Objective: To investigate the time course of serum S-100 concentrations of patients with acute cerebral infarction,and their relation with the clinical data and the prognosis. Methods: Serum S-100 levels were serially...Objective: To investigate the time course of serum S-100 concentrations of patients with acute cerebral infarction,and their relation with the clinical data and the prognosis. Methods: Serum S-100 levels were serially determined in 36 patients with acute cerebral infarction within 12 h, at 24 h and day 2, 3, 4, 5, 7 and 10 after acute cerebral infarction and in 20 age- and sex-matched control subjects. An S-100 content assay was performed using a two-site radioimmunoassay technique. The clinical status was assessed using NIH Stroke Scale. The functional deficit at 4 weeks after acute cerebral infarction was scored using the modified Rankin scale. A cranial computed tomography was performed initially. Results: Elevated concentrations of S-100 (>0.2 μg/L) were observed in 29 of 36 patients with acute cerebral infarction,but none of the control subjects. The S-100 peak levels were at day 2 and 3 after acute cerebral infarction and were significantly high in those patients with severe neurological deficit at admission, with extensive infarction or with space-occupying effect of ischemic edema as compared with the rest of the populations. Conclusion: Serum S-100 level assay can be used as a peripheral marker of ischemic brain damage, and may be helpful for evaluation of therapeutic effects in acute ischemic stroke.展开更多
Objective Primary malignant melanomas of the liver are exceedingly rare.Only 19 cases have been reported in the literature worldwide.In this report,we describe our pathological findings and review the literature in or...Objective Primary malignant melanomas of the liver are exceedingly rare.Only 19 cases have been reported in the literature worldwide.In this report,we describe our pathological findings and review the literature in order to improve our understanding of the disease and prevent misdiagnosis,as well as provide evidence for its treatment and prognosis.Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence of a primary cutaneous or ocular lesion.Similarly,serial physical examinations,auxiliary examinations,and bone scans did not demonstrate any other lesions in the brain,respiratory tract,and gastrointestinal tract.Microscopic examination of the resected specimen revealed malignant melanoma,which was confirmed by immunohistochemical staining for S-100 protein(+),ki67(30%+),EMA(+),CD10(+),and HMB-45(++).Conclusion Primary malignant melanoma may occur in the liver,and should be considered when the histopathological appearance is atypical of other hepatic neoplasms.The diagnostic criteria for hepatic malignant melanoma depend mainly on the clinical,radiographic,and histopathological findings.Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis.展开更多
文摘Objective: To investigate the time course of serum S-100 concentrations of patients with acute cerebral infarction,and their relation with the clinical data and the prognosis. Methods: Serum S-100 levels were serially determined in 36 patients with acute cerebral infarction within 12 h, at 24 h and day 2, 3, 4, 5, 7 and 10 after acute cerebral infarction and in 20 age- and sex-matched control subjects. An S-100 content assay was performed using a two-site radioimmunoassay technique. The clinical status was assessed using NIH Stroke Scale. The functional deficit at 4 weeks after acute cerebral infarction was scored using the modified Rankin scale. A cranial computed tomography was performed initially. Results: Elevated concentrations of S-100 (>0.2 μg/L) were observed in 29 of 36 patients with acute cerebral infarction,but none of the control subjects. The S-100 peak levels were at day 2 and 3 after acute cerebral infarction and were significantly high in those patients with severe neurological deficit at admission, with extensive infarction or with space-occupying effect of ischemic edema as compared with the rest of the populations. Conclusion: Serum S-100 level assay can be used as a peripheral marker of ischemic brain damage, and may be helpful for evaluation of therapeutic effects in acute ischemic stroke.
文摘Objective Primary malignant melanomas of the liver are exceedingly rare.Only 19 cases have been reported in the literature worldwide.In this report,we describe our pathological findings and review the literature in order to improve our understanding of the disease and prevent misdiagnosis,as well as provide evidence for its treatment and prognosis.Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence of a primary cutaneous or ocular lesion.Similarly,serial physical examinations,auxiliary examinations,and bone scans did not demonstrate any other lesions in the brain,respiratory tract,and gastrointestinal tract.Microscopic examination of the resected specimen revealed malignant melanoma,which was confirmed by immunohistochemical staining for S-100 protein(+),ki67(30%+),EMA(+),CD10(+),and HMB-45(++).Conclusion Primary malignant melanoma may occur in the liver,and should be considered when the histopathological appearance is atypical of other hepatic neoplasms.The diagnostic criteria for hepatic malignant melanoma depend mainly on the clinical,radiographic,and histopathological findings.Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis.
