techniques including ID and 2D NMR spectroscopy. Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-（4＇- methoxyphenylethyl）ether （1）, 1-（2-hydroxy-2-methylbutanoate）-β-D-glucopyranose （2）, 4-ethoxy-phenylethanol acetate （3）, p- hydroxyacetophenone （4）, p-hydroxy-benzoic acid ethylester （5）, 4-hydroxybenzoic acid （6）, 4-hydroxybenzaldehyde （7）, R（-）- mellein （8）, stigrnasterol （9）, 4-methoxy-phenylethanol （10）, and methylgallate （11）. Among them, 1 and 2 are new compounds; compounds 3, 5, 7, 8, and 10 were isolated from Rhodiola genus for the first time; and compounds 4, 6, 9, and 11 were isolated from Rhodiola kirilowii （Reg 1） Maxim. for the first time.展开更多
基金National Natural Science Foundation of China (Grant No.30973628).
文摘Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy.Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-(4'- methoxyphenylethyl)ether(1),1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose(2),4-ethoxy-phenylethanol acetate(3),p-hydroxyacetophenone (4),p-hydroxy-benzoic acid ethylester(5),4-hydroxybenzoic acid(6),4-hydroxybenzaldehyde(7),R(-)-mellein (8),stigmasterol(9),4-methoxy-phenylethanol(10),and methylgallate(11).Among them,1 and 2 are new compounds; compounds 3,5,7,8,and 10 were isolated from Rhodiola genus for the first time;and compounds 4,6,9,and 11 were isolated from Rhodiola kirilowii(Regl) Maxim.for the first time.
基金Foundation item： National Natural Science Foundation of China （Grant No. 30973628）.
文摘Chemical constituents of the whole herb ofRhodiola kirilowii （Regl） Maxim. were investigated. The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic techniques including ID and 2D NMR spectroscopy. Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-（4＇- methoxyphenylethyl）ether （1）, 1-（2-hydroxy-2-methylbutanoate）-β-D-glucopyranose （2）, 4-ethoxy-phenylethanol acetate （3）, p- hydroxyacetophenone （4）, p-hydroxy-benzoic acid ethylester （5）, 4-hydroxybenzoic acid （6）, 4-hydroxybenzaldehyde （7）, R（-）- mellein （8）, stigrnasterol （9）, 4-methoxy-phenylethanol （10）, and methylgallate （11）. Among them, 1 and 2 are new compounds; compounds 3, 5, 7, 8, and 10 were isolated from Rhodiola genus for the first time; and compounds 4, 6, 9, and 11 were isolated from Rhodiola kirilowii （Reg 1） Maxim. for the first time.
