[Objectives]We intend to conduct a study to predict habitat suitability and geographic distribution of Rubia cordifolia L.,to find the most suitable ecological environment for its growth,and to provide a theoretical b...[Objectives]We intend to conduct a study to predict habitat suitability and geographic distribution of Rubia cordifolia L.,to find the most suitable ecological environment for its growth,and to provide a theoretical basis for the development and cultivation of R.cordifolia L.industry.[Methods]Based on the environmental factors and the occurrence data,we predicted the potential geographic distribution of R.cordifolia L.in China by combining the MaxEnt model and ArcGIS.[Results]The training set and test set AUC were respectively 0.963 and 0.946,indicating that the MaxEnt model predicted well.The wettest monthly precipitation,precipitation in July,precipitation of driest season,and average monthly temperature in September and April were the dominant environmental factors affecting the distribution of R.cordifolia L.The highly habitable areas were mainly concentrated in central,eastern and northern China.[Conclusions]The results of this study can be used as a reference for the development of R.cordifolia L.industry in related areas.展开更多
Qian Cao(Radix et Rhizoma Rubiae)is a perennial grass with red and yellow pigments in its roots.It has been used since ancient times for fabric dyeing and painting,and it’s the oldest red dye in both Europe and China...Qian Cao(Radix et Rhizoma Rubiae)is a perennial grass with red and yellow pigments in its roots.It has been used since ancient times for fabric dyeing and painting,and it’s the oldest red dye in both Europe and China.Xi Yang Qian(Rubia tirctorum L.)spread from the East to the West,while Zhong Guo Qian(Rubia cordifolia L.)spread from the West to the East.Both were integral in the development of Chinese and Western color cultures.Nowadays,although it is no longer commonly used in dyes and paints,Qian Cao is still used in clinical medicine as a medicinal herb.展开更多
Rubia cordifolia L.belongs to Rubiaceae family.Its medicinal parts are mainly root and rhizome,which is included in the Chinese Pharmacopoeia(2020),has the effect of cooling blood and stopping bleeding,removing stasis...Rubia cordifolia L.belongs to Rubiaceae family.Its medicinal parts are mainly root and rhizome,which is included in the Chinese Pharmacopoeia(2020),has the effect of cooling blood and stopping bleeding,removing stasis and channeling menstruation.However,studies on the hemostatic effect of R.cordifolia mainly focus on extracts,and the hemostatic components are less studied.Therefore,chemical constituents and coagulant activity of R.cordifolia were investigated in this paper.Eleven compounds were isolated and identified from R.cordifolia,including 1-hydroxy-2-methyl-9,10-anthraquinone(1),1,4-dihydroxy-2-methylanthraquinone(2),palmitic acid(3),tricosanoic acid(4),ω-hydroxypachybasin(5),ursolic acid(6),oleanolic acid(7),rubilactone(8),β-sitosterol(9),cordifoliol(10),1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone(11).ω-Hydroxypachybasin was isolated from Rubia genus for the first time.1,4-Dihydroxy-2-methylanthraquinone,rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro,thus indicating that they had procoagulant activity.展开更多
Tuberculosis (TB) remains a public health challenge and one of the leading causes of death worldwide. TB is preventable and curable. However, treatment of tuberculosis has continued to be difficult as a result of rapi...Tuberculosis (TB) remains a public health challenge and one of the leading causes of death worldwide. TB is preventable and curable. However, treatment of tuberculosis has continued to be difficult as a result of rapid increase of multidrug and extensively drug resistant strains of Mycobacterium tuberculosis. Medicinal plants have for centuries been traditionally used in treatment of tuberculosis and similar ailments. They possess antimicrobial properties which render them a new hope as a source of novel bioactive leads in the development of antimycobacterial agents. In this study, 2 plant species commonly used traditionally in Uganda for treatment of tuberculosis, Zanthoxylum leprieurii and Rubia cordifolia were screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis strains;pan sensitive MTB H37Rv, Rifampicin resistant TMC 331 strain and two wild strains (one rifampicin resistant and another one rifampicin susceptible). Antimycobacterial activity of aqueous, ethanolic and methanolic plant extracts was determined using Resazurin Microtiter Assay (REMA). Both plant extracts exhibited significant in vitro antimycobacterial activity against all strains of Mycobacterium tuberculosis. Minimum inhibitory concentrations (MIC) of methanolic crude extracts of both plants ranged from 23.4 μg/mL to 187.5 μg/mL. Comparatively, methanol extracts of both plants possessed superior antimycobacterial activity against all Mycobacterium tuberculosis strains. Our findings indicated that both plants exhibited activity against susceptible and resistant strains of Mycobacterium tuberculosis. While antimycobacterial activity of Z. leprieurii confirms results from previous studies, activity of the extracts of R. cordifolia is reported for the first time in East Africa. Further studies aimed at determining the effects of combination of these plant extracts and standard anti-TB drugs should be carried out.展开更多
OBJECTIVE: To investigate the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding(AUB) in rat...OBJECTIVE: To investigate the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding(AUB) in rats with incomplete abortion, and to study the possible mechanism. METHODS: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) were observed. RESULTS: Statistical analysis revealed that the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) to treat AUB in this study was 2∶1. CONCLUSION: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) on AUB.展开更多
文摘[Objectives]We intend to conduct a study to predict habitat suitability and geographic distribution of Rubia cordifolia L.,to find the most suitable ecological environment for its growth,and to provide a theoretical basis for the development and cultivation of R.cordifolia L.industry.[Methods]Based on the environmental factors and the occurrence data,we predicted the potential geographic distribution of R.cordifolia L.in China by combining the MaxEnt model and ArcGIS.[Results]The training set and test set AUC were respectively 0.963 and 0.946,indicating that the MaxEnt model predicted well.The wettest monthly precipitation,precipitation in July,precipitation of driest season,and average monthly temperature in September and April were the dominant environmental factors affecting the distribution of R.cordifolia L.The highly habitable areas were mainly concentrated in central,eastern and northern China.[Conclusions]The results of this study can be used as a reference for the development of R.cordifolia L.industry in related areas.
基金This study was financed by the grant from the National Social Science Fund of China(No.18BG126).
文摘Qian Cao(Radix et Rhizoma Rubiae)is a perennial grass with red and yellow pigments in its roots.It has been used since ancient times for fabric dyeing and painting,and it’s the oldest red dye in both Europe and China.Xi Yang Qian(Rubia tirctorum L.)spread from the East to the West,while Zhong Guo Qian(Rubia cordifolia L.)spread from the West to the East.Both were integral in the development of Chinese and Western color cultures.Nowadays,although it is no longer commonly used in dyes and paints,Qian Cao is still used in clinical medicine as a medicinal herb.
基金This work was supported by Research on Precision Nutrition and Health Food,Department of Science and Technology of Henan Province(CXJD2021006)Science and Technology Development Program of Henan Province(212102310354)Key Scientific Research Projects of Higher Education Institutions in Henan Province(21B360001).
文摘Rubia cordifolia L.belongs to Rubiaceae family.Its medicinal parts are mainly root and rhizome,which is included in the Chinese Pharmacopoeia(2020),has the effect of cooling blood and stopping bleeding,removing stasis and channeling menstruation.However,studies on the hemostatic effect of R.cordifolia mainly focus on extracts,and the hemostatic components are less studied.Therefore,chemical constituents and coagulant activity of R.cordifolia were investigated in this paper.Eleven compounds were isolated and identified from R.cordifolia,including 1-hydroxy-2-methyl-9,10-anthraquinone(1),1,4-dihydroxy-2-methylanthraquinone(2),palmitic acid(3),tricosanoic acid(4),ω-hydroxypachybasin(5),ursolic acid(6),oleanolic acid(7),rubilactone(8),β-sitosterol(9),cordifoliol(10),1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone(11).ω-Hydroxypachybasin was isolated from Rubia genus for the first time.1,4-Dihydroxy-2-methylanthraquinone,rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro,thus indicating that they had procoagulant activity.
文摘Tuberculosis (TB) remains a public health challenge and one of the leading causes of death worldwide. TB is preventable and curable. However, treatment of tuberculosis has continued to be difficult as a result of rapid increase of multidrug and extensively drug resistant strains of Mycobacterium tuberculosis. Medicinal plants have for centuries been traditionally used in treatment of tuberculosis and similar ailments. They possess antimicrobial properties which render them a new hope as a source of novel bioactive leads in the development of antimycobacterial agents. In this study, 2 plant species commonly used traditionally in Uganda for treatment of tuberculosis, Zanthoxylum leprieurii and Rubia cordifolia were screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis strains;pan sensitive MTB H37Rv, Rifampicin resistant TMC 331 strain and two wild strains (one rifampicin resistant and another one rifampicin susceptible). Antimycobacterial activity of aqueous, ethanolic and methanolic plant extracts was determined using Resazurin Microtiter Assay (REMA). Both plant extracts exhibited significant in vitro antimycobacterial activity against all strains of Mycobacterium tuberculosis. Minimum inhibitory concentrations (MIC) of methanolic crude extracts of both plants ranged from 23.4 μg/mL to 187.5 μg/mL. Comparatively, methanol extracts of both plants possessed superior antimycobacterial activity against all Mycobacterium tuberculosis strains. Our findings indicated that both plants exhibited activity against susceptible and resistant strains of Mycobacterium tuberculosis. While antimycobacterial activity of Z. leprieurii confirms results from previous studies, activity of the extracts of R. cordifolia is reported for the first time in East Africa. Further studies aimed at determining the effects of combination of these plant extracts and standard anti-TB drugs should be carried out.
文摘OBJECTIVE: To investigate the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) used to produce decoction for the treatment of abnormal uterine bleeding(AUB) in rats with incomplete abortion, and to study the possible mechanism. METHODS: The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) were observed. RESULTS: Statistical analysis revealed that the most effective weight ratio of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) to treat AUB in this study was 2∶1. CONCLUSION: The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao(Radix Rubiae Cordifoliae) and Haipiaoxiao(Endoconcha Sepiellae) on AUB.
