Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects ...Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.展开更多
BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation...BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.展开更多
The Voice over Internet Protocol (VoIP) network greatly saves the communication expanses for enterprises. This paper introduces ZXR10 General Access Router (GAR), the VoIP equipment developed by ZTE Corporation, and i...The Voice over Internet Protocol (VoIP) network greatly saves the communication expanses for enterprises. This paper introduces ZXR10 General Access Router (GAR), the VoIP equipment developed by ZTE Corporation, and its technical advantages. Moreover, it discusses three ZXR10-based VoIP solutions for different scale enterprises.展开更多
Foreign trade enterprises in China are now reviving up their efforts in transforming their foreign trade operational mechanism in line with the requirements of a socialist market economic structure, and State enterpri...Foreign trade enterprises in China are now reviving up their efforts in transforming their foreign trade operational mechanism in line with the requirements of a socialist market economic structure, and State enterprises are being restructured into modern enterprises. Over the past few years, Chinese foreign trade enterprises have undergone progressively deepening reform, changing from carrying out State mandatory planning during the early days of reform into self-governing and profit-展开更多
The mother-in-law and daughter-in-law effect is a widely existing contradiction effect in the family.Analyzing the causes and countermeasures of labor-capital contradiction in enterprise from the perspective of mother...The mother-in-law and daughter-in-law effect is a widely existing contradiction effect in the family.Analyzing the causes and countermeasures of labor-capital contradiction in enterprise from the perspective of mother-in-law and daughter-in-law effect has innovative value inspired by prototype.The mother-in-law and daughter-in-law effect means that although the harmony of the family is beneficial to both mother-in-law and daughter-in-law,the unequal relationship between mother-in-law and daughter-in-law,the gradual awakening of daughter-in-law’s power consciousness,the lack of effective communication between mother-in-law and daughter-in-law,the husband’s favoritism and other reasons produce the phenomenon of“differentiated behavior”or“mutual distrust”between mother-in-law and daughter-in-law,which makes the family contradictions accumulate continuously.Through the method of literature research,this research finds that the causes of mother-in-law and daughter-in-law effect and labor-capital contradiction in enterprise are highly similar.The solution of the mother-in-law and daughter-in-law effect,which has been continuously proved in thousands of households,can be used to analyze the countermeasures and suggestions of the labor-capital contradiction in enterprise.This article analyzes the national and provincial statistical yearbooks,the strategic thinking of the ancient classics Sun Tzu’s Art of War and Sun Bin's Art of War,and modern well-known enterprises’methods of solving labor-capital contradiction in enterprise.It provides a basis for the argument of this article and focuses on analyzing and solving labor-capital contradiction in enterprise.It has the innovative value of combining ancient and modern.展开更多
Jiangsu Suntory Food Co. Ltd.The company was established by jointinvestment from the China International TrustInvestment Corporation, the Jiangsu ProvincialInternational Trust Investment Corporation,
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1605000)National Natural Science Foundation of China(Grant No.31871806)the Beijing Livestock Industry Innovation Team(BAIC05-2023)。
文摘Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.
基金Supported by the National Natural Science Foundation of China,No.3206080019 and No.32060182Science and Technology Support Plan of Guizhou Province in China,No.[2020]4Y129Qiannan Prefecture Science and Technology Plan Project,No.[2022]01.
文摘BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.
文摘The Voice over Internet Protocol (VoIP) network greatly saves the communication expanses for enterprises. This paper introduces ZXR10 General Access Router (GAR), the VoIP equipment developed by ZTE Corporation, and its technical advantages. Moreover, it discusses three ZXR10-based VoIP solutions for different scale enterprises.
文摘Foreign trade enterprises in China are now reviving up their efforts in transforming their foreign trade operational mechanism in line with the requirements of a socialist market economic structure, and State enterprises are being restructured into modern enterprises. Over the past few years, Chinese foreign trade enterprises have undergone progressively deepening reform, changing from carrying out State mandatory planning during the early days of reform into self-governing and profit-
文摘The mother-in-law and daughter-in-law effect is a widely existing contradiction effect in the family.Analyzing the causes and countermeasures of labor-capital contradiction in enterprise from the perspective of mother-in-law and daughter-in-law effect has innovative value inspired by prototype.The mother-in-law and daughter-in-law effect means that although the harmony of the family is beneficial to both mother-in-law and daughter-in-law,the unequal relationship between mother-in-law and daughter-in-law,the gradual awakening of daughter-in-law’s power consciousness,the lack of effective communication between mother-in-law and daughter-in-law,the husband’s favoritism and other reasons produce the phenomenon of“differentiated behavior”or“mutual distrust”between mother-in-law and daughter-in-law,which makes the family contradictions accumulate continuously.Through the method of literature research,this research finds that the causes of mother-in-law and daughter-in-law effect and labor-capital contradiction in enterprise are highly similar.The solution of the mother-in-law and daughter-in-law effect,which has been continuously proved in thousands of households,can be used to analyze the countermeasures and suggestions of the labor-capital contradiction in enterprise.This article analyzes the national and provincial statistical yearbooks,the strategic thinking of the ancient classics Sun Tzu’s Art of War and Sun Bin's Art of War,and modern well-known enterprises’methods of solving labor-capital contradiction in enterprise.It provides a basis for the argument of this article and focuses on analyzing and solving labor-capital contradiction in enterprise.It has the innovative value of combining ancient and modern.
文摘Jiangsu Suntory Food Co. Ltd.The company was established by jointinvestment from the China International TrustInvestment Corporation, the Jiangsu ProvincialInternational Trust Investment Corporation,
