Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

GENERALIZED RIEMANN INTEGRAL ON FRACTAL SETS

The theory of integration to mathematical analysis is so important that many mathematicians continue to develop new theory to enlarge the class of integrable functions and simplify the Lebesgue theory integration. In this paper, by slight modifying the definition of the Henstock integral which was introduced by Jaroslav Kurzweil and Ralph Henstock, we present a new definition of integral on fractal sets. Furthermore, its integrability has been discussed, and the relationship between differentiation and integral is also established. As an example, the integral of Cantor function on Cantor set is calculated.

Some New Delay Integral Inequalities Based on Modified Riemann-Liouville Fractional Derivative and Their Applications

By using the properties of modified Riemann-Liouville fractional derivative, some new delay integral inequalities have been studied. First, we offered explicit bounds for the unknown functions, then we applied the results to the research concerning the boundness, uniqueness and continuous dependence on the initial for solutions to certain fractional differential equations.

New Majorized Results on Hilbert's Integral Inequality

In this paper, some new majorized results on Hilbert’s integral inequality are showed.

AN NUMERICAL ALGORI THM FOR LAPLACE′S INTEGRAL BY B-SPLINE

Algorithm for Laplace ′s integral is given when the inverse image function has high order discontinui ty. The multi-node technique of B-spline is used to describe the interruption point, cusp and non-smooth point of the inverse image function. The difference quotient and de Boor algorithm are used to derive the image function of the Lapl ace′s integral under non-uniform partition. And a set of practical formula is got when the partition is quasi-uniform. The scheme enables the image function to be approximated within any prescribed tolerance. Experiments also show that g ood result is achieved. It is much faster than that of Simpsons rule, and much s impler than that of Berge method, the traditional efficient method. It is no lon ger to find the zero points and coefficients of Gauss-Laguerre or Gauss-Legend re polynomials. The image function of Laplace′s integral can also be computed while the inverse image function is hyper-function with high order discontinuity.

AN INTEGRAL ESTIMATE AND THE EQUIVALENT NORMS ON F(p, q, s, k) SPACES IN THE UNIT BALL

In this article, the authors give a typical integral＇s bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F（p, q, s, k） space in theunit ball of Cn are given.

THE HADAMARD INEQUALITY FOR CONVEX FUNCTION VIA FRACTIONAL INTEGRALS

In this paper, we establish several inequalities for some differantiable mappings that are connected with the Riemann-Liouville fractional integrals. The analysis used in the proofs is fairly elementary.

ON THE METHOD OF SOLUTION FOR A KIND OFNONLINEAR SINGULAR INTEGRAL EQUATION

The solutions of the nonlinear singular integral equation , t 6 L, are considered, where L is a closed contour in the complex plane, b ≠ 0 is a constant and f(t) is a polynomial. It is an extension of the results obtained in [1] when f(t) is a constant. Certain special cases are illustrated.

Integral Inequalities of Hermite-Hadamard Type for Functions Whose 3rd Derivatives Are <i>s</i>-Convex

In the paper, the authors find some new inequalities of Hermite-Hadamard type for functions whose third derivatives are s-convex and apply these inequalities to discover inequalities for special means.

The discrete variational principle and the first integrals of Birkhoff systems＊

This paper shows that first integrals of discrete equation of motion for Birkhoff systems can be determined explicitly by investigating the invariance properties of the discrete Pfaffian. The result obtained is a discrete analogue of theorem of Noether in the calculus of variations. An example is given to illustrate the application of the results.

Functional Integrals and Excitation Energy in Three-Band Hubbard Model

The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum are derived. In addition, excitation energy of Fermi fields are calculated under long wave approximation.

A Hilbert-Type Inequality with Some Parameters and the Integral in Whole Plane

In this paper, by introducing some parameters and estimating the weight coefficient, we give a new Hilbert’s inequality with the integral in whole plane and with a non-homogeneous and the equivalent form is given as well. The best constant factor is calculated by the way of Complex Analysis.

The Method of Solutions for some Kinds of Singular Integral Equations of Convolution Type with Both Reflection and Translation Shift

In this paper,some kinds of singular integral equations of convolution type with reflection and translation shift are discussed and they are turned into Riemann boundary value problems with both discontinuous coefficients and reflection by using the Fourier transform.In spite of the classical method for solution,we are to give another method,therefore the general solution and condition of solvability are obtained in class{0}.

EXISTENCE AND UNIQUENESS OF SOLUTIONS FOR NONLINEAR FRACTIONAL DIFFERENTIAL EQUATIONS WITH NON-SEPARATED TYPE INTEGRAL BOUNDARY CONDITIONS

In this paper, we study a boundary value problem of nonlinear fractional dif- ferential equations of order q （1 〈 q 〈 2） with non-separated integral boundary conditions. Some new existence and uniqueness results are obtained by using some standard fixed point theorems and Leray-Schauder degree theory. Some illustrative examples are also presented. We extend previous results even in the integer case q = 2.

Boundedness of singular integrals along surfaces on Lebesgue spaces

In the paper, we establish the LP（Rn＋1）-boundedness for a class of singular integral operators associated to surfaces of revolution {（y,γ（｜y｜）, y ∈ Rn} with rough kernels. We also give several applications of this inequality.

Hermite-Hadamard Type Fractional Integral Inequalities for Preinvex Functions

In this article, we extend some estimates of the right-hand side of the Hermite-Hadamard type inequality for preinvex functions with fractional integral.The notion of logarithmically s-Godunova-Levin-preinvex function in second sense is introduced and then a new Herrnite-Hadarnard inequality is derived for the class of logarithmically s-Godunova-Levin-preinvex function.

Some integral inequalities on time scales

In this article, we study the reverse HSlder type inequality and HSlder inequality in two dimensional case on time scales. We also obtain many integral inequalities by using HSlder inequalities on time scales which give Hardy＇s inequalities as spacial cases.

Precise geoid computation using Stokes-Helmert’s scheme and strict integrals of topographic effects

The high-precision local geoid model was computed based on the improved Stokes-Helmert0 s boundary value problem and strict integrals of topographic effects. This proposed method involves three steps.First, the mathematical form of Stokes-Helmert0 s boundary value problem was derived, and strict computational formulas regarding topographic effects were provided to overcome the disadvantage of planar approximations. Second, a gravimetric geoid model was constructed using the proposed StokesHelmert0 s scheme with a heterogeneous data set. Third, a least squares adjustment method combined with a multi-surface function model was employed to remove the bias between the gravimetric geoid model and the GNSS/leveling data and to refine the final local geoid model. The accuracy of the final geoid model was evaluated using independent GNSS/leveling data. Numerical results show that an external precision of 1.45 cm is achievable.

Continuous solutions for fractional integral inclusion in locally convex topological space

The existence of continuous solutions for fractional integral inclusion via its singlevalued problem and fixed point theorem for set-valued function in locally convex topological spaces is discussed. The proof of the single-valued problem will be based on the Leray- Schauder fixed point theorem. Moreover, the controllability of this solution is studied.

Mixture of a New Integral Transform and Homotopy Perturbation Method for Solving Nonlinear Partial Differential Equations

In this paper, we present a new method, a mixture of homotopy perturbation method and a new integral transform to solve some nonlinear partial differential equations. The proposed method introduces also He’s polynomials [1]. The analytical results of examples are calculated in terms of convergent series with easily computed components [2].