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快速右房起搏制备猪房颤模型及其心肌组织中抗凝血酶测定的研究
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作者 李飞 张卓琦 +2 位作者 张超群 徐晤 王志荣 《山东医药》 CAS 北大核心 2011年第23期1-3,共3页
目的观察快速右房起搏法制备猪房颤(AF)模型的可靠性及AF易并发血栓形成的可能机制。方法将12只健康家猪随机分为模型组和对照组各6只,模型组以闭胸法快速右房起搏建立AF模型并采用程序刺激或Burst刺激进行鉴定,对照组仅植入电极,不予... 目的观察快速右房起搏法制备猪房颤(AF)模型的可靠性及AF易并发血栓形成的可能机制。方法将12只健康家猪随机分为模型组和对照组各6只,模型组以闭胸法快速右房起搏建立AF模型并采用程序刺激或Burst刺激进行鉴定,对照组仅植入电极,不予起搏。两组均于心脏电生理检查结束后迅速开胸取心肌组织,采用双向凝胶电泳分离心肌差异表达蛋白,采用图像分析及质谱法测定抗凝血酶表达情况。结果模型组均成功建立AF模型,且其心肌组织中抗凝血酶表达明显低于对照组(P<0.05)。结论快速右房起搏法制备猪AF模型稳定可靠;AF易并发血栓形成的可能机制为其心肌组织中抗凝血酶表达降低。 展开更多
关键词 双向电泳 质谱分析 心房颤动 快速右房起搏 抗凝血酶
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Transthoracic echo: A sensitive tool for detecting cardiac extension of renal cell carcinoma?
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作者 Michelle Bejarano Yara L Cameron +1 位作者 Theodore C Koutlas Assad Movahed 《World Journal of Clinical Cases》 SCIE 2014年第8期377-379,共3页
Renal cell carcinoma is a common urological malignancy with the unique ability to invade the inferior vena cava(IVC) and to extend into the right atrium of the heart. Of those with Renal cell carcinoma only 4%-25% are... Renal cell carcinoma is a common urological malignancy with the unique ability to invade the inferior vena cava(IVC) and to extend into the right atrium of the heart. Of those with Renal cell carcinoma only 4%-25% are found to have IVC invasion and of those only 2%-10% extend into the right atrium. If treated surgically, extension of tumor thrombus is not a determinant of survival; therefore it is imperative to determine the presence and extent of tumor thrombus in order to determine surgical approach and tumor resection. To date this has been primarily accomplished by magnetic resonance imaging and computed tomography. We present a case of 61 years old African American woman in which transthoracic echocardiography provided a more accurate determination/characterization of the presence and degree of tumor thrombus and extension. 展开更多
关键词 Renal cell carcinoma Tumor THROMBUS CARDIAC EXTENSION right atrial mass
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