Landslides distribute extensively in Rongxian county, the southeast of Guangxi province, China and pose great threats to this county. At present, hazard management strategy is facing an unprecedented challenge due to ...Landslides distribute extensively in Rongxian county, the southeast of Guangxi province, China and pose great threats to this county. At present, hazard management strategy is facing an unprecedented challenge due to lack of a landslide susceptibility map. Therefore, the purpose of this paper was to construct a landslide susceptibility map by adopting three widely used models based on an integrated understanding of landslide’s characteristics.These models include a semi-quantitative method(SQM), information value model(IVM) and logistical regression model(LRM).The primary results show that(1) the county is classified into four susceptive regions, named as very low, low, moderate and high, which covered an area of 13.43%, 32.40%, 31.19% and 22.99% in SQM, 0.86%, 26.82%, 44.11%, and 28.21% in IVM, 9.88%, 17.73%, 46.36% and 26.03% in LRM;(2) landslides are likely to occur within the areas characterized by following obvious aspects: high intensity of human activities, slope angles of 25°～35°, the thickness of weathered soil is larger than 15 m; the lithology is granite, shale and mud rock;(3) the area under the curve of SQM, IVM and LRM is 0.7151, 0.7688 and 0.7362 respectively, and the corresponding success rate is 71.51%, 76.88% and 73.62%. It is concluded that these three models are acceptable because they have an effective capability of susceptibility assessment and can achieve an expected accuracy. In addition, the susceptibility outcome obtained from IVM provides a slightly higher quality than that from SQM, LRM.展开更多
AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, co...AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, control group and 3 treatment groups (12 rats in each group). Except for the normal control group, all the rats received 1% DMN (10 μL/kg body weight, i.p), 3 times a week for 4 wk. The rats in the 3 treatment groups including a high-dose DMN group (10 mL/kg), a medium-dose DMN group (7 mL/kg), and a low-dose DMN group (4 mL/kg) were daily gavaged with Qianggan-Rongxian Decoction, and the rats in the model and normal control groups were given saline vehicle. Enzyme-linked immunosorbent assay (ELISA) was used to determine the changes in serum hyaluronic acid (HA), laminin (LN), and type IV collagen levels. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured using routine laboratory methods. Pathologic changes, particularly fibrosis, were examined by hematoxylin and eosin (HE) and Sirius red staining. Hepatic stellate cells (HSC) were examined by transmission electron microscopy. RESULTS: Compared with the model control group, the serum levels of HA, LN, type Ⅳ collagen, ALT and AST were decreased markedly in the other groups after treatment with Qianggan-Rongxian Decoction, especially in the medium-dose DMN group (P < 0.05).Moreover, the area-density percentage of collagen fibrosis was lower in the Qianggan-Rongxian Decoction treatment groups than in the model group, and a more significant drop was observed in the medium-dose DMN group (P < 0.05). CONCLUSION: Qianggan-Rongxian Decoction can inhibit hepatic fibrosis due to chronic liver injury, delay the development of cirrhosis, and notably ameliorate liver function. It may be used as a safe and effective thera-peutic drug for patients with fibrosis.展开更多
基金funded by the National Natural Science Foundation of China (No. 51609041)the Natural Scientific Project of Guangxi Zhuang Autonomous Region (No. 2018GXNSFAA138187)+2 种基金the Project of the Education Department of Guangxi Zhuang Autonomous Region (No. 2018KY0027)the Project of Department of Land and Resources of Guangxi Zhuang Autonomous Region (GXZC2018G3-19302-JGYZ)the Project of Xi’an Geological survey center of China Geological survey (DD20189270)
文摘Landslides distribute extensively in Rongxian county, the southeast of Guangxi province, China and pose great threats to this county. At present, hazard management strategy is facing an unprecedented challenge due to lack of a landslide susceptibility map. Therefore, the purpose of this paper was to construct a landslide susceptibility map by adopting three widely used models based on an integrated understanding of landslide’s characteristics.These models include a semi-quantitative method(SQM), information value model(IVM) and logistical regression model(LRM).The primary results show that(1) the county is classified into four susceptive regions, named as very low, low, moderate and high, which covered an area of 13.43%, 32.40%, 31.19% and 22.99% in SQM, 0.86%, 26.82%, 44.11%, and 28.21% in IVM, 9.88%, 17.73%, 46.36% and 26.03% in LRM;(2) landslides are likely to occur within the areas characterized by following obvious aspects: high intensity of human activities, slope angles of 25°～35°, the thickness of weathered soil is larger than 15 m; the lithology is granite, shale and mud rock;(3) the area under the curve of SQM, IVM and LRM is 0.7151, 0.7688 and 0.7362 respectively, and the corresponding success rate is 71.51%, 76.88% and 73.62%. It is concluded that these three models are acceptable because they have an effective capability of susceptibility assessment and can achieve an expected accuracy. In addition, the susceptibility outcome obtained from IVM provides a slightly higher quality than that from SQM, LRM.
基金the Research Program of Department of Scienceand Technology of Hebei Province, No. 200721047
文摘AIM: To study the preventive effects of Qianggan-Rongxian Decoction on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. METHODS: Male Wistar rats were randomly divided into hepatic fibrosis model group, control group and 3 treatment groups (12 rats in each group). Except for the normal control group, all the rats received 1% DMN (10 μL/kg body weight, i.p), 3 times a week for 4 wk. The rats in the 3 treatment groups including a high-dose DMN group (10 mL/kg), a medium-dose DMN group (7 mL/kg), and a low-dose DMN group (4 mL/kg) were daily gavaged with Qianggan-Rongxian Decoction, and the rats in the model and normal control groups were given saline vehicle. Enzyme-linked immunosorbent assay (ELISA) was used to determine the changes in serum hyaluronic acid (HA), laminin (LN), and type IV collagen levels. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured using routine laboratory methods. Pathologic changes, particularly fibrosis, were examined by hematoxylin and eosin (HE) and Sirius red staining. Hepatic stellate cells (HSC) were examined by transmission electron microscopy. RESULTS: Compared with the model control group, the serum levels of HA, LN, type Ⅳ collagen, ALT and AST were decreased markedly in the other groups after treatment with Qianggan-Rongxian Decoction, especially in the medium-dose DMN group (P < 0.05).Moreover, the area-density percentage of collagen fibrosis was lower in the Qianggan-Rongxian Decoction treatment groups than in the model group, and a more significant drop was observed in the medium-dose DMN group (P < 0.05). CONCLUSION: Qianggan-Rongxian Decoction can inhibit hepatic fibrosis due to chronic liver injury, delay the development of cirrhosis, and notably ameliorate liver function. It may be used as a safe and effective thera-peutic drug for patients with fibrosis.
