A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction bet...A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction between the antibody and target antigen. Compared with a unmodified S-taper fiber structure, the silanized fiber had a detection limit of approximately 8.33 × 10-5 RIU when the concentration of antigen solution was changed1%. The antibody and antigen binding processing was monitored in real time by analyzing and investigating the transmission spectral characteristics of the modified S-taper fiber. The cost-effectiveness, real-time detection,and high integration properties of the fiber enable its use in a modal interferometer for biosensing applications including disease diagnosis and biological specificity recognition.展开更多
基金supported partly by the National Natural Science Foundation of China (Grant No. 11804171, 11674177, 61775107)partly by Natural Science Foundation of Tianjin, China (Grant No. 16JCZDJC31000)partly by Self-made experiment teaching instrument project of Nankai University 2018 (Grant No. 2018NKZZYQ04)。
文摘A biosensor based on a modified S-taper fiber was proposed and experimentally demonstrated for antigen detection. Antibody was immobilized over the activated S-taper waist, where the fiber detected the interaction between the antibody and target antigen. Compared with a unmodified S-taper fiber structure, the silanized fiber had a detection limit of approximately 8.33 × 10-5 RIU when the concentration of antigen solution was changed1%. The antibody and antigen binding processing was monitored in real time by analyzing and investigating the transmission spectral characteristics of the modified S-taper fiber. The cost-effectiveness, real-time detection,and high integration properties of the fiber enable its use in a modal interferometer for biosensing applications including disease diagnosis and biological specificity recognition.
