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Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds 被引量:1
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作者 Moraes Fabricio Tarso Galvão Anderson Dourado +6 位作者 Fortaleza Dário Batista Amorin Kelly Aparecida da Encarnação Sousa Claudia Cristina Honorio-França Adenilda Cristina França Eduardo Luzia Costa Daniel Tizo Santos Wagner Batista 《Advances in Biological Chemistry》 2020年第3期86-98,共13页
<span style="font-family:Verdana;">To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl</span>&... <span style="font-family:Verdana;">To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl</span><sub><span style="font-family:Verdana;">4</span></sub><span style="font-family:Verdana;">(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru</span><sup><span style="font-family:Verdana;">+3</span></sup><span style="font-family:Verdana;"> with bipy and L-trip. The spectroscopic characterization in the mi</span><span style="font-family:Verdana;">ddle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for</span><span><span style="font-family:Verdana;"> higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">(bipy)(L-trip)]1/2H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O. Evaluation of the</span></span><span><span style="font-family:Verdana;"> antitumor potential of precursor K[RuCl</span><sub><span style="font-family:Verdana;">4</span></sub><span style="font-family:Verdana;">(bipy)] showed the toxic effects on MCF-7 cell line, but </span></span><span style="font-family:Verdana;">did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.</span> 展开更多
关键词 ruthenium compounds Pyridine Ligands Antitumor Activity Tryptophan Amino Acid MCF-7 Cells Ligand N-Heterocyclic
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Synthesis and electrochemical and spectroscopic studies of a N,N,N',N'- tetraphenylbenzidine-bridged bis(2,2'-bipyridine) ligand and diruthenium complex
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作者 Jun Feng Jiang-Yang Shao +2 位作者 Hai-Jing Nie Zhong-Liang Gong Yu-Wu Zhong 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第3期385-389,共5页
A N,N,N',N'-tetraphenylbenzidine-bridged bis(2,2'-bipyridine) ligand and corresponding diruthenium complexes were synthesized and characterized. They show rich multistep redox processes due to the stepwise oxidat... A N,N,N',N'-tetraphenylbenzidine-bridged bis(2,2'-bipyridine) ligand and corresponding diruthenium complexes were synthesized and characterized. They show rich multistep redox processes due to the stepwise oxidations of the amine units and ruthenium components. Their absorption and emission spectral changes in response to electrochemical stimulus were examined by spectroelectrochemical measurements. DFT and TDDFF calculations were performed to complement the experimental results. 展开更多
关键词 ruthenium Spectroelectrochemistry Electrochromism Redox-active compounds Bipyridine
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Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes 被引量:2
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作者 Sreekanth Thota Srujana Vallala +1 位作者 Rajeshwar Yerra Eliezer J.Barreiro 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第6期721-726,共6页
Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biologic... Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium(ll) arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium(ll) arene compounds has been evaluated in several cell lines (Molt 4/C8, LI 210, CEM, HL60 and BEL7402). Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range. 展开更多
关键词 Cytotoxic Ligand ruthenium compounds Structure activity relationships
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