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Application of ^(18) F-FDG PET/CT Imaging in Diagnosing Bladder Tumor Metastasis Lesions
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作者 李杨 杨中青 +2 位作者 叶慧 齐琳 胡军武 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2013年第2期234-237,共4页
Bladder tumor is the most common malignant tumor in urinary system and always com- panied with lymph node metastasis. The accurate staging plays a significant role in treatment for bladder tumor and prognostic evaluat... Bladder tumor is the most common malignant tumor in urinary system and always com- panied with lymph node metastasis. The accurate staging plays a significant role in treatment for bladder tumor and prognostic evaluation, and the distant metastasis predicts worse prognosis. The objective of this study was to assess the clinical significance of 18F-FDG PET/CT imaging in diagnosing bladder tumor metastasis lesions. A retrospective analysis of 60 patients with bladder tumor from October 2008 to May 2010 was done. The patients were stratified based on the imaging technique. Among all 60 cases, besides the primary lesion, 81 suspected lesions were spotted and 73 confirmed as metastasis, including 50 lymph node metastases, 22 distant metastases, and 1 bone metastasis. For PET/CT imaging, its sensitivity was 94.5%, specificity 87.5%, positive predictive value 98.6%, negative predictive value 63.6% and accuracy 93.8% respectively. For CT, its sensitivity was 82.2%, specificity 50%, positive predictive value 93.8%, negative predictive value 23.5% and accuracy 79% respectively. PET/CT im- aging was superior to CT in sensitivity, specificity and accuracy. In conclusion, 18F-FDG PET/CT imaging is more significant in diagnosing bladder tumor metastasis lesions. 展开更多
关键词 PET FDG Application of F-FDG PET/CT Imaging in Diagnosing Bladder Tumor metastasis lesions CT
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Individualized treatment for gastric cancer with rib metastasis: Acase report
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作者 Yu Zhang Zhen-Xing Zhang +4 位作者 Zeng-Xin Lu Fang Liu Geng-Yuan Hu Feng Tao Min-Feng Ye 《World Journal of Gastrointestinal Surgery》 SCIE 2020年第12期555-563,共9页
BACKGROUND Gastric cancer (GC) with bone metastasis is rare, and rib metastasis is even lesscommon. The clinical prognosis of GC with bone metastasis is poor given the lackof an effective treatment.CASE SUMMARY A 70 y... BACKGROUND Gastric cancer (GC) with bone metastasis is rare, and rib metastasis is even lesscommon. The clinical prognosis of GC with bone metastasis is poor given the lackof an effective treatment.CASE SUMMARY A 70 year old man was referred to Shaoxing People’s Hospital with left chest painand slight dyspnea. Chest computed tomography (CT) revealed a metastaticlesion in the left 3rd rib. Esophagogastroduodenoscopy revealed several ulcers inthe angle and antrum of the stomach, and tumor biomarkers including CEA andCA-199 were clearly increased. In addition, lymph node metastasis in the lessercurvature of the stomach was identified by positron emission tomography/CTscanning. Further pathological examination confirmed metastatic adenocarcinomain the rib and medium-low differentiated adenocarcinoma in the gastric space.The patient had GC with rib metastasis, and was clinically staged as T3NxM1 (IVB).Based on multidisciplinary team opinions, the patient received five courses ofchemotherapy (CAPOX plus aptinib), and then underwent rib resection andlaparoscopic radical distal gastrectomy. The patient started four courses ofchemotherapy after surgery, and then capecitabine and aptinib were administeredorally for 3 mo. Follow-up was performed on an outpatient basis usingabdominal/chest CT and tumor biomarkers. The patient exhibited an overallsurvival greater than 2 years, and the disease-free survival was approximately 18mo. His adverse events were tolerable.CONCLUSION The incidence of GC with rib metastases is extremely low, and patients can obtainmore benefits from individualized treatment formulated by multidisciplinaryteam. Chemotherapy plus surgery might represent an alternative option for GCwith rib metastasis. 展开更多
关键词 Gastric cancer rib metastasis Chemotherapy Apatinib Surgery Case report©The Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved.
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Solitary rib metastasis of nasopharyngeal carcinoma
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作者 Francesca De Felice Daniela Musio +3 位作者 Anna Lisa Magnante Nadia Bulzonetti Irene De Francesco Vincenzo Tombolini 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2014年第2期219-221,共3页
We report a case of a 49-year-old man who developed solitary rib metastasis of nasopharyngeal cancer. Patient had been treated for primary carcinoma with radiation therapy and concomitant chemotherapy. The bone metast... We report a case of a 49-year-old man who developed solitary rib metastasis of nasopharyngeal cancer. Patient had been treated for primary carcinoma with radiation therapy and concomitant chemotherapy. The bone metastasis presented as bulky, solid, painful mass in the posterior arch of 10th rib, within nine months the end of treatment. Biopsy of the solitary lesion presented the same histological characteristics as those of primary lesion. Although there are reported in literature series of nasopharyngeal cancer metastasizing to bone, we did not find previously pubfished report of a nasopharyngeal carcinoma metastasizing only to a rib. 展开更多
关键词 NASOPHARYNGEAL rib metastasis SOLITARY
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First description of cervical intradural thymoma metastasis 被引量:3
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作者 Nicola Marotta Cristina Mancarella +3 位作者 Davide Colistra Alessandro Landi Demo Eugenio Dugoni Roberto Delfini 《World Journal of Clinical Cases》 SCIE 2015年第11期946-950,共5页
Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic"(types A, AB, B1, B2, and B3) and "non-o... Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic"(types A, AB, B1, B2, and B3) and "non-organotypic"(thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma. 展开更多
关键词 THYMOMA metastasis INTRADURAL lesion SPINAL tumor SPINAL surgery
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Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition 被引量:3
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作者 Filippo Antonini Liboria Laterza +5 位作者 Lorenzo Fuccio Massimo Marcellini Lucia Angelelli Sonia Calcina Corrado Rubini Giampiero Macarri 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2017年第11期452-456,共5页
We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB).... We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an SET.This case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis. 展开更多
关键词 metastasis Subepithelial lesion Gastric cancer OVARIAN Endoscopic ultrasonography
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Sternal metastasis-the forgotten column and its effect on thoracic spine stability 被引量:1
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作者 Robert Pearse Piggott Mark Curtin +3 位作者 Sudarshan Munigangaiah Mutaz Jadaan John Patrick McCabe Aiden Devitt 《World Journal of Orthopedics》 2017年第6期455-460,共6页
Sternal metastases are not studied extensively in the literature. There is a paucity of information on their role in metastatic disease. The concept of the fourth column was described by Berg in 1993, and has been pro... Sternal metastases are not studied extensively in the literature. There is a paucity of information on their role in metastatic disease. The concept of the fourth column was described by Berg in 1993, and has been proven in case report, clinically and biomechanical studies. The role of the sternum as a support to the thoracic spine is well documented in the trauma patients, but not much is known about its role in cancer patients. This review examines what is known on the role of the fourth column. Following this we have identified two likely scenarios that sternal metastases may impact management:(1) sternal pathological fracture increases the mobility of the semi-rigid thorax with the loss of the biomechanical support of the sternum-rib-thoracic spine complex; and(2) a sternal metastasis increases the risk of fracture, and while being medical treated the thoracic spine should be monitored for acute kyphosis and neurological injury secondarily to the insufficiency of the fourth column. 展开更多
关键词 FOURTH COLUMN Sternal fracture Sternal metastasis Sternal-rib-thoracic SPINE complex SPINE STABILITY
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Relationship between the Expression of CD44v6 and Development,Progress, Invasion and Metastasis of Laryngeal Carcinoma
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作者 刘邦华 孔维佳 +3 位作者 龚树生 杨成章 汪广平 朱立新 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2005年第3期351-353,364,共4页
The expression of CD44v6 and its relationship with the development, progress, invasion and metastasis of laryngeal carcinoma was investigated. The expression and content of CD44v6 mRNA in tissuess were detected by bot... The expression of CD44v6 and its relationship with the development, progress, invasion and metastasis of laryngeal carcinoma was investigated. The expression and content of CD44v6 mRNA in tissuess were detected by both RT-PCR and FCM which were respectively extracted from normal laryngeal mucosa, leukoplakia of larynx, laryngeal papilloma, polyp of vocal cord, tissues of laryngeal carcinoma, metastatic and nonmetastatic lymph nodes of neck, and tissues close to carcinoma. The outcome of RT-PCR indicated that the expression rate of CD44v6 mRNA involved in tissues of laryngeal carcinoma and metastatic lymph nodes of neck was the highest (90 %-100 %) compared with that of leukoplakia of larynx, laryngeal papilloma, tissues close to carcinoma by 0.5 cm (55.56 %-60.00 %) and that of normal laryngeal mucosa, polyp of vocal cord, nonmetastatic lymph nodes and tissues close to carcinoma by 1.0 cm was the lowest ( 13.33 %-20 %). The result from FCM was highly consistent with that from RT-PCR. It was suggested that CD44v6 was closely related with the development, progress, invasion and metastasis of laryngeal carcinoma. The outcome from the tissues close to carcinoma by different distance could do help to the determination of incisal edge in surgery abstractly. 展开更多
关键词 laryngeal carcinoma metastasis precancerous lesion CD44V6
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Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway 被引量:1
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作者 Fanchun Zeng Chunrong Zhao +7 位作者 Rujie Wang Lingyan Ren Hao Qiu Zhi Zou Haibin Ding Zhongyi Sun Jianmei Li Shiwu Dong 《Genes & Diseases》 SCIE CSCD 2023年第4期1626-1640,共15页
More than 50%of prostate cancer(PCa)patients have bone metastasis with osteo-blastic lesions.MiR-18a-5p is associated with the development and metastasis of PCa,but it remains unclear whether it is involved in osteobl... More than 50%of prostate cancer(PCa)patients have bone metastasis with osteo-blastic lesions.MiR-18a-5p is associated with the development and metastasis of PCa,but it remains unclear whether it is involved in osteoblastic lesions.We first found that miR-18a-5p was highly expressed in the bone microenvironment of patients with PCa bone metastases.To address how miR-18a-5p affects PCa osteoblastic lesions,antagonizing miR-18a-5p in PCa cells or pre-osteoblasts inhibited osteoblast differentiation in vitro.Moreover,injection of PCa cells with miR-18a-5p inhibition improved bone biomechanical properties and bone mineral mass in vivo.Furthermore,miR-18a-5p was transferred to osteoblasts by exosomes derived from PCa cells and targeted the Hist1h2bc gene,resulting in Ctnnb1 up-regulation in the Wnt/β-catenin signaling pathway.Translationally,antagomir-18a-5p significantly improved bone biomechanical properties and alleviated sclerotic lesions from osteoblastic me-tastases in BALB/c nude mice.These data suggest that inhibition of exosome-delivered miR-18a-5p ameliorates PCa-induced osteoblastic lesions. 展开更多
关键词 Bone metastasis MiR-18a-5p Osteoblastic lesions Prostate cancer Wnt/β-catenin pathway
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Carcinoembryonic antigen in the diagnosis,treatment,and follow-up of focal liver lesions
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作者 Osman Nuri Dilek Dilaraİrem Arslan Kahraman Gökhan Kahraman 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期999-1007,共9页
In this editorial review,we comment on the article published in the recent issue of the World Journal of Gastrointestinal Surgery.Carcinoembryonic antigen(CEA)is a fetal glycoprotein and can be secreted in very small ... In this editorial review,we comment on the article published in the recent issue of the World Journal of Gastrointestinal Surgery.Carcinoembryonic antigen(CEA)is a fetal glycoprotein and can be secreted in very small amounts from healthy adults after birth.CEA is widely used not only for diagnostic tumor markers but also importantly for the management of some gastrointestinal tumors.The most common clinical use is surveillance for the monitoring of colorectal carcinoma.However,CEA can become elevated in several malign or benign characterized pathologies.Serum CEA level may vary depending on the location of the lesion,whether it metastasizes or not,and its histopathological characteristics.It has been determined that cases with high preoperative CEA have a more aggressive course and the risk of metastasis to the lymph tissue and liver increases.In this editorial review,we focused on evaluating the role of CEA in clinical practice with a holistic approach,including the diagnostic and prognostic significance of CEA in patients with focal liver lesions,the role of CEA in follow-up after definitive surgery,and also hepatic resection for metastasis,and the management of all patients with raised CEA. 展开更多
关键词 Carcinoembriyonic antigen LIVER Focal liver lesions metastasis Surgery PROGNOSIS SURVEILLANCE
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U-Net Based Dual-Pooling Segmentation of Bone Metastases in Thoracic SPECT Bone Scintigrams
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作者 Yang He Qiang Lin +1 位作者 Yongchun Cao Zhengxing Man 《Journal of Computer and Communications》 2024年第4期60-71,共12页
In order to enhance the performance of the CNN-based segmentation models for bone metastases, this study proposes a segmentation method that integrates dual-pooling, DAC, and RMP modules. The network consists of disti... In order to enhance the performance of the CNN-based segmentation models for bone metastases, this study proposes a segmentation method that integrates dual-pooling, DAC, and RMP modules. The network consists of distinct feature encoding and decoding stages, with dual-pooling modules employed in encoding stages to maintain the background information needed for bone scintigrams diagnosis. Both the DAC and RMP modules are utilized in the bottleneck layer to address the multi-scale problem of metastatic lesions. Experimental evaluations on 306 clinical SPECT data have demonstrated that the proposed method showcases a substantial improvement in both DSC and Recall scores by 3.28% and 6.55% compared the baseline. Exhaustive case studies illustrate the superiority of the methodology. 展开更多
关键词 Tumor Bone metastasis Bone Scintigram lesion Segmentation CNN Dual Pooling
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99mTc-MDP全身骨断层融合显像半定量技术对前列腺癌骨转移病灶识别的价值研究
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作者 倪效波 梁瑞 +2 位作者 杨勇 王婷 高英 《中国CT和MRI杂志》 2024年第8期152-154,共3页
目的探讨99mTc-MDP全身骨断层融合显像半定量技术对前列腺癌骨转移病灶识别的价值。方法选择我院于2021年5月~2023年5月前列腺癌患者80例,术后病理显示前列腺癌骨转移患者54例,无骨转移患者26例。所有患者均行99mTc-MDP全身骨断层融合... 目的探讨99mTc-MDP全身骨断层融合显像半定量技术对前列腺癌骨转移病灶识别的价值。方法选择我院于2021年5月~2023年5月前列腺癌患者80例,术后病理显示前列腺癌骨转移患者54例,无骨转移患者26例。所有患者均行99mTc-MDP全身骨断层融合显像半定量技术检查。由1名主治医师和1名主任医师独立完成图像分析。经QMetrix分析即可获得平均标准化摄取值(SUV_(mean))和最大标准化摄取值(SUV_(max))。比较骨转移组与无骨转移组血清前列腺特异性抗原(PSA),SUV_(mean)和SUV_(max)变化;分析99mTc-MDP全身骨断层融合显像诊断骨转移准确率、灵敏度和特异度;Pearson分析PSA与SUV_(mean)和SUV_(max)相关性。结果骨转移组血清PSA水平高于无骨转移组(P<0.05)。骨转移组SUV_(mean)和SUV_(max)值大于无骨转移组(P<0.05)。99mTc-MDP全身骨断层融合显像诊断骨转移准确率为88.89%(48/54)。99mTc-MDP全身骨断层融合显像诊断骨转移灵敏度为79.63%,特异度为80.77%。经Pearson相关性分析显示,PSA与SUV_(mean)和SUV_(max)呈线性正相关(P<0.05)。结论99mTc-MDP全身骨断层融合显像半定量技术对前列腺癌骨转移病灶诊断准确率较高,且具有良好诊断灵敏度和特异度,值得临床借鉴。 展开更多
关键词 99mTc-MDP全身骨断层融合显像半定量技术 前列腺癌 骨转移病灶
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犬膀胱移行上皮癌伴发远端肋骨转移的病例分析
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作者 刘成武 许文洋 +1 位作者 朱思雨 叶俊华 《动物医学进展》 北大核心 2024年第1期136-139,共4页
犬膀胱移行上皮癌是犬的恶性肿瘤,有50%的病例发生远端转移。临床接诊1例长期血尿并出现渐进性跛行的德国牧羊犬,经过临床基本检查、血液学检查(血常规检查和血液生化检查)、影像学检查(DR检查和CT检查)、细胞学检查等方法进行诊断,确... 犬膀胱移行上皮癌是犬的恶性肿瘤,有50%的病例发生远端转移。临床接诊1例长期血尿并出现渐进性跛行的德国牧羊犬,经过临床基本检查、血液学检查(血常规检查和血液生化检查)、影像学检查(DR检查和CT检查)、细胞学检查等方法进行诊断,确诊为膀胱移行上皮癌并伴有远端肋骨转移。采用米托蒽醌和吡罗昔康联合化疗方案,6个月后病情恶化。该病例的诊治过程为膀胱移行上皮癌的诊断和治疗提供了参考。 展开更多
关键词 膀胱移行上皮癌 肋骨转移
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Analyses of the clinical characteristics of 49 cases of malignancy with multiple bone lesions as the first manifestation
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作者 Yu Huang Ping Peng +2 位作者 Peng Zhang Lei Zhou Yingying Wu 《Oncology and Translational Medicine》 CAS 2021年第2期83-87,共5页
Objective To investigate the clinical features of several cases of malignancy with multiple bone lesions as the first manifestation.Methods Forty-nine cases of malignancy with multiple bone lesions as the first manife... Objective To investigate the clinical features of several cases of malignancy with multiple bone lesions as the first manifestation.Methods Forty-nine cases of malignancy with multiple bone lesions as the first manifestation were retrospectively analyzed from May 2018 to July 2019.All patients complained of“pain at the site of bone lesion”upon admission.Baseline patient information,such as age,gender,location of bone lesions,etiology,diagnosis method,time of onset was collected.Results The median age of the patients was 56 years old,of which 83.7%(41/49)were aged≥50 years.The median time of onset was 2 months.Among the cases,40 were confirmed as solid tumor bone metastasis,whereas the remaining 9 cases as hematological system tumor.Lung cancer and multiple myeloma were the main tumor types,accounting for 40.8%(20/49)and 16.3%(8/49),respectively.Other common causes were seven cases of cancer affecting the digestive system(three cases of liver cancer,three cases of gastric cancer,and one case of esophageal cancer),as well as seven cases of unknown primary cancer.Half of the solid tumors had only multiple bone metastases but no other distant metastasis.Conclusion Multiple bone lesions accompanied by pain may be the first clinical manifestation in various malignant tumors.The common tumor types were lung cancer,multiple myeloma,and digestive system tumor.It is more common in people aged 50 years and older.Multiple bone lesions might be the only metastasis site of some solid tumors,and its mechanism needs further investigation. 展开更多
关键词 Bone lesions MALIGNANCY bone metastasis clinical characteristics
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CT能谱成像技术在评估结直肠癌病灶周围淋巴结术前转移的临床价值
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作者 刘岩 王萌 +3 位作者 冷磊 申吉山 项坤 夏洪波 《中国CT和MRI杂志》 2024年第10期133-135,共3页
目的 探究CT能谱成像技术在评估结直肠癌(CRC)病灶周围淋巴结术前转移的临床价值。方法选取2021年5月至2023年5月于影像科进行CT检查且经病理证实的CRC患者104例,经检查共纳入131枚淋巴结,其中转移性淋巴结79枚,非转移性淋巴结52枚。利... 目的 探究CT能谱成像技术在评估结直肠癌(CRC)病灶周围淋巴结术前转移的临床价值。方法选取2021年5月至2023年5月于影像科进行CT检查且经病理证实的CRC患者104例,经检查共纳入131枚淋巴结,其中转移性淋巴结79枚,非转移性淋巴结52枚。利用CT能谱成像技术进行扫描分析,比较两种淋巴结短径、形态学差异、动脉期与静脉期碘浓度(IC)、标准化碘浓度(NIC)和斜率(λ_(HU))等能谱参数,绘制受试者工作特征(ROC)曲线评估CT能谱参数对淋巴结转移的诊断效能。结果CRC病灶周围转移性淋巴结的轴位短径、矢状位短径和冠状位短径均大于非转移性淋巴结(P<0.05);转移性淋巴结边缘模糊、有聚集和强化不均的占比均高于非转移性淋巴结(P<0.05);转移性淋巴结动脉期与静脉期IC、NIC和λ_(HU)均低于非转移性淋巴结(P<0.05);经ROC曲线分析,CT能谱成像参数对淋巴结转移诊断具有一定应用价值(P<0.05),动脉期IC、NIC及静脉期NIC诊断效能最高,AUC分别为0.894、0.895、0.892,敏感度分别为91.14%、86.08%、93.67%,特异度分别为73.08%、82.69%、76.92%。结论CT能谱成像可鉴别非转移性淋巴结与转移性淋巴结短径和形态学差异,CT能谱参数可较为准确地判断CRC患者病灶周围淋巴结术前转移情况。 展开更多
关键词 CT能谱成像技术 结直肠癌 淋巴结术前转移 临床价值
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食管癌患者术后病灶转移流行病学调查及相关危险因素分析 被引量:6
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作者 时冬梅 邵红刚 《河北医药》 CAS 2023年第3期451-454,共4页
目的调查食管癌术后患者发生病灶转移的流行病并分析其相关危险因素。方法回顾性分析2018年8月至2019年7月确诊并行食管癌手术患者153例,按照其术后有无发生病灶转移分为转移组与未转移组,其中转移组患者有75例,未转移组患者78例。采用... 目的调查食管癌术后患者发生病灶转移的流行病并分析其相关危险因素。方法回顾性分析2018年8月至2019年7月确诊并行食管癌手术患者153例,按照其术后有无发生病灶转移分为转移组与未转移组,其中转移组患者有75例,未转移组患者78例。采用本院自拟的调查问卷对术后患者进行流行病学调查;结合术前食管癌诊断结果单因素分析影响食管癌患者术后病灶转移的相关因素,采用二元Logistic回归模型分析影响食管癌术后患者病灶转移的危险因素;对术后患者进行跟踪随访2年,观察病灶不同转移位置对存活率的影响。结果在153例食管癌术后患者中,发生病灶转移75例(49.02);在5例病灶转移的患者中区域性转移46例(61.33),远处病灶转移29例(38.67);单因素分析表明分化程度、病灶转移到淋巴结情况、患者血清中血管内皮生长因子-C(VEGF-C)、组织多肽特异抗原(TPS)水平是影响食管癌术后患者病灶转移的相关因素(P<0.05);Logistic回归多因素表明分化程度中等以下、区域淋巴结有2枚以上癌转移、VEGF-C水平>8.52μg/L、TPS水平>259.64 U/L是食管癌术后患者发生病灶转移的危险因素(P<0.05);随访2年显示病灶发生区域转移的死亡率略高于远处病灶转移。结论影响食管癌术后患者病灶发生转移的主要危险因素为分化程度、病灶转移到淋巴结数量及患者血清中TPS及VEGF-C水平升高,且病灶远处转移的死亡率低于区域性病灶转移。 展开更多
关键词 食管癌术后 病灶转移 相关因素 流行病学调查
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单细胞转录组测序技术在胃癌研究中的应用
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作者 张鑫 王艳春 刘纯杰 《世界华人消化杂志》 CAS 2023年第2期48-55,共8页
胃癌(gastric cancer,GC)发病率居全球常见癌症第五位,死亡率居第三位.随着单细胞RNA测序(single-cell RNA-sequencing,scRNA-seq)技术的发展,人们对GC的研究已经开始逐渐从组织病理学水平发展到单细胞转录水平.本文对scRNA-seq技术原... 胃癌(gastric cancer,GC)发病率居全球常见癌症第五位,死亡率居第三位.随着单细胞RNA测序(single-cell RNA-sequencing,scRNA-seq)技术的发展,人们对GC的研究已经开始逐渐从组织病理学水平发展到单细胞转录水平.本文对scRNA-seq技术原理及其在GC研究中的应用,包括其在揭示GC癌前病变的转录特征与起源、原发性肿瘤的瘤内异质性、肿瘤微环境和转移性播散等方面的应用进行了综述. 展开更多
关键词 胃癌 单细胞转录组测序 癌前病变 肿瘤异质性 肿瘤微环境 肿瘤转移
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良性脑膜瘤术后单发性颅外肋骨转移1例
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作者 张秀美 刘鹏涛 《国际医药卫生导报》 2023年第6期839-841,共3页
脑膜瘤是颅内常见的肿瘤,大多数脑膜瘤表现为良性。良性脑膜瘤发生颅外转移在临床中极其罕见。本文介绍威海市中心医院1例单发性肋骨肿瘤患者,既往有良性脑膜瘤手术史,影像检查提示肋骨肿瘤符合恶性肿瘤表现,最终手术病理证实为脑膜瘤... 脑膜瘤是颅内常见的肿瘤,大多数脑膜瘤表现为良性。良性脑膜瘤发生颅外转移在临床中极其罕见。本文介绍威海市中心医院1例单发性肋骨肿瘤患者,既往有良性脑膜瘤手术史,影像检查提示肋骨肿瘤符合恶性肿瘤表现,最终手术病理证实为脑膜瘤转移。 展开更多
关键词 良性脑膜瘤 颅外转移 肋骨肿瘤
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子宫内膜癌初始病灶大小与淋巴结转移及复发的关系
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作者 吴乐策 乔丽娟 袁超群 《实用癌症杂志》 2023年第7期1148-1151,共4页
目的分析子宫内膜癌(EC)初始病灶大小与淋巴结转移及复发的关系。方法选取EC患者138例,收集患者年龄、病灶大小、体质量指数(BMI)、高血压疾病、疾病分化程度、淋巴结转移等信息,统计不同临床病理特征EC患者初始病灶大小,分析初始病灶... 目的分析子宫内膜癌(EC)初始病灶大小与淋巴结转移及复发的关系。方法选取EC患者138例,收集患者年龄、病灶大小、体质量指数(BMI)、高血压疾病、疾病分化程度、淋巴结转移等信息,统计不同临床病理特征EC患者初始病灶大小,分析初始病灶大小与淋巴结转移及复发的关系。结果年龄、绝经状态、分娩史、分化程度、病理分期、附件转移、肌层浸润深度、淋巴结转移是EC患者初始病灶大小的影响因素(P<0.05)。临界值为3、4、5 cm时,EC患者淋巴结转移率比较差异有统计学意义,初始病灶>5 cm患者淋巴结转移率(26.47%)较初始病灶为4~5 cm患者(19.23%)、3~4 cm患者(6.06%)、2~3 cm患者(3.70%)、<2 cm患者(0.00%)高,且EC患者初始病灶越大淋巴结转移率越高(P<0.05);临界值为3、4、5 cm时,EC患者复发率比较差异有统计学意义,初始病灶>5 cm患者复发率(26.47%)较初始病灶为4~5 cm患者(15.38%)、3~4 cm患者(6.06%)、2~3 cm患者(3.70%)、<2 cm患者(0.00%)高,且EC患者初始病灶越大复发率越高(P<0.05)。结论EC初始病灶大小与患者年龄、分娩史、病理分期、肌层浸润深度等存在明显关联性,且初始病灶越大,淋巴结转移及复发率越高,临床可根据初始病灶大小合理制定手术及治疗方案,改善预后。 展开更多
关键词 子宫内膜癌 初始病灶大小 淋巴结转移 复发
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甲状腺微小乳头状癌颈部淋巴结转移的原发灶超声特征及诊断价值研究
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作者 郝玲丽 张美 《智慧健康》 2023年第24期5-8,13,共5页
目的 探究甲状腺微小乳头状癌(PTMC)颈部淋巴结转移的原发灶超声特征及诊断价值。方法选取2019年1月—2023年3月南京市江宁医院收治的133例PTMC患者为研究对象,根据疾病类型分为对照组(无颈部淋巴结转移,n=74)与观察组(存在颈部淋巴结转... 目的 探究甲状腺微小乳头状癌(PTMC)颈部淋巴结转移的原发灶超声特征及诊断价值。方法选取2019年1月—2023年3月南京市江宁医院收治的133例PTMC患者为研究对象,根据疾病类型分为对照组(无颈部淋巴结转移,n=74)与观察组(存在颈部淋巴结转移,n=59),均行超声诊断,对比两组超声特征。结果 超声检查诊断阳性患者50例、阴性65例;超声检查敏感度86.21%、特异度87.84%、准确度87.12%;病理学检查诊断一致性为最强,而超声检查为高度;两组结节最大直径、与甲状腺被膜接触、结节形态、纵横径比、钙化对比差异具有统计学意义(P<0.05)。结论 采取超声检查诊断PTMC疾病,效果良好,可通过两组结节最大直径、与甲状腺被膜接触、结节形态、纵横径比、钙化等指标判断是否存在淋巴结转移,临床意义显著。 展开更多
关键词 甲状腺微小乳头状癌 淋巴结转移 原发灶 超声检查
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放射性核素骨显像不典型表现248例临床分析 被引量:9
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作者 黄定德 李前伟 +3 位作者 厉红民 谢来平 罗朝学 刘广元 《重庆医学》 CAS CSCD 2005年第8期1137-1138,共2页
目的探讨放射性核素骨显像不典型表现的临床价值.方法对248例核素骨显像呈不典型表现的病例,分别进行病理活检,或X线、CT、MRI检查,或定期复查核素骨显像等进行随访,评价随访结果.结果 (1)骨显像不典型表现的病例中,有肿瘤病史者骨转移... 目的探讨放射性核素骨显像不典型表现的临床价值.方法对248例核素骨显像呈不典型表现的病例,分别进行病理活检,或X线、CT、MRI检查,或定期复查核素骨显像等进行随访,评价随访结果.结果 (1)骨显像不典型表现的病例中,有肿瘤病史者骨转移的阳性率为22.4%(47/210),无肿瘤病史者骨转移的阳性率为7.9%(3/38),二者相差显著(P<0.01);(2)肺癌、乳腺癌、前列腺癌患者中,好发部位的骨转移阳性率为30.5%(29/95),非好发部位则为19.4%(7/36),二者相差显著(P<0.01);(3)60.4%(150/248)的骨显像表现不典型的病例是通过补充X线、CT、MRI检查或随访而最终明确诊断的;(4)28.0%(10/48)的不典型表现病例随访3个月时病灶无明显变化而6个月或12个月后病灶明显扩大或出现新的病灶.结论肿瘤骨转移非好发部位或无肿瘤病史患者的放射性异常浓聚灶也须高度重视,必要时考虑'双癌';应密切结合X线、CT、MRI检查综合分析;骨显像随访时间一般应为3~6个月以上,必要时可超过12个月. 展开更多
关键词 放射性核素骨显像 不典型表现 肿瘤转移
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