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Effects of a Cocktail Supplement of Ginkgo Biloba and Acai Extract on Cognitive Symptoms of Parkinson’s Disease
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作者 Yulia Dubrovensky 《Advances in Parkinson's Disease》 CAS 2024年第3期57-72,共16页
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects a... Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal Cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767). 展开更多
关键词 Parkinson’s Disease (PD) Cognitive Function Ginkgo Biloba Acai Extract neurodegenerative disorders Natural Supplements Cognitive Symptoms Montreal Cognitive Assessment (MoCA) Dopaminergic Neurons Antioxidants Neuroprotection Non-Motor Symptoms oxidative stress POLYPHENOLS
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芦丁对神经细胞氧化损伤的保护作用 被引量:11
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作者 张浪 赖永长 +3 位作者 汪海涛 王日康 孟茜 郑文华 《中药材》 CAS CSCD 北大核心 2014年第4期640-644,共5页
目的:考察芦丁(RUT)对硝普钠(sodium nitroprusside,SNP)致神经细胞损伤的保护作用,并探讨其作用的信号通路。方法:通过不同剂量SNP处理PC12细胞,建立细胞损伤模型;采用噻唑蓝(MTT)法考察RUT对细胞存活的影响;以Hoechst Stain、PI Stai... 目的:考察芦丁(RUT)对硝普钠(sodium nitroprusside,SNP)致神经细胞损伤的保护作用,并探讨其作用的信号通路。方法:通过不同剂量SNP处理PC12细胞,建立细胞损伤模型;采用噻唑蓝(MTT)法考察RUT对细胞存活的影响;以Hoechst Stain、PI Stain观察细胞形态;以蛋白印迹(Western blot)检测细胞外调节蛋白激酶(ERK1/2)磷酸化水平;在原代皮质神经元上验证RUT的神经保护作用。结果:MTT结果显示SNP能剂量依赖性地降低PC12细胞的存活,25μg/mL的RUT能显著增加SNP(800μmol/L)处理后PC12细胞的存活率(P<0.05)。Hoechst Stain、PI Stain证实RUT能显著减少PC12细胞的死亡。Western blot结果显示RUT能显著促进ERK1/2的磷酸化,在皮质神经元上也证实了RUT的保护作用。结论:RUT对SNP诱导神经细胞损伤具有显著的保护作用,其神经保护作用可能是通过ERK1/2信号通路介导的。 展开更多
关键词 芦丁 氧化应激 神经元损伤 神经退行性疾病
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