A multi-center study of Restylane for treatment of nasolabial folds in China

Background Restylane, a hyaluronic acid gel, has been widely used as a dermal filler in USA and European countries. This study was designed to study the safety and efficacy of Restylane as a non-permanent dermal filler for facial augmentation therapy in China for the correction of nasolabial folds during a follow-up period of 6 months. Methods The study consisted of a screening visit, a baseline visit during which injection with Restylane was given, and follow-up visits after four weeks, three months and six months. The efficacy was subjectively assessed by comparing the treatment results between pre-treatment and post-treatment. Adverse events were analyzed by severity and duration. Results At six months post-baseline, the subjects and the investigators＇ independent assessment score of Wrinkle Severity Rating Scale was decreased. Global Aesthetic Improvement Scale was considered to have improved by over 90% in some cases. Adverse events related to product and injection was reported in 21.5% of the injections. A vast majority of the post-treatment reactions were mild. Conclusions The efficacy of Restylane for nasolabial fold in a Chinese population was excellent. Restylane was well tolerated and no systemic reactions or other safety concerns were raised.

Improvements in the cervical angle and anthropometric distances using elasticum suspension

Aim:This study aims to characterize the effects of elastic facelifts using the elasticum suspension technique on the cervical angle and anthropometric distances.Methods:Forty-six patients underwent surgery.Two 4-5 mm incisions a few centimetres apart were made at sideburn.Through blunt dissection,the deep temporal fascia was approached.An elastic thread(Elasticum®)was anchored to this fascia.A 1.0 cm incision was made just in front of the earlobe.The elastic thread was anchored to the tympanoparotid fascia.Jano needle was passed under the skin surface,as determined by the depth mark of the needle along the cervicomandibular angle,and the elastic threads were looped around the contralateral tympanoparotid fascia.Standard lateral photographs were taken and evaluated.Results:The elasticum suspension significantly decreased the cervical angle(P<0.001,-5.5±9.8%).This procedure significantly decreased the distance from the gonion-gnathion to the labiale inferioris(Gn-Li)(P<0.001,-18.4±25.5%).The ratio of the distance from Gn to the cervical point(Gn-C)to Gn-Li increased significantly(P<0.001,62.8±85.8%)and the ratio of the distance from C to the visible thyroid cartilage(C-T)to Gn-C decreased significantly(P=0.007,-7.1±45.2%).Conclusion:Elasticum suspension may be a satisfactory minimally invasive method for facelifts,brow lifts,and neck lifts.