Objective:To investigate the effects of rhubarb enema on the expression of inflammatory factors and interleukin-33(IL-33)and its prognosis in patients with SAP complicated with sepsis.Methods:A total of 47 patients wi...Objective:To investigate the effects of rhubarb enema on the expression of inflammatory factors and interleukin-33(IL-33)and its prognosis in patients with SAP complicated with sepsis.Methods:A total of 47 patients with SAP complicated with ARDS admitted to the Department of Critical Care Medicine,the First Affiliated Hospital of Chongqing Medical University from June 2016 to December 2018 were randomly divided into SAP with ARDS sepsis group(sepsis group)and SAP.In the ARDS non-sepsis group(non-sepsis group),20 patients were treated according to the guidelines for the diagnosis and treatment of acute pancreatitis in China in 2013.They were given regular fasting,gastrointestinal decompression,fluid resuscitation,acid suppression,and growth.On the basis of the inhibition of water,electrolytes,acid-base balance,add rhubarb 3 g/kg,water 200 mL,filter the slag juice to 37~38℃for retention enema for more than 15min,2 times a day For a total of 7 days.The inflammatory markers WBC,PCT,heart rate,respiratory rate,oxygenation index(PaO2/FiO2),pancreatic severity score(BISAP),and IL-33 and various cytokine changes were recorded in the two groups.Results:On the first day of admission,the patients in the sepsis group had more severe inflammation index(WBC:14.23±2.95,PCT:3.62±2.04,heart rate:104.02±8.89,respiration:26.81±2.44),and the oxygenation index was more.Poor(PaO2/FiO2:164.08±21.05),IL-33(46.32±7.82)and higher cytokine expression(TNF-α:266.78±72.89,IL-1:53.47±10.52,IL-6:1824.68±598.53,IL-8:160.42±50.34),the difference was statistically significant compared with the non-sepsis group,P<0.01.After the treatment of rhubarb enema,the above indicators were significantly decreased in both groups,and admission.The difference was statistically significant on the first day,P<0.01.However,on the seventh day after treatment,the sepsis patients hadΔIL-33(41.63±7.86)and cytokines(ΔTNF-α:258.90±72.18,ΔIL-1:47.87±11.85,ΔIL-6:1775.57±598.31,ΔIL-8:143.12±51.98),oxygenation index(162.01±43.23)improved better than non-sepsis group,P<0.01,and the rate of invasive ventilation was not statistically significant.P>0.05.Conclusion:SAP combined with sepsis leads to the use of rhubarb enema in patients with ARDS to significantly improve the concentration of IL-33 as a"target"factor and reduce the proinflammatory factors TNF-α,IL-1,IL-6 and IL-8.Level,improve the patient's oxygenation,has clinical application value.展开更多
Severe acute pancreatitis accounts for 15% - 20% of acute pancreatitis and is a kind of serious systemic disease because it involves multiple organ damage and dysfunction. Emodin is the most important active ingredien...Severe acute pancreatitis accounts for 15% - 20% of acute pancreatitis and is a kind of serious systemic disease because it involves multiple organ damage and dysfunction. Emodin is the most important active ingredient of rhubarb and has been used for the treatment of severe acute pancreatitis. This review mainly summarizes the study progress of emodin in severe acute pancreatitis treatment.展开更多
目的:对比研究经胃管和鼻空肠管不同途径给予大黄治疗急性重症急性胰腺炎的治疗效果.方法:SAP患者43例随机分为A组(n=20)和B组(b=23).在综合治疗基础上A组给予胃管注入大黄,B组给予鼻空肠管注入大黄,观察患者住院7、14 d时APACHE-Ⅱ评分...目的:对比研究经胃管和鼻空肠管不同途径给予大黄治疗急性重症急性胰腺炎的治疗效果.方法:SAP患者43例随机分为A组(n=20)和B组(b=23).在综合治疗基础上A组给予胃管注入大黄,B组给予鼻空肠管注入大黄,观察患者住院7、14 d时APACHE-Ⅱ评分,Balthazar CT积分以及CRP及血淀粉酶,肠道功能恢复时间.结果:治疗7 d时B组APACHE-Ⅱ评分较A组有明显降低(3.76±2.82 vs 4.58±2.07,P<0.05),Balthazar CT积分无明显差别(P>0.05):治疗14 d时A组与B组APACHE-Ⅱ评分、Balthazar CT积分均无明显差别(P>0.05);B组CRP及肠功能恢复时间较A组有明显缩短(8.3±1.7 vs 9.1±3.6,P<0.05:6.2±2.9 vs 8.5±2.3.P<0.01).结论:鼻空肠管途径应用大黄能更有效的地控制急性重症胰腺炎的全身炎症反应,缩短病程.展开更多
基金Chongqing Municipal Health and Family Planning Commission Chinese Medicine Science and Technology Project(No.ZY201702071)Chongqing Municipal Health and Family Planning Commission Medical Research Project(No.2018MSXM097)。
文摘Objective:To investigate the effects of rhubarb enema on the expression of inflammatory factors and interleukin-33(IL-33)and its prognosis in patients with SAP complicated with sepsis.Methods:A total of 47 patients with SAP complicated with ARDS admitted to the Department of Critical Care Medicine,the First Affiliated Hospital of Chongqing Medical University from June 2016 to December 2018 were randomly divided into SAP with ARDS sepsis group(sepsis group)and SAP.In the ARDS non-sepsis group(non-sepsis group),20 patients were treated according to the guidelines for the diagnosis and treatment of acute pancreatitis in China in 2013.They were given regular fasting,gastrointestinal decompression,fluid resuscitation,acid suppression,and growth.On the basis of the inhibition of water,electrolytes,acid-base balance,add rhubarb 3 g/kg,water 200 mL,filter the slag juice to 37~38℃for retention enema for more than 15min,2 times a day For a total of 7 days.The inflammatory markers WBC,PCT,heart rate,respiratory rate,oxygenation index(PaO2/FiO2),pancreatic severity score(BISAP),and IL-33 and various cytokine changes were recorded in the two groups.Results:On the first day of admission,the patients in the sepsis group had more severe inflammation index(WBC:14.23±2.95,PCT:3.62±2.04,heart rate:104.02±8.89,respiration:26.81±2.44),and the oxygenation index was more.Poor(PaO2/FiO2:164.08±21.05),IL-33(46.32±7.82)and higher cytokine expression(TNF-α:266.78±72.89,IL-1:53.47±10.52,IL-6:1824.68±598.53,IL-8:160.42±50.34),the difference was statistically significant compared with the non-sepsis group,P<0.01.After the treatment of rhubarb enema,the above indicators were significantly decreased in both groups,and admission.The difference was statistically significant on the first day,P<0.01.However,on the seventh day after treatment,the sepsis patients hadΔIL-33(41.63±7.86)and cytokines(ΔTNF-α:258.90±72.18,ΔIL-1:47.87±11.85,ΔIL-6:1775.57±598.31,ΔIL-8:143.12±51.98),oxygenation index(162.01±43.23)improved better than non-sepsis group,P<0.01,and the rate of invasive ventilation was not statistically significant.P>0.05.Conclusion:SAP combined with sepsis leads to the use of rhubarb enema in patients with ARDS to significantly improve the concentration of IL-33 as a"target"factor and reduce the proinflammatory factors TNF-α,IL-1,IL-6 and IL-8.Level,improve the patient's oxygenation,has clinical application value.
文摘Severe acute pancreatitis accounts for 15% - 20% of acute pancreatitis and is a kind of serious systemic disease because it involves multiple organ damage and dysfunction. Emodin is the most important active ingredient of rhubarb and has been used for the treatment of severe acute pancreatitis. This review mainly summarizes the study progress of emodin in severe acute pancreatitis treatment.
文摘目的:对比研究经胃管和鼻空肠管不同途径给予大黄治疗急性重症急性胰腺炎的治疗效果.方法:SAP患者43例随机分为A组(n=20)和B组(b=23).在综合治疗基础上A组给予胃管注入大黄,B组给予鼻空肠管注入大黄,观察患者住院7、14 d时APACHE-Ⅱ评分,Balthazar CT积分以及CRP及血淀粉酶,肠道功能恢复时间.结果:治疗7 d时B组APACHE-Ⅱ评分较A组有明显降低(3.76±2.82 vs 4.58±2.07,P<0.05),Balthazar CT积分无明显差别(P>0.05):治疗14 d时A组与B组APACHE-Ⅱ评分、Balthazar CT积分均无明显差别(P>0.05);B组CRP及肠功能恢复时间较A组有明显缩短(8.3±1.7 vs 9.1±3.6,P<0.05:6.2±2.9 vs 8.5±2.3.P<0.01).结论:鼻空肠管途径应用大黄能更有效的地控制急性重症胰腺炎的全身炎症反应,缩短病程.
