脱丙烷塔用高效阻聚剂RIPP1461的研制与应用

研制了一种用于乙烯装置脱丙烷塔的高效阻聚剂RIPP14 6 1,从阻聚效果实验室的评价试验和运行周期、塔压差、再沸介质流量及污垢形态变化的工业试验结果对比 ,证明RIPP14 6 1性能超过同类进口阻聚剂。

基于深度学习识别RiPPs前体肽及裂解位点

得益于基因测序技术的快速发展,基因组测序数据呈现爆炸式增长,核糖体合成和翻译后修饰肽(RiPPs)是近十年逐渐进入人们视野的一大类肽类天然产物。这类化合物在自然界中分布极其广泛,具有丰富的结构多样性和生物活性多样性,是天然药物的重要来源。RiPPs的发现主要依赖低通量生物实验,传统方法精确但成本高昂,随着新型计算机技术的更新迭代,包括antiSMASH、RiPP-PRISM等在内的生物信息学工具能够极大加速RiPPs挖掘进程,但依然无法突破基于同源性方法(例如搜索保守的生物合成酶)的限制——无法有效识别具有不同生物合成机制的新型RiPPs。在这里,本文首次基于自然语言处理预训练模型BERT,提出四种可以完全依赖序列数据识别RiPPs而非基于同源性及基因组上下文信息的深度学习模型,通过对各模型进行验证分析和对比,最终确定在RiPPs识别赛道上表现卓越的最佳模型BERiPPs(bidirectional language model for enhancing the performance of identification of RiPPs precursor peptides)。BERiPPs能够在不考虑基因组背景的情况下以无偏见的方式识别RiPPs前体肽,并可通过条件随机场生成对前导肽裂解位点的预测,为高通量挖掘全新RiPPs提供了思路,并在一定程度下揭示了前体肽和修饰酶间的生物学底层关系。

茂名乙烯装置脱丙烷塔用高效阻聚剂RIPP1461的研制与应用

针对茂名乙烯装置脱丙烷塔系统运行中出现的问题,研制出一种新型脱丙烷塔用高效阻聚剂PIPP1461,实验室的评价对比试验和工业试验证明R IPP1461性能超过同类进口阻聚剂。

NEW REFORMING CATALYST DEVELOPED BY RIPP

To meet the demands for high octane gasoline and aromatics, catalytic reforming process has been advancing quickly in China. The reforming catalysts developed by RIPP have been used in more than 80% capacity of domestic CCR and SR units. This paper introduces the properties of PS VI CCR catalyst developed by RIPP in recent years and also the result from commercial units. The PS VI catalyst has high activity and good selectivity, under the same reaction conditions, the carbon on catalyst was lowered by 26% in mass as compared with that of the reference catalyst. Among the SR reforming catalysts, the new type of PRT series catalysts have excellent performance at low reaction pressure compared with the ref. Cat A. The aromatics and reformate mass yields of PRT catalyst were 2%～3% and 3%, respectively, higher than those of Cat A, and the run length was 30%～40% longer as well, which exhibits good prospect of application.

Successful Commercial Application of Selective Polymerization Technology Developed by SINOPEC's RIPP

On July 2, 2018 the commercial test unit for selective polymerization of C_4 olefins jointly developed by the SINOPEC Research Institute of Petroleum Processing (RIPP) and the SINOPEC Shijiazhuang Refining and Chemical Branch Company in collaboration with other institutions had been successfully put on stream

Preparation of High-efficiency Ultrastable Zeolite and Catalysts Developed by SINOPEC's RIPP

In April 2018 the SINOPEC Corporation had launched its "green enterprise action program" by proposing to set up the clean, highly efficient, low-carbon, and recyclable green enterprises under its jurisdiction by 2023.All SINOPEC’s catalyst factories are confronted with double pressures demanding an improved green produc-

First Successful Commercial Application of Sulfuric Acid Alkylation Process Developed by SINOPEC's RIPP

Recently the sulfuric acid alkylation process, jointly developed by the SINOPEC Research Institute of Petroleum Processing (RIPP) and the SINOPEC Shijiazhuang Refining and Chemical Branch Company,has been delivering qualified product from the 200

RHT Catalysts Developed by SINOPEC's RIPP Set A Record of Longest Operating Cycle in Taiwan

In March 2012 after competing with several internationalmajor oil companies on the same arena the SINOPEC ResearchInstitute of Petroleum Processing （RIPP）, proppedup by the outstanding performance and good commercialapplication records of the third-generation RHT seriesresid hydrotreating catalysts, had successfully won thebid for the 19th cycle for application of the hydrotreatingcatalyst in the 1.5 Mt/a RDS unit at Taiwan CPC Corporation＇sDalin

Official Issue of ASTM Standard Test Method Drawn up by SINOPEC'S RIPP

Recently the ASTM standard test method (ASTM D8144-18)―"The standard test method for separation and determination of aromatics, non-aromatics and fatty acid methyl ester (FAME) fractions in middle distillates by solid phase extraction andgas chromatography"―drafted and drawn up by the SINOPEC Research Institute of Petroleum Processing (RIPP), has been

Green Technology for Preparation of High-Efficiency Ultrastable Zeolite and Catalysts Developed by RIPP

In April 2018 the Sinopec Corporation launched "The Green Enterprises Action Program" by proposing to construct all clean,high-efficiency,low-carbon and recyclable green enterprises by 2023.The catalyst factories under the Sinopec Corporation are faced with the double pressure on enhancing the green production capability

Technology Relating to Catalyst for Boosting Gasoline Yield Developed by RIPP Passed Appraisal

Currently the project'Development and commercia application of FCC catalyst for boosting gasoline yield'jointly undertaken by the SINOPEC Research Institute of Petroleum Processing(RIPP),the SINOPEC Yanshan Branch Co.and the Branch of SINOPEC Catalyst Company has passed the appraisal.The catalyst aimed at boosting

RIPP炼油技术创新的实践与思考

经济是一个国家的基础，经济决定了我国的上层建筑。而当前，中国正从一个农业大国逐渐转入工业大国，石油是工业动脉，尤其国家将汽车产业作为支柱产业，加上传统石油化工，以及与石油相关生活日用品制造等行业，这些行业都是基于石油的应用。因此，石油在经济发展中的重要性是显而易见的。而与石油发展密不可分的便是RIPP炼油技术。RIPP实质上是中国石油化工科学研究学院的简称，它的发展与石油的发展从根本上来看，具有一致性。通过对近几年RIPP炼油技术的发展进行仔细考量，我们将会受益匪浅。而本文主要就是针对于RIPP技术的创新历程，发表作者对其的感慨。

Challenges and advances in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs)

Ribosomally synthesized and post-translationally modified peptides(RiPPs)are a class of cyclic or linear peptidic natural products with remarkable structural and functional diversity.Recent advances in genomics and synthetic biology,are facilitating us to discover a large number of new ribosomal natural products,including lanthipeptides,lasso peptides,sactipeptides,thiopeptides,microviridins,cyanobactins,linear thiazole/oxazole-containing peptides and so on.In this review,we summarize bioinformatic strategies that have been developed to identify and prioritize biosynthetic gene clusters(BGCs)encoding RiPPs,and the genome mining-guided discovery of novel RiPPs.We also prospectively provide a vision of what genomics-guided discovery of RiPPs may look like in the future,especially the discovery of RiPPs from dominant but uncultivated microbes,which will be promoted by the combinational use of synthetic biology and metagenome mining strategies.

含氨基乙烯半胱氨酸核糖体肽的生物合成与化学合成

核糖体肽是一类拥有化学结构和生物活性多样性的多肽天然产物家族,在药物开发方面具有巨大的发展潜力。氨基乙烯半胱氨酸(AviCys)是部分核糖体肽类天然产物中存在的一种特殊C末端交联结构单元。含有AviCys单元的核糖体肽类天然环肽往往具有优良的抗菌或抗肿瘤活性,且AviCys大环结构对其生物活性至关重要。本文围绕此类天然环肽的生物合成和化学合成进行了总结:①羊毛硫肽、lipolanthines、linaridins和thioamitides四类核糖体肽天然产物中AviCys结构单元的生物合成研究进展,主要包括C末端半胱氨酸的氧化脱羧反应,丝氨酸/苏氨酸或半胱氨酸脱水或脱硫反应,以及AviCys环化反应;②针对含AviCys结构单元环肽的化学合成方法,包括自由基硫醇-炔偶联、氧化脱羧/脱羰、酰胺与缩醛缩合等。本综述同时对相关研究中存在的若干挑战和尚待解决的问题进行了梳理和总结,包括生物合成过程中尚未得到深入解析的环化步骤、化学合成中尚未解决的立体选择性和化学兼容性等。综上,对含AviCys结构单元天然环肽的生物合成途径全面解析及化学合成方法的开发,有望为此类生物功能环肽及其衍生物的制备与生物工程改造奠定基础,推动该类功能环肽在生命科学和药物科学领域的应用。

石油炼制中的加氢催化剂和技术

以石油炼制过程中汽油、柴油、渣油加氢催化剂和技术的开发为例,说明应用基础研究在催化剂和技术开发中的作用。这些研究包括加氢过程的各种基本反应(如加氢脱氮、加氢脱硫、烯烃加氢和芳烃饱和等)的热力学研究、基本反应动力学及与催化剂组成及结构特征间的关系、活性组分与载体间的相互作用、反应物分子平均扩散半径与催化剂空间结构的匹配、结焦失活的机理及其抑制措施等。

加氢催化剂系列的开发与进展

石油化工科学研究院自1987年将RN-1加氢精制催化剂成功地用于工业装置以来,共开发了11个系列18种催化剂,其中14种催化剂获得工业应用,取得了良好的经济效益和社会效益,其技术水平达到国际先进水平.

First DCC-plus Unit Comes Online Successfully at IRPC in Thailand

The SINOPEC’s Research Institute of Petroleum Processing (RIPP) on the basis of its proprietary DCC technology has increased the propylene output through enhancing the propylene formation reaction and reducing the dry gas and coke yield, resulting in the development of a reinforced version of DCC process, viz.: the DCC-plus technology. This technology has been used in commercial scale at CNOOC’s Dongfang Petrochemical Company and CNOOC’s Daxie Petrochemical Company.