BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predi...BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.AIM To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS levels.METHODS This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service.The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography.The patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were explored.RESULTS Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female patients.Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects.In male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total scores.CONCLUSION Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.展开更多
目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院...目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院超声科实习的医学影像专业本科实习生48名为研究对象,随机分为观察组24名学生,对照组24名学生,察组采用PBL、情景教学法联合RIS进行教学,对照组采用传统教学法进行教学,对2组出科考核成绩(理论、操作技能)、问卷调查进行比较。结果观察组的出科成绩理论为(88.24±2.18)分,操作为(84.47±3.49)分,均高于对照组的出科成绩理论(74.48±2.32)分,操作(71.33±3.24)分,差异有统计学意义(P<0.001);观察组满意度为95.83%,对照组满意度为79.17%,差异有统计学意义(P<0.05);观察组83.33%的学生认为PBL教学法+情景教学+RIS激发了学习兴趣,87.50%的学生认为训练了临床思维能力,91.67%的学生认为培养了团队协作能力,83.33%的学生认为提高了沟通能力,而对照组54.17%学生认为传统教学激发了学习兴趣,54.17%的学生认为训练了临床思维能力,45.83%的学生认为培养了团队协作能力,50.00%的学生认为提高了沟通能力,观察组的学习兴趣、学习主动性、团队协作意识、人文关怀意识、沟通能力、理论知识掌握、技能操作熟练程度、临床思维能力方面均优于对照组,差异有统计学意义(P<0.05)。结论PBL、情景学法联合RIS在超声实习教学中不仅有助于提高学生的专业素养,还有助于提高学生的综合素质,能提高教学效果,提升学生对教学的满意度。展开更多
车联网作为未来智慧交通系统中的重要组成部分,对通信和感知的要求也越来越高。通信感知一体化(Integrated Sensing and Communication,ISAC)作为车联网方向极具潜力的一项技术,因可以解决通信场景下的位置感知问题而引起业内的广泛关...车联网作为未来智慧交通系统中的重要组成部分,对通信和感知的要求也越来越高。通信感知一体化(Integrated Sensing and Communication,ISAC)作为车联网方向极具潜力的一项技术,因可以解决通信场景下的位置感知问题而引起业内的广泛关注。由于城市场景中电磁环境更加随机和不可控,使得当前传统的通信系统架构已经无法满足车-路侧单元(Vehicle-to-Infrastructure,V2I)系统中的通信与感知需求。对此,考虑在传统的V2I系统加入智能反射面(Reconfigurable Intelligent Surface,RIS),将其与ISAC技术结合,构建多径场景下新的被动感知模型。深入分析了在新的被动感知模型下,RIS辅助ISAC通信系统的抗多径性能优化。提出一种大尺寸RIS单元优化分组方法,使部分单元参与信号的反射,并将单元优化分组后的大尺寸RIS与相同单元数的小尺寸RIS进行系统性能对比。仿真结果表明,优化设计大尺寸RIS实现了高于小尺寸RIS大约1.5 bit/s的信号传输效率,在提升系统信号传输性能的同时有效地减少了信道的估计开销。展开更多
基金Supported by Shanghai Civil Administration Bureau,No.8-2-50.
文摘BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is uncertain.AIM To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS levels.METHODS This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric service.The plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid chromatography.The patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were explored.RESULTS Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female patients.Age and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 subjects.In male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total scores.CONCLUSION Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.
文摘目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院超声科实习的医学影像专业本科实习生48名为研究对象,随机分为观察组24名学生,对照组24名学生,察组采用PBL、情景教学法联合RIS进行教学,对照组采用传统教学法进行教学,对2组出科考核成绩(理论、操作技能)、问卷调查进行比较。结果观察组的出科成绩理论为(88.24±2.18)分,操作为(84.47±3.49)分,均高于对照组的出科成绩理论(74.48±2.32)分,操作(71.33±3.24)分,差异有统计学意义(P<0.001);观察组满意度为95.83%,对照组满意度为79.17%,差异有统计学意义(P<0.05);观察组83.33%的学生认为PBL教学法+情景教学+RIS激发了学习兴趣,87.50%的学生认为训练了临床思维能力,91.67%的学生认为培养了团队协作能力,83.33%的学生认为提高了沟通能力,而对照组54.17%学生认为传统教学激发了学习兴趣,54.17%的学生认为训练了临床思维能力,45.83%的学生认为培养了团队协作能力,50.00%的学生认为提高了沟通能力,观察组的学习兴趣、学习主动性、团队协作意识、人文关怀意识、沟通能力、理论知识掌握、技能操作熟练程度、临床思维能力方面均优于对照组,差异有统计学意义(P<0.05)。结论PBL、情景学法联合RIS在超声实习教学中不仅有助于提高学生的专业素养,还有助于提高学生的综合素质,能提高教学效果,提升学生对教学的满意度。
