Objective To evaluate the clinical and pathological features of Riedel's thyroiditis(RT),and current diagnostic and treatment methods for that disease.Methods Five RT cases identified by surgery and pathological e...Objective To evaluate the clinical and pathological features of Riedel's thyroiditis(RT),and current diagnostic and treatment methods for that disease.Methods Five RT cases identified by surgery and pathological examinations at Peking Union Medical College Hospital from 1985 to 2009 were analyzed and compared with the cases reported in the literature in terms of clinical and pathological features.Immunohistochemical staining of kappa and lambda light chains was carried out for RT tissues from all the five patients.Results All the five cases were females,aged 45-55 years.Elevation of serum thyroid autoantibodies was found in only one patient,who had longer disease duration than the others.Pathological examination revealed invasive fibrosclerosis of the thyroid follicles,thyroid capsule,and the surrounding tissues.In RT tissues,the number of cells containing lambda chains was a little higher than those containing kappa chains.Conclusions RT is a rare disease which might be more common in middle-aged females than in other populations.Pathological features include the destruction of thyroid follicle,extension into surrounding tissues by inflammatory cells and fibrous tissues.Immunohistochemical staining of kappa and lambda chains could help diagnose RT.展开更多
BACKGROUND In context of suboptimal liver utilisation,grafts with various risk factors are under consideration today.For example,impaired vascularity with severe arterial calcifications and modified liver shapes are n...BACKGROUND In context of suboptimal liver utilisation,grafts with various risk factors are under consideration today.For example,impaired vascularity with severe arterial calcifications and modified liver shapes are no longer contraindications and their use depends on the centre policy and experience of the surgical team.Riedel liver lobes represent a tongue-like liver shape with inferior projection in the right liver lobe.Such development modifications were initially described when patients developed a lesion and subsequently presented with symptoms.We here present the first case report in the literature,where such livers with anatomical variations were used for transplantation.CASE SUMMARY We describe here two cases of adult human liver transplantation,where we have accepted two donor livers with modified shape.The technical considerations for transplantation of such livers,found with enlarged right lobes,or Riedel shape,and hypo-trophic left lateral segment are highlighted.Both recipients experienced immediate liver function and overall good outcomes with a minimum follow up of 1 year.We also provide detailed pictures and outcome analysis in combination with a literature review.CONCLUSION The utilisation of donor livers with modified shape,such as Riedel’s Lobe appears safe and will increase the donor pool.展开更多
文摘Objective To evaluate the clinical and pathological features of Riedel's thyroiditis(RT),and current diagnostic and treatment methods for that disease.Methods Five RT cases identified by surgery and pathological examinations at Peking Union Medical College Hospital from 1985 to 2009 were analyzed and compared with the cases reported in the literature in terms of clinical and pathological features.Immunohistochemical staining of kappa and lambda light chains was carried out for RT tissues from all the five patients.Results All the five cases were females,aged 45-55 years.Elevation of serum thyroid autoantibodies was found in only one patient,who had longer disease duration than the others.Pathological examination revealed invasive fibrosclerosis of the thyroid follicles,thyroid capsule,and the surrounding tissues.In RT tissues,the number of cells containing lambda chains was a little higher than those containing kappa chains.Conclusions RT is a rare disease which might be more common in middle-aged females than in other populations.Pathological features include the destruction of thyroid follicle,extension into surrounding tissues by inflammatory cells and fibrous tissues.Immunohistochemical staining of kappa and lambda chains could help diagnose RT.
文摘BACKGROUND In context of suboptimal liver utilisation,grafts with various risk factors are under consideration today.For example,impaired vascularity with severe arterial calcifications and modified liver shapes are no longer contraindications and their use depends on the centre policy and experience of the surgical team.Riedel liver lobes represent a tongue-like liver shape with inferior projection in the right liver lobe.Such development modifications were initially described when patients developed a lesion and subsequently presented with symptoms.We here present the first case report in the literature,where such livers with anatomical variations were used for transplantation.CASE SUMMARY We describe here two cases of adult human liver transplantation,where we have accepted two donor livers with modified shape.The technical considerations for transplantation of such livers,found with enlarged right lobes,or Riedel shape,and hypo-trophic left lateral segment are highlighted.Both recipients experienced immediate liver function and overall good outcomes with a minimum follow up of 1 year.We also provide detailed pictures and outcome analysis in combination with a literature review.CONCLUSION The utilisation of donor livers with modified shape,such as Riedel’s Lobe appears safe and will increase the donor pool.
