The fifth intergovernmental negotiations on marine BBNJ(Biodiversity beyond Areas of National Jurisdiction)concluded in August 2022,in which there are still major differences regarding access to marine genetic resourc...The fifth intergovernmental negotiations on marine BBNJ(Biodiversity beyond Areas of National Jurisdiction)concluded in August 2022,in which there are still major differences regarding access to marine genetic resources,management,and technology transfer.China’s participation in the development of marine genetic resources in ABNJ(areas beyond national jurisdiction)has many dilemmas,which are linked to the difficulties faced in advancing the BBNJ negotiations.The following countermeasures are proposed at the institutional and practical levels respectively:clarifying the legal attributes and applicability of the principles of marine genetic resources;establishing mechanisms for access,management,environmental impact assessment and benefit sharing of marine genetic resources;and using the“Blue Partnership”to build a governance mechanism for marine genetic resources to achieve mutual benefits.展开更多
Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects ...Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.展开更多
BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation...BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.展开更多
With the rapid development of modern society,the protection and inheritance of traditional culture are becoming increasingly important.As a part of Chinese traditional culture,Tongyu New Year’s Paintings,with their u...With the rapid development of modern society,the protection and inheritance of traditional culture are becoming increasingly important.As a part of Chinese traditional culture,Tongyu New Year’s Paintings,with their unique artistic style and rich cultural connotation,have become an excellent resource for exploring the beauty of tradition and inspiring creativity.Based on this,LH Kindergarten in Baicheng City,Jilin Province,has utilized Tongyu New Year’s Paintings as a curriculum resource to develop a school-based curriculum,“The Beauty of Tongyu New Year’s Paintings:Artistic Exploration for Teachers and Children.”Through diversified learning styles,teachers and children will learn about the history of New Year’s paintings,incorporate certain features of the paintings into their art activities,and cultivate creativity and the spirit of teamwork,so as to pass on the precious essence of traditional culture to children and carry forward the spirit of teamwork in their hearts.This program will lead children to experience the treasures of traditional culture and the rich connotations behind Chinese New Year’s paintings,laying a solid foundation for their growth and lifelong learning.展开更多
BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-re...BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil.展开更多
Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21...Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.展开更多
This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and n...This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.展开更多
Focusing on the region of Yarlung Zangbo River and the middle reaches of itstwo tributaries of Nianchu River and Lhasa River in Tibet (Hereafter referred to as the 'One Riverand Two Tributaries' region), and b...Focusing on the region of Yarlung Zangbo River and the middle reaches of itstwo tributaries of Nianchu River and Lhasa River in Tibet (Hereafter referred to as the 'One Riverand Two Tributaries' region), and based on the data from China 3rd, 4th and5th population censuses,the article has analyzed change patterns of this region' s labor force. Major findings from thestudy are summarized as follows; (1) Compared with the data from the 3rd census, labor forcepopulation in 2000 has increased significantly. (2) Children dependency coefficient has dropped,while old people dependency coefficient has changed very slightly with an increase of 0. 047% only.(3) Compared 2000 with 1982, illiteracy and semi-illiteracy rate of the population above 15 yearsold have decreased significantly by 30. 69 percentage points, but still higher than the nationalaverage. (4) Women' s illiteracy rate has dropped faster than men's, but up to 2000 it was generallyquite high. The upgrading of the entire population's overall quality has a long way to go.展开更多
Graphite is a rare and important nonmetallic mineral. Till 2017, the global graphite resource reserves had exceeded one billion tons, which are mainly distributed in China (0.45 billion tons), Mozambique (0.14 bill...Graphite is a rare and important nonmetallic mineral. Till 2017, the global graphite resource reserves had exceeded one billion tons, which are mainly distributed in China (0.45 billion tons), Mozambique (0.14 billion tons), Madagascar (0.1 billion tons), Turkey (0.09 billion tons), Brazil (0.07 billion tons), and Tanzania (0.07 billion tons). These six countries include about 92% of the global graphite resource reserves, of which China accounts for about 45% of the world's total resource reserves.展开更多
文摘The fifth intergovernmental negotiations on marine BBNJ(Biodiversity beyond Areas of National Jurisdiction)concluded in August 2022,in which there are still major differences regarding access to marine genetic resources,management,and technology transfer.China’s participation in the development of marine genetic resources in ABNJ(areas beyond national jurisdiction)has many dilemmas,which are linked to the difficulties faced in advancing the BBNJ negotiations.The following countermeasures are proposed at the institutional and practical levels respectively:clarifying the legal attributes and applicability of the principles of marine genetic resources;establishing mechanisms for access,management,environmental impact assessment and benefit sharing of marine genetic resources;and using the“Blue Partnership”to build a governance mechanism for marine genetic resources to achieve mutual benefits.
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1605000)National Natural Science Foundation of China(Grant No.31871806)the Beijing Livestock Industry Innovation Team(BAIC05-2023)。
文摘Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.
基金Supported by the National Natural Science Foundation of China,No.3206080019 and No.32060182Science and Technology Support Plan of Guizhou Province in China,No.[2020]4Y129Qiannan Prefecture Science and Technology Plan Project,No.[2022]01.
文摘BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.
基金This paper is a stage result of the research of“Tongyu New Year’s Paintings Inheritance and Development Based on the Cultivation of Art Literacy of Early Childhood Teachers”(Project number:GH23649),which is a 2023 project of the 14th Five-Year Plan of Educational Science in Jilin Province.
文摘With the rapid development of modern society,the protection and inheritance of traditional culture are becoming increasingly important.As a part of Chinese traditional culture,Tongyu New Year’s Paintings,with their unique artistic style and rich cultural connotation,have become an excellent resource for exploring the beauty of tradition and inspiring creativity.Based on this,LH Kindergarten in Baicheng City,Jilin Province,has utilized Tongyu New Year’s Paintings as a curriculum resource to develop a school-based curriculum,“The Beauty of Tongyu New Year’s Paintings:Artistic Exploration for Teachers and Children.”Through diversified learning styles,teachers and children will learn about the history of New Year’s paintings,incorporate certain features of the paintings into their art activities,and cultivate creativity and the spirit of teamwork,so as to pass on the precious essence of traditional culture to children and carry forward the spirit of teamwork in their hearts.This program will lead children to experience the treasures of traditional culture and the rich connotations behind Chinese New Year’s paintings,laying a solid foundation for their growth and lifelong learning.
文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil.
文摘Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.
文摘This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.
文摘Focusing on the region of Yarlung Zangbo River and the middle reaches of itstwo tributaries of Nianchu River and Lhasa River in Tibet (Hereafter referred to as the 'One Riverand Two Tributaries' region), and based on the data from China 3rd, 4th and5th population censuses,the article has analyzed change patterns of this region' s labor force. Major findings from thestudy are summarized as follows; (1) Compared with the data from the 3rd census, labor forcepopulation in 2000 has increased significantly. (2) Children dependency coefficient has dropped,while old people dependency coefficient has changed very slightly with an increase of 0. 047% only.(3) Compared 2000 with 1982, illiteracy and semi-illiteracy rate of the population above 15 yearsold have decreased significantly by 30. 69 percentage points, but still higher than the nationalaverage. (4) Women' s illiteracy rate has dropped faster than men's, but up to 2000 it was generallyquite high. The upgrading of the entire population's overall quality has a long way to go.
文摘Graphite is a rare and important nonmetallic mineral. Till 2017, the global graphite resource reserves had exceeded one billion tons, which are mainly distributed in China (0.45 billion tons), Mozambique (0.14 billion tons), Madagascar (0.1 billion tons), Turkey (0.09 billion tons), Brazil (0.07 billion tons), and Tanzania (0.07 billion tons). These six countries include about 92% of the global graphite resource reserves, of which China accounts for about 45% of the world's total resource reserves.