An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
Using over 3 500 first P arrival times recorded by nine digital seismic stations from Hainan Digital Seismic Net-work during 1999～2005,a 3-D P-wave velocity model of the crust under Hainan Island and adjacent regions...Using over 3 500 first P arrival times recorded by nine digital seismic stations from Hainan Digital Seismic Net-work during 1999～2005,a 3-D P-wave velocity model of the crust under Hainan Island and adjacent regions has been determined. The results show that the pattern of velocity anomalies in the shallower upper crust is somewhat associated with the surface geological tectonics in the region. A relative low-velocity anomaly appears north of the Wangwu-Wenjiao fault zone and a relative high-velocity anomaly appears south of the Wangwu-Wenjiao fault zone,corresponding to the depressed areas in north Hainan Island,where many volcanoes are frequently active and geothermal values are relatively higher,and the uplifted and stable regions in central and south of the Hainan Is-land. In the middle and lower crust velocities are relatively lower in east Hainan than those in west Hainan,possi-bly suggesting the existence of the upwelling of hot materials from the mantle in east Hainan. The pattern of veloc-ity anomalies also indicates that NW faults,i.e.,the Puqian-Qinglan fault,may be shallower,while the E-W Wangwu-Wenjiao fault may be deeper,which perhaps extends down to Moho depth or deeper.展开更多
Effective teaching is every teacher's teaching goal.How to reach the aim is to reflect on the teaching.The following document describes the development on how to reflect the teaching.The main purpose of this analy...Effective teaching is every teacher's teaching goal.How to reach the aim is to reflect on the teaching.The following document describes the development on how to reflect the teaching.The main purpose of this analysis is to show how effective and important the reflection on the teaching and to show how useful the reflection which can make the teacher change the way of teaching,encouraging the students to adopt a deep approach in their learning.展开更多
This paper is about a reflective practice happened in the author' s College English teaching.Since 2005,a 5-minute oral-presentation was required for all the students in turn,in order to raise opportunities for th...This paper is about a reflective practice happened in the author' s College English teaching.Since 2005,a 5-minute oral-presentation was required for all the students in turn,in order to raise opportunities for them to practice oral English.But the students' responses were always disappointing since they only took the task as a burden.After the teacher lift the limits on presentation time,form,sequence,partner,etc.,better learning outcomes were achieved.When reflecting on this change,Biggs'3P Models of "constructive alignment" is taken into account.Any teaching and learning activity (TLA) cannot put the students' and the teacher' s presage aside since the students' ability,interests,motivation as well as the teacher' s objective,assessment approach and so on are co-determinants of a successful TLA.Further suggestions are given based on this reflection at the end of the paper.展开更多
Background:The role of autophagy in the formation of hypertrophic scars(HS)remains unclear.This study aimed to explore the role and potential mechanism of autophagy during the development of HS.Methods:RNA and protein...Background:The role of autophagy in the formation of hypertrophic scars(HS)remains unclear.This study aimed to explore the role and potential mechanism of autophagy during the development of HS.Methods:RNA and protein expression levels of Beclin-1,p62,and LC3II in normal skin tissues and HS specimens from different patients were examined.Autophagy inducers and inhibitors were used to cure established HS in rabbit ears,and the expression of Beclin-1,p62,and LC3II at the RNA and protein level was determined.Lastly,the effects of autophagy inducers and inhibitors on HS development were analyzed.Results:Compared to normal skin tissues,the expression of LC3II and Beclin-1 was higher(P<0.05),while that of p62 was lower(P<0.05)in HS tissues.In addition,the LC3II/LC3I ratio was increased during HS formation,and the altered expression of the three proteins stabilized after one year.Administration of autophagy inducers enhanced the formation of HS as well as the expression levels of LC3II and Beclin-1 but decreased p62 expression.Meanwhile,administration of autophagy inhibitors increased the expression of LC3II,Beclin-1,and p62,along with reduced HS formation.Conclusion:Autophagic activity increased during HS initiation and subsequent stabilization.In addition,autophagy inhibitors were able to inhibit HS formation by suppressing autophagy,whereas autophagy inducers promoted scar hyperplasia by enhancing autophagy。展开更多
The first three-fold and four-fold fragmentation measurements in hot compound nuclei pro-duced in the reactions of a 25 MeV/u <sup>40</sup>At beam with targets of <sup>209</sup>Bi,<sup>19...The first three-fold and four-fold fragmentation measurements in hot compound nuclei pro-duced in the reactions of a 25 MeV/u <sup>40</sup>At beam with targets of <sup>209</sup>Bi,<sup>197</sup>Au,<sup>159</sup>Tb,<sup>115</sup>In,<sup>103</sup>Rh,and<sup>93</sup>Nb are presented.Various distributions are measured for these fragments,including distributions of ve-locities,relative velocities,angles,relative angles,masses,fragment mass ratios,total kinetic energies（TKE）,as well as the yield ratios of three-fold fragmentation to fission P<sub>32</sub> and the time difference △t be-tween two scissions after the formation of one compound nucleus.展开更多
Background: Breast cancer patients who are positive for hormone receptor typically exhibit a favorable prognosis. It is controversial whether chemotherapy is necessary for them after surgery. Our study aimed to establ...Background: Breast cancer patients who are positive for hormone receptor typically exhibit a favorable prognosis. It is controversial whether chemotherapy is necessary for them after surgery. Our study aimed to establish a multigene model to predict the relapse of hormone receptor-positive early-stage Chinese breast cancer after surgery and direct individualized application of chemotherapy in breast cancer patients after surgery. Methods: In this study, differentially expressed genes (DEGs) were identified between relapse and nonrelapse breast cancer groups based on RNA sequencing. Gene set enrichment analysis (GSEA) was performed to identify potential relapse-relevant pathways. CIBERSORT and Microenvironment Cell Populations-counter algorithms were used to analyze immune infiltration. The least absolute shrinkage and selection operator (LASSO) regression, log-rank tests, and multiple Cox regression were performed to identify prognostic signatures. A predictive model was developed and validated based on Kaplan-Meier analysis, receiver operating characteristic curve (ROC). Results: A total of 234 out of 487 patients were enrolled in this study, and 1588 DEGs were identified between the relapse and nonrelapse groups. GSEA results showed that immune-related pathways were enriched in the nonrelapse group, whereas cell cycle- and metabolism-relevant pathways were enriched in the relapse group. A predictive model was developed using three genes ( CKMT1B , SMR3B , and OR11M1P ) generated from the LASSO regression. The model stratified breast cancer patients into high- and low-risk subgroups with significantly different prognostic statuses, and our model was independent of other clinical factors. Time-dependent ROC showed high predictive performance of the model. Conclusions: A multigene model was established from RNA-sequencing data to direct risk classification and predict relapse of hormone receptor-positive breast cancer in Chinese patients. Utilization of the model could provide individualized evaluation of chemotherapy after surgery for breast cancer patients.展开更多
The unobserved J^P= 0^-radial excitation Ds（2^1S0） is anticipated to have mass 2650 Me V（denoted as Ds（2650））. Study of hadronic production is an important way to identify highly excited states. We study hadroni...The unobserved J^P= 0^-radial excitation Ds（2^1S0） is anticipated to have mass 2650 Me V（denoted as Ds（2650））. Study of hadronic production is an important way to identify highly excited states. We study hadronic production of Ds（2650） from higher excited resonances in a3P0 model. Relevant hadronic partial decay widths are found to be very small, which implies it is difficult to observe Ds（2650） in hadronic decays of higher excited resonances. Hadronic decay widths of radially excited Ds（3P） have also been estimated. The total decay widths of four Ds（3P） are large, but the branching ratios in the Ds（2650）η channel are very small, which implies that it seems impossible to observe Ds（2650） in hadronic decays of Ds（3P）. The dominant decay channels of the four Ds（3P） have been pointed out, and D1（2420）, D1（2430）, D＊2（2460）, D（2550）, D（2600）,（1-1D2）D（2750） and D3^（2760） are possible to observe in hadronic production from Ds（3P）.展开更多
基金the National Natural Science Foundation of China ! 29672031 Fang Min FU of Chengdu institute of or
文摘An improved procedure for the preparation of China, BAD(P)H model. (S_s)- 1 -benzyl-3- (p-tolylsulfinyl)-1.4-dihydropyridine with satisfactary chemical yield and excellent enantiopurity is reported.
基金The special project of Detection of Haikou City Earthquake Active Faults from the Tenth Five-year Plan of China Earthquake Administration (0106512)Joint Seismological Science Foundation of China (105086)CAS Key Laboratory of Marginal Sea Geology (MSGL0503).
文摘Using over 3 500 first P arrival times recorded by nine digital seismic stations from Hainan Digital Seismic Net-work during 1999～2005,a 3-D P-wave velocity model of the crust under Hainan Island and adjacent regions has been determined. The results show that the pattern of velocity anomalies in the shallower upper crust is somewhat associated with the surface geological tectonics in the region. A relative low-velocity anomaly appears north of the Wangwu-Wenjiao fault zone and a relative high-velocity anomaly appears south of the Wangwu-Wenjiao fault zone,corresponding to the depressed areas in north Hainan Island,where many volcanoes are frequently active and geothermal values are relatively higher,and the uplifted and stable regions in central and south of the Hainan Is-land. In the middle and lower crust velocities are relatively lower in east Hainan than those in west Hainan,possi-bly suggesting the existence of the upwelling of hot materials from the mantle in east Hainan. The pattern of veloc-ity anomalies also indicates that NW faults,i.e.,the Puqian-Qinglan fault,may be shallower,while the E-W Wangwu-Wenjiao fault may be deeper,which perhaps extends down to Moho depth or deeper.
文摘Effective teaching is every teacher's teaching goal.How to reach the aim is to reflect on the teaching.The following document describes the development on how to reflect the teaching.The main purpose of this analysis is to show how effective and important the reflection on the teaching and to show how useful the reflection which can make the teacher change the way of teaching,encouraging the students to adopt a deep approach in their learning.
文摘This paper is about a reflective practice happened in the author' s College English teaching.Since 2005,a 5-minute oral-presentation was required for all the students in turn,in order to raise opportunities for them to practice oral English.But the students' responses were always disappointing since they only took the task as a burden.After the teacher lift the limits on presentation time,form,sequence,partner,etc.,better learning outcomes were achieved.When reflecting on this change,Biggs'3P Models of "constructive alignment" is taken into account.Any teaching and learning activity (TLA) cannot put the students' and the teacher' s presage aside since the students' ability,interests,motivation as well as the teacher' s objective,assessment approach and so on are co-determinants of a successful TLA.Further suggestions are given based on this reflection at the end of the paper.
基金the National Natural Science Foundation of China(grant no.81872219)Science and Technology Project of Hunan Provincial Health Commission(grant no.B2015-040)+2 种基金Major Scientific and Technological Projects in Hunan Province(grant no.2019SK1010)2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(grant nos.2020LKSFG18B,2020LKSFG02E)Guangdong University Innovation Team Project(grant no.2021KCXTD047).
文摘Background:The role of autophagy in the formation of hypertrophic scars(HS)remains unclear.This study aimed to explore the role and potential mechanism of autophagy during the development of HS.Methods:RNA and protein expression levels of Beclin-1,p62,and LC3II in normal skin tissues and HS specimens from different patients were examined.Autophagy inducers and inhibitors were used to cure established HS in rabbit ears,and the expression of Beclin-1,p62,and LC3II at the RNA and protein level was determined.Lastly,the effects of autophagy inducers and inhibitors on HS development were analyzed.Results:Compared to normal skin tissues,the expression of LC3II and Beclin-1 was higher(P<0.05),while that of p62 was lower(P<0.05)in HS tissues.In addition,the LC3II/LC3I ratio was increased during HS formation,and the altered expression of the three proteins stabilized after one year.Administration of autophagy inducers enhanced the formation of HS as well as the expression levels of LC3II and Beclin-1 but decreased p62 expression.Meanwhile,administration of autophagy inhibitors increased the expression of LC3II,Beclin-1,and p62,along with reduced HS formation.Conclusion:Autophagic activity increased during HS initiation and subsequent stabilization.In addition,autophagy inhibitors were able to inhibit HS formation by suppressing autophagy,whereas autophagy inducers promoted scar hyperplasia by enhancing autophagy。
基金The project partially supported by the National Natural Science Foundation of China
文摘The first three-fold and four-fold fragmentation measurements in hot compound nuclei pro-duced in the reactions of a 25 MeV/u <sup>40</sup>At beam with targets of <sup>209</sup>Bi,<sup>197</sup>Au,<sup>159</sup>Tb,<sup>115</sup>In,<sup>103</sup>Rh,and<sup>93</sup>Nb are presented.Various distributions are measured for these fragments,including distributions of ve-locities,relative velocities,angles,relative angles,masses,fragment mass ratios,total kinetic energies（TKE）,as well as the yield ratios of three-fold fragmentation to fission P<sub>32</sub> and the time difference △t be-tween two scissions after the formation of one compound nucleus.
基金supported by the National Key Research and Development Program of China(2019YFE0110000)National Natural Science Foundation of China(82072097)+1 种基金CAMS Innovation Fund for Medical Science(CIFMS)(2020-I2M-C&T-B-069,2021-I2M-1-014)and Beijing Hope Run Special Fund of Cancer Foundation of China(LC2020A18).
文摘Background: Breast cancer patients who are positive for hormone receptor typically exhibit a favorable prognosis. It is controversial whether chemotherapy is necessary for them after surgery. Our study aimed to establish a multigene model to predict the relapse of hormone receptor-positive early-stage Chinese breast cancer after surgery and direct individualized application of chemotherapy in breast cancer patients after surgery. Methods: In this study, differentially expressed genes (DEGs) were identified between relapse and nonrelapse breast cancer groups based on RNA sequencing. Gene set enrichment analysis (GSEA) was performed to identify potential relapse-relevant pathways. CIBERSORT and Microenvironment Cell Populations-counter algorithms were used to analyze immune infiltration. The least absolute shrinkage and selection operator (LASSO) regression, log-rank tests, and multiple Cox regression were performed to identify prognostic signatures. A predictive model was developed and validated based on Kaplan-Meier analysis, receiver operating characteristic curve (ROC). Results: A total of 234 out of 487 patients were enrolled in this study, and 1588 DEGs were identified between the relapse and nonrelapse groups. GSEA results showed that immune-related pathways were enriched in the nonrelapse group, whereas cell cycle- and metabolism-relevant pathways were enriched in the relapse group. A predictive model was developed using three genes ( CKMT1B , SMR3B , and OR11M1P ) generated from the LASSO regression. The model stratified breast cancer patients into high- and low-risk subgroups with significantly different prognostic statuses, and our model was independent of other clinical factors. Time-dependent ROC showed high predictive performance of the model. Conclusions: A multigene model was established from RNA-sequencing data to direct risk classification and predict relapse of hormone receptor-positive breast cancer in Chinese patients. Utilization of the model could provide individualized evaluation of chemotherapy after surgery for breast cancer patients.
基金Supported by National Natural Science Foundation of China(11475111)
文摘The unobserved J^P= 0^-radial excitation Ds（2^1S0） is anticipated to have mass 2650 Me V（denoted as Ds（2650））. Study of hadronic production is an important way to identify highly excited states. We study hadronic production of Ds（2650） from higher excited resonances in a3P0 model. Relevant hadronic partial decay widths are found to be very small, which implies it is difficult to observe Ds（2650） in hadronic decays of higher excited resonances. Hadronic decay widths of radially excited Ds（3P） have also been estimated. The total decay widths of four Ds（3P） are large, but the branching ratios in the Ds（2650）η channel are very small, which implies that it seems impossible to observe Ds（2650） in hadronic decays of Ds（3P）. The dominant decay channels of the four Ds（3P） have been pointed out, and D1（2420）, D1（2430）, D＊2（2460）, D（2550）, D（2600）,（1-1D2）D（2750） and D3^（2760） are possible to observe in hadronic production from Ds（3P）.
