Objective： To research the clinical curative effect and explore the mechanism of penetrating of scalp-point on acute hypertensive intracerebral hemorrhage （ICH）. Methods： 66 patients were randomly divided into two...Objective： To research the clinical curative effect and explore the mechanism of penetrating of scalp-point on acute hypertensive intracerebral hemorrhage （ICH）. Methods： 66 patients were randomly divided into two groups： one is the scalp-point therapeutic group, the other is the western medicine group. The two groups were all treated by dehydration, etc. In addition, there are 20 normal people to be set as the healthy group. To select the nervous functional deficit mark, activity of daily living （ADL） form, the amount S-100B protein as indexes and analysis the results. Results： the recordings indicate the patients＇ Serum S-100B protein are related with nervous functional deficiency mark. After 28 days, the recovery of patients＇ nervous function of scalp acupuncture group was obviously superior to that of control group （P〈0.05）. Conclusions： The results suggested that the patients＇ Serum S-100B had positive correlation with nervous functional deficit; The penetrating of scalp-point had the better regulatory effect on the level of Serum S-100B, and could improve the nervous functional deficit and ADL, so as to improve the coordination and compensation function and the general nervous function between cortical functional areas展开更多
Objective: To analyze the dynamic change of serum protein S100b in patients with traumatic brain injury and its clinical value in assessing brain damage. Methods: According to Glasgow coma scale (GCS), 102 cases of tr...Objective: To analyze the dynamic change of serum protein S100b in patients with traumatic brain injury and its clinical value in assessing brain damage. Methods: According to Glasgow coma scale (GCS), 102 cases of traumatic brain injury were divided into mild brain injury group (GCS≥13, n=31, Group A), moderate brain injury group (8<GCS<13, n=37, Group B) and severe brain injury group (GCS≤8, n=34, Group C). Serial S100b concentrations were analyzed by enzyme-linked immunosorbent assay (ELISA) in blood samples taken on admission, 12 h, 24 h, 48 h, 72 h and 7 days after traumatic brain injury. Results: The severe brain injury group showed significantly higher concentration of serum S100b, with earlier increase and longer duration, than the mild and moderate brain injury groups. The patients with higher S100b exhibited lower GCS scores and poor clinical prognosis. The increase in S100b could emerge before clinical image evidence indicated so. Conclusions: Serum S100b can be used as a sensitive index for assessment and prediction of traumatic brain injury severity and prognosis.展开更多
Objective： To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury. Methods： In this study, we reviewed the domestic and foreign research reports abo...Objective： To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury. Methods： In this study, we reviewed the domestic and foreign research reports about the relationship between S100B protein and craniocerebral injury. Results： The concentration of S100B protein had a different increase based on the degree of injury in early stage after craniocerebral injury, and the increasing degree of S100B protein showed a positive correlation with the grading of pathogenetic condition and prognosis of craniocerebral injury. Conclusions： S100B protein may be taken as a specific index of early diagnosis, grading of pathogenetic condition, and prognosis judgement after craniocerebral injury. To grasp and regulate the mechanism of neurotoxicity and to elucidate the therapeutic effect of S100B protein will be a research direction in clinical treatment of craniocerebral injury.展开更多
文摘Objective： To research the clinical curative effect and explore the mechanism of penetrating of scalp-point on acute hypertensive intracerebral hemorrhage （ICH）. Methods： 66 patients were randomly divided into two groups： one is the scalp-point therapeutic group, the other is the western medicine group. The two groups were all treated by dehydration, etc. In addition, there are 20 normal people to be set as the healthy group. To select the nervous functional deficit mark, activity of daily living （ADL） form, the amount S-100B protein as indexes and analysis the results. Results： the recordings indicate the patients＇ Serum S-100B protein are related with nervous functional deficiency mark. After 28 days, the recovery of patients＇ nervous function of scalp acupuncture group was obviously superior to that of control group （P〈0.05）. Conclusions： The results suggested that the patients＇ Serum S-100B had positive correlation with nervous functional deficit; The penetrating of scalp-point had the better regulatory effect on the level of Serum S-100B, and could improve the nervous functional deficit and ADL, so as to improve the coordination and compensation function and the general nervous function between cortical functional areas
文摘Objective: To analyze the dynamic change of serum protein S100b in patients with traumatic brain injury and its clinical value in assessing brain damage. Methods: According to Glasgow coma scale (GCS), 102 cases of traumatic brain injury were divided into mild brain injury group (GCS≥13, n=31, Group A), moderate brain injury group (8<GCS<13, n=37, Group B) and severe brain injury group (GCS≤8, n=34, Group C). Serial S100b concentrations were analyzed by enzyme-linked immunosorbent assay (ELISA) in blood samples taken on admission, 12 h, 24 h, 48 h, 72 h and 7 days after traumatic brain injury. Results: The severe brain injury group showed significantly higher concentration of serum S100b, with earlier increase and longer duration, than the mild and moderate brain injury groups. The patients with higher S100b exhibited lower GCS scores and poor clinical prognosis. The increase in S100b could emerge before clinical image evidence indicated so. Conclusions: Serum S100b can be used as a sensitive index for assessment and prediction of traumatic brain injury severity and prognosis.
文摘Objective： To explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury. Methods： In this study, we reviewed the domestic and foreign research reports about the relationship between S100B protein and craniocerebral injury. Results： The concentration of S100B protein had a different increase based on the degree of injury in early stage after craniocerebral injury, and the increasing degree of S100B protein showed a positive correlation with the grading of pathogenetic condition and prognosis of craniocerebral injury. Conclusions： S100B protein may be taken as a specific index of early diagnosis, grading of pathogenetic condition, and prognosis judgement after craniocerebral injury. To grasp and regulate the mechanism of neurotoxicity and to elucidate the therapeutic effect of S100B protein will be a research direction in clinical treatment of craniocerebral injury.
