Clinical Study on Rhubarb Extract Tablet in Treating Simple Obesity

Objective: To study the clinical efficacy of Jinghuang tablet (Rhubarb extract tablet, RET) in treating simple obesity.Methods: Four hundred and seventy-two simple obesity patients were randomly divided into 3 pairs of groups: (1) RET-2 treated group (50 cases): treated with RET vs western drug fenfluramine control group (50 cases). (2) RET treated group vs Chinese patent drug Xiaopangmei (XPM) control group with 50 cases randomly divided into each. (3) RET-1 treated group with 137 cases vs blank control of 135 cases. The aim was to observe markedly effective rate, effective rate and side-effect of RET group and fenfluramine and XPM control groups. At the same time, the slimming efficacy of RET-1 treated group and the blank control group were observed.Results: The slimming effective rate of RET is similar to that of fenfluramine (P < 0. 05), and better than domestically well accepted slimming Chinese patent drug XPM (P < 0.05). In comparing RET-1 group with blank control group, the difference of weight loss of the 2 groups after 1 week treatment was 0.93 kg on average, which was significant.Conclusion: The efficacy of RET in treating simple obesity was similar to that of fenfluramine, but the side-effect was obviously less than that of fenfluramine, while the markedly effective rate and effective rate in slimming were significantly better than that of XPM.

大黄乳酸菌素分散片的研制

目的:筛选大黄乳酸菌素分散片的制剂处方。方法:以崩解时间为指标,考察不同种类的辅料及用量,确定最佳的处方及制备工艺。结果:选用适量交联聚乙烯吡咯烷酮(PVPP)与羧甲基淀粉钠(CMS-Na)为崩解剂,微晶纤维素为稀释剂,海藻酸钠为溶胀辅料,硬脂酸镁为润滑剂,80%乙醇为润湿剂,采用内加法,湿法制粒。所制得的分散片符合《中国药典》(2005年版)中分散片的标准。结论:本法研制的大黄乳酸菌素分散片处方合理,工艺可行,并体现了分散片的特点。

多指标正交试验优选保健食品蓝参降脂咀嚼片醇提工艺

目的:建立蓝参降脂咀嚼片最佳醇提工艺。方法:采用正交试验,以总浸出物、总黄酮及大黄酚含量为指标进行多指标综合评价,通过考察乙醇浓度、加醇量、回流次数及回流时间4个因素,对蓝参降脂咀嚼片醇提工艺进行优化。结果:最佳工艺为用10倍量60%乙醇回流提取3次,每次2 h。结论:该提取工艺稳定可行,重复性好,可作为蓝参降脂咀嚼片醇提工艺。

新健胃包芯片中大黄总蒽醌类成分提取因素的优化

目的优化提取新健胃包芯片中大黄总蒽醌类成分的影响因素,完善质量标准,加强产品质量控制。方法对提取方式进行单因素考察,对提取温度、时间,水解时间等影响因素进行优化处理,以HPLC法测定制剂中大黄总蒽醌类成分含量为质控指标。结果新健胃包芯片制剂中最佳提取条件为75℃甲醇回流提取1.5 h,8%盐酸酸化后,再提取2.0 h,有效成分的提取率最高,总蒽醌类成分最稳定。结论该方法稳定可行,可以作为该制剂的质量控制方法。