By using red yeast (Rhodotorula rubra AS 2.166) resting cells which possess the phenylalanine ammonia-lyase (PAL, EC 4.3.1.5) activity as biocataiyst, enantiomerically pure S-3-(2-chloro-phenyl) alanine (2a) and S-3-(...By using red yeast (Rhodotorula rubra AS 2.166) resting cells which possess the phenylalanine ammonia-lyase (PAL, EC 4.3.1.5) activity as biocataiyst, enantiomerically pure S-3-(2-chloro-phenyl) alanine (2a) and S-3-(3-hydroxyphenyl) alanine (2d) have been synthesized from the corresponding 3-aryl substituted acrylic acid (1a and 1d) and ammonia.展开更多
S)-(+)-2-Amino-1-propanol, the key chiral intermediate of levofloxacin, was preparation from L-2-aminopropionic acid by methyl esterification, and then direct reduction by KBH 4 without purification with an overall yi...S)-(+)-2-Amino-1-propanol, the key chiral intermediate of levofloxacin, was preparation from L-2-aminopropionic acid by methyl esterification, and then direct reduction by KBH 4 without purification with an overall yield of 70%.展开更多
基金Project supported by the Chengdu Branch of Chinese Academy of Sciences and Chengdu Institute of Biology,Chinese Academy of Sciences.
文摘By using red yeast (Rhodotorula rubra AS 2.166) resting cells which possess the phenylalanine ammonia-lyase (PAL, EC 4.3.1.5) activity as biocataiyst, enantiomerically pure S-3-(2-chloro-phenyl) alanine (2a) and S-3-(3-hydroxyphenyl) alanine (2d) have been synthesized from the corresponding 3-aryl substituted acrylic acid (1a and 1d) and ammonia.
文摘S)-(+)-2-Amino-1-propanol, the key chiral intermediate of levofloxacin, was preparation from L-2-aminopropionic acid by methyl esterification, and then direct reduction by KBH 4 without purification with an overall yield of 70%.
