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O-(β-hydroxyethyl)rutosides determination by micellar flow injection(FI)-spectrofluorimetry
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作者 Cecilia Mariana Peralta Liliana Patricia Fernndez 《Journal of Pharmaceutical Analysis》 SCIE CAS 2014年第6期368-373,共6页
A simple,eco-friendly.sensitive and economic flow injection spectrofluorimetric method was developed for the determination of O-(β-hydroxyethyl)rutosidcs.The procedure was based on the use of an anionic surfactant ... A simple,eco-friendly.sensitive and economic flow injection spectrofluorimetric method was developed for the determination of O-(β-hydroxyethyl)rutosidcs.The procedure was based on the use of an anionic surfactant such as sodium dodecyl sulfate to provide an appreciable O-(β-hydroxyethyl)rutosides fluorescence enhancement,increasing considerably the sensitivity of detection.All the variables affecting the fluorescence intensity were studied and optimized.The flow rate was 5 mL/min with detection at 450 nm(after excitation at 346 nm).A linear correlation between drug amount and peak area was established for 0-(β-hydroxyethyl)rulosides in the range of 0.01-200 μg/mL with a detection limit of0.001 μg/mL(s/n = 3).Validation processes were performed by recovering studies with satisfactory results.The new methodology can be employed for the routine analysis of 0-(P-hydroxyethyl)rutosides in bulks as well as in commercial formulations. 展开更多
关键词 O-(β-hydroxyethyl)rutosides Micellar enhancement Flow injection SPECTROFLUORIMETRY Pharmaceuticals
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